Patents Assigned to University
  • Method of synthesizing novel adsorbent titanosilicate material (UPRM-5) using NR4+ type cations
    Patent number: 10369544
    Abstract: The invention employs tetrapropylammonium (TPA+) and tetrabutylammonium (TBA+) as structure directing agents (SDAs), respectively for the preparation of the flexible titanium silicate UPRM-5. Both UPRM-5 variants are detemplated and modified to include extraframework Sr2+ and produce materials for carbon dioxide adsorption.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: August 6, 2019
    Assignee: University of Puerto Rico
    Inventors: Arturo J. Hernandez-Maldonado, Marietta E. Marcano-Gonzalez, Jose N. Primera-Pedrozo
  • Methods and compositions for preventing and treating damage to the heart
    Patent number: 10369195
    Abstract: Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (MI) resulting from harmful fibrotic remodeling, thereby improving cardiac function and reducing mortality from subsequent heart failure.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 6, 2019
    Assignees: MandalMed, Inc., The Regents of the University of California
    Inventors: Constance M. John, Meenakshi Gaur, Matthew L. Springer, Xiaoyin Wang
  • Stereoretentive cross-coupling of boronic acids
    Patent number: 10370393
    Abstract: The present disclosure provides tri-orthoalkylphenyl phosphine catalysts of formula I wherein A is CH2, C?O, or NRA; R1 is aryl, heteroaryl, isopropyl, tert-butyl, cycloalkyl, or heterocycloalkyl, wherein aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted; R2 is H, (C1-C8)alkyl, (C1-C8)alkoxy, N(RA)2, or an electron withdrawing group; and each RA is independently H or (C1-C8)alkyl; that are tuned electrically and sterically.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Ian Crouch, Jonathan Lehmann, Andrea Palazzolo, Claire Simons
  • Method and system for noncontact vision-based 3D cognitive fatigue measuring by using task evoked pupillary response
    Patent number: 10368740
    Abstract: Provided are a method and system for noncontact vision-based 3D cognitive fatigue measuring. The method comprises: acquiring pupil images of a subject exposed to visual stimuli; extracting a task evoked pupillary response (TEPR) by using the pupil images; detecting dominant peaks from the TEPR; calculating latency of dominant peaks; and determining cognitive fatigue of the subject by comparing a value of the latency to a predetermined reference value.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: August 6, 2019
    Assignees: Sangmyung University Industry-Academy Cooperation Foundation, Center Of Human Centered Interaction For Coexistence
    Inventors: Min Cheol Whang, Sang In Park, Myoung Ju Won, Dong Won Lee
  • Sustained delivery of therapeutic agents to an eye compartment
    Patent number: 10369107
    Abstract: Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or IOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 6, 2019
    Assignee: The Johns Hopkins University
    Inventors: Peter J. McDonnell, Yasin A. Khan, Samuel K. Lai, Renata T. Kashiwabuchi, Ashley Behrens, Justin S. Hanes
  • Systems and methods for dental abutments with cement-retained crowns
    Patent number: 10368965
    Abstract: Devices and methods for dental abutments. Particular embodiments include a dental abutment comprising a base portion, and a generally cylindrical neck portion extending from the base portion, where the generally cylindrical neck portion comprises a first end proximal to the base portion, a second end distal from the base portion, an outer surface, and an inner surface forming a central lumen. Certain embodiments include a plurality of vent holes extending from the outer surface of the generally cylindrical neck portion to the central lumen, where the plurality of vent holes are located proximal to the base portion of the abutment.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: August 6, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Danieli C. Rodrigues, Lucas C. Rodriguez, Juliana Saba, Chandur Wadhwani
  • Treatment method and product for uterine fibroids using purified collagenase
    Patent number: 10369110
    Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 6, 2019
    Assignees: BioSpecifics Technologies Corporation, Duke University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman
  • Data selection
    Patent number: 10372941
    Abstract: A method of selecting data, the method comprising, receiving data indicating a first requirement and identifying first records stored in a first database. The first records relate to first data subjects and the identification is based upon the first requirement. The first data subjects cannot be identified from the records of the first database. Second records are identified, the second records being stored in a second database and relating to the first data subjects. The first data subjects can be identified from the identified records of the second database. Each of the second records corresponds to a respective one of the first records, and the identification of the second records is based upon the first requirement.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 6, 2019
    Assignees: The University of Manchester, Salford Royal NHS Foundation Trust
    Inventors: John Philip New, John Martin Gibson, Iain Edward Buchan, John David Ainsworth
  • Shape-memory-actuated materials for accelerated healing of orthopedic injuries
    Patent number: 10368993
    Abstract: A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substrate for engineering periosteal grafts.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: August 6, 2019
    Assignee: Syracuse University
    Inventors: James Henderson, Patrick T. Mather
  • Integrated antennas and phased arrays with mode-free electromagnetic bandgap materials
    Patent number: 10374274
    Abstract: A multifunctional electromagnetic structure is presently disclosed. Said structure is a true electromagnetic bandgap (“EBG”) material, with both surface and leaky waves suppressed from the whole structure along all lateral directions. It is also an antenna element, configured to radiate to the broadside direction. The structure has two metallization layers of concentric rings between a square-shaped radiating top metal layer and a bottom ground plane. The lower concentric ring is connected to the ground plane through a plurality of vias, while the patch of the top metal layer is fed with a probe. The EBG unit cells may be used as antenna elements in a phased array environment, where they eliminate scan blindness from the array structure along all scan directions.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: August 6, 2019
    Assignee: The Regents of the University of California
    Inventors: Enver Adas, Franco De Flaviis, Nicolaos G. Alexopoulos
  • Probes for rapid and specific detection of mycobacteria
    Patent number: 10370538
    Abstract: The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular ?-lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a ?-lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Yunfeng Cheng, Jinghang Xie
  • Host regulatory factor that enhances replication and/or propagation of vaccinia virus
    Patent number: 10370647
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: August 6, 2019
    Assignee: National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
  • Quantitative MRI measurements near metal objects
    Patent number: 10369385
    Abstract: A method for providing at least one measurement by a magnetic resonance imaging (MRI) system of a tissue property or underlying tissue property in a region sufficiently close to a metal object, so that the metal object induces artifacts is provided. At least one magnetic resonance imaging signal from the region is acquired through the MRI system. The acquired at least one MRI signal is processed to correct for artifacts induced by the metal object. At least one tissue property or underlying tissue property measurement is extracted from the processed at least one MRI signal.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hans Weber, Daehyun Yoon, Valentina Taviani, Brian A. Hargreaves
  • Method and apparatus for estimating down-hole process variables of gas lift system
    Patent number: 10370945
    Abstract: A method and apparatus for estimating a down-hole annulus pressure, and/or a down-hole tubing pressure, and/or a down-hole lift gas rate through a gas injection valve of gas lift system, which comprises at least one gas lift choke and at least one gas injection valve and at least one production choke. A state estimator is proposed to obtain the values of these down-hole process variables. The estimator contains a number of local estimators and an interpolation module.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 6, 2019
    Assignee: Khalifa University of Science and Technology
    Inventors: Igor Boiko, Mohammad Luai Hammadih, Khalifa Hasan Al Hosani
  • Dendrimer compositions and their use in treatment of diseases of the eye
    Patent number: 10369124
    Abstract: The treatment of many ocular disorders is hampered because of poor penetration of systemically administered drugs into the eye. The tight junctional complexes (zonulae occludens) of the retinal pigment epithelium and retinal capillaries are the site of the blood-ocular barrier. This barrier inhibits penetration of substances, including antibiotics, into the vitreous. Over the last 18 years we have evaluated the nontoxic doses of various drugs. These include antibiotics and antifungals for treatment of bacterial and fungal endophthalmitis, antivirals for treatment of viral retinitis (specifically, when medication with these drugs poses the threat of toxicity to other organs). Intravitreal antineoplastic drugs have been studied to prevent cell proliferation in the vitreous cavity after retinal attachment surgery, which can lead to proliferative vitreoretinopathy (PVR).
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: August 6, 2019
    Assignee: The Johns Hopkins University
    Inventors: Kannan Rangaramanujam, Gerard Lutty, Siva Pramodh Kambhampati, Manof Mishra, Imran Bhutto
  • Position/weight-activated knee locking mechanism
    Patent number: 10369017
    Abstract: A passive knee locking mechanism using the position of the shank and the weight of the user to lock. The mechanism has translational motion, which allows the shank to move linearly along the sagittal/vertical plane, which locks and unlocks the knee, and rotational motion for the shank to swing when unlocked. The knee block, which is disposed at the top of the shank, has a spur gear that locks with a matching gear rack on the top plate of the knee housing. The side plates for the knee housing have a linear path that makes for the translational motion. During heel strike, the stopper in the front plate of the knee housing positions the shank in a straight position. When the user applies their weight for initiating stance phase, the knee block traverses up the path and the spur gear meshes with the matching rack, locking the knee.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 6, 2019
    Assignee: University of South Florida
    Inventors: Tyagi Ramakrishnan, Kyle B. Reed
  • Genes related to salt or drought stress resistances and transformed plants with the same
    Patent number: 10370676
    Abstract: The present invention relates to a composition for improving a tolerance to a salt stress or a drought stress of a plant, and a method for preparing transformed plant exhibiting improved tolerance to salt stress or drought stress. The nucleotide sequences of the present invention are involved in salt or drought stress-tolerance, therefore may be effectively used for cultivating the plants with novel functional features which are less affected by climates and environments of the cultivated areas.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 6, 2019
    Assignee: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Woo Taek Kim, Jae Hwan Hwang, Dong Hye Seo
  • Production of lysergic acid by genetic modification of a fungus
    Patent number: 10370689
    Abstract: The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: August 6, 2019
    Assignee: West Virginia University
    Inventors: Daniel G. Panaccione, Sarah L. Robinson
  • Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing biguanide derivative compound as active ingredient
    Patent number: 10369121
    Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-?, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: August 6, 2019
    Assignee: The Catholic University of Korea Industry-Academic Cooperation Foundation
    Inventors: Mi-La Cho, Chul-Woo Yang, Dong-Yun Shin, Min-Jung Park, Seon-Yeong Lee, Sung-Hee Lee, Eun-Ji Yang, Hye-Jin Son, Eun-Kyung Kim, Jae-Kyung Kim
  • Dome theater ride system and method
    Patent number: 10369482
    Abstract: A dome ride system includes a dome, a cartridge, receptacles of the cartridge configured to secure users, a media system configured to communicate a narrative to the users disposed within the cartridge utilizing an interior surface of the dome to display a visual aspect of the narrative, and a drive system. The cartridge is configured to be disposed within the dome, the dome is engaged with the drive system and configured to rotate in multiple directions about a center of the dome in response to input from the drive system, and the cartridge is configured to be coupled to and rotate with the dome.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 6, 2019
    Assignee: Universal City Studios LLC
    Inventors: Daniel M. Freedman, Nathanael G. White