Abstract: The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising salinomycin as an active ingredient, which acts differently depending on the type of senescent cells, and it was confirmed that salinomycin exhibits a senomorphics effect of restoring the function and morphology of fibroblasts and vascular endothelial cells in which senescence is induced and exhibits a senolytics effect of selectively killing aging-induced retinal pigmented epithelial cells, and exhibits a senomorphics effect of restoring the function and morphology of cells, and thus the salinomycin acts differently depending on the type of cells to effectively prevent or treat senile eye disease, tissue fibrosis disease, atherosclerosis, osteoarthritis, degenerative brain disease, chronic skin damage, obesity and diabetes caused by cellular aging and can be provided as a composition for life extension.

Abstract: An ultramarine fluorescent protein, is a protein selected from (a) and (b) protein: (a) a protein consisting of an amino acid sequence set forth in SEQ ID:NO. 2; (b) a protein derived from (a) by substitution, deletion or addition with one or more amino acids in the amino acid sequence of (a) and having activity of the ultramarine fluorescent protein. The ultramarine fluorescent protein (UFP) has the characteristics of pH-insensitivity and light stability, and its chromophore can absorb long-wavelength ultraviolet (UVA) and release fluorescence at wavelength longer than 400 nm. And the aromatic amino acids residue (with content of 9.2%) can absorb medium wavelength ultraviolet (UVB) and release UVA.

Abstract: The present invention provides a method for producing a pluripotent stem cell released from resistance to differentiation into mesendodermal lineage, including subjecting a pluripotent stem cell to a treatment for activating an integrin ?1-?-catenin signal transduction pathway (excluding contacting the pluripotent stem cell with laminin 421 or a fragment thereof and/or laminin 121 or a fragment thereof), and the like.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: Disclosed is a spirally heating submarine pipeline including: a conduit which transports a high temperature high pressure fluid from a submarine oil well; and a heating unit disposed in a spiral structure inside based on an outer circumferential surface of the conduit. The heating unit includes an electric heating wire that is installed along the spiral structure to generate heat; a heat insulator that is installed in the form of fully surrounding the electric heating wire and preserves the generated heat; and a heat insulating cap for isolating the heat insulator from the conduit or the heat insulating layer and is provided so as to increase the temperature of the flow in the pipe to prevent the production of a pipe flow interfering material when the fluid is transported in the conduit.

Abstract: The presently disclosed subject matter provides systems and methods for producing a three-dimensional model of a human cervix. A microdevice is provided for culturing human cervical cells. The microdevice can include an upper microchannel including live ectocervical epithelial cells. The microdevice can include a lower microchannel including a first parallel lane and a second parallel lane including stromal media. The first and the second parallel lanes can be lined with live vascular endothelial cells. The lower microchannel can include a third parallel lane including uterine fibroblasts and live smooth muscle cells embedded in hydrogel. The first, second, and third lanes of the lower microchannel can be separated by protrusion structures. The third parallel lane can be positioned in the lower microchannel in between the first and the second parallel lanes. The microdevice can further include a porous membrane positioned in between the upper microchannel and the lower microchannel.

Abstract: A myocardium image analysis method comprising acquiring a target image including precontrast-enhanced myocardium, based on a type of coronary artery related to the myocardium, distinguishing the myocardium included in the target image, using an artificial neural network, providing information on the distinguished myocardium, wherein the artificial neural network is trained based on a training database generated by matching images for training of precontrast-enhanced coronary artery and myocardium and images for training of postcontrast-enhanced coronary artery and myocardium.

Abstract: Disclosed are recombinant phages that infect and kill bacterial hosts in response to user-defined inputs. The components that encode the user-defined inputs can be combined, such that multiple inputs are maintained on a single recombinant phage, enabling precise control over the targeting strategy. The phages can be engineered to kill a specific bacterial species or multiple species simultaneously. Recombinant phages can also be engineered to harbor fluorescent and bioluminescent reporter genes that enable them to be used for tracking, detection, and in biosensing applications. Recombinant phages can also be used to lyse bacterial cells that produce recombinant proteins, as a rapid method to enable extraction and high-level purification of potentially valuable and/or industrially important proteins.

Abstract: The present disclosure provides an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-related diseases, each comprising a nucleic acid analogue as an active ingredient. The problem can be solved by 2?-deoxy-2?-fluoro-?-2-fluoro-D-adenosine or its prodrug, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

Abstract: Disclosed is a memory device including a lower electrode, a seed layer, a synthetic antiferromagnetic layer, a magnetic tunnel junction, and an upper electrode laminated on a substrate, wherein the magnetic tunnel junction includes a pinned layer, a tunnel barrier layer, and free layers, wherein the free layers include a first free layer, a spacer layer, a coupling layer, a buffer layer, and a second free layer laminated in sequential order.

Abstract: Aspects of the present application relate to techniques of diagnosing whether a pathogen (e.g., SARS-CoV-2) is present in a subject using infrared (IR) spectroscopy and machine learning techniques. The techniques use spectral data obtained from performing IR spectroscopy on a biological sample (e.g., saliva or nasal sample, or genetic material extracted therefrom) to generate a set of feature values. The feature values are provided as input to a machine learning model to obtain output indicating whether the pathogen is present in the biological sample. The output of the machine learning model may be used to determine a diagnosis result for a subject.

Abstract: An optical pulse measuring method measuring an optical pulse generated from a pulse light source is provided. The method includes: splitting the optical pulse and then focusing them at a measuring point, so as to generate gas plasma by the autocorrelation of the split optical pulses; receiving the sound signal from the gas plasma and generate a plasma sound signal; and using the plasma sound signal to calculate the characteristics of the optical pulse. A measuring device is also provided.

Abstract: A method for producing a brain organoid is provided, including a step of culturing a neuroectoderm marker-positive cell aggregate in a medium containing an extracellular matrix with a concentration of more than 10% by volume.

Abstract: According to the present invention, blood pressure surges is detected from time-series data on blood pressure of a subject that varies with pulsation based on predetermined determination criteria. A feature amount indicating a characteristic of each blood pressure surge thus detected is obtained. Statistical processing is performed on an occurrence number of the blood pressure surges thus detected and/or the feature amount to obtain a statistical amount for each of time slots. A required attention degree indicating a level of attention being required to the blood pressure surge is obtained for each of the time slots based on the statistical amount of the occurrence number of the blood pressure surges and/or the feature amount. The required attention degree thus obtained and/or the statistical amount are displayed side by side for each of the time slots on a display screen.

Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.

Abstract: A carbon isotope analysis method, including the steps of: generating carbon dioxide isotope from carbon isotope; feeding the carbon dioxide isotope into an optical resonator having a pair of mirrors; applying irradiation light having an absorption wavelength of the carbon dioxide isotope into the optical resonator; adjusting a relative positional relationship between the mirrors so that an optical axis of the irradiation light and an optical axis of light generated by the etalon effect are not matched; measuring the intensity of the transmitted light generated by resonance of carbon dioxide isotope excited by the irradiation light; and calculating the concentration of the carbon isotope from the intensity of the transmitted light. An optical resonator that can be suppressed in the parasitic etalon effect, and a carbon isotope analysis device and a carbon isotope analysis method, by use of the optical resonator, are provided.

Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output.

Abstract: A wireless ultrasound sensor 404 for non-destructive testing of a test object 502, the sensor comprising: an ultrasound transducer 406; a first induction coil 408, electrically coupled to the ultrasound transducer; a second induction coil 414, electrically coupled in parallel with the first induction coil; wherein the first and second induction coils are arranged to enable the transducer to be inductively operated by a remote device 504; and wherein the diameter of the second induction coil is greater than the diameter of the first induction coil.

Abstract: Compositions and methods for preventing, treating, or delaying the onset of rheumatoid arthritis involving 14-3-3?, are described. Provided is a method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising administering an effective amount of 14-3-3?, or a variant thereof, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.

Abstract: Embodiments herein describe systems and methods to enhance RNA translation and stability and uses thereof. Many embodiments generate RNA molecules possessing increased structure and/or reduced free energy over an initial sequence. Such RNA molecules can be used as therapeutics and/or vaccines.