Patents Assigned to University
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Patent number: 10364318Abstract: Methods and systems for producing prescribed unit size azido-poly(3-hydroxyalkanoate) (azido-PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one ?-azidofatty acid substrate that is equal in carbon length to the prescribed or desired unit size of an azido-PHA polymer to be produced. Azido-PHA polymers or azido-PHA co-polymers can be conjugated via copper-catalyzed alkyne-azide cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. The prescribed unit size conjugated azido-PHA polymer or orthogonally conjugated azido-PHA co-polymer that is produced is then isolated and/or purified.Type: GrantFiled: May 21, 2018Date of Patent: July 30, 2019Assignee: The Research Foundation for The State University of New YorkInventors: Christopher T. Nomura, Atahualpa Pinto
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Patent number: 10363421Abstract: Systems and methods for spinal cord electrode placement and spinal cord stimulation their use for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a spinal cord stimulating electrode in a target region of the brain of a patient, a temperature of brown adipose tissue may be monitored, e.g., via a supraclavicular temperature sensor implanted in the patient, and used to identify an optimal location of electrode stimulation which causes an increase in BAT temperature. Additionally, BAT temperature measurements may be used to provide regulated closed-loop control to increase efficiency of spinal cord stimulation while reducing energy consumption of the pulse generator. Further, core temperature measurements may be obtained from the electrode in the spinal cord and used to adjust spinal cord stimulation.Type: GrantFiled: April 2, 2018Date of Patent: July 30, 2019Assignee: Oregon Health & Science UniversityInventors: Kim Burchiel, Christopher J. Madden, Shaun F. Morrison
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Patent number: 10366872Abstract: A quadrupole mass filter and method for operating the filter are described. Sample ions, each having a mass-to-charge ratio, are passed to a quadrupole at least one AC voltage is applied thereto to separate the ions by incrementally varying a frequency of the at least one AC voltage within a first range of frequencies and, for each of at least some of the incremental frequencies in the first range of frequencies, incrementally varying an amplitude of the at least one AC voltage within a range of amplitudes, wherein each incremental frequency and incremental amplitude pair of the at least one AC voltage creates a different band pass filter in the quadrupole through which produced ions having a different corresponding mass-to-charge ratio pass to a detector.Type: GrantFiled: January 31, 2019Date of Patent: July 30, 2019Assignee: The Trustees of Indiana UniversityInventors: Martin F. Jarrold, Deven L. Shinholt, Staci N. Anthony, Andrew W. Alexander
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Patent number: 10364451Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.Type: GrantFiled: December 21, 2016Date of Patent: July 30, 2019Assignee: Duke UniversityInventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
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Patent number: 10368246Abstract: In the static and exclusive spectrum allocation paradigm, the spectrum-access parameters for a service are chosen to mitigate potential harmful-interference and ensure minimum performance under worst-case conditions. The new dynamic spectrum-sharing paradigm necessitates dynamically defining and enforcing the spectrum-access rights while accommodating the dynamics of the RF environment and the spectrum-access scenarios. To enforce spectrum-access rights, emphasis is placed on capturing the use of spectrum by an individual transceiver. Spectrum-access rights are articulated in terms of the characterization of the spectrum used by an individual transceiver in the space, time, and frequency dimensions. In order to estimate the use of spectrum in real time, an RF-sensor network is employed, the network uses interference-tolerant algorithms to estimate the transceiver spectrum-access parameters and to characterize the propagation environment.Type: GrantFiled: October 26, 2016Date of Patent: July 30, 2019Assignee: The Research Foundation for The State University of New YorkInventors: Nilesh Khambekar, Vipin Chaudhary, Chad Spooner
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Patent number: 10365088Abstract: The present invention discloses a distributed device for simultaneously measuring strain and temperature based on optical frequency domain reflection, comprising a tunable laser, a 1:99 beam splitter, a main interferometer system, a light source phase monitoring system based on an auxiliary interferometer, an acquisition device and a computer processing unit, wherein the main interferometer system comprises two Mach-Zehnder interferometers, and two optical fibers having different cladding diameters are arranged in parallel as sensing fibers. Due to the difference in temperature and strain coefficients of optical fibers of the same diameter, the temperature and strain values during changing the temperature and strain simultaneously can be obtained by matrix operation, thereby achieving an effect of eliminating cross sensitivity of temperature and strain sensing in optical frequency domain reflection.Type: GrantFiled: October 27, 2016Date of Patent: July 30, 2019Assignee: Tianjin UniversityInventors: Zhenyang Ding, Di Yang, Tiegen Liu, Yang Du, Zhexi Xu, Kun Liu, Junfeng Jiang
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Patent number: 10364264Abstract: Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.Type: GrantFiled: May 24, 2017Date of Patent: July 30, 2019Assignee: Ohio UniversityInventor: Rathindra N. Bose
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Patent number: 10365281Abstract: Methods and kits for identifying rapidly progressing lung cancer in a subject are provided. The method includes obtaining a biological sample from the subject and assaying a level of a biomarker in a biomarker panel in the biological sample where the panel includes at least one biomarker selected from Table I or Table II. The method further includes determining with the subject is treatment naive or has received at least one treatment; and comparing the level of the biomarker in the subject's sample to a cutoff value listed in Table I for treatment naive subjects or Table II for previously treated subjects. The method further includes determining whether the subject's level is above or below the cutoff value to determine whether the subject has rapidly progressing lung cancer.Type: GrantFiled: December 8, 2014Date of Patent: July 30, 2019Assignee: Rush University Medical CenterInventors: Jeffrey A. Borgia, Sanjib Basu
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Patent number: 10365242Abstract: An electrode that comprises a nanostructured material that comprises pyrolyzed date palm leaves that are obtained from a pyrolysis of an agro-waste containing date palm leaves in an inert gas and in a temperature range of 800 to 1600° C., an electrochemical cell thereof, and a method of determining a hydroquinone concentration in a hydroquinone-containing solution with the electrochemical cell. Various combinations of embodiments are also provided.Type: GrantFiled: October 4, 2017Date of Patent: July 30, 2019Assignee: King Fahd University of Petroleum and MineralsInventor: Md. Abdul Aziz
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Patent number: 10367055Abstract: The disclosure relates to an epitaxial structure. The epitaxial structure includes a substrate, an epitaxial layer, and a nanotube film. The substrate has an epitaxial growth surface. The epitaxial layer is located on the epitaxial growth surface of the substrate. The nanotube film is located between the substrate and the epitaxial layer. The nanotube film includes a number of nanotubes orderly arranged and combined with each other by ionic bonds.Type: GrantFiled: December 9, 2014Date of Patent: July 30, 2019Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Yang Wei, Shou-Shan Fan
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Patent number: 10364195Abstract: In some examples, a technique may include positioning a first part comprising a ceramic or ceramic matrix composite and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region at the interface of the first part and the second part. In some examples, the joint region may be heated using at least one of a laser or a plasma arc source to heat the joint region to an elevated temperature. The first and second parts may be pressed together and cooled to join the first and second parts at the joint region. In other examples, a solid braze material including a filler material and a metal or alloy may be delivered to the joint region and locally heated to cause a constituent of the filler material and a constituent of the metal or alloy to react. When reacted, the constituents may form a solid material, which may join the first and second parts.Type: GrantFiled: May 22, 2015Date of Patent: July 30, 2019Assignees: Rolls-Royce Corporation, The Curators of the University of MissouriInventors: Sean E. Landwehr, Scott Nelson, Jeremy Lee Watts, Gregory Eugene Hilmas, William Gene Fahrenholtz, Derek Scott King
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Patent number: 10362781Abstract: Methods of controlling the feeding and/or breeding behavior of a target insect are disclosed in which a host plant is provided a substantial distance from a plant of interest, chemical attractant that induces the target insect to lay eggs on the host plant is applied to the host plant, application of the chemical attractant to the host plant is repeated as required to induce residual target-insect populations to lay eggs on the host plant, and wherein the behavior is controlled when a substantial number of offspring belonging to subsequent generations themselves mature and display a preference for laying eggs on the same type of host plant on which they were reared without further application of the chemical attractant is provided. Also disclosed are methods of deterring target insect feeding and breeding on plants of interest by applying toxic plant extract to the plants of interest.Type: GrantFiled: July 16, 2015Date of Patent: July 30, 2019Assignee: University of the West Indies, a Regional Institution, established by Royal CharterInventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway
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Patent number: 10364169Abstract: The disclosure generally relates to reactive electrochemical membranes (REMs); and in particular, to asymmetric reactive electrochemical membranes to be used for aqueous separations and membrane fouling regeneration.Type: GrantFiled: November 30, 2016Date of Patent: July 30, 2019Assignee: The Board of Trustees of the University of IllinoisInventors: Brian Chaplin, Yun Guo, Yin Jing, Sasmita Nayak
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Patent number: 10363008Abstract: Computed tomography perfusion (CTP) is used in a method to identify cancerous lesions having genetic mutations and treat them accordingly. Also, CTP values are used to distinguish primary versus metastatic lesions. For example, pulmonary blood flow is identified as one biomarker for EGFR and KRAS genetic mutations in lung cancer, lesion having dual-input pulmonary blood flow exceeding a threshold (e.g., 103 ml/min/100 mL with sensitivity 100% and specificity 62%) are determined as having mutations. The CTP values are calculated using a lesion region-of-interest (ROI) placed to include the area of maximum perfusion intensity within the lesion base and surrounding blush, while avoiding regions of perfusion inhomogeneity (e.g., due to necrosis). In certain implementations, instead of a binary determination, the method can generate probabilities associated with respective alternatives (e.g.Type: GrantFiled: November 27, 2017Date of Patent: July 30, 2019Assignees: Canon Medical Systems USA, Inc., Board of Regents of the University of Texas SystemInventors: Eugene A. Mensah, Cecelia Brewington, Erin Angel, Gary Arbique, Shaun Nordeck
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Patent number: 10364437Abstract: The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.Type: GrantFiled: November 10, 2016Date of Patent: July 30, 2019Assignee: Iowa State University Research Foundation, Inc.Inventors: Patrick S. Schnable, Sudhansu Dash
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Patent number: 10364470Abstract: The invention described in the application relates to a long non-coding RNA expressed in cancer. The invention thus provides methods and compositions for evaluating levels of the long non-coding RNA to assess the aggressiveness of a cancer and for modulating levels of the long non-coding RNA.Type: GrantFiled: November 16, 2016Date of Patent: July 30, 2019Assignee: The Regents of the University of CaliforniaInventors: Terumi Kohwi-Shigematsu, Yoshinori Kohwi, Ellen C. Ordinario, Michael A. Balamotis, Hye-Jung Han
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Patent number: 10363117Abstract: A dental implant including a base, a central shaft and a shock absorber spacing and allowing limited movement between the base and the central shaft. The shock absorber may also contain a plurality of flex struts. The dental implant may further include an index collar covering an upper portion in the base.Type: GrantFiled: May 11, 2016Date of Patent: July 30, 2019Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gulshan Neville Sunavala-Dossabhoy, Kevin McCarthy
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Patent number: 10364452Abstract: Methods, systems, and devices are disclosed for providing test strip electrochemical sensors for rapid quantitative analysis of analytes in physiological fluids. In one aspect, an electrochemical sensor includes a substrate; an electrode contingent including a first electrode having a coating of carbon nanotubes (CNTs) and a second electrode on the substrate; and an entrapment layer formed on the first electrode to attach an enzymatic substance capable of causing a redox reaction in the presence of a target analyte of a fluid sample which produces a redox-active product, in which the entrapment layer is structured to include a conductive polymer film that is reversibly dopable to conduct charge carriers across the entrapment layer and at the first electrode. For example, the electrochemical sensor can be provided on a disposable test strip to quantify L-DOPA levels in whole blood, plasma, or serum samples.Type: GrantFiled: June 1, 2015Date of Patent: July 30, 2019Assignees: The Regents of the University of California, Biolinq IncorporatedInventors: Joseph Wang, Irene Litvan, Joshua Ray Windmiller
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Patent number: 10367190Abstract: A cylindrical single-piece lithium-ion battery of 400 Ah includes: a cylindrical battery enclosure (1), a battery mandrel (3), a plurality of tabs (4), a wiring terminal (6), a positive and negative electrode cover (11); a positive electrode sheet, said battery positive electrode is composed of LiFePO4, conductive carbon-black, graphite, adhesive such as PVDF, and solvent such as NMP; a negative electrode sheet, the battery negative electrode is composed of lithium titanate, conductive carbon-black, graphite, adhesive such as PVDF, and solvent such as NMP. The cylindrical lithium-ion battery made by the invention has a capacity of 400 Ah which is the one reportedly having the largest capacity in the world presently.Type: GrantFiled: September 28, 2016Date of Patent: July 30, 2019Assignee: Tianjin UniversityInventors: Zhiyuan Tang, Lei Sun, Qi Wang, Guowei Ling
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Patent number: 10363226Abstract: Disclosed herein is a platelet membrane-coated nanovehicle having an inner core comprising a drug delivery matrix, and an outer shell platelet membrane coating the inner core. The inner core can be any drug delivery matrix capable of delivering a therapeutic agent to a cell. The outer shell platelet membrane can be a natural or synthetic membrane comprising platelet proteins capable of interacting with cancer cells. Also disclosed is a method for treating cancer in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein. Also disclosed is a method for treating vascular disease in a subject that involves administering to the subject a platelet membrane-coated nanovehicle disclosed herein.Type: GrantFiled: August 12, 2016Date of Patent: July 30, 2019Assignee: North Carolina State UniversityInventors: Zhen Gu, Quanyin Hu