Abstract: A deposition system for forming a stress distributed coating layer is provided which comprises a deposition apparatus comprising a source from which a coating material emanates, the source configured to restrict a flux of the coating material towards a backside of an optical substrate; a holder configured to hold the optical substrate; a drive system configured to provide relative translation of the source and the optical substrate; and a bias voltage power supply operably coupled to the source and the optical substrate and configured to apply a bias voltage between the source and the backside of the optical substrate.
Type:
Grant
Filed:
November 27, 2017
Date of Patent:
April 30, 2019
Assignee:
Northwestern University
Inventors:
Youwei Yao, Melville Paul Ulmer, Jian Cao, Xiaoli Wang
Abstract: In some examples, a method of forming alane (AlH3), the method comprising reacting one of: 1) a MAlH4, wherein M is an alkali metal; 2) alkali-metal hydride, MH; or 3) alkali-metal with one or more aluminum halides (AlX3, where X is a halogen), via a mechanochemical process, to form the alane, wherein the reaction is substantially solvent free and carried out in an environment with a temperature between approximately 250 K and approximately 330 K.
Type:
Grant
Filed:
February 12, 2015
Date of Patent:
April 30, 2019
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Shalabh Gupta, Vitalij K. Pecharsky, Takeshi Kobayashi, Marek Pruski, Ihor Hlova
Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
Type:
Grant
Filed:
September 12, 2018
Date of Patent:
April 30, 2019
Assignee:
The University of British Columbia
Inventors:
Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
Type:
Grant
Filed:
April 15, 2016
Date of Patent:
April 30, 2019
Assignees:
Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.
Inventors:
Lee Daniel Arnold, Hans Maag, William W. Turner, Jr.
Abstract: Provided are a coating solution for a non-light-emitting organic semiconductor device having high carrier mobility that contains a compound represented by Formula (2) and a solvent having a boiling point of equal to or higher than 100° C., an organic transistor, a compound, an organic semiconductor material for a non-light-emitting organic semiconductor device, a material for an organic transistor, a method for manufacturing an organic transistor, and a method for manufacturing an organic semiconductor film. (In Formula (2), R11 and R12 each independently represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxy group and may have a substituent, and an aromatic portion in Formula (2) may be substituted with a halogen atom.
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
April 30, 2019
Assignees:
FUJIFILM Corporation, The University of Tokyo
Abstract: A process for making an iron oxide impregnated carbon nanotube membrane. In this template-free and binder-free process, iron oxide nanoparticles are homogeneously dispersed onto the surface of carbon nanotubes by wet impregnation. The amount of iron oxide nanoparticles loaded on the carbon nanotubes range from 0.25-80% by weight per total weight of the doped carbon nanotubes. The iron oxide doped carbon nanotubes are then pressed to form a carbon nanotube disc which is then sintered at high temperatures to form a mixed matrix membrane of iron oxide nanoparticles homogeneously dispersed across a carbon nanotube matrix. Methods of characterizing porosity, hydrophilicity and fouling potential of the carbon nanotube membrane are also described.
Type:
Grant
Filed:
July 17, 2017
Date of Patent:
April 30, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Inventors:
Muataz Ali Atieh, Ihsanullah, Tahar Laoui
Abstract: Provided are a gene carrier using cell-derived nanovesicles and a method for preparing the same. The gene carrier prepared by inserting a gene into the nanovesicles artificially outbudded from a plasma membrane has excellent delivery efficiency to a target organ and cells, induces long-term regulation of gene expression, and facilitates mass production due to a simple preparation process, and thus can be used as a core technique for the gene or cell therapeutic agent field.
Type:
Grant
Filed:
April 24, 2017
Date of Patent:
April 30, 2019
Assignee:
University-Industry Foundation, Yonsei University
Abstract: Working memory deficits are treated and working memory is improved with a composition that comprises a therapeutically effective amount of one or more respective selective dopamine D4 receptor agonists and/or pharmaceutically acceptable analogs, salts or hydrates of the respective one or more selective dopamine D4 receptor agonists. This composition can be administered to a subject to improve the subject's working memory.
Type:
Grant
Filed:
September 12, 2014
Date of Patent:
April 30, 2019
Assignees:
Florida State University Research Foundation, Inc., The General Hospital Corporation
Inventors:
Pradeep G. Bhide, Jinmin Zhu, Joseph Biederman, Thomas J. Spencer
Abstract: A target tissue can be treated with a radioisotope. Some methods for treating a target tissue with a radioisotope include determining a distance between a target tissue and a surface of a matrix material to be positioned adjacent the target tissue and, based on the determined distance, determining an activity to be mixed with the matrix material to obtain a desired activity concentration. Some methods further include mixing the radioisotope with the matrix material. In some embodiments, the matrix material comprises bone cement, and the target tissue is a tumor in a bone. The radioisotope may be a beta-emitting radioisotope mixed in the cement at a concentration to form a radioactive cement.
Type:
Grant
Filed:
March 20, 2017
Date of Patent:
April 30, 2019
Assignee:
The Regents of the University of California
Inventors:
Joyce H. Keyak, Tadashi Kaneko, Harry B. Skinner, Varun Sehgal
Abstract: A method and apparatus for receiving feedback information of a transmitter in a mobile communication system are provided. The method includes determining a parameter related to a first user signal; transmitting the first user signal based on the parameter related to the first user signal to a receiver; and receiving feedback information associated with the first user signal and an interference signal based on the first user signal.
Type:
Grant
Filed:
September 18, 2015
Date of Patent:
April 30, 2019
Assignees:
Samsung Electronics Co., Ltd, Dongguk University Industry-Academic Cooperation Foundation
Inventors:
Jongsoo Choi, Byoung Jo Choi, Seung Hoon Hwang, Eun Sun Hwang
Abstract: A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.
Abstract: A semiconductor device includes a semiconductor substrate comprising a group III element and a group V element, and a gate structure on the semiconductor substrate. The semiconductor substrate includes a first region which contacts a bottom surface of the gate structure and a second region which is disposed under the first region. The concentration of the group III element in the first region is lower than that of the group V element in the first region, and the concentration of the group III element in the second region is substantially equal to that of the group V element in the second region.
Type:
Grant
Filed:
October 27, 2016
Date of Patent:
April 30, 2019
Assignees:
Samsung Electronics Co., Ltd., Seoul National University R&DB Foundation
Inventors:
Ha-Jin Lim, Hyeong-Joon Kim, Nae-In Lee
Abstract: A secondary alkaline battery using manganese dioxide is described. The battery includes a mixed cathode material with birnessite-phase manganese dioxide or electrolytic manganese dioxide (EMD), a bismuth compound and a copper compound selected from the group consisting of elemental copper and a copper salt. In some embodiments, a conductive carbon and/or a binder may also be included.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
April 30, 2019
Assignee:
Research Foundation of the City University of New York
Inventors:
Gautam G. Yadav, Joshua Gallaway, Michael Nyce, Sanjoy Banerjee
Abstract: Methods of generating second harmonic generation (SHG) signals from interfaces formed with, or formed over, a noncentrosymmetric material, e.g., ?-quartz, are provided. The methods make use of the noncentrosymmetric material as an internal phase reference for the determination of a variety of interfacial electrostatic parameters, including interfacial potential, interfacial charge density, and the sign of the interfacial charge (i.e., net positive or net negative).
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
April 30, 2019
Assignees:
Northwestern University, Battelle Memorial Institute, The Trustees of Columbia University in the City of New York
Inventors:
Franz M. Geiger, Paul E. Ohno, Hong-fei Wang, Kenneth B. Eisenthal
Abstract: The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject.
Type:
Grant
Filed:
November 23, 2011
Date of Patent:
April 30, 2019
Assignee:
Northwestern University
Inventors:
Richard P. Van Duyne, Matthew R. Glucksberg, Joseph T. Walsh, Jr., Jonathan M. Yuen, Nilam C. Shah
Abstract: A fiber optic-based communications network includes: a power insertion device, connected to multiple fiber links from a data source, configured to provide power insertion to a hybrid fiber/power cable connected to at least one fiber link of the multiple fiber links; the hybrid fiber/power cable, connecting the power insertion device to a connection interface device, configured to transmit data and power from the power insertion device to the connection interface device; and the connection interface device, configured to provide an interface for connection to an end device via a power over Ethernet (PoE)-compatible connection and to provide optical to electrical media conversion for data transmitted from the power insertion device to an end device via the hybrid fiber/power cable and the PoE-compatible connection.
Abstract: A noninvasive arterial condition detecting system includes a processing device and an electronic stethoscope configured for auscultating carotid artery to receive sound signals. The processing device is connected to the electronic stethoscope. The processing device records the sound signals, preprocesses the sound signal to reduce noise, measures a trough-peak distance and a trough-peak time, and generates an estimate result of arterial conditions according to the trough-peak distance and the trough-peak time. The trough-peak distance and the trough-peak time are related to the health of the carotid artery walls.
Abstract: The present invention provides drug delivery compositions that allow for immediate and/or sustained release of a therapeutic agent contained within the system. The present invention also provides drug delivery compositions that preserve the stability of the therapeutic agent contained within during the sustained release. The present invention further provides a method of treating, ameliorating, or preventing an inflammation-related disease or disorder in a subject using the compositions of the invention.
Abstract: A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft configured to connect the first interface portion and the second interface portion, and a sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The sensor may be configured to provide a DC signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures. The sensor may also be configured to provide an AC signal output indicative of a frequency response of the implant in response to the sensor being coupled to an output device.
Type:
Grant
Filed:
July 10, 2017
Date of Patent:
April 30, 2019
Assignee:
The Johns Hopkins University
Inventors:
Dawnielle Farrar-Gaines, George L. Coles, Jr., David A. Kitchin, Howard W. Francis, Ioan Lina