Abstract: The intraoral attachment clip for attaching objects to edentulous ridges has a flexible body configured as an elongated U-shaped strip that is designed to be conformed to an edentulous ridge. The clip has a lower or tissue surface adapted for contacting the mucosal surface of the ridge and an upper or oral surface facing the oral cavity. The tissue surface of the clip includes a plurality of micro-projections and an adhesive for securing the device to the underlying mucosal surface of the edentulous ridge. Tracking sensors and/or radiopaque fiducial markers can be attached to the oral surface of the clip for use with surgical navigation systems and imaging procedures. Sustained release drugs may be added to the tissue surface of the device for administering time-release medications through the mucosa over a prolonged period of time.

Abstract: The present disclosure provides intramedullary mandibular implants for the temporomandibular joint. The mandibular implants include a stem portion, a collar portion and a head portion. The stem, collar and head portions may be integral. The stem portion may define an inferior end and the head portion may define a superior end of the implants. The head portion may be arcuate in the sagittal plane to provide an articulating surface with a fossa or a fossa component. The collar portion may be intermediate of the head and stem portions and form a channel between an interior surface of the collar portion and an exterior surface of the stem portion. In use, the stem portion may be implanted within a condyle of a mandible such that an end portion of the condyle is situated within the channel of the implant and the head portion articulates with the fossa or fossa component.

Abstract: Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed.

Abstract: The steel panel with an integrated corrosion sensor is a steel panel having an integrated sensor for monitoring dissolution of a magnetite layer during acid cleaning of the steel panel. The steel panel has an opening formed therethrough, and a hollow insulator is secured to the steel panel within the opening. The hollow insulator is formed from an electrical insulation material and electrically isolates the steel panel from a steel core, which is mounted within the hollow insulator. A reference electrode is positioned near the steel panel. A voltmeter is electrically connected between the reference electrode and a first surface of the steel core. An opposed second surface of the steel core has a layer of magnetite formed thereon. An alarm is in electrical communication with the voltmeter, such that the alarm generates an alarm signal when the voltmeter detects a corrosion potential at a preset threshold potential.

Abstract: A memory element includes a free magnetization layer (“FR-ML”) in a film form, a nonmagnetic layer (“NML”), and a fixed magnetization layer (“FX-ML”), The NML and FX-ML are stacked on the FR-ML. The FR ML stores a single bit of data “0” or “1” according to a magnetization direction and rewrites the data by reversing the magnetization direction. An antiferromagnet that exhibits the anomalous Hall effect and has a reversible magnetization direction is used for the FR-M. The reversal of the magnetization direction of the FR-ML is performed using the FX-ML by the spin-transfer torque technique. To read data, a reading current is caused to flow in one direction, and a Hall voltage generated in the FR-ML by the anomalous Hall effect is extracted from the FR-ML. The polarity of the Hall voltage is reversed in accordance with the magnetization direction of the FR-ML.

Abstract: A CubeSat satellite has a solar cell and an arc propulsion system. The arc propulsion system includes a power source, a first lead coupled to the power source and to a cathode, and a second lead coupled to the power source and to an anode. The solar cell is used as the cathode of the propulsion system.

Abstract: An array of rolled-up power inductors for on-chip applications comprises at least two rolled-up power inductors connected in series and formed from a stack of multilayer sheets. The array includes a first rolled-up power inductor comprising a first multilayer sheet in a rolled configuration about a first longitudinal axis and second rolled-up power inductor comprising a second multilayer sheet in a rolled configuration about a second longitudinal axis. The first and second rolled-up power inductors are laterally spaced apart. The first multilayer sheet comprises a first patterned conductive layer on a first strain-relieved layer, and the second multilayer sheet comprises a second patterned conductive layer on a second strain-relieved layer. Prior to roll-up of the second and first multilayer sheets, the second multilayer sheet is disposed on the first multilayer sheet, and a through-thickness first via connects the second patterned conductive layer with the first patterned conductive layer.

Abstract: This invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. Specifically, the present invention provides a polymer comprising rigorously alternating AB subunits and methods of formation of the AB alternating polymers. In the polymers and process of the invention, the A monomer is derived from a cyclobutene derivative, and the B monomer is derived from a cyclohexene derivative. The polymerization takes place in the presence of an olefin metathesis catalyst.

Abstract: The disclosure provides methods for selecting modified plants with a mutation in a target gene and plants produced by the methods. Specifically, the disclosure provides methods comprising introducing a recombinant expression cassette encoding a genome editing protein into meristematic or germline cells of a parent plant, wherein the genome editing protein specifically recognizes a target gene; crossing or selfing the parent plant, thereby producing a plurality of progeny seeds; and selecting progeny plants grown from the progeny seeds that express a phenotype that can be selected at the intact plant level.

Abstract: Systems and methods are described for determining an orientation and position of a capsule inserted into the body of a patient. A magnetic field is applied to an area of the patient where the capsule is located. Sensor data, including inertial data from an inertial sensor and magnetic field data indicative of the applied magnetic field as detected by at least one magnetic field sensor, is wirelessly received from the capsule. An orientation angle of the capsule is determined based at least in part on the inertial data. The magnetic field data is compared to known characteristics of the applied magnetic field and a location of the capsule is determined based on the comparison.

Abstract: The present application provides solvent-free methods for decarboxylation of amino acids via imine formation with a ketone, enone, enal, aldehyde co-reagent or combination thereof, under heated conditions, with optional recovery of the co-reagent and/or co-reagent byproduct.

Abstract: A system for use in controlling operating functions of a controllable device includes a hand-held device and an intermediate device in communication with the hand-held device and the controllable device. The hand-held device is adapted to receive a gesture based input and to transmit a signal having data representative of the gesture based input. The intermediate device has programming for translating the data representative of the gesture based input in a signal received from the hand-held device into a command signal to be communicated to the controllable device wherein the command signal has a format appropriate for controlling an operating function of the controllable device that is associated with the gesture based input.

Abstract: Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.

Abstract: A hybrid distributed amplification method based on a random fiber laser generated within erbium fiber with low doping concentration, i.e. weak erbium-doped fiber (WEDF), which includes: Step 1. constructing a fiber link via WEDF; Step 2. generating the random fiber laser based on the fiber link, the pump source, the wavelength division multiplexer and the strong feedback module; Step 3. constructing the spatial equalized gain based on hybrid gain of the erbium fiber and random fiber laser; Step 4. the signal is amplified by the hybrid spatial equalized gain. The present invention solves the typical problem of high laser threshold and low pump conversion efficiency when conventional fiber is used to generate random fiber laser for distributed amplification.

Abstract: The subject disclosure presents systems and computer-implemented methods for assessing a risk of cancer recurrence in a patient based on a holistic integration of large amounts of prognostic information for said patient into a single comparative prognostic dataset. A risk classification system may be trained using the large amounts of information from a cohort of training slides from several patients, along with survival data for said patients. For example, a machine-learning-based binary classifier in the risk classification system may be trained using a set of granular image features computed from a plurality of slides corresponding to several cancer patients whose survival information is known and input into the system. The trained classifier may be used to classify image features from one or more test patients into a low-risk or high-risk group.

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

Abstract: A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

Abstract: A carbon nanotube (CNT) based electrode and method of making the same is disclosed. The CNT based electrode can have a microelectrode made substantially from a substantially inert metal, a first CNT sheet and a second CNT sheet, wherein the first and second CNT sheets are embedded in a collagen film.

Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.

Abstract: A method and apparatus for deploying edge servers are provided. The method includes: obtaining IP addresses of target users for the edge server to be deployed; mapping the IP addresses of the target users into a virtual geometric space; clustering the target users based on coordinates of the target users in the virtual geometric space, to obtain a plurality of user groups; and determining locations of the edge servers corresponding to the plurality of user groups based on the coordinates of the target users in the plurality of user groups.