Abstract: Monodisperse carboxylate functionalized gold nanoparticles comprising a capping agent layer of pamoic acid and colloidal suspensions thereof are disclosed. These gold nanoparticles have an average particle size of greater than 15 nm or less than 8 nm and demonstrate significant fluorescent properties. In addition, a method for the size controlled preparation of these monodisperse carboxylate functionalized gold nanoparticles wherein pamoic acid acts as both a reducing and capping agent and wherein the size of the particles can be controlled by the pH of the process is disclosed. In addition, a method for the size controlled preparation of these monodisperse carboxylate functionalized gold nanoparticles utilizing seed mediated growth is disclosed.

Abstract: The present disclosure relates to a novel portable electric vehicle, which comprises two front-rear folding mechanisms, a left-right folding mechanism, and an operating mechanism, wherein the two front-rear folding mechanisms for supporting a driver are arranged respectively on the left side and the right side of the bottom of the electric vehicle, the rear ends of the front-rear folding mechanisms are both provided with driving wheel mechanisms, and the front ends of the front-rear folding mechanisms are both provided with rotating wheel mechanisms; two ends of the left-right folding mechanism for driving the two front-rear folding mechanisms to get close to each other are connected respectively to the two front-rear folding mechanisms; and the operating mechanism for controlling the running of the electric vehicle is mounted on the left-right folding mechanism.

Abstract: Embodiments of the present disclosure describe a negative photochromatic material. Embodiments of the present disclosure further describe a method of tuning a negative photochromatic material comprising selecting an amine donor group, selecting an acceptor group, and contacting at least the selected amine donor group and the selected acceptor group to form a negative photochromatic material, wherein one or more of the selected amine donor group and the selected acceptor group tune at least an absorption range of the negative photochromatic material.

Abstract: Described herein are expression vectors encoding the Wolbachia protein WalE1. Also described are insects transformed with an expression vector of the present disclosure, and progeny thereof. Also described are methods for improving Wolbachia replication and transmission in its insect host by overexpressing WalE1 in the insect host. Improved Wolbachia replication and transmission provides for insect population control and pathogen resistance in insects, which can reduce disease transmission.

Abstract: Microwave and millimeter wave imaging. An antenna array in communication with a signal source comprises a plurality of antennas by which a signal generated by the signal source is transmitted incident to an object located remotely from the antenna array and by which a signal reflected from the object is received by the antenna array. The signals transmitted by the antennas collectively have an effective electric field resembling a plane-wave within a target region in front of the antenna array. A plurality of detectors each connected to one of the antennas is configured to simultaneously receive the reflected signal and provide an output signal representative thereof. An image processor configured to execute an imaging algorithm generates a multi-dimensional profile representative of the object based on the output signals from the detectors.

Abstract: A method for producing a metal foil comprising depositing metal onto an oxidizable substrate to form a metal film on the substrate; oxidizing the substrate at an interface between the metal film and the substrate; and removing the metal film from the substrate to yield a metal foil. A method for forming a thin metal film comprising pre-polarizing a single-crystal Si substrate by application of a potential which is negative of a potential at which Si oxidizes, which pre-polarization occurs in the presence of metal ions to form metal growth nucleation sites on the substrate, followed by application of a potential at which both oxidation of Si and electrodeposition of the metal occur to grow the metal film and oxidize the Si to SiOx, which potential is more positive than the potential applied in the pre-polarization step.

Abstract: Gold(I)-carbene complexes having a selenium donor ligand with anti-cancer activity and a method of treating cancer. Methods of treating cancer comprising administering the complexes are also provided.

Abstract: Systems, methods and software products determine an overall motion and/or flexibility envelope for an individual. Movement and position data of the individual is captured and processed to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual. The systems include a flexibility server with memory and a processor adapted to receive movement and position data of the individual, a motion and/or flexibility analyzer, implemented as machine readable instructions stored in the memory and executed by the digital processor, capable of processing the movement and position data to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.

Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: Therapeutic application of mild to moderate hypothermia in a medical procedure has been found to provide benefits to patients. For example, application of mild hypothermia in the auditory pathway can prevent functional hearing loss post cochlear implant surgery. Devices have been conceived and reduced to practice that apply localized cooling to a small area such as the basal or middle turn of the cochlea. The devices include a cooling tip with at least one thermo-conductive surface. A heat-transporting fluid is circulated through the cooling tip. After absorbing heat, the heat-transporting fluid may be controllably cooled with a thermoelectric cooling device.

Abstract: Provided is an active clamp full bridge converter, which includes: a transformer having a primary coil and a secondary coil and configured to convert a voltage; a primary circuit connected to an input capacitor for supplying an input power and including a full bridge circuit having first to fourth switches to transmit the input power to the primary coil according to a switching operation of the first to fourth switches; and a secondary circuit connected to the secondary coil and including a rectifying bridge circuit having first to fourth diodes, an active clamp circuit connected to the rectifying bridge circuit and composed of an active clamp switch and a clamping capacitor connected in series, and an output inductor connected to the active clamp circuit, to transmit an energy received from the primary circuit by the transformer to an output capacitor connected to the output inductor and the active clamp circuit.

Abstract: A stitched sensor including a plurality of threads stitched to a textile in a stitch geometry is described. The plurality of threads includes a conductive thread, and the stitch geometry is configured such that an electrical property of the stitched sensor changes based on at least one of stretching, relaxation, or bending of the textile. Methods for forming a stitched sensor are also described.

Abstract: Na+-SAPO-34 sorbents were ion-exchanged with several individual metal cations for CO2 absorption at different temperatures (273-348 K) and pressures (<1 atm). In general, the overall adsorption performance of the exchanged materials increased as follows: Ce3+<Ti3+<Mg2+<Ca2+<Ag+<Na+<Sr2+. The strontium exchanged materials excelled at low-pressure ranges, exhibiting very sharp isotherms slopes at all temperatures. The Sr2+ species were responsible for the surface strong interaction and the cations were occupying exposed sites (SII?) in the materials Chabazite cages. All the sorbent materials exhibited higher affinity for CO2 over the other gases tested (i.e., CH4, H2, N2 and O2) due to strong ion-quadrupole interactions. Sr2+-SAPO-34 sorbents are by far the best option for CO2 removal from CH4 mixtures, especially at low concentrations.

Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.

Abstract: A method is disclosed for reducing the level of gossypol in cottonseed. The method generally includes selectively inducing RNA gene silencing in the seed of a transgenic cotton plant, to interfere with expression of the ?-cadinene synthase gene or the ?-cadinene-8-hydroxylase gene in the seed of the cotton plant without substantially affecting expression of that gene in the foliage, floral parts, and roots of the plant. The transgenic cotton plant comprises at least one of a ?-cadinene synthase gene trigger sequence and/or a ?-cadinene-8-hydroxylase gene trigger sequence operably linked to one or more a seed-specific promoter gene sequences, and the trigger sequence(s) is/are able to induce RNA gene silencing when expressed in cottonseed of the plant.

Abstract: An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.

Abstract: The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that can entrap FASN inhibitor compounds. In one embodiment, the FASN inhibitor compounds include Orlistat. In one embodiment, the hydrophobic moieties comprise 5-?CA, Pba, or ODA, or combinations thereof. In a variation, the present invention relates to a composition comprising NPs based upon HLA, Orlistat, one or more of the hydrophobic moieties comprising 5-?CA, Pba, or ODA, and one or more of members selected from the group consisting of PEG and a dilute solution containing SDS.

Abstract: Methods of treating hemophilia A in a subject with an F8 gene mutation, wherein the F8 gene is repaired and the resultant repaired gene, upon expression, confers improved coagulation functionality to the encoded FVIII protein of the subject compared to the non-repaired F8 gene. The invention also includes methods of inducing immune tolerance to a FVIII replacement product ((r)FVIII) in a subject having a FVIII deficiency, wherein the F8 gene mutation is repaired and the repaired gene, upon expression, provides for the induction of immune tolerance to an administered replacement FVIII protein product. The invention also includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to repair the F8 gene.