Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.

Abstract: The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the ?Klotho-FGF receptor complex involving the use of chimeric proteins of the present invention.

Abstract: The present disclosure provides supercapacitors that may avoid the shortcomings of current energy storage technology. Provided herein are electrochemical systems, comprising three dimensional porous reduced graphene oxide film electrodes. Prototype supercapacitors disclosed herein may exhibit improved performance compared to commercial supercapacitors. Additionally, the present disclosure provides a simple, yet versatile technique for the fabrication of supercapacitors through the direct preparation of three dimensional porous reduced graphene oxide films by filtration and freeze casting.

Abstract: The present invention is based on the finding that in addition to interfering with or blocking, preventing and/or inhibiting the interaction between a pathogen and, for example, a sialic acid containing cell surface receptor, certain sialic acid binding molecules have immunomodulatory properties. The invention provides methods and uses which exploit sialic acid binding molecules in the treatment and/or prevention of disease by modulation and/or priming of the host immune response.

Abstract: Systems and methods for multi-robot gradient-based adaptive navigation are provided.

Abstract: A system, computer-readable medium and method can include receiving three-dimensional imaging data of a subject's heart, the subject having an ICD, wherein the ICD causes an imaging artifact in the three-dimensional imaging data that includes regions that are free of the artifact and regions that are affected by the artifact; segmenting the regions that are free of the artifact into a plurality of normal tissue regions and remodeled tissue regions for the subject; extrapolating from the regions that are free of the artifact to provide extrapolated three-dimensional imaging data corresponding to the regions that are affected by the artifact; and simulating at least one of electrophysiological or electromechanical activity of the subject's heart using the segmented and extrapolated three-dimensional imaging data, the simulating including providing a preselected alteration of electrophysiological or electromechanical behavior of the subject's heart for a target of said subject-specific cardiac ablation procedure

Abstract: A photocatalytic nanocomposite hollow sphere comprising a shell surrounding a hollow core, and the shell comprising zirconium dioxide, hydroxyapatite, and platinum, as well as a method for producing the nanocomposite hollow sphere and a method employing the nanocomposite hollow sphere in reducing an aromatic nitro compound to an aromatic amine compound under visible light are disclosed.

Abstract: The present invention relates to a method for pretreating lignocellulose by using an acid-base mixture catalyst. The method pretreats lignocellulose, by using a mixture catalyst of an acid and a base, so as not to pass through additional neutralization steps, and carries out pretreatment and simultaneous saccharification and fermentation through an identical single reactor process, thereby having an effect of producing ethanol in an excellent production yield from lignocellulosic biomass while simplifying the total process and reducing equipment costs and total processing costs.

Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Abstract: Provided are an OLED device and a method of manufacturing the OLED device that may provide improved luminance uniformity. The disclosed OLED may have a first electrode that has a first sheet resistance Rs, and a second electrode that has a second sheet resistance, wherein the second sheet resistance may be in the range of 0.3 Rs-1.3 Rs. In addition, the disclosed OLED may have a plurality of equal potential difference between points on a first electrode and a second electrode. The equal potential difference may be provided by a gradient resistance formed on at least one of the electrodes.

Abstract: Methods, systems, and media for automatically authenticating a user account using multiple services are provided. In accordance with some embodiments of the disclosed subject matter, methods for authenticating a user using multiple services are provided, the methods comprising: receiving, from a client device, first credentials for a target service account; authenticating the target service account based on the first credentials; issuing a redirecting request that directs the client device to at least one vouching service in response to authenticating the target service account; receiving a vouching response indicating that the client device has authenticated a vouching service account with the at least one vouching service, wherein the vouching response includes a vouching token; and providing the client device with access to the target service account in response to determining that the vouching service account is associated with the target service account.

Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.

Abstract: The kit for measuring vertical dimension for dental impression provides a tool for measuring a difference between a dental patient's desired vertical dimension and the patient's vertical dimension prior to a dental restoration procedure. The kit includes a base, a plurality of measurement sheets, and dental impression wax. The base includes a planar member having first and second longitudinally opposed ends and opposed upper and lower surfaces. The upper surface has at least one longitudinally extending groove defined therein. First and second legs are secured to the first and second longitudinally opposed ends of the planar member and extend downward from the lower surface. Each measurement sheet has opposed upper and lower surfaces and at least one longitudinally extending rib formed on the lower surface and at least one longitudinally extending groove defined in the upper surface. Each of the plurality of measurement sheets has a known thickness.

Abstract: Disclosed are a method and an apparatus for image encoding/decoding. The method for image decoding includes comparing whether a size of a current transform block and a size of a smallest transform block (smallest transform unit (STU)) are the same as each other, and decoding information indicating whether transformation is performed on the current transform block and determining whether to perform inverse transformation on the current transform block based on the decoded information indicating whether the transformation is performed when the size of the current transform block and the size of a smallest transform block are the same as each other.

Abstract: The present invention relates to the 14-3-3 protein which is a non-alcoholic fatty liver regulating factor. According to the present invention, two isoform proteins of 14-3-3, i.e., 14-3-3? and 14-3-3?, are different regulating factors for regulating the transcriptional activity of PPAR?2. 14-3-3? increases the transcriptional activity of PPAR?2 by binding to PPAR?2, on the other hand, 14-3-3? plays a role in decreasing the transcriptional activity of PPAR?2. Thus, 14-3-3? and 14-3-3?, which are PPAR?2 regulating factors, are proteins that play a vital role in lipid metabolism, and may be used as a target for the prevention or treatment of fatty liver.

Abstract: This disclosure provides systems, methods, and apparatus related to deposition techniques using laser ablation. In one aspect, an optical fiber and target of a material to be deposited on a first region of an interior surface of a hollow component are positioned in the hollow component. A first end of the optical fiber is coupled to a laser system. A second end of the optical fiber is proximate the target. The material is deposited on the first region of the interior surface of the hollow component by directing a first laser pulse from the laser system through the optical fiber to impinge on the target.

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

Abstract: A novel approach for CEST MR imaging is called Multi-echo Length and Offset VARied Saturation (Me-LOVARS) CEST. This method allows efficient collection of additional CEST data without penalty in scan time, which could be useful for enhancing the contrast, increasing the specificity or improving quantification of exchange. As CEST-MRI has shown promise at both the pre-clinical and clinical levels, including for detecting and grading brain tumors and evaluating ischemia, using either endogenous CEST contrast or through administration of CEST contrast agents. This fast and robust imaging method is suitable for accelerating image collection and widening the scope of applications for CEST-MRI.

Abstract: A system and method of authentication that avoids authentication challenges is described. In operation, an authenticator receives a first request to access a resource generated by a requestor and a participation message generated by a collaborator. The authenticator computing device then analyzes the first request and the participation message to determine whether the requestor requesting access to the resource should be granted access and grants the requestor access to the resource based upon the analysis of the first request to access a resource and the participation message.

Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.