Abstract: Disclosed herein are methods involving the targeting of 5HT biosynthesis in gut insulin-negative cells to convert them into insulin-positive cells. Also disclosed are methods for treating a disease or disorder in a mammal, preferably a human, associated with impaired pancreatic endocrine function, by administering a therapeutically effective amount of an enumerated active agent that reduces the expression, biosynthesis, signaling or biological activity of serotonin or increases its degradation, wherein administering comprises delivering the agent to Gut Ins? cells in the mammal. Other embodiments of the method are directed to therapy wherein an agent that significantly reduces FOXO1 expression, biosynthesis, signaling or biological activity or increases its degradation is administered in addition to the agent that reduces serotonin, or alternatively an agent that reduces FOXO1 expression is targeted to serotonin-positive gut enteroendocrine cells.

Abstract: A codeset is described in a Public Codeset Communication Format (PCCF) as a format block including a plurality of fields having readily decipherable values, such as ASCII character values. One field is a mark/space information field that includes a sequence of mark time indicators and space time indicators for an operational signal of the codeset. A second field is a signal characteristic information field for the operational signal. Signal characteristic information may include carrier on/off information, repeat frame information, toggle control information, and last frame information. The PCCF is a codeset interchange format of general applicability.

Abstract: Disclosed are D-peptide compositions and methods for inhibiting HIV entry into host cells.

Abstract: Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CGC) under isotonic conditions. The hypotonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectum at its CGC will form a “plug” of gel in the lumen.

Abstract: The present disclosure provides a zeolite-based compound having a high crystallinity, a method for producing the zeolite-based compound, and a method for producing methyl acetate using the zeolite-based compound. The zeolite-based compound includes a zeolite-based core; and a surface-portion formed on at least a portion of a surface of the zeolite-based core and made of ferrierite.

Abstract: A method to coat oxide-based color pigments with an ultrasound-assisted coating of nanofiber or other nanostructures in order to enhance heat-fastness and color performance to said color pigments is presented. In particular, the present invention provides a method to coat oxide-based color pigments with nano-coating materials, including but not limited to, alumina and/or silica at different dosage levels, with nanospike, nanoneedle, nanoplate, and/or nanoflower morphology towards enhancing the heat-fastness and color performance of said color pigments.

Abstract: The present invention relates to a composition comprising at least one ISCOM complex and at least one ectodomain from at least one hemagglutinin (HA) domain and at least one ectodomain from at least one neuraminidase (NA) domain from one or more influenza virus, wherein the extodomains represent ectodomains isolated from the influenza virus. The invention also regards a kit. The composition may be used as an immune stimulating medicine, immune modulating pharmaceutical or a vaccine e.g. against influenza for vertebrates, e.g. birds and mammals.

Abstract: A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s—NH—(CH2)t, (CH2)s—O—(CH2)t, or (CH2)s—C(NH2)—(CH2)v—NH—(CH2)t, where s, t and v are each, independently an integer from 1 to 5; A and B are each, independently, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; C and D are each, independently, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-C1-6 alkyl, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; each Rg is, independently, halogen, C1-6 alkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, or di-C1-6alkylamino; and n1 and p1 are each, independently, integers from 1 to 10.

Abstract: A musical instrument for electronically producing music from audio segments. The musical instrument comprises: an apparatus having a first surface; a plurality of selectable elements disposed in a substantially circular geometry on the first surface; and at least one memory storing the plurality of audio segments, each of the plurality of audio segments being associated with a respective selectable element in the plurality of selectable elements, wherein, in response to detecting selection of a subset of the plurality of selectable elements, the system is configured to generate music using audio segments in the plurality of audio segments that are associated with the selected subset of the plurality of selectable elements.

Abstract: Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.

Abstract: The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor.

Abstract: Provided is a piezo-actuated planar motor, comprising a planar substrate and a mover installed on the planar substrate, the piezo-actuated planar motor further comprising: at least one piezo driving leg which is disposed on said mover so as to drive said mover to move on said planar substrate omnidirectionally in the plane. Further provided is a method of driving a planar motor by using piezo driving legs, which implements three movement modes, i.e., a sliding mode, a walking mode, and a fine tuning mode. The sliding mode has the fastest speed of motion, the walking mode has a relatively slow speed of motion but has a high positioning accuracy and a high-accuracy tracking capability, and the fine tuning mode is used for the adjustment of the planar motor at a final position and has the highest positioning accuracy. The piezo-actuated planar motor of the present invention can effectively overcome the defects of a small movement range and a low speed in a conventional nano-positioning platform.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solid-phase particles in a liquid that comprises at least one precursor compound, which comprises one or more metallic elements of at least one metal oxide, to form droplets of said slurry, and calcining the droplets to at least partially decompose the at least one precursor compound and form the metal oxide-containing powder having a non-hollow morphology.

Abstract: The present invention discloses a new series of host materials for OLEDs based on fused indolocarbazoles. These compounds can improve the device EQE and lifetime.

Abstract: An electric device for detecting pressure and a pressure sensor includes an electric current channel arranged to conduct an electric current, wherein the electric current channel is disposed adjacent or proximate to a pressure sensitive structure. Upon the pressure sensitive structure being subjected to a change of an external pressure, the pressure sensitive structure is arranged to manipulate a first electrical characteristic of the electric current channel.

Abstract: A composition of graphene oxide free-standing film, a method of making the film, and a method of using the film to shield electromagnetic radiation particularly at microwave frequencies from 1 GHz to 12 GHz. The composition comprises stacked layers of graphene oxide nanosheets oriented parallel to the film surface and stacked layers of graphene oxide nanosheets oriented perpendicular to the film surface. The method of making the composition includes forming graphene oxide by arc-discharge between graphite electrodes in the presence of oxygen gas to form a graphene oxide soot, suspending the graphene oxide soot in water to form a colloid, depositing the colloid onto a substrate to form a wet paper, and drying the wet paper to form the film. The method of using the composition to shield electromagnetic radiation includes enclosing and/or encapsulating an electromagnetic radiation generating source with the free-standing film to shield electromagnetic radiation.

Abstract: An inventive approach is disclosed to integrate Digital Image Correlation (DIC) with the Acoustic Emission method that may be used for structural health monitoring and assessment of critical structural components in civil, mechanical, and aerospace industries. The inventive approach relies on passively recording acoustic emission across the specimen being tested and activating the DIC cameras automatically to measure deformation on the specimen's surface. The resulting acousto-optic system can be used to determine damage initiation, progressive damage development, identify critical regions and make lifetime predictions of the tested specimen.

Abstract: This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.

Abstract: A system and method for providing multivariate climate change forecasting are provided that obtain, from one or more climate model datasets, simulated historical and future climate model data, and from one or more climate observational datasets, historical observed climate data. A statistical distribution, using a Bayesian model, is provided of extremes or climate indices for one or more variable climate features using the simulated climate model data and the observed climate data. One or more metrics are determined, including a prediction of a future climate variable for a determined future time period, a confidence bound of the prediction of the future climate variable for the determined future time period, and a prediction bound for the future climate variable for the determined future time period. The metrics can be transmitted to a variety of applications in a variety of formats.