Abstract: A power insertion device includes: an input interface, configured for receiving a fiber connection from a fiber network; an output interface, comprising one or more hybrid cables for connection to one or more end devices, each of the hybrid cables including fiber for data communication and wire for power transmission; a mains power interface, configured to receive alternating current (AC) mains power; one or more power supplies, configured to convert the AC mains power to direct current (DC) power; and a power insertion board, configured to provide power insertion of the DC power out through the one or more hybrid cables.

Abstract: The present application relates to systems and methods for performing a computerized cardiac simulation for at least one of diagnosis, risk assessment or treatment planning including: receiving, by a computer, a plurality of three-dimensional cardiac images of a subject's heart such that each three-dimensional cardiac image corresponds to a different phase of a single cardiac cycle of the subject's heart; modeling structure, using the computer, of the left atrium of the subject as a function of time using the plurality of three-dimensional cardiac images of the subject's heart; modeling blood flow, using the computer, within, into and out of the left atrium of the subject as a function of time using computational fluidic dynamics and using structure of said left atrium obtained from at least one of said plurality of three-dimensional cardiac images or said modeling structure of said left atrium; simulating at least one of time dependent structural function or time-dependent blood flow of said left atrium usin

Abstract: A method for manufacturing a graphene composite film includes preparing a zeolite suspension containing zeolite nanocrystals with a concentration of 50-100 ppm and with a particle size of 50-80 nm. The zeolite suspension has a pH value of 11-13. A graphene oxide suspension containing graphene oxide with a concentration of 50-200 ppm is mixed with the zeolite suspension to form a composite solution. The composite solution is transferred into a 15° C. water bath when a color of the composite solution turns from brownish-yellow into deep brown. A surfactant is added into the composite solution in the 15° C. water bath. The composite solution is then sonicated for 5-30 minutes and removed out of the 15° C. water bath, with the color of the composite solution turning from deep brown into black. The composite solution is further processed to form a graphene composite film having not more than 5 layers.

Abstract: Antibody VRC01 represents a human immunoglobulin that neutralizes—˜90% of diverse HIV-1 isolates. To understand how such broadly neutralizing HIV-1 antibodies develop and recognize the viral envelope, we used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding of different antibodies to the same CD4-binding-site epitope. Antibody recognition was achieved through the evolution of complementary contact domains that were generated in diverse ways. Phylogenetic analysis of expressed heavy and light chains determined by deep sequencing revealed a common pathway of antibody heavy chain maturation confined to IGHV1-2*02 lineage that could pair with different light chains.

Abstract: An architectural structure for constructing a variety of goods in a variety of configurations is provided. The architectural structure includes a plurality of paired slat-like members and a spine configured to hold the plurality of paired slat-like members in an expanded state. Each paired slat-like members includes joined upper ends, joined lower ends and an expandable central region joined to an adjacent paired slat-like members.

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

Abstract: The present invention discloses a fiducial node DC voltage based DC voltage droop control method with dead-band for HVDC grids. Two levels of DC voltage control e.g. primary and secondary DC voltage regulation are introduced to realize load sharing and DC voltage control in HVDC grids. In the process of primary DC voltage regulation, the power flow regulation ability of the entire HVDC grids can be significantly improved, and the DC voltage and stability of the HVDC grids will be quickly controlled and guaranteed for the benefit of droop characteristic. Secondary DC voltage regulation is achieved by by introducing the load-DC voltage controller. In the process of secondary DC voltage regulation, the burden of accommodating power imbalance by the DC voltage fiducial node will be alleviated, thus improving the ability to resist disturbances of the entire HVDC grids.

Abstract: Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

Abstract: Disclosed is a composition for use in the prevention, treatment, and management of diabetes in human and animal subjects that contains 2,3,5,4-tetrahydroxystilbene 2-O-b-glucopyranoside collected from one or more plants selected from the group consisting of Fallopia genera of plants.

Abstract: A wireless communication device includes an array of helical antennas on a substrate. Each helical antenna comprises a strain-relieved sheet with a conductive strip thereon, where the strain-relieved sheet and the conductive strip are in a rolled configuration about a longitudinal axis. The conductive strip is oriented at an angle ? with respect to a rolling direction so as to comprise a helical configuration about the longitudinal axis with a non-zero helix angle ?. The array exhibits a maximum gain of at least about 10 dB at a working frequency of at least about 0.1 THz.

Abstract: The present disclosure describes the fusogenic activity of the Myomaker protein. This polypeptide, when expressed in non-muscle cells, is able to drive fusion of the cell with a muscle cell, but not with other non-muscle cells. The use of this protein and cell expressing it in the delivery of exogenous genetic material to muscle cells also is described.

Abstract: A device for use by a dental patient fits in the patient's ear and has at least one curved resonator tube to reduce the perceived volume of a dental drill. The device can have multiple layers of resonator tubes and a port into which recorded music can be played to calm the patient further.

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

Abstract: The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes.

Abstract: A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to generate an integrated voltage. A self-resetting continuous-time differentiator is configured to differentiate the integrated voltage on one of a plurality of differentiating capacitors to generate an output voltage proportional to the input current. A fixed-threshold window comparator is configured to reset one of the plurality of integration capacitors, reset one of the plurality of differentiating capacitors, open a second one of the plurality of integration capacitors and open a second one of the plurality of differentiating capacitors in response to the integrated voltage exceeding a voltage range.

Abstract: The present invention provides methods and compositions for detecting multiple citrus pathogens using a multiplex branched DNA signal amplification reaction.

Abstract: Provided is a high-frequency power generator with an enhanced pulse function, which supplies high-frequency power to a plasma load. The high-frequency power generator may include: a rectifier configured to receive AC power and rectify the received AC power; a DC-DC converter configured to adjust an output voltage by switching an output of the rectifier; an RF power amplifier configured to amplify an output of the DC-DC converter, and transfer high-frequency power with a pulse waveform to the plasma load; an RF power controller configured to control the output and pulse waveform of the RF power amplifier; and a DC-DC converter controller configured to receive a pulse signal from the RF power controller, and control a duty ratio of switching elements constituting the DC-DC converter.

Abstract: Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles.

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

Abstract: The present disclosure relates generally to microneedle devices and methods for fabricating microneedles from a biocompatible polymer using photolithography. More particularly, aspects of the present disclosure are directed to the fabrication of microneedle devices using a biocompatible polymer (biopolymer) by way of biocompatible, essentially biocompatible, or substantially biocompatible fabrication techniques.