Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
Type:
Grant
Filed:
December 1, 2021
Date of Patent:
December 24, 2024
Assignees:
Virginia Commonwealth University, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Inventors:
Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
Abstract: An apparatus and a method for controlling a vehicle sound are provided. The apparatus a detection device that detects driving information and drive mode setting information and a processing device electrically connected with the detection device. The processing device determines an emotional state of a driver based on at least one of the driving information or the drive mode setting information, determines a sound concept depending on the emotional state of the driver, and controls a vehicle sound depending on the sound concept.
Type:
Grant
Filed:
May 25, 2022
Date of Patent:
December 24, 2024
Assignees:
Hyundai Motor Company, Kia Corporation, Seoul National University R&DB Foundation
Inventors:
Ki Chang Kim, Dong Chul Park, Myung Hwan Yun, Sung Ho Kim
Abstract: Provided are an essential oil composition and a preparation method thereof. The essential oil composition includes a eutectic composition and an essential oil; the eutectic composition includes a hydrogen-bond donor and a hydrogen-bond acceptor; the hydrogen-bond donor is geranic acid or derivatives of the geranic acid; the hydrogen-bond acceptor is choline or derivatives or hydrates of the choline; a mass ratio of the hydrogen-bond donor to the hydrogen-bond acceptor is 1-10:1-10.
Type:
Grant
Filed:
March 13, 2024
Date of Patent:
December 24, 2024
Assignee:
Jiangxi University of Chinese Medicine
Inventors:
Zhenfeng Wu, Wei He, Di Wang, Ming Yang, Na Wan
Abstract: A plasma injection module includes a fuel receiving end, a discharge end opposite the fuel receiving end, and an axial fluid pathway extending between the fuel receiving end and the discharge end. An insulator assembly defines a first portion of the axial fluid pathway proximate to the fuel receiving end. An injection tube assembly having a permanent magnet is positioned downstream of the insulator. A voltage input connection is arranged downstream of the insulator assembly and upstream of the injection tube assembly. The voltage input connection secures a voltage source to the injection tube to form a plasma filament within and adjacent to the axial fluid pathway. During operation a permanent magnet produces a magnetic field that interacts with the plasma filament to rotate the plasma filament and increase an area of ignition between the plasma filament and the combustible material at the discharge end.
Abstract: According to various aspects of the present invention, a positive electrode composition for a lithium-ion secondary battery includes an active material capable of inserting and extracting lithium ions, and a conductor, wherein the active material is a lithium-nickel-cobalt-manganese complex oxide; the conductor is a carbon black and carbon nanotubes; the carbon black has a BET specific surface area of 100 to 400 m2/g, and a DBP absorption of 210 to 380 ml/100 g; and the carbon nanotubes have an average diameter of 7 to 15 nm.
Type:
Grant
Filed:
September 28, 2018
Date of Patent:
December 24, 2024
Assignees:
Denka Company Limited, Jiangxi University of Science and Technology
Inventors:
Shinichiro Osumi, Tatsuya Nagai, Tetsuya Ito, Sheng Wen Zhong, Jun Chen, Qian Zhang, Min Zeng
Abstract: A method of treating cancer is disclosed. The method involves applying one or more direct current electric fields (DC-EFs) to a subject and administering to the subject an additional treatment selected from the group consisting of radiation, an effective amount of one or more chemotherapy agents, SapC-DOPS, anti-phosphatidylserine targeted drugs, and combinations thereof.
Type:
Grant
Filed:
October 15, 2020
Date of Patent:
December 24, 2024
Assignee:
University of Cincinnati
Inventors:
Xiaoyang Qi, Ahmet Kaynak, Daria Narmoneva, Andrei Kogan
Abstract: A BMOFs nanosheet based on a ZIF/MIL topology, and a preparation method and an application thereof are provided. The preparation method includes dispersing a MOF material of a ZIFs series in an organic phase, then adding an aqueous phase to obtain a mixture; and adding a MOF material of a MILs series into the mixture, sealing, standing for 1-5 days, filtering, performing centrifugal washing, drying, and performing acetone ultrasonic exfoliation to obtain the BMOFs nanosheet based on the ZIF/MIL topology. The preparation method is simple to operate and moderate in conditions, and the prepared ZIF/MIL BMOFs nanosheet has good electrocatalytic activity and stability in an OER.
Type:
Grant
Filed:
May 3, 2024
Date of Patent:
December 24, 2024
Assignees:
Zhejiang University of Technology, Zhejiang Marine Fisheries Research Institute
Inventors:
Lei Qin, Xiaoyan Mao, Tiejun Li, Yingyu Tan, Wenjie Liu, Lei Jin
Abstract: Disclosed herein is a tricyclic octacationic cyclophane and complexes comprising the tricyclic octacationic cyclophane and a perylene diimide dye complexed therein and methods of using and making the cyclophane and complexes.
Abstract: The present disclosure is related to a multi-stage control negative Poisson self-expanding anchor apparatus. The apparatus is constructed to solve the problem of poor effect or even failure of anchor bolts owing to insufficient force area of the bolt and easy damage of the locking section under the action of large tension in the existing technology. The anchorage section mainly comprises a plurality of circular platform bodies spaced with larger outward and smaller inward along the axial direction. The axial inner segment of the round platform body is coaxial connected with the force resistant body, and the axial outer segment of the round platform body is opened with an axial inward through the hole of the force resistant body. The axial inner part of the force resistant body is fixed on the anchorage segment.
Type:
Grant
Filed:
September 23, 2022
Date of Patent:
December 24, 2024
Assignee:
North China University of Water Resources and Electric Power
Abstract: A fountain system is provided. The fountain system includes a fountain nozzle that includes a body configured to telescope during extension and retraction and a nozzle outlet coupled to an end of the body. The fountain system also includes an extension system configured to actuate the extension and retraction of the body. The fountain system also includes an actuation system configured to activate discharge of a liquid, such as water, from the nozzle outlet. The extension system and the actuation system are discrete systems.
Abstract: Provided is a method for preparing a hard carbon anode of a lithium/sodium ion battery by biochar, which includes the following steps: S1 biochar pretreatment, S2, preparing a precursor material and S3 pyrolysis carbonization, by a modification of the biochar, setting carbonization temperature and carbonization time, and controlling a cooling rate, so that the obtained biochar generates amorphous carbon after carbonization with low graphitization degree, few surface defects, larger charge-discharge specific capacity, and stable performance in the cycle charging and discharging process; at the same time, the process of the application is relatively simple, and a special complex process is reduced; the present method is suitable for a large-scale industrial production without special adjustment or control of a morphology; and the product performance is relatively good and thus has certain competitive advantages.
Type:
Grant
Filed:
October 12, 2021
Date of Patent:
December 24, 2024
Assignee:
Hainan University
Inventors:
Yong Chen, Heng Zheng, Yan Mo, Bokai Cao
Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecule and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells within the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.
Type:
Grant
Filed:
June 2, 2020
Date of Patent:
December 24, 2024
Assignees:
Duke University, MacroGenics, Inc., The University of North Carolina at Chapel Hill
Inventors:
Barton F. Haynes, Guido Ferrari, Scott Koenig, Leslie S. Johnson, Chia-Ying Kao Lam, Julia A. Sung, David M. Margolis, Liqin Liu, Jeffrey Lee Nordstrom
Abstract: In one aspect, the disclosure relates to fluorescent dyes that absorb and emit in the near infrared II (NIR II) range of the electromagnetic spectrum, methods of making same, compositions comprising same and methods of using the compositions to perform imaging on biological samples, and optoelectronic devices using the dyes. The dyes are small organic molecules that are inexpensive and facile to produce, can be water-soluble, have tunable properties, and are biocompatible and/or possess low toxicity.
Type:
Grant
Filed:
August 20, 2021
Date of Patent:
December 24, 2024
Assignees:
University of Mississippi, Mississippi State University
Inventors:
Jared Delcamp, Nathan Hammer, Colleen Scott
Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.
Type:
Grant
Filed:
November 25, 2020
Date of Patent:
December 24, 2024
Assignees:
The Johns Hopkins University, Academia Sinica, National Yang Ming Chiao Tung University
Inventors:
Ru Chih C. Huang, Jong Ho Chun, Yu-Ling Lin, Yu-Chuan Liang, Kuang-Wen Liao, Tiffany Jackson, David Mold, Chien-Hsien Lai
Abstract: This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.
Type:
Grant
Filed:
February 6, 2021
Date of Patent:
December 24, 2024
Assignee:
The University of British Columbia
Inventors:
Veronika Schmitt, John K. Jackson, Martin E. Gleave, Claudia Kesch
Abstract: A nanomaterial and a method of preparing the nanomaterial are provided. The nanomaterial is a product formed by a reaction of functionalized carbon nanotube comprising first and second aminoalkyl groups covalently bonded to a surface of the carbon nanotube and a porphyrin ring of formula (I). A method of removing a pollutant from an aqueous solution by contacting the aqueous solution having an initial concentration of the pollutant with the nanomaterial is also provided.
Abstract: A measurement device includes an electric field generator, an electric field detector, a thickness gauge, and a processor. The electric field generator generates an alternating current electric field. The electric field detector detects the alternating current electric field generated by the electric field generator. The thickness gauge measures a thickness of a measurement target in a non-contact manner. The processor derives a calibration curve representing a relationship between a specific dielectric constant and an intensity of an alternating current electric field. The measurement target is insertable between the electric field generator and the electric field detector. The electric field detector detects an intensity of the alternating current electric field attenuated by the measurement target.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
December 24, 2024
Assignees:
Yokogawa Electric Corporation, Hosei University
Inventors:
Jun Katsuyama, Yoshinori Matsumoto, Mitsuru Shinagawa
Abstract: The present disclosure provides an image decoding method based on a wavelet transform. The method includes: performing entropy decoding on the compressed bitstream to obtain a reconstructed wavelet coefficient; dequantizing the reconstructed wavelet coefficient to obtain a dequantized wavelet coefficient; and performing N inverse wavelet transforms on the dequantized wavelet coefficient based on the wavelet transform model to obtain a reconstructed image, where the wavelet transform model is implemented based on a convolutional neural network (CNN).
Type:
Grant
Filed:
January 14, 2022
Date of Patent:
December 24, 2024
Assignees:
Huawei Technologies Co., Ltd., University of Science and Technology of China
Inventors:
Feng Wu, Haichuan Ma, Dong Liu, Haitao Yang
Abstract: Embodiments of the present systems and methods may provide improved capability to predict the risk of recurrence of ductal carcinoma in situ (DCIS) conditions using whole slide image analysis based on machine learning techniques. For example, in an embodiment, a computer-implemented method for determining treatment of a patient may comprise receiving an image of living tissue of a patient, annotating the entire image into tissue structures, extracting texture features from the annotated image, determining a distribution of the extracted texture features relative to tissue conditions, classifying the patient into a risk group based on the distribution, and treating the patient accordingly based on the risk group.
Type:
Grant
Filed:
December 16, 2019
Date of Patent:
December 24, 2024
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
Sergey Klimov, Yi Jiang, Arkadiusz Gertych
Abstract: A system and method for real-time detection of anomalies in high-dimensional systems. Various embodiments detect anomalies quickly and accurately to allow adequate time for appropriate countermeasures to be implemented. The sequential and multivariate anomaly detection method scales well to high-dimensional datasets using a nonparametric and semi-supervised approach that trains only on nominal data.