Abstract: Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.

Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

Abstract: The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2???. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.

Abstract: Described here is a method for increasing the transfer of a gas substrate in microbial fermentation, comprising incubating an emulsion comprising an oil phase and an aqueous phase droplet dispersed in the oil phase, and supplying the gas substrate to the oil phase, wherein the aqueous phase droplet comprises a microorganism, and wherein the emulsion is stabilized by a surfactant or an amphiphilic particle that is adsorbed to an interface of the oil phase and the aqueous phase. Also described is an emulsion for microbial fermentation, comprises an oil phase and an aqueous phase droplet dispersed in the oil phase, wherein the aqueous phase droplet comprises a microorganism, wherein the emulsion comprises a gas substrate externally-supplied to the oil phase, and wherein the emulsion is stabilized by a surfactant or an amphiphilic particle that is adsorbed to an interface of the oil phase and the aqueous phase.

Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.

Abstract: Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.

Abstract: Embodiments of the present invention disclose a composition of matter comprising a silicon (Si) nanoparticle coated with a conductive polymer. Another embodiment discloses a method for preparing a composition of matter comprising a plurality of silicon (Si) nanoparticles coated with a conductive polymer comprising providing Si nanoparticles, providing a conductive polymer, preparing a Si nanoparticle, conductive polymer, and solvent slurry, spraying the slurry into a liquid medium that is a non-solvent of the conductive polymer, and precipitating the silicon (Si) nanoparticles coated with the conductive polymer. Another embodiment discloses an anode comprising a current collector, and a composition of matter comprising a silicon (Si) nanoparticle coated with a conductive polymer.

Abstract: A wire shaped carbon fiber electrode is disclosed. The carbon fiber electrode includes braided strings of carbon fiber. The carbon fiber electrode is fabricated in a simple process, facilitating its practical application to clothes. In addition, the carbon fiber electrode possesses high capacitance and structural stability and is easily applicable to various wearable devices. Also disclosed are a wire-type supercapacitor including the carbon fiber electrode, a NO2 sensor including the supercapacitor, and a UV sensor including the supercapacitor.

Abstract: A device and methodology for concomitant ejection and suction of a perfusate (CESOP) within a region of interest without spillover of the perfusate to a juxtaposed anatomical region. An inflow line, connected to a perfusate cistern, is coupled to an outflow line, connected to outflow control mechanisms, via an elongate rigid support. Perfusate can flow through the inflow line to the region of interest, and nearly simultaneously, the outflow line can suction the perfusate out of the region of interest. The amount of time that the perfusate remains in the region of interest is sufficient to take effect in the region of interest. The rigid support helps control the inflow and outflow lines. A micromanipulator can also be used to control the lines and application tip thereof. Either or both lines may also have adjustable flow rates therethrough and may include stoppers/regulators.

Abstract: Disclosed herein are embodiments of sensor devices comprising a sensing component able to determine the presence of, detect, and/or quantify detectable species in a variety of environments and applications. The sensing components disclosed herein can comprise MOF materials, plasmonic nanomaterials, redox-active molecules, a metal, or any combinations thereof. In some exemplary embodiments, optical properties of the plasmonic nanomaterials and/or the redox-active molecules combined with MOF materials can be monitored directly to detect analyte species through their impact on external conditions surrounding the material or as a result of charge transfer to and from the plasmonic nanomaterial and/or the redox-active molecule as a result of interactions with the MOF material.

Abstract: Disclosed herein are stable organic photosensitive devices including at least one exciton-blocking charge carrier filter. The filters comprise a mixture of at least one wide energy gap material having a sufficiently high glass transition temperature, e.g., higher than the temperature or temperature range at which the device typically operates, higher than a highest operating temperature of the device, higher than a threshold temperature value, etc. and at least one electron or hole conducting material. As described herein, the novel filters simultaneously block excitons and conduct the desired charge carrier (electrons or holes).

Abstract: Disclosed are methods for treating cisplatin-induced peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a histone deacetylase 6 selective inhibitor.

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: A block-base error measure method for object segmentation includes the steps of dividing a reference image having an object into plural non-overlapping blocks, superimposing the reference image with a segmented image to obtain an error ratio of the block to define an enhanced equation and a modification equation to suppress the scattered error and enhance the contribution of the region error, so as to calculate the error amount of the segmented image and evaluate the performance of image segmentation. Compared with the conventional error measure method based on pixels, the present invention provides a more accurate high-level semantic.

Abstract: Techniques are disclosed relating to wide towing of marine survey signal sources. In one embodiment, an apparatus includes a signal source and a wing coupled to the signal source. In this embodiment, the wing is configured to impart a force to the signal source when towed through a body of water by a survey vessel. In this embodiment, the force includes a lateral component and a vertical component. The wing may be configured to impart the force based on a shape of the wing and an orientation of the wing. The wing may extend over at least a third of a length of a keel of the apparatus. At least a majority of a top surface of the wing may be oriented within 20 degrees of parallel to a surface of the body of water. The wing may include a plurality of wing sections.

Abstract: Provided is a negative active material for a secondary battery which provides high capacity, high efficiency charging-discharging characteristics. The negative active material includes: a silicon single phase; and a silicon-metal alloy phase interfaced with the silicon single phase and surrounding the silicon single phase, wherein an X-ray diffraction spectrum of the negative active material has first and second peaks that are originated from the silicon-metal alloy phase, and the first peak is located at 49.1+/?0.5 degrees (°) and the second peak is located at 38.0+/?0.5 degrees (°), and a diffraction intensity of the first peak is 2 or less times that of to the second peak.

Abstract: A method of micropatterning a substrate is provided. The method comprises providing a template substrate having a patterned surface inked with a composition of interest; contacting the patterned surface with an intermediate substrate, thereby transferring the composition to the surface of the intermediate substrate; contacting the surface of the intermediate substrate comprising the composition with the substrate; and removing the intermediate substrate by dissolution using a solvent. A patterned substrate formed using the method, as well as a biosensor comprising the patterned substrate is also provided.

Abstract: The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.

Abstract: The present invention provides a Voigt line shape fitting method, including step 1: Calculate a Gauss line shape function and a Lorentz line shape function, and calculate a Voigt line shape function. Step 2: For determined line shape parameters to be fitted, calculate partial derivatives of the Voigt line shape function with respect to the parameters, convert a partial derivative of the Voigt line shape function with respect to a parameter into a partial derivative of the Gauss line shape function or the Lorentz line shape function with respect to the parameter. Step 3: Substitute the Voigt line shape function and the partial derivative of the Voigt line shape function with respect to the parameter to be fitted, into a least squares algorithm step, perform least squares fitting calculation, and determine whether to terminate the least squares fitting calculation or return to step 1 to perform next iterative calculation.

Abstract: Disclosed herein are expression vectors suitable for transfection in amoebas. The vectors may include a promoter from a protein-encoding gene from an amoeba, a selection marker, and a polynucleotide sequence encoding a polypeptide of interest, operably linked to the promoter. The promoter may be from the ACT1 gene from Naegleria fowleri.