Abstract: Among the various aspects of the present disclosure is the provision of transgenic hookworm compositions and systems and methods of use thereof. The present teachings include compositions for a transgenic hookworm that treats a disease, condition, or indication. Also disclosed is a personal protective biosystem based on the transgenic hookworm, and methods to treat a disease, condition, or indication of a subject using transgenic hookworm compositions.

Abstract: A method of pretreating wastewater sludge including applying an amount of at least 0.01 g/g TSS Ca(ClO)2 to wastewater sludge to enhance digestibility of the sludge and reduce phosphorus concentration therein and then allowing sufficient time for the wastewater sludge to densify to a treated sludge having a specific resistance to filtration (SRF) of 3 to 4 (1010 m/Kg). The resulting treated sludge composition being sterilized, free of harmful bacteria, and useful as a fertilizer, particularly for growing mushrooms.

Abstract: Flushable wet wipes, and methods of making and using the same, are described. The flushable wet wipes include a biopolymer comprising a carrageenan and optionally a monovalent or multivalent salt on a substrate.

Abstract: Provided is a recombinant adeno-associated virus (rAAV) having an AAV capsid and a vector genome which comprises a nucleic acid sequence encoding a functional CDKL5 (hCDKLK5). Also provided are a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having CDD, or ameliorating symptoms of CDD, or delaying progression of CDD via administrating an effective amount of the rAAV to a subject in need thereof.

Abstract: The present invention relates to the technical field of network security, and in particular to an abnormal data detection method, system and device for industrial Internet. This detection method compares data distribution of an initial node with a normal feature expression performance in first normal data distribution subject to extraction processing to obtain a first anomaly score, compares the data distribution of the initial node with the normal feature expression performance in second normal data distribution subject to enhancement processing to obtain a second anomaly score, obtains a risk level of the node based on the first anomaly score and the second anomaly score, and immediately provides corresponding limits on a node communication permission; and the method provides dual detection, is high in accuracy and stable in detection results, and facilitates the maintenance of industrial Internet security.

Abstract: A device for hand rehabilitation includes a glove to be donned on a user's hand, and a wrist flexion assembly that facilitates passive or assisted ulnar/radial flexion of the user's wrist. The wrist flexion assembly includes a first wrist actuator and a second wrist actuator, each of which is attached to the glove. In one embodiment, a wrist rotation assembly is attached to the glove and cooperates with the wrist flexion assembly to provide for passive or assisted supination/pronation of the user's wrist. Further, at least one finger actuation assembly can be attached to the glove for passive or assisted flexion/extension of a corresponding finger of the user.

Abstract: The invention relates to a method of preparing titanium dioxide-coated nanostars. Titanium precursors are hydrolyzed into crystalline TiO2 polymorphs at low temperatures, allowing the delicate morphology of the nanostars to be preserved while maintaining their desirable photocatalytic properties.

Abstract: A method for treating a microbial infection, especially pneumonia, comprising administering an aqueous-ethanol extract of Thymus or Boswellia or a composition containing the extract. Aqueous-ethanol extracts of Thymus and/or Boswellia.

Abstract: A shoe organizer unit, a method of using a shoe organizer unit, and a method for storing shoes in a plurality of shoe storing shelves of a shoe organizer unit are described. The shoe organizer unit includes a plurality of shoe storing shelves adapted to store shoes therein. A plurality of linear actuators moves the plurality of shoe storing shelves in a path within a cabinet. A controller manages operation of the linear actuators to move the shoes along the path. Transparent panels secure the shoes within the cabinet. Secure storage and retrieval of the shoes is controlled by electronics including a keypad, a push button and a shoe shelf identification code card printer. The shoe organizer unit provides for sterilization of the shoes stored and secure storing and retrieval of the shoes.

Abstract: A first communication node may include the steps of: performing communication with a second communication node using a first beam from among multi-beams formed by the second communication node, on the basis of a first polarized wave and one or more first BWPs allocated by the second communication node; generating a measurement report including a measurement value for at least the first beam; transmitting the generated measurement report to the second communication node; receiving, from the second communication node, BWP configuration change information generated on the basis of beam switching determination based on the measurement report; and performing communication with the second communication node using a second beam from among the multi-beams, on the basis of information of a second polarized wave and information of one or more second BWPs identified on the basis of the BWP configuration change information.

Abstract: An ultrafast wide-field quantum sensing device using a neuromorphic event-based vision sensor includes a laser generating a laser beam; a dichroic mirror directing the laser beam onto a diamond sample and passing the laser beam reflected from the diamond, and an event camera receiving from the dichroic mirror the beam reflected from the diamond. A source of microwave energy applied to the diamond. A pulse generator synchronizes the microwave source and the event camera to create CW-ODMR measurements, wherein trigger pulses from the pulse generator are applied to the camera and microwave source. The optically detected magnetic resonance (ODMR) resonance frequency is determined based on the CW-ODMR measurements.

Abstract: This disclosure provides a novel magnetic nanoparticle-assisted genome editing (MAGE) platform, which significantly improves transfection efficiency and biocompatibility in stem cells as well as the efficiency of CRISPR-Cas systems. Due to the great potential of CRISPR-Cas systems, the disclosed MAGE platform can be used for a host of applications in stem cell therapy for genetic disorders.

Abstract: An object of the present invention is to provide a method for easily evaluating residual fibrinolytic resistance activity by PAI-1 and ?2AP in blood plasma.

Abstract: A RollingCache system and methodology defends against contention side-channel cache attacks by dynamically changing the set of addresses contending for cache sets. Unlike prior defenses, RollingCache system does not rely on address encryption, decryption, data relocation, or cache partitioning. One or more levels of indirection are used to implement dynamic mapping controlled by the whole-cache runtime behavior. The RollingCache system does not depend on having defined security domains and can defend against an attacker running on the same or another core.

Abstract: A real-time position location system can include one or more location modules configured to be attached to a user or a weapon of the user and to output location data associated with each user and one or more kinematic base station modules configured to receive the location data from each location module. The system can include a position module operatively connected to the one or more kinematic base stations and configured to determine a real-time location of each of the one or more location modules and to output module position data for each of the one or more location modules in real-time.

Abstract: A high efficiency microfluidic biobarrier platform, system, and method permit an in vitro examination of a biobarrier under physiological flow conditions. The platform comprises an inlet, a first member, and an outlet. The inlet receives an influx of fluid. The first member retains the biobarrier, and the member includes a channel in fluid communication with the inlet to receive the fluid and to pass the fluid adjacent to the biobarrier. The outlet directs an outflux of the fluid. The microfluidic platform features built-in plastic electrodes to assess changes in biobarrier impedance in real-time. A system includes the platform, a pump to provide the fluid, a media collecting reservoir to receive the fluid from the platform, and an impedance analyzer to measure changes in biobarrier impedance. A method uses the platform in the system to determine the integrity of the biobarrier and its permeability across the cell barrier.

Abstract: A method of forming a lanthanide or transition metal doped metal halide perovskite material whereby the method includes combining a monovalent metal cation-halide compound, a divalent metal cation-halide compound, and a lanthanide or transition metal halide compound in a solvent; evaporating the solvent to form a powder; and annealing the powder to form the lanthanide or transition metal doped metal halide perovskite material. The resultant materials or devices may be applied to various industrial applications or implemented as a scintillator and applied to various industrial applications.

Abstract: The present disclosure relates to a novel hydrophobic peptide consisting of short amino acid sequences as repeat units, having a perfectly stabilized ?-helix structure without help from outside. The peptide has no cytotoxicity and has magnetic responsiveness, i.e., its arrangement and orientation are controlled by a magnetic field. In addition, the hydrophobic peptide according to the present disclosure can not only form complexes of various structures with hydrophilic molecules but also provide suitable nanostructures such as nanoribbons and artificial chromosome-like structures through stepwise association with nucleic acid materials.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: The CRISPR-Cas12a system is more advantageous than the widely used CRISPR-Cas9 system in terms of specificity and multiplexibility. However, its on-target editing efficiency is typically much lower than that of the CRISPR-Cas9 system. Provided herein are methods and compositions for improvement of Cas12a on-target editing efficiency by incorporating 2-aminoadenine (base Z, which alters canonical Watson-Crick base pairing) into the crRNA to increase the binding affinity between crRNA and its complementary DNA target. The resulting CRISPR-Cas12a (named zCRISPR-Cas12a thereafter) shows an on-target editing efficiency comparable to that of the CRISPR-Cas9 system but with much lower off-target effects than the CRISPR-Cas9 system in mammalian cells. In addition, zCRISPR-Cas12a can be used for precise gene knock-in and highly efficient multiplex genome editing. Overall, the zCRISPR-Cas12a systems are superior to the CRISPR-Cas9 system.