Abstract: A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: The present disclosure presents a dual-channel filter based on a dielectric resonator, which includes a metal cavity, a dielectric resonator, two tuning metal probes, and four feeding metal probes. The dielectric resonator is disposed at the center of the metal cavity. The four feeding metal probes are disposed around the metal cavity, and coupled to the dielectric resonator. The two tuning metal probes are connected to the metal cavity, and respectively located at a central position directly above and below the dielectric resonator. The dual-channel filter integrates two channel filters with good isolation between them, and has two input ports and two output ports.

Abstract: A method determines a total velocity average cross-section parameter ?tot? in a relationship of the form ?loss(U)=nb?tot?·ƒ(U, Ud), where: ?loss(U) is a rate of exponential loss of sensor atoms from a cold atom sensor trap of trap depth potential energy U in a vacuum environment due to collisions with residual particles in the vacuum environment; nb is a number density of residual particles in the vacuum environment; Ud is a parameter given by U d = 2 ? k B ? T / m bg ? 4 ? ? ? ? ? 2 m t ? ? ? tot ? v ? which relates the masses of the sensor atoms mt and residual particles mbg to the total velocity average cross-section parameter ?tot?; and ƒ(U, Ud) is a function of the trap depth potential energy U and the parameter Ud which models a naturally occurring dependence of the loss rate ?loss(U) on the trap depth potential energy U and the parameter Ud, where ƒ(U=0, Ud) is unity for all Ud.

Abstract: A vapor and/or gas concentration and temperature sensor includes a resonating structure having a first side with a functionalized surface and a second side opposite the first side, a first resonant frequency of a first vibration mode, and a second resonating frequency of a second vibration mode. Drive and sensing electrodes face the second side of the resonating structure. A direct current bias source is coupled to the resonating structure. A first AC voltage source provides the resonating structure with a first voltage having a frequency corresponding to the first resonant frequency. A second AC voltage source provides the resonating structure with a second voltage having a frequency corresponding to the second resonant frequency.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: An integrated power semiconductor device, includes devices integrated on a single chip. The devices include a vertical high voltage device, a first high voltage pLDMOS device, a high voltage nLDMOS device, a second high voltage pLDMOS device, a low voltage NMOS device, a low voltage PMOS device, a low voltage NPN device, and a low voltage diode device. A dielectric isolation is applied to the first high voltage pLDMOS device, the high voltage nLDMOS device, the second high voltage pLDMOS device, the low voltage NMOS device, the low voltage PMOS device, the low voltage NPN device, and the low voltage diode device. A multi-channel design is applied to the first high voltage pLDMOS device, and the high voltage nLDMOS device. A single channel design is applied to the second high voltage pLDMOS device.

Abstract: A lane line detection method using a fusion network based on an attention mechanism, and a terminal device are provided. The method includes: synchronously acquiring natural images and point cloud data of a road surface; and inputting the natural images and the point cloud data into a pre-built and trained fusion network to output a lane line detection result. Time series frames and an attention mechanism are added to the fusion network to perform information fusing on the point cloud data and the natural images. Specifically, continuous frames are used to improve detection network performance to deal with complex situations such as label loss and vehicle being blocked; low-dimensional features are stitched with high-dimensional features by Skip Connection to make up for image detail information that is continuously lost as the network goes deeper, and the Decoder module is used to restore image dimensions to obtain a final result.

Abstract: Computer-based systems and methods for discovering neighborhood clusters in a geographic region, where the clusters have a mix of venues and are determined based on venue check-in data. The mix of venues for the clusters may be based on the social similarity between pairs of venues; or emblematic of certain neighborhood typologies; or emblematic of temporal check-in pattern types; or combinations thereof. The neighborhood clusters that are so discovered through venue-check in data could be used for many commercial and civic purposes.

Abstract: The present invention provides a new filter cleaning method that has cleaning performance superior to that of ultrasonic cleaning. The method for cleaning a filter of the present invention includes the steps of: generating a shock wave; and bringing the shock wave into contact with a filter to which a filler adhered, wherein in the shock wave contacting step, a pressure applied to the filter by the shock wave is 0.07 MPa or more.

Abstract: An immunogenic CD40-targeted trimeric MERS-CoV S1 fusion polypeptide as well as a corresponding polynucleotide encoding it and its use for safely inducing immune responses directed against MERS-CoV without inducing vaccine associated respiratory pathologies associated with non-targeted vaccines.

Abstract: A method for determining past exposure to chemical agents or heavy metals may include coating a capture material with a capture reagent. The capture reagent may be selected based on an ability of the capture reagent to bind with a target antibody, and the target antibody may be an indicator associated with a particular chemical agent or heavy metal. The method may further include interrogating a clinical sample associated with an individual by forming a mixture of the capture material and the clinical sample, and determining an exposure status of the individual to the particular chemical agent or heavy metal based on whether the capture material demonstrates capture of the indicator.

Abstract: A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.

Abstract: Tumor infiltrating lymphocytes (TILs) are white blood cells that are actively recruited to the tumor site to mount an immune response against tumor growth and metastasis. The disclosure provides methods for treating cancer that comprise steps of isolating CD8+ T cells from a sample derived from a subject, expanding the CD8+ T cells in the presence of interleukin-10, and ad ministering the expanded CD8+ T cells to the subject. Methods of treating cancer may be used in combination with inhibitors of the complement signaling pathway.

Abstract: A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a solvent. The ternary liquid mixture is contacted with water. A bijel includes a stable mixture of two immiscible liquids separated by an interfacial layer of colloidal particles. The bijel has temperature-independent stability, and the domain sizes are below one micrometer.

Abstract: The present invention improves a sense of participation in a topic and enables a dialogue to continue for a long time. A dialogue system 12 includes at least an input part 1 that receives a user's utterance and a presentation part 5 that presents an utterance. In an utterance receiving step, the input part 1 receives an utterance performed by the user. In a first presentation step, the presentation part 5 presents an utterance determined based on scenarios stored in advance. In a second presentation step, the presentation part 5 presents the utterance determined based on the user's utterance contents. A dialogue control part 8 performs control to execute a dialogue at least including a first dialogue flow which is a dialogue including the utterance receiving step and the first presentation step at least one time respectively based on a predetermined scenario, and a second dialogue flow which is a dialogue including the utterance receiving step and the second presentation step at least one time respectively.

Abstract: Clamp-on ultrasonic flow metering is provided by collectively exciting and receiving circumferential modes of the pipe. The pipe wall supports an infinite number of circumferential acoustic resonances. Each of these modes, in contact with a fluid, can mode-convert into the flow at a different rate. The mode-converted waves in the flow mode-convert back into the circumferential waves in the pipe once they travel across the flow. Furthermore, the moving fluid alters the rate of mode-conversion as a function of the flow velocity. At low frequencies, the wavelength is larger, thus the penetration depth in the flow is larger. As the frequency increases, the penetration depth becomes smaller. The variable penetration depth provides a methodology to sample the flow velocity profile.

Abstract: The disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-generation (4G) communication system such as long term evolution (LTE). An operation of a base station to location-based user classification and power allocation in a wireless communication system is provided. The method performed by a base station includes forming a pre-defined terminal group beam, classifying terminals into a plurality of terminal group by using location information of the plurality of terminals, received from the base station, allocating transmit (Tx) power to a terminal in a terminal group based on the location information of the plurality of terminals existing in each terminal group, and adjusting Tx power distributed to each terminal group so that an overall system communication capacity is greatest.

Abstract: The present invention provides an asymmetric EEG-based coding and decoding methods for BCIs, the BCI system includes an evoked stimulus module, an acquisition module and an EEG signal data set including a training set Xk and a testing sample Y, and an EEG signal decoding module; the evoked stimulus module sends a hybrid coding visual stimulus to subjects to evoke a specific EEG signal as required; the acquisition module obtains data information by amplifying and filtering the EEG signal so as to constitute EEG signal module; the decoding module coverts the data information into an instruction set for outputting the coding method of the present invention uses asymmetric characteristics of brain electrophysiological activity response to stimulus, combines with coding strategies such as SDMA, CDMA, FDMA and phase division multiple access coding.

Abstract: A scalpel that safely and efficiently removes excess dental composite from the surfaces of teeth. A method for removing excess dental composite from a dental surface using this dental scalpel.