Abstract: The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.

Abstract: Devices and methods for super-resolution optical microscopy are described. Devices include an optical multiplexer to develop an excitation/illumination optical beam that includes alternating pulses of different profiles. Devices also include a signal processing unit to process a sample response to excitation/illumination beam and to subtract the neighboring pulses of the different profiles from one another on a pulse-to-pulse basis. Devices can be incorporated in existing confocal microscopy designs. As the subtraction effectively reduces the volume of the response signal, the spatial resolution of the systems can be markedly improved as compared to previously known optical microscopy approaches.

Abstract: Methods treating pulmonary hypertension, including pulmonary arterial hypertension, are provided, and include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Administration of the polypeptide antagonist reduces pulmonary artery acceleration time, reduces an amount of right ventricular hypertrophy, reduces right ventricular wall thickness, reduces an amount of pulmonary vessel wall thickness, reduces an amount of plexiform lesions in a lung of the subject, reduces an amount of collagen deposition in a pulmonary blood vessel, reduces an amount of collagen deposition in a pulmonary blood vessel media or adventitia, and/or reduces an amount of right ventricular fibrosis. Methods of reducing pulmonary vessel wall thickness are also provided and include the administration of the polypeptide antagonist of a Na/K ATPase/Src receptor complex.

Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.

Abstract: The present invention directs to a method for treating a smooth muscle cell proliferative disease by using a recombinant expression vector comprising a polynucleotide encoding FGF12, or by using FGF12 protein or a fragment thereof; and a method for detecting a marker for diagnosis of smooth muscle cell proliferative disease, comprising the measurement of FGF12 expression level.

Abstract: An apparatus for determining unknown radio frequencies is described. The apparatus modulates a first optical signal from tunable optical source with RF signal that includes unknown center frequency value to generate modulated optical signal. The apparatus combines modulated optical signal with second optical signal to generate combined modulated optical signal. The apparatus receives output electrical signal from photodetector in response to receiving combined modulated optical signal at photodetector, splits output electrical signal into first output electrical signal and second output electrical signal, and filter first output electrical signal by applying first optical bandpass filter centered to generate first filtered RF signal. The apparatus tunes tunable optical source to first beat frequency value to determine unknown frequency value of RF signal.

Abstract: The present disclosure relates to a thermoelectric material, and more specifically to a superlattice thermoelectric material and a thermoelectric device using the same. The superlattice thermoelectric material has a composition of a following Chemical Formula 1: (AX)n(D2X?3)m??,<Chemical Formula 1> wherein, in the Chemical Formula 1, A is at least one of Ge, Sn, and Pb, X is a chalcogen element, and at least one of S, Se, and Te, D is at least one of Bi and Sb, each of n and m is an integer between 1 and 100, and A or X is at least partially substituted with a dopant.

Abstract: A freeform surface off-axis three-mirror optical system comprises a primary mirror, a secondary mirror, a tertiary mirror, an aperture stop located on the secondary mirror, and an image surface. An incident light beam emitted from an object irradiates and is reflected on the primary mirror to form a first reflected light beam. The first reflected light beam irradiates and is reflected on the secondary mirror to form a second reflected light beam. The second reflected light beam passes through the incident light beam, and then irradiates and is reflected on the tertiary mirror to form a third reflected light beam. The third reflected light beam passes through the incident light beam and does not pass through the secondary mirror, and finally reaches the image surface for imaging. A reflective surface of each of the primary mirror, the secondary mirror, and the tertiary mirror is an xy polynomial freeform surface.

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

Abstract: Methods and software for electrochemical energy storage management including operation, planning, and valuation. The decision objective for operation is to maximize the total/remaining life-cycle benefit of electrochemical energy storage, subject to degradation and other operational constraints. The operational decisions are both short term and long term, to address the intertemporal trade-offs brought by degradation issues. Two metrics are proposed for operational and planning decisions respectively: marginal benefit of usage and average benefit of usage. A sample algorithm is provided to solve the multi-timescale optimization problem.

Abstract: Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof.

Abstract: A multi-angle spinneret for forming hollow fibers is provided. The multi-angle spinneret includes a body defining a dope chamber, a bore needle channel, and multiple dope channels being oriented at a minimum of two distinct dope channel angles relative to the dope chamber. The body includes a bore needle disposed in the bore needle channel and oriented substantially perpendicular relative to the dope chamber. The bore needle extends though the dope chamber, such that a bore fluid flow through the bore needle is kept separate from a dope flow through the dope channels. A bore fluid outlet is positioned within a dope outlet of the dope chamber, such that a bore fluid flow out of the bore fluid outlet is substantially coaxial with and substantially centered within a dope flow out of the dope outlet.

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: A method for locating human remains in a clandestine or undocumented burial includes providing a spectroscopy assembly including a spectroscopy probe with a distal end to a location that may include human remains, wherein the spectroscopy assembly is configured to identify whether a salt of a fatty acid is present based on overtone wavelengths of the salt of the fatty acid; inserting the distal end of the spectroscopy probe into a testing spot at the location that may include human remains; and analyzing, with the spectroscopy assembly and after the step of inserting, whether the salt of the fatty acid having the overtone wavelengths is present in the location that may include human remains. The step of analyzing may include near-infrared spectroscopy, and the overtone wavelengths may be characterized by an absorption band contour extending from about 1670 nm to about 1800 nm.

Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

Abstract: The present invention, at least in part, relates to the discovery of efficacious delivery of an RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue. Organ rejection, transplantation-mediated transmission of viral infection, and triggering of apoptosis in transplanted tissues can each be minimized by the methods and compositions of the instant invention. The RNAi agent(s) of the instant invention can be delivered as “naked” molecules, or using liposomal and other modes of delivery, to transplantable tissues. Such delivery can occur via perfusion of the RNAi agent in solution through the vasculature of a whole or partial organ; or tissues including transplantable cells and cell lines may be bathed, injected or otherwise treated with RNAi agents. Preferred transplantable tissues include, for example, pancreas, liver, kidney, heart, lung, and all cells and cell lines derived from such tissues (e.g., pancreatic islet cells that may, e.g.

Abstract: A method of manufacturing a group-III nitride crystal includes: a seed crystal preparation step of preparing a plurality of dot-shaped group-III nitrides on a substrate as a plurality of seed crystals for growth of a group-III nitride crystal; and a crystal growth step of bringing surfaces of the seed crystals into contact with a melt containing an alkali metal and at least one group-III element selected from gallium, aluminum, and indium in an atmosphere containing nitrogen and thereby reacting the group-III element with the nitrogen in the melt to grow the group-III nitride crystal.