Abstract: Disclosed herein is a method of making polymerizable bio-based monomers containing one phenolic hydroxyl group which has been derivatized to provide at least one polymerizable functional group which is an ethylenically unsaturated functional group (such as a [meth]acrylate group), where the precursors of the polymerizable bio-based monomers are derived from raw lignin-containing biomass. Also disclosed herein are bio-based copolymers prepared from such bio-based monomers and a co-monomer, and methods of making and using such bio-based copolymers. In particular, the bio-based copolymers can be used as pressure sensitive adhesives, binders, and polymer electrolytes.

Abstract: Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IVA, MPS-VI, and MPS VII.

Abstract: A method of using machine learning algorithms in analyzing laboratory test results of body fluid to detect microbes in the body fluid includes using a body fluid detection module for analytic measurements in body fluid of a person to create biological samples; sending the biological samples of a plurality of persons and corresponding microbes infection statuses to perform machine learning algorithms to establish a microbes in body fluid prediction model; and sending data obtained from the body fluid detection of a patient for testing to the microbes in body fluid prediction model for operation and analysis in order to determine whether the microbes is present in body fluid.

Abstract: Disclosed are computational modeling methods employing RMS fluctuation values associated with energy functions to compute binding properties of a subject biomolecule and an identified target. An energy function (or force field) that relates the molecular structure of a biomolecule to an energy value, modified with terms calculated from sets of RMS fluctuation values of the biomolecule, the target and the complex, are used to identify a potential mutation or modification suitable for imparting a selected property to a biomolecule of interest. Uses of the method in the manufacture of non-native proteins having a selected modified property are also provided. Therapeutic agents (proteins, antibodies, TCRs) enzymes, etc., prepared according to the present methods are also provided. Non-native biomolecules having improved properties, for example, weaker or enhanced binding affinity in a modified TCR, are described. Enzymes, industrial reagents, and the like, created using the disclosed methods are also presented.

Abstract: The disclosure, in some aspects, relates to methods and compositions for recombinant adeno-associated virus (rAAV)-mediated delivery of genome editing molecules to a pre-implantation embryo.

Abstract: The present application provides a Capillary number-based method of isolating circulating rare cells from a blood sample from a subject using filtration parameters determined based on the measurement of hemorheological parameters of the sample. The present application also provides a method for determining filtration parameters in a microfluidic elasto-filtration process for isolating circulating rare cells from a blood sample from a subject. The present application further provides a device for isolating circulating rare cells from a blood sample from a subject and a non-transitory computer storage medium for performing methods described in the present application.

Abstract: The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.

Abstract: Systems and methods for fixing a stent in position in an anatomical lumen. Such systems and methods include an intra-luminal stent and a magnet, implanted, for example, in the subcutaneous layer of the subject. The stent and the magnet are magnetically coupled such that the magnetic forces fix the stent in position. Use of the invention permits fixation of an intra-luminal stent to avoid stent migration while minimizing tissue damage.

Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.

Abstract: An electrode material of a sodium-ion battery, a method of manufacturing the same, and an electrode of the sodium-ion battery are provided. The electrode material of the sodium-ion battery includes an oxide comprising sodium, vanadium, and phosphorus represented by formula 2 below: Na3+x2?yV2(PO4?yFy)3, wherein 0.01?x2?0.99 and 0.01?y?0.3.

Abstract: The present disclosure relates to an integration of automatic generation control and economic dispatch to achieve real-time optimization for power grid operation. Specifically, the present disclosure combines the above such that automatic generation control serves as an inner control loop and feedback-control-based economic dispatch serves as an outer loop. Moreover, a system equivalent generator and load are employed to represent a total system load.

Abstract: Disclosed herein methods for combating biofouling in a liquid, e.g. an aqueous medium by providing a surface coated with at least one laser-induced graphene (LIG) layer in said liquid medium. Particularly disclosed herein method and devices for treating water comprising passing a water stream through a membrane module equipped with at least one spacer coated with at least one layer of LIG, and optionally by applying an electric potential to the at least one LIG layer to achieve a bactericidal effect in the water stream. Specifically, disclosed herein a polymeric mesh suitable for use as a spacer in a membrane module in water treatment application, said mesh being at least partially coated with LIG.

Abstract: Provided are molecular entities capable of transforming, aggregating or assembling into a three dimensional biosensors.

Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.

Abstract: Provided are a cell for X-ray analysis and an X-ray analysis apparatus that enable simultaneous X-ray diffraction and X-ray absorption fine structure measurements of a material (sample) in the same field of view on the sample (same position on the sample). The cell for X-ray analysis of the present invention enables simultaneous X-ray diffraction and X-ray absorption fine structure measurements of a sample in the same field of view on the sample and includes a furnace including a space where the sample is held and a focused heater heating the sample, a first window provided to the furnace and through which X-rays directed at the sample is incident, a second window provided to the furnace and from which X-rays emerging from the sample exit, a third window provided to the furnace, and a holder that positions the sample in the space.

Abstract: An innovative nonlinear hybrid dynamic model of survival data analysis implemented in a systematic and unified way that is independent on any particular form of survival distributions functions or data sets. The introduction of one or more intervention processes provides a measure of influence for new tools, procedures and approaches continuous-time states of a time-to-event dynamic process.

Abstract: Embodiments of the invention generally provide compositions of crystalline zeolite materials with tailored crystal habits and the methods for forming such crystalline zeolite materials. The methods for forming the crystalline zeolite materials include binding one or more zeolite growth modifiers (ZGMs) to the surface of a zeolite crystal, which results in the modification of crystal growth rates along different crystallographic directions, leading to the formation of zeolites having a tailored crystal habit. The improved properties enabled by the tailored crystal habit include a minimized crystal thickness, a shortened internal diffusion pathlength, and a greater step density as compared to a zeolite having the native crystal habit prepared by traditional processes. The tailored crystal habit provides the crystalline zeolite materials with an aspect ratio of about 4 or greater and crystal surfaces having a step density of about 25 steps/?m2 or greater.

Abstract: A resource recovery method includes: feeding raw water to a first-stage raw water tank; supplying high-temperature vapor to a first-stage heat exchanger; performing heat exchange between the supplied high-temperature vapor and the raw water in the first-stage raw water tank, changing a portion of the water into vapor and supplying the changed vapor to a subsequent-stage heat exchanger; repeatedly performing the performing step for each of the raw water tanks sequentially in the order from a second state to a n-th stage; being feed to a crystallizer from the n-th stage raw water tank; detecting a turbidity of the raw water fed to the crystallizer from the n-th-stage raw water tank; and extracting crystals of valuable resources contained in the raw water fed to the crystallizer from the n-th-stage raw water tank when the turbidity of the raw water becomes a predetermined value.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A translational control method using an RNA-protein interaction motif is provided. The method comprises a step of introducing an mRNA having: a 5?UTR regulation structure comprising: (1) a cap structure at the 5? terminus, (2) a spacer positioned on the 3? side of the cap structure, and (3) one or more RNA motifs positioned on the 3? side of the spacer, which comprises an RNA-protein interaction motif-derived nucleotide sequence or a variant thereof; and a nucleotide sequence encoding a target protein gene on the 3? side of the 5?UTR regulation structure, into a cell in the presence of a protein specifically binding to the RNA motifs, wherein a translational level is decreased as the number of bases of the spacer decreases, and the translational level is decreased as the number of the RNA motifs increases.