Abstract: The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

Abstract: Disclosed are methods and apparatus for determining the properties of artificial membranes (e.g., artificially prepared lipid bilayers and biomimetic membranes comprising amphiphilic copolymers). Multiple physical properties of the membranes can be determined via a combination of electrical and optical measurements. The optical and electrical measurements can be determined using a single apparatus, which can also be used to prepare the artificial membrane. Methods are also disclosed for determining the effects changes in the composition of the artificial membrane, such as the addition of a drug or a change in lipid content.

Abstract: Provided is a caption replacement service system and method for servicing an interactive advertisement on a video on demand (VOD). A system for making an annotation may include an annotation creator configured to create annotation information on a moving object included in a video and an annotation player configured to play a preview on the annotation information based on a frame unit or a shot unit of the video. The video and the annotation information may be used to provide an interactive advertisement by replacing a caption system of the video with a meaningful annotation.

Abstract: Flexible electrical devices comprising electrode layers on softening polymers and methods of manufacturing such devices, including lift-off processes for forming electrodes on softening polymers, processes for forming devices with a patterned double softening polymer layer, and solder reflow processes for forming electrical contacts on softening polymers.

Abstract: A superconductive coil module includes a superconductive coil a superconductive coil and a shaking coil. The superconductive coil includes a bobbin having a cylindrical shape, and a superconductive wire member of superconductive property, which surrounds an outer circumferential surface of the bobbin. The superconductive coil is configured to generate a magnetic field along a radial direction in case of a charging event. The shaking coil is disposed adjacent to the superconductive wire member, and is configured to generate an alternating magnetic field to decrease a magnitude of a screening current induced magnetic field formed in the superconductive wire member. Thus, the superconductive coil module includes the shaking coil to decrease the magnitude of a screening current induced magnetic field formed in the superconductive wire member using a voltex shaking effect to maintain a central magnetic field uniform.

Abstract: The lack of clear predictors of prostate cancer progression leads to subjective decision-making regarding courses of treatment. The identification of new biomarkers that are predictive of recurrence after radical prostatectomy would advance the field of prostate cancer treatment. Disclosed are miRNAs that can be used as molecular biomarkers to detect or predict the progression of prostate cancer and to adjust a treatment plan accordingly. Furthermore, kits are included for the detection of these miRNAs.

Abstract: Described herein are a processor and a method of operating the processor to simulate a many-core target machine. The processor includes a plurality of processing cores arranged in a predetermined manner and a global target clock counter (GTCC) configured to count a number of simulated clock cycles in the target machine. A global stall controller (GSC) configured to halt execution of all the processing cores based on a determination of at least one processing core being in a fault condition; and wherein the processor acquires a base clock per instruction (CPI) of a target machine, the CPI corresponding to an average number of clock cycles required by the target machine to execute a single instruction, translates an application of the target machine to a compact executable trace to be executed by the processor, and adjusts a speed of simulation by adjusting an update rate of the global target clock counter.

Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys. and thereby is immune to traditional database hacking attacks.

Abstract: Provided are a method and a device for transmitting and receiving multimedia data. The present invention comprises: receiving of multimedia data and confirming of loss data; determining, with respect to the degree of the loss of the received data, of whether or not the lost data can be recovered by means of application layer forward error correction (AL-FEC); if data recovery by means of the AL-FEC is not possible, making of an automatic retransmission request (ARQ) with respect to the lost data; and receiving of data retransmitted with respect to the ARQ and recovering of the lost data.

Abstract: A method of detecting single molecule includes: providing a carrier, wherein the carrier includes a substrate, and a plurality of three-dimensional nanostructures are located on the substrate; disposing single molecule samples on the plurality of three-dimensional nanostructures; detecting the single molecule samples with a detector; wherein each three-dimensional nanostructure includes a first rectangular structure, a second rectangular structure, and a triangular prism structure; the first rectangular structure, the second rectangular structure, and the triangular prism structure are stacked in that order, a first width of a bottom surface of the triangular prism structure is equal to a second width of a first top surface of the second rectangular structure and greater than a third width of a second top surface of the first rectangular structure, and the first rectangular structure comprises a first metal and the triangular prism structure comprises a second metal.

Abstract: The present invention provides a pharmaceutical composition for use in treating an intractable heart tissue fibrosis disease accompanied by chronic heart failure. The pharmaceutical composition for use in treating an intractable heart tissue fibrosis disease accompanied by chronic heart failure comprises, as an active ingredient, at least one member selected from the group consisting of protease inhibitors, thromboxane A2 synthase inhibitors, thromboxane A2 synthase antagonists, phosphodiesterase (PDE) inhibitors, tyrosine kinase inhibitors, HMG-CoA reductase inhibitors, and antifibrotic agents. (The pharmaceutical composition includes biodegradable polymer-encapsulated, long-acting preparations thereof.

Abstract: An OLED is disclosed that includes an enhancement layer having optically active metamaterials, or hyperbolic metamaterials, which transfer radiative energy from the organic emissive material to a non-radiative mode, wherein the enhancement layer is disposed over the organic emissive layer opposite from the first electrode, and is positioned no more than a threshold distance away from the organic emissive layer, wherein the organic emissive material has a total non-radiative decay rate constant and a total radiative decay rate constant due to the presence of the enhancement layer, and the threshold distance is where the total non-radiative decay rate constant is equal to the total radiative decay rate constant; and an outcoupling layer disposed over the enhancement layer, wherein the outcoupling layer scatters radiative energy from the enhancement layer to free space.

Abstract: An object of the present invention is to provide a therapeutic strategy in the solid tumor area and a means useful therefor to further advance the clinical application of CAR therapy. There is prepared a gene-modified lymphocyte which expresses a chimeric antigen receptor having an EphrinB2 extracellular domain at the antigen recognition site.

Abstract: In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder, a gas-generating component configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an actuator configured to activate the gas-generating component; a sensor configured to sense one or more physiological parameters of the user; and an inflation control system configured to receive physiological parameter data from the sensor, to determine whether or not the user is experiencing a medical event that places the user at risk of drowning, and, if the user is experiencing such a medical event, to signal the actuator to activate the gas-generating component so as to provide floatation to the user.

Abstract: An annuloplasty ring including a spring-like inner element that is able to be stretched to accept a prosthetic valve that, when stretched, places a circumferential constrictive force on the valve to prevent paravalvular leakage.

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

Abstract: The present invention provides a preparation method for a nitrogen-doped carbon-loaded metal monatomic catalyst, including: mixing a soluble metallic salt, a hydroxylamine hydrochloride, a soluble carbon source, water, and ethanol, to obtain a mixed solution, then performing drying and precipitation, to obtain a catalyst precursor, and finally performing calcination, to obtain a nitrogen-doped carbon-loaded metal monatomic catalyst. In the present invention, the metallic salt, the hydroxylamine hydrochloride, and the carbon source are fully mixed in the solution, and after being dried, are calcined, to carbonize the carbon source, so that ammonium ions are decomposed into nitrogen-doped carbon, and meanwhile, metal atoms are loaded onto the nitrogen-doped carbon. The method is simple, and costs are low.

Abstract: The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide with an amine in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.

Abstract: Provided herein are compositions including a probiotic including at least one strain of live bacteria and a Marek's Disease vaccine. Compositions including a probiotic or a probiotic and a Marek's Disease vaccine may be administered to subjects, including poultry. The compositions may be administered in ovo to increase early lactic acid bacteria in the gastrointestinal tract of the subject, to decrease the gram negative bacteria in the gastrointestinal tract of the subject, to reduce the level of Salmonella in the gastrointestinal tract of the subject and to increase the body weight gain of the subject. Also provided are kits including a probiotic and a Marek's Disease vaccine.

Abstract: This disclosure relates to variant AAVrh.10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.