Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.

Abstract: Disclosed is a targeted delivery system for a hydrophobic antitumor drug, referring to conjugates of E-selectin polypeptide ligand-polyethylene glycol-antitumor drug connected by different link bridges containing disulfide bonds. The synthesis of the conjugates, antitumor activity evaluation, the particle size and morphology characteristics of nanoparticles self-assembled by the conjugates in an aqueous solution, and the release of the antitumor drug in different conditions are comprised. The conjugates can actively target at vessels of a tumor site by the E-selectin peptide ligand, and can also self-assemble into nanoparticles in an aqueous solution, so as to be passively targeted at the tumor site by EPR effect.

Abstract: The present disclosure relates to wheat plants having grain with high ?-glucan content, methods for constructing said wheat plants, grain therefrom and uses thereof. Wheat lines homozygous for the HvCslF6 gene from barley having five times the fiber content and an increased ?-glucan content of TA5790, TA5792, and TA5795 are disclosed.

Abstract: Methods and apparatus for a three-stage ventricular cardioversion and defibrillation therapy that treats ventricular tachycardia and fibrillation at low energy levels. An implantable therapy generator adapted to generate and selectively deliver a three-stage ventricular therapy and at least two leads operably each having at least one electrode adapted to be positioned proximate the ventricle of the patient. The device is programmed to deliver a three-stage therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of a ventricular arrhythmia. The three-stage therapy includes a first stage for unpinning of one or more singularities associated with the ventricular arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities associated delivered via the near-field configuration of the electrodes.

Abstract: A microelectromechanical system (MEMS) sensor includes a substrate having a piezoelectric layer thereon; a MEMS piezoelectric resonator including a reference electrode on a first side of the piezoelectric layer, a first port (port 1) including a capacitor coupling electrode on a side of the piezoelectric layer opposite the first side, and a second port (port 2) for excitation signal coupling including another electrode on the side opposite the first side. The MEMS piezoelectric resonator has a natural resonant frequency. A variable capacitor on the substrate is positioned lateral to the MEMS piezoelectric resonator having a first and a second plate are connected to port 1. An antenna or an oscillator circuit is connected to port 2. Responsive to a physical parameter a capacitance of the variable capacitor changes which changes a frequency of the MEMS piezoelectric resonator relative to the natural resonant frequency to generate a frequency shift.

Abstract: The present invention relates to a method for reducing the complexity of bio-crudes. The method includes (a) obtaining experimental data of quantitative and qualitative analyses for the bio-crudes, (b) grouping compounds contained in the bio-crudes according to a predetermined basis based on the experimental data, (c) selecting representative compounds from among the compounds belonging to the same group, and (d) reconstituting the bio-crudes as a mixture of the representative compounds. In the method for reducing the complexity of the bio-crudes for process simulation according to the present invention, the number of constituent compounds of the bio-crudes is minimized and the physical properties of the bio-crudes are accurately represented using only experimental data obtained through GC-MS, thereby enabling accurate and efficient process simulation of the bio-crudes.

Abstract: A method of verifying randomness of a bitstream is disclosed. The method includes receiving a bitstream consisting of n consecutive bits and dividing the bitstream into a plurality of bit blocks. In this case, n is a natural number of two or greater, each of the bit blocks consists of m consecutive bits, and m is a natural number of two or greater and is smaller than n. Further, the method includes allocating the plurality of bit blocks to a plurality of core groups in a graphics processing unit (GPU), processing the allocated bit blocks in the plurality of core groups in parallel, calculating random number level values of the allocated bit blocks, and determining whether the bitstream has randomness based on the calculated random number level values. Each of the core groups includes a plurality of cores capable of performing identical or similar tasks without separate synchronization.

Abstract: The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of these cells obtained from non-enriched, i.e., the mononuclear fraction of the biological sample. The present invention further describes the transplantation regimen of the expanded hematopoietic graft developed through xenotransplantation studies. In a preferred embodiment, the combination comprising the azole based compounds and cytokines selected from SCF, TPO, FLT-3L and IGFBP-2 and results in the expansion of expansion of CD45+CD34+CD38?CD45RA?CD90+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA?CD90+CD49f+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA? hematopoietic progenitor cells from the mononucleated cells isolated from umbilical cord blood.

Abstract: Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

Abstract: Disclosed are systems and methods of sensor fusion for exemplary use with robotic navigation control. Systems and methods include providing local estimates of a target location from a plurality of expert modules that process sensor data. The local estimates are weighted based upon a Mahalanobis distance from an expected estimated value and based upon a Euclidean distance between the local estimates. The local estimates are fused in a Bayesian fusion center based upon the weight given to each of the local estimates.

Abstract: An encryption method is provided. According to the encryption method, a scaling factor may be reflected in a message and then, a homomorphic ciphertext may be generated using a public key. The generated ciphertext is, when decryption is performed, generated in a form that a result value obtained by adding an error value to a value obtained by reflecting the scaling factor in the message is restored. Accordingly, a homomorphic ciphertext capable of being computed in a ciphertext state can be effectively generated.

Abstract: A system for providing a virtual data storage medium according to an embodiment of the invention may be a system for providing a virtual data storage medium using data storage federation, where the system may include: heterogeneous data storage media including a multiple number of data storage media using different interfaces, protocols, and commands for using stored data; and a federation unit configured to generate a virtual data storage medium by federating the heterogeneous data storage media.

Abstract: A biological model creation apparatus sets a plurality of control points respectively corresponding to a plurality of target points set on a plurality of valve annuli of a specified heart, on a plurality of valve annuli in a mesh model of a heart. Then, the biological model creation apparatus determines the positions of the control points in the mesh model on the basis of a first and second evaluation value regarding the positions of the plurality of control points. The first evaluation value indicates a degree of matching to relative positions among target points belonging to the same valve annulus. The second evaluation value indicates a degree of matching to relative positions among target points belonging to different valve annuli. Then, the biological model creation apparatus deforms the mesh model such that the positions of the plurality of control points coincide with the positions of their corresponding target points.

Abstract: An object of the present invention is to provide: an anti-GPC3 antibody that recognizes an epitope different from that for existing antibodies (e.g., GC33 and GC199) and can specifically bind, even in the form of single chain antibody, to GPC3 localized on a cell membrane; CAR comprising the anti-GPC3 single chain antibody; an immunocompetent cell expressing the CAR; a gene of the anti-GPC3 antibody or a gene of the CAR; a vector comprising the anti-GPC3 antibody gene or the CAR gene; a host cell in which the vector has been introduced; a method for specifically detecting GPC3; and a kit for specifically detecting GPC3. An antibody comprising particular heavy chain CDR1 to CDR3 and particular light chain CDR1 to CDR3 defined in claim 1, and specifically binding to a human-derived GPC3 polypeptide specifically binds to GPC3 localized on a cell membrane. CAR-immunocompetent cells prepared on the basis of CAR comprising such single chain antibody are useful for cancer immunotherapy.

Abstract: A peptide consisting of an amino acid sequence of GPPGPAG (SEQ ID NO: 1) is disclosed. According to the present invention, a novel compound for improving memory disorder is provided.

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Abstract: The present disclosure describes the fusogenic activity of the Myomaker protein. This polypeptide, when expressed in non-muscle cells, is able to drive fusion of the cell with a muscle cell, but not with other non-muscle cells. The use of this protein and cell expressing it in the delivery of exogenous genetic material to muscle cells also is described.

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

Abstract: There is provided a glaucoma surgery visualization apparatus. The apparatus has a goniolens which is rotationally coupled to a novel scleral retention device. The apparatus allows for viewing of the irido-corneal angle structures of the eye and related surgical procedures. The scleral retention device uses vacuum to temporarily adhere the apparatus to the sclera. Surgical apertures allow for surgical access, while the goniolens can rotate within the scleral retention device to facilitate proper viewing of the irido-corneal angle structures before, during and after surgery. An optional light source serves to illuminate the field of viewing to further assist the surgeon during various procedures that involve the glaucoma surgery visualization apparatus.