Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.

Abstract: An electrochemical sensor for an analyte is provided. The electrochemical sensor includes CDMOF-2. The CDMOF-2 is capable of binding reversibly to CO2 as an analyte, thereby quantitatively detecting the analyte in a mixture. The CDMOF-2 is formed from reaction of ?-cyclodextrin with RbOH in the presence of methanol.

Abstract: The present disclosure provides systems and methods for universal mapping of T1 in abdominal organs using cardiac gating. A region of interest is selected for mapping or imaging. A determination is made whether any one or more of heart associated motion, high heart rate and irregular heart beat are detected in the region of interest. A multi-pathway gating of T1 maps is then employed providing a universal method of T1 mapping of moving as well as non-moving visceral organs.

Abstract: A scanning LASER ophthalmoscope (SLO) system for real-time montaging includes an adaptive optics scanning light ophthalmoscope (AOSLO) and a wide field scanning light ophthalmoscope (WFSLO). At least one stabilization mirror is controlled by a computer to optically stabilize the AOSLO based at least in part on feedback from the WFSLO. The SLO system also includes a steering means. The SLO system continues to acquire and combine a plurality of AOSLO image frames forming a combined AOSLO image at each of a plurality of narrow field of view (FOV) sites until a predetermined number of images or a predetermined image quality metric (IQM) at each of the combined AOSLO images is achieved. A plurality of the combined AOSLO images is combined to form a SLO montaged image of a wide FOV. A method to montage a plurality of scanning LASER ophthalmoscope (SLO) narrow field of view (FOV) images is also described.

Abstract: A new class of molecules, C1—OH tributanoylated hexosamines, including, for example, GalNAc, GlcNAc and ManNAc, are demonstrated to increase cartilage-like tissue accumulation by IL-1?-stimulated chondrocytes. Furthermore, all three molecules reduced NFKB1 and I?B? driven gene expression, consistent with NF?B inhibitory properties of these analogs. GalNAc-a exposure produced the greatest ECM accumulation by IL-1?-stimulated chondrocytes. However, GalNAc-a exposure produced an opposite effect on MSC exposure, where a decrease in ECM accumulation was observed. These findings are in support of the function of NF?B signaling during limb development and growth plate chondrogenesis. The present invention shows the capability of this new class of hexosamine analogs as disease-modifying agents for treating cartilage damage.

Abstract: A system for producing an ion concentration gradient and a temperature-responsive electrolyte material which are utilizable, for example, for efficiently converting heat energy that has been discarded into reusable energy or for efficiently recovering an acid gas, such as carbon dioxide is provided. A temperature-responsive electrolyte is used to produce an ion concentration gradient by means of a temperature gradient. The temperature-responsive electrolyte is used in the state of an aqueous solution and also in the state of a solid phase.

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

Abstract: The present application discloses a previously unknown function of CD24 expressed on a subset of dendritic cells. The invention encompasses regulating CD24 on these cells to regulate erythropoiesis, induce EPO production and levels, increase RBC levels, and to treat, for example, stress-mediated erythropoiesis. The compositions and methods of the invention are useful, for example, in treating anemia.

Abstract: A fibre-based sensor for yarn senses strain or pressure and includes: (a) a fibre extending along a centerline with a first longitudinal portion thereof forming a first fibre member that is elastic and has a first stiffness, first hysteresis, and first electrical conductivity; and (b) a second fibre member selected as a second fibre or a second longitudinal portion of the fibre, the second fibre member being elastic, having a second stiffness, second hysteresis, and second conductivity, wherein the first and second fibre members are non-slidable relative to each other along the centerline, the first stiffness being greater than the second stiffness so sensor stiffness is dominated by the first stiffness, the first hysteresis being less than the second hysteresis so sensor hysteresis is dominated by the first hysteresis, the first conductivity being less than the second conductivity so sensor conductivity is dominated by the second electrical conductivity.

Abstract: The present technology is directed to vestibular prostheses and associated systems and methods. In several embodiments, for example, a vestibular prosthesis includes an external rotational sensor configured to receive velocity and orientation information. The prosthesis further includes an external processor configured to convert the velocity and orientation information into an audio signal. The audio signal is sent to a cochlear implant, which applies stimulation to a semicircular ear canal in response to receiving the audio signal. In some embodiments, the processor and cochlear implant communicate in real time via an inductive link.

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

Abstract: Microfluidic diatomaceous earth analytical devices (?DADs) comprising highly porous photonic crystal biosilica channels are disclosed. The ?DADs can simultaneously perform on-chip chromatography to separate small molecules from complex samples and acquire the surface-enhanced Raman scattering spectra of the target chemicals with high specificity. The ultra-small dimensions of the diatomaceous earth microfluidic channels and the photonic crystal effect from the fossilized diatom frustules allow unprecedented sensitivity down to ppb-level.

Abstract: The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.

Abstract: The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using 3D printing. A layer of prepolymer is deposited on a build plate to form a powder bed. The deposited powder bed is heated to about 50° C. to about 170° C. Then, a solution of activating agent is printed on the powder bed in a predetermined pattern, and a stimulus is applied converting the prepolymer to the final polymer. After a predetermined period of time, sequential layers are printed to provide the three-dimensional article. The three-dimensional object can be cured to produce the three-dimensional article composed of the final polymers.

Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).

Abstract: A compound having an ancillary ligand L1 having the formula: Formula I is disclosed. The ligand L1 is coordinated to a metal M having an atomic number greater than 40, and two adjacent substituents are optionally joined to form into a ring. Such compound is suitable for use as emitters in organic light emitting devices.

Abstract: In one embodiment, a digital holography system includes logic configured to receive raw interferograms obtained by illuminating an object field with incoherent light, the raw interferograms comprising multiple phase-shifted raw interferograms for each of multiple different colors, logic configured to combine like-colored raw interferograms to generate a separate complex hologram for each different color, logic configured to combine the separate complex holograms to generate a full-color complex hologram, and logic configured to reconstruct a full-color holographic image of the object field.

Abstract: The system uses natural language to paths of a transition diagram via answer set programming system and provides: an approach for mapping events described in natural language sources to a logical formalism; and integration of Natural Language Processing and constraint-based reasoning inspired by Reasoning about Actions and Change. The system further uses (a) a non-trivial variant of IR in which sources include sequences of events, and queries are made about the state of the world after such events; (b) the extension of techniques for representing dynamic domains to increase the flexibility of the reasoning processes in the presence of uncertainty; (c) a formalization of the IR task based on action languages; (d) an automated IR procedure based on Answer Set Programming (ASP).

Abstract: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that detects or binds to Bcl-2 protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with Bcl-2 protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of Bcl-2 in a bodily fluid and methods for rapidly measuring Bcl-2 in a bodily fluid.

Abstract: Provided are a method for obtaining an HNL gene and HNL derived from a millipede other than Chamberlinius hualienensis, and preparing a practically useable amount of HNL; and a method for producing optically active cyanohydrin using this HNL. A method for producing a millipede-derived HNL gene. A method that includes the selection of a gene having a base sequence that encodes a conserved amino acid sequence TAX1DIX2G (SEQ ID NO: 15) or VPNGDKIH (SEQ ID NO: 16) of millipede-derived HNL from genes present in an organism belonging to the Diplopoda. A protein having an amino acid sequence of any of (1)-(3) and having HNL activity. (1) An amino acid sequence listed in any of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 83, 85, 87, or 89; (2) an amino acid sequence having amino acids deleted, substituted, and/or added in an amino acid sequence of (1); or (3) an amino acid sequence having 90% or greater identity to an amino acid sequence of (1).