Abstract: An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.

Abstract: Disclosed are very high optically pure D- and L-lactic acid fermentation production strains and construction methods thereof and the method for preparing very high optically pure D- and L-lactic acids using the strains, wherein the deposit number of the D-lactic acid fermentation production strain is CGMCC No. 11059, and the deposit number of the L-lactic acid fermentation production strain is CGMCC No. 11060.

Abstract: The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(1-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1—R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.

Abstract: A method of decreasing a water contact angle and/or increasing a surface energy of a liquid is disclosed herein, the method comprising exposing the liquid to a plasma treatment. Further disclosed is a plasma-treated liquid exhibiting a decreased water contact angle and/or increased surface energy, compared to the water contact angle and/or surface energy, respectively, of a non-treated corresponding liquid. Methods for combining a first liquid and a second liquid, or for enhancing an adhesion between a liquid and a surface of another substance, the methods comprising exposing a liquid to plasma treatment, are further disclose herein, as well as a method of predicting an apparent contact angle of a liquid droplet on a surface of a substance.

Abstract: Compounds having a structure of Formula I, or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.

Abstract: Adaptive windowing of insufficient cyclic prefix (CP) for joint minimization of intersymbol interference (ISI) and adjacent channel interference (ACI) is provided. The proposed subcarrier specific windowing scheme improves the signal-to-interference ratio (SIR) even when the cyclic prefix (CP) is insufficient. Average optimal window lengths depend only on the power density profiles (PDPs), and although instantaneous optimal window lengths depend on users' channel impulse responses (CIRs), fluctuation is little. Therefore, subcarrier specific windowing outperforms fixed windowing, even with outdated window lengths in the case of powerful interferers.

Abstract: A method for stepwise construction of a preferential gas migration pathway at a stope in a coal seam. First, a gas migration pathway is preliminarily formed at a stope depending on a mining effect of mining in a first mined seam. construction and stabilization method of gob-side entry retaining in deep strata, and a method of manual-guided pre-fracturing boreholes are then used to perform active construction respectively in external space and the outside of coal-rock mass to form preferential gas migration pathways. Eventually, under the effect of mining-induced stress, a system of preferential gas migration pathways connected to each other at the stope is further formed.

Abstract: A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.

Abstract: The invention provides a construct comprising two or more fusion proteins of Formulas (I)-(IV): A-(optional linker)-C-(optional linker)-B (Formula I), B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II), A-(optional linker)-C (Formula III), and B-(optional linker)-D-(optional linker)-E (Formula IV), wherein A denotes an antibody or antibody fragment, B denotes a single domain CD4, C denotes an immunoglobulin light chain constant region D denotes an immunoglobulin heavy chain constant region, and E denotes an Fc region or a portion thereof that is optionally defucosylated.

Abstract: The present disclosure relates to a 5G generation or pre-5G communication system for supporting a higher data transmission rate than a 4G communication system such as LTE. The present disclosure relates to uplink transmission in a wireless communication system, and an operating method of a terminal includes: determining a second codebook for a reference signal, based on a first codebook for data; and transmitting at least one reference signal generated by using the second codebook, and at least one data signal generated by using the first codebook.

Abstract: An experimental system for laser beam measurement and steering control, and relates to the technical field of optical, mechanical and electronic integration experimental systems. It includes: a high-precision optical mirror, a piezoelectric micro-actuator, a vibration exciter, a signal collection subsystem, a laser emitter, a beam splitter mirror, a fast steering mirror, a mechanical vibration isolation air bearing table, an optical vibration isolation air bearing table, a data processing and analyzing subsystem, and data transmission lines and power supply lines between subsystems and components. It uses a deflection angle of the laser beam as a control variation, can not only precisely measure the deflection angle of the laser beam, but also inhibit vibration of the high-precision optical mirror by using the piezoelectric micro-actuator and directly adjust the steering of the emitted laser beam by using the fast steering mirror, thereby improving precision of beam steering control.

Abstract: A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer.

Abstract: Apparatus for measuring spectral reflectance of a surface, the apparatus comprising: a chamber comprising a wall formed having an aperture defined by an aperture boundary; a light source mounted to the chamber and having a field of illumination (FOI) configured to intersect the aperture at an illumination intersection; and an optical fiber mounted to the chamber and having a field of view (FOV) configured to intersect the aperture at an imaging intersection; wherein the chamber is configured so that when the aperture is positioned on a surface the chamber substantially prevents light from entering a volume of the chamber.

Abstract: A radiation detection device (10) comprising a data processor (14) arranged to be communicatively coupled to a position sensor (16) mounted on an unmanned vehicle and a solid state radiation sensor (18) mounted on the unmanned vehicle. The data processor is configured to receive position data from the position sensor, receive radiation data from the solid state radiation sensor and periodically associate the position data with radiation data to form combined data.

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Abstract: Provided is an angle detection device capable of detecting the angle with high sensitivity by a very simple assembly process without requiring complicated processing. The angle detection device is provided with: a rotor (5) which is formed by a disk plate body produced from a magnetic substance having uniaxial magnetic anisotropy, the disk plate body rotating around a center point within the disk plate surface; a stator (3) which is provided to face the plate surface of the disk plate body of the rotor (5), has approximately the same external shape as that of the rotor, and is divided into a plurality of fan-shaped regions, and in which an exciting coil or a detection coil is wound along the outer periphery of each of the divided regions.