Abstract: A frequency comb generator including a semiconductor, wherein the semiconductor outputs a frequency comb in response to frequency mixing of an optical field and at terahertz field in the semiconductor using a high order sideband (HSG) mechanism. The frequency comb spans a bandwidth sufficient for self-referencing and may be used in optical clock applications, for example.

Abstract: A system for embedding phase and amplitude into a real valued unipolar signal suitable for intensity modulation (IM) by optical transmitters. The system includes a complex-to-unipolar conversion engine configured to receive complex symbols in Cartesian format and convert the complex symbols from the Cartesian format to a polar coordinate format and generate real valued unipolar symbols including embedded phase and amplitude information of complex symbols in the Cartesian format.

Abstract: The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.

Abstract: The present invention describes the use of the Chinese medicinal compounds ginsenoside RB1, dihydromyricetin and salvianohc acid B, for use in diagnosing, monitoring and treating synucleinopathies, such as Parkinson's disease, in patients.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: Aspects of the disclosure provide a method and system for power amplifier characterization and digital predistortion. The method includes receiving a test signal including K samples with a sampling rate fS, generating a synthetic test signal including the test signal and a sequence of (N?1) delayed versions of the test signal, generating an under-sampled signal including M samples by sampling, at a sampling rate fS/N, an output signal of a device-under-test (DUT) with the synthetic test signal as an input of the DUT, the M samples of the under-sampled signal including N segments each including K/N samples, and generating a reconstructed signal including the M samples of the under-sampled signal.

Abstract: A structure includes an electronically controllable ferromagnetic oxide structure that includes at least three layers. The first layer comprises STO. The second layer has a thickness of at least about 3 unit cells, said thickness being in a direction substantially perpendicular to the interface between the first and second layers. The third layer is in contact with either the first layer or the second layer or both, and is capable of altering the charge carrier density at the interface between the first layer and the second layer. The interface between the first and second layers is capable of exhibiting electronically controlled ferromagnetism.

Abstract: Provided herein are methods and compositions for the treatment of wounds in a mammalian subject. Particularly, novel bioactive polypeptides are provided that promote tissue repair and regeneration, including the activation of/stimulation of wound healing and wound closure, stimulate keratinocyte and endothelial cell motility and/or proliferation.

Abstract: A Pediococcus acidilactici derived antimicrobial hexapeptide and a preparation method thereof are disclosed herein. The antimicrobial peptide ENGEEE (SEQ ID NO: 1) is reported for the first time. Antimicrobial peptide lactein R16 has good pH stability and thermal stability, has an effect on inhibiting Escherichia coli, Listeria monocytogenes and Staphylococcus aureus and is capable of effectively reducing the amount of the Escherichia coli in soybean meal. Secondly, the antimicrobial peptide lactein R16 has a certain effect on proliferating Saccharomyces cerevisiae and Lactobacillus plantarum and has certain capability of clearing hydrogen peroxide, hydroxyl radicals, DPPH radicals and superoxide anions. The antimicrobial peptide lactein R16 can be used for biological control and can be used as a feed additive to play important roles in substituting antibiotics and solving the feed safety problem.

Abstract: Methods are generally disclosed for attaching a cell binding motif to a carboxy end of a coat protein of a Tobacco Mosaic Virus particle to form a modified-TMV particle; and attaching a cell to the cell binding motif of the modified-TMV particle. Methods are also disclosed for incorporated virus particles, e.g., TMV virus particles into hydrogels.

Abstract: A method for constructing networked preferential gas migration pathways and diverting and extracting gas. The method proposes that a fracture generation hole, a fracture guidance and development hole, a lateral rupture hole, and a fracture connection hole are respectively constructed in a roof in roadways on two sides of a working face in advance of an advance stress change area. Artificial guided fractures are actively constructed and formed inside the hard roof. Under a mining-induced stress effect, the artificial guided fractures and mining-induced fractures intersect with and are connected to each other to form networked preferential gas migration pathways. Meanwhile, boreholes for artificial guided fractures accelerate roof fracturing to form a rupture bed separation fracture area in a roof. Gas flows and migrates in a timely and efficient manner along networked fracture pathways and concentrates in the rupture bed separation fracture area in the roof.

Abstract: The invention provides a metallopolymer coordination network comprising one or more coinage or similar metals and a glyme or glyme-equivalent. The composition has an amorphous polymer network that is significantly stronger than previously reported supramolecular hydrogels synthesized without glyme. Glyme chain length and water content strongly influence the mechanical, electronic, and optical behavior of the network.

Abstract: Provided herein are systems, methods, and apparatuses for simulating ailments that can be diagnosed by an abdominal palpation exam. Furthermore, provided herein are systems, methods, and apparatuses for analyzing an abdominal palpation exam. An abdominal simulator may include a surface layer, a sensor layer beneath the surface layer, a muscle layer beneath the sensor layer, a tensing layer beneath the muscle layer, an ailment module layer beneath the tensing layer, and a control portion. The abdominal simulator may simulate an ailment that can be diagnosed by an abdominal palpation exam. The abdominal simulator may also detect at least one abdominal palpation that is performed by a user on the abdominal simulator to diagnose the ailment that was simulated by the abdominal simulator. Moreover, the abdominal simulator may determine data for the at least one abdominal palpation that was detected.

Abstract: Hyaluronic acid modified with sphingosine-1-phosphate, and a medicine comprising the hyaluronic acid as an active ingredient, wherein the medicine can alleviate hepatic disorder caused by hypoxia/reoxygenation by protecting the liver sinusoidal endothelial cells, and the medicine can prevent and/or treat liver failure due to liver transplantation, hepatectomy, or other surgeries associated with liver ischemia/reperfusion.

Abstract: A growing medium for a plant production apparatus utilized in greenhouse crop production is provided. The growing medium comprises a fibrous, non-woven matrix media material wherein the media material is constructed from a plastic material.

Abstract: The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects.

Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, R4 and ring A have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as anti-cancer agents.

Abstract: Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a microwell having a volume less than one microliter, and wherein the acoustic transducer is coupled to the microfluidic chip via a coupling medium.

Abstract: Apparatuses, methods, and computer program products for analyzing target compounds. An excitation signal comprising light having a time-varying intensity is transmitted into a target compound. In response to receiving the excitation signal, the target compound generates an emission signal. To increase the intensity of the emission signal, a fluorophore may be provided to the target compound. The fluorophore may be configured to react with a characteristic of the target compound so that the fluorophore generates the emission signal in response to the presence of both the characteristic and the excitation signal. The emission signal may be compared to the excitation signal in a frequency domain to determine a phase of the emission signal relative to the excitation signal. The phase may be used to determine a luminescence lifetime of the emission signal. If the detected luminescence lifetime matches an expected luminescence lifetime, the target compound likely includes the characteristic.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.