Abstract: This disclosure describes an imaging radiation detection module with novel configuration of the scintillator sensor allowing for simultaneous optimization of the two key parameters: detection efficiency and spatial resolution, that typically cannot be achieved. The disclosed device is also improving response uniformity across the whole detector module, and especially in the edge regions. This is achieved by constructing the scintillation modules as hybrid structures with continuous (also referred to as monolithic) scintillator plate(s) and pixelated scintillator array(s) that are optically coupled to each other and to the photodetector.

Abstract: This invention relates to an IgG-binding peptide, an IgG-binding peptide modified with a cross-linking agent, a conjugate of the IgG-binding peptide modified with a cross-linking agent and IgG, and a method for producing the conjugate, etc.

Abstract: OLED-based devices that include at least two colors of emissive regions are provided, in which one region is optically coupled to a microcavity and the other is not. Devices including pixels in which only a portion of sub-pixels within the pixel are coupled to a microcavity are provided.

Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one or more functional fragments or variants thereof. The functional fragments generally comprise at least one of the nine Fibronectin Type III-like Region of the NC1 region of collagen 7.

Abstract: A method and apparatus are disclosed for measuring polarization of electromagnetic illumination. The method includes the steps of modulating a polarization state of illumination received from a target object to generate modulated intensity illumination, selectively measuring an intensity of the modulated intensity illumination by periodically gating an exposure of an imaging device to the modulated intensity illumination at a first gating frequency; responsive to the measured intensity, determining polarization parameters of the received illumination, and generating image data corresponding to the target object with a plurality of the polarization parameters, wherein the illumination from the target object is modulated in accordance with a first frequency and the first gating frequency is associated with and synchronized with at least the first frequency.

Abstract: Methods are provided for treating autoimmune disease in a subject by inhibiting the activity of DGAT1.

Abstract: Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.

Abstract: The present disclosure relates generally to the integration of isotachophoresis (ITP) and isothermal nucleic acid amplification methods such as recombinase polymerase amplification (RPA). One aspect of the disclosure relates to a method for concentrating and amplifying a nucleic acid, the method including an isotachophoresis device, the isotachophoresis device including a porous matrix, and first and second electrodes, having a leading electrolyte, a trailing electrolyte and a set of isothermal nucleic acid amplification reaction reagents disposed in the porous matrix as described herein, and applying a voltage across the first electrode and the second electrode for a time sufficient to provide a first isotachophoresis (ITP) plug comprising an amplification product of the nucleic acid, wherein the concentration of the nucleic acid is substantially higher in the first FTP plug than in the first and/or second fluids outside of the first ITP plug.

Abstract: An organic EL element having a luminescence peak in a near-infrared range comprises a positive electrode, a negative electrode, and at least one organic layer including a luminescent layer located between the positive electrode and the negative electrode. The luminescent layer comprises a host material, a delayed fluorescent material and a luminescent material. The LUMO and HOMO energy levels of the delayed fluorescent material and the luminescent material, the absorption spectrum of the luminescent material, and the emission spectrum of the delayed fluorescent material satisfy predetermined relationships.

Abstract: A first multi phase niobium silicide alloy composition consists essentially of: from 15 to 24 at % of Si; from 0 to 25 at % of one or more sp outer electron configuration element which is not Si; from 1 to 26 at % of one or more sd outer electron configuration element which is not Nb; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance of an article, for example a gas turbine engine blade. A second multi phase niobium silicide alloy composition consists essentially of: from 1 to 24 at % of Si; from 0 to 34 at % of one or more sp outer electron configuration element which is not Si; from 19.5 to 48.5 at % of one or more sd outer electron configuration element which is not Nb or Cr; from 0.5 to 9 at % Cr; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance and/or to increase the oxidation resistance of an article, for example a gas turbine engine blade.

Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.

Abstract: The disclosure provided herein relates generally to mesenchymal-like stem cells “hES-T-MiSC” or “T-MSC” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hES-T-MSC or T-MSC, T-MSC derived cells and cell lineages “T-MSC-DL” are also described. Disclosed also herein are solutions and pharmaceutical compositions comprising the T-MSC and/or T-MSC-DL, methods of making the T-MSC and T-MSC-DL, and methods of using the T-MSC and T-MSC-DL for treatment and prevention of diseases, specifically, T-MSC and T-MSC-DL are used as immunosuppressive agents to treat multiple sclerosis and autoimmune diseases.

Abstract: Methods, agents and compositions thereof for treating psoriatic arthritis (PsA) are encompassed herein.

Abstract: The invention provides a catalyst and method for producing hydrocarbons from a carbon dioxide source comprising carbides, in particular one or more metal carbides. The one or more metal carbides are formed with one or more elements selected from the group consisting of molybdenum, titanium, tungsten, iron, and tantalum. In one embodiment, the one or more metal carbides are nanostructures. In another embodiment, the one or more metal carbide nanostructures are supported by a carbon substrate. In a further embodiment, the one or more metal carbides nanostructures is dimolybdenum carbide. In still another embodiment, the carbon substrate is graphene or graphene oxide. In another embodiment, the dimolybdenum carbide nanostructures are supported by the graphene or graphene oxide substrate.

Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a ?Klotho polypeptide, optionally a folded ?Kiotho or optionally with a dissociation constant (KD) of about 2 nM or less, as measured by competitive ELISA assay, methods 0 of making and using to diagnose kidney diseases.

Abstract: A system for detecting gas leaks and determining their location and size. A data gathering portion of the system utilizes a hub and spoke configuration to collect path-integrated spectroscopic data over multiple open paths around an area. A processing portion of the system applies a high resolution transport model together with meteorological data of the area to generate an influence function of possible leak locations on gas detector measurement paths, and applies an inversion model to the influence function and the spectroscopic data to generate gas source size and location.

Abstract: Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in parasitic heme auxotrophic organisms, thereby limiting their growth or killing the parasites.

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Abstract: Embodiments of the present disclosure include vaccine compositions comprising a TcdB toxin or toxoid derived therefrom. The TcdB toxin may be derived from a hypervirulent strain of C. difficile. A further embodiment is directed to a method of conferring an active immunity against a C. difficile infection in a subject by administering the vaccine composition to the subject.