Abstract: Bivalent immunogenic compositions against anthrax and plague are disclosed herein. One bivalent immunogenic composition comprises a triple fusion protein containing three antigens, F1 and V from Yersinia pestis and PA antigen from Bacillus anthracis fused in-frame and retaining structural and functional integrity of all three antigens. Another bivalent immunogenic composition comprises bacteriophage nanoparticles arrayed with these three antigens on the capsid surface of the bacteriophage nanoparticles. These bivalent immunogenic compositions are able to elicit robust immune response in a subject administered said the bivalent immunogenic compositions and provide protection to the subject against sequential or simultaneous challenge with both anthrax and plague pathogens.

Abstract: A method of forming birnessite ?-MnO2 nanosheets is provided. The method includes oxidizing manganese (Mn2+) in the presence of a source of nitrate and a light source.

Abstract: The exemplified disclosure presents a highly power efficient amplifier (e.g., front-end inverter and/or amplifier) that achieves significant current reuse (e.g., 6-time for a 3-stack embodiments) by stacking inverters and splitting the capacitor feedback network. In some embodiments, the exemplified technology facilitates N-time current reuse to substantially reduced power consumption. It is observed that the exemplified disclosure facilitates significant current-reuse operation that significantly boost gain gm while providing low noise performance without increasing power usage. In addition, the exemplified technology is implemented such that current reuse and number of transistor has a generally linear relationship and using fewer transistors as compared to known circuits of similar topology.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.

Abstract: A passive MRI enhancing embodiment includes a plurality of resonators and increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the magnetic field component of radiofrequency energy during signal transmission from the MRI machine to the specimen, and/or reception of signals from the specimen to the MRI machine. Use of the apparatus improves the images generated by the MRI machine, and/or reduces the time necessary for the MRI machine to capture the image. An isolator embodiment has a nonlinear resonator controllably configurable alternately into an isolation configuration and a transmission configuration, and a second resonator.

Abstract: A detection element includes an exposed electrode on the first surface of an insulating substrate, the exposed electrode including first exposed electrode, second exposed electrode, third exposed electrode, and fourth exposed electrode provided; a first electrode pattern provided on a side opposite to the first surface, the first electrode pattern including a pattern connected to the first exposed electrode and the second exposed electrode, a pattern connected to the third exposed electrode and the fourth exposed electrode, a second electrode pattern having a first exposed portion and a pattern provided along the second direction, and a third electrode pattern having a second exposed portion and a pattern provided along the third direction, provided so as to sandwich the third electrode pattern between the first electrode pattern and the second electrode pattern.

Abstract: Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV1-4 viral infections.

Abstract: Disclosed herein are compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis.

Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

Abstract: A mount bush includes a tubular member, a shaft member disposed inside the tubular member coaxially with an axis of the tubular member and including a coil, a permanent magnet provided on at least one of the tubular member and the shaft member, a magnetic viscoelastic fluid filled in an internal space, a first liquid chamber disposed in the internal space at a first side, a second liquid chamber communicating with the first liquid chamber, and a third liquid chamber communicating with the second liquid chamber, wherein the coil is disposed such that a magnetic path passing through the second liquid chamber in an orientation along at least one of the axial direction and the radial direction perpendicular to the axial direction is formed through electrical conduction, and the permanent magnet is disposed such that a magnetizing direction is formed along the magnetic path.

Abstract: In certain embodiments osteoadsorptive fluorogenic substrates of cathepsin K (or other proteases) are provided. Utilizing a bisphosphonate targeting moiety, the fluorogenic substrates provide effective bone-targeted protease sensor(s). In certain embodiments the “probes” comprise cleavable fluorophore-quencher pair linked by a cathepsin K (or other protease) peptide substrate and tethered to a bisphosphonate. Unlike existing probes that are cleared within a few days in vivo, the probes described herein (e.g., OFS-1) allow for monitoring resorption over the course of longer time periods with a single dose.

Abstract: Embodiments relate to a system for providing a first fluid and a second fluid. The system includes a catheter hub, a flexible cover, and a catheter. The flexible cover is configured to attach to the catheter hub and provide a seal therewith. The catheter is configured to be at least partially arranged within the catheter hub and the flexible cover and pass through the seal. The catheter includes a primary lumen and a secondary lumen, wherein the primary lumen is configured to provide the first fluid at a distal end of the catheter, and the secondary lumen is configured to provide the second fluid at each of a plurality of apertures arranged on an outer radial wall of the catheter.

Abstract: A methodology and/or system to automatically generate an optimal collaborative agreement, according to which multiple vessel arrival time windows, start and end times for each time window, and multiple handling rates during each time window are offered by the marine container terminal operator to the liner shipping company at each port of the given liner shipping route. The vessel scheduling problem is formulated as a mixed integer nonlinear programming model, where the total liner shipping route service cost is minimized. A set of linearization techniques are applied to the original model, and the linearized model is solved using CPLEX. A number of computational experiments were performed for the Pacific Atlantic 1 liner shipping route, served by the NYK liner shipping company, with results showing effectiveness of the proposed collaborative agreement and the adopted solution methodology to improve liner shipping operations.

Abstract: Apparatuses and methods are provided for quantifying an analyte in a gas or liquid phase. A light source with an emission spectrum overlapping an absorption of the analyte, and a pair of reflective mirrors located on an optical axis to form an optical cavity can be included. An off-axis photon detector can be configured as a fluorescence detector and located off the cavity axis and arranged to provide a first signal in response to fluorescence within the cavity. An axial photon detector can be located axially, and external, to the cavity and arranged to provide a second signal. The portion of the apparatus including the light source, the cavity, and the axial photon detector can be configured with a cavity-enhanced absorption spectrometer, and the portion of the apparatus including the off-axis photon detector can be configured with a cavity-enhanced laser-induced fluorescence (CELIF) spectrophotometer.

Abstract: The present invention relates to an elastic conductor with high conductivity and stable electrical performance under stretching. The elastic conductor comprises a matrix material; a plurality of electrically conductive structures embedded in the matrix; and one or more particles embedded in the matrix, wherein the particles are configured to release an electrically conductive material upon stretching of the elastic conductor. In a preferred embodiment, each of the particles comprises a core of the electrically conducting material, such as liquid eutectic gallium indium alloy, and an outer shell surrounding the core, such as gallium oxide.

Abstract: Disclosed is a method for fabricating a spherical concave mirror in an optical waveguide based on ultraviolet (UV) grayscale lithography. A key component is a specially designed mask pattern composed of a rectangle as well as a semicircle adjacent to the rectangle, where a rectangular area has no grayscale distribution, and UV light penetrating through different portions of the rectangular area has the same intensity; a semicircular area has the grayscale distribution, and the UV light penetrating through the semicircular area with the grayscale distribution is changed in intensity from the center of a circle in the radius direction according to a special function distribution law; an interlayer photoresist in the rectangular area is irradiated by the UV light penetrating through a mask plate and is developed to form an optical waveguide core.

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract: A system for illuminating medical tubes is disclosed. The system includes an optical fiber secured to and extending along a length of a medical tube, and a light source configured to transmit a light through the optical fiber. The system further includes a controller in communication with the light source, and configured to control the light source. Additionally, the system includes an optical junction having a first input configured to secure a portion of medical tubing, a second input configured to receive and direct the light from the light source to the optical fiber, and an output configured to secure the optical fiber and the medical tube. The first input and the output are fluidly connected via the optical junction. The light illuminates the medical tubing via the optical fiber.

Abstract: A method and a device of acquiring an appearance model, a computer device and a storage medium. The method includes acquiring a set of target point clouds, the set of target point clouds including at least two point clouds, each of the point clouds being obtained by sampling a local area of a target object; then performing a registration and a completion for the at least two point clouds to obtain a processed point cloud, wherein the registration is to transform different point clouds into a same coordinate system, and the completion is to add points in other areas of the object according to existing points in a point cloud to be completed; and finally acquiring the appearance model of the target object according to the processed point cloud. The method can improve applicability of the appearance model of the target object acquired only by registration technique.