Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.
Type:
Application
Filed:
February 9, 2017
Publication date:
February 14, 2019
Applicants:
The United States of America, as represented by the Secretary, Department of Healthe and Human, Arizona Board of Regents on Behalf of the University of Arizona
Inventors:
Thomas Joseph Sayers, Alan David Brooks, Curtis J. Henrich, Poonam Tewary, James Brislin McMahon, Leslie Gunatilaka, Ya-Ming Xu, Kithsiri Wijeratne
Abstract: A method for suggesting nutrient intake includes: by a statistical platform, the steps of obtaining a training sample, building a classification model based on physical data, nutrient intake data and effect data of the training sample thus obtained, and providing the classification model to a management platform; and by the management platform, a step of when receiving a to-be-classified sample that includes physical data from a client device, determining suggested nutrient intake data by inputting the physical data of the to-be-classified sample into the classification model to obtain an output of the classification model which serves as the suggested nutrient intake data.
Abstract: Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.
Abstract: The present disclosure provides a structure having a low reflectance surface, wherein the structure comprises: a base plate; and a plurality of inclined rods protruding from a first face of the base plate and inclined relative to a normal line to the first face, wherein the inclined rods are spaced from each other. Travel paths of light beams in the structure may be longer along the inclined rods. As a result, a larger amount of light may be absorbed by the structure having a low reflectance surface. The amount of light-beams as reflected from the structure having a low reflectance surface may be significantly reduced.
Type:
Application
Filed:
August 7, 2018
Publication date:
February 14, 2019
Applicant:
Ajou University Industry-Academic Cooperation Foundation
Abstract: A multiple arrayed parallel nanowire device includes one or more arrays connected in series, wherein each array includes a plurality of narrow nanowires flanked by one or more wide nanowires, a top electrode, an applied current, a bottom ground electrode, and one or more lateral electrodes where one or more currents or one or more probing voltages can be applied to detect voltage changes in each array. The device detects single and multiple photons without destroying superconductivity in all the nanowires in the array and is thus capable of remaining sensitive to subsequent photon impacts. Moreover, the device can resolve the location of each photon impact.
Type:
Application
Filed:
February 16, 2018
Publication date:
February 14, 2019
Applicant:
King Fahd University of Petroleum and Minerals
Abstract: A system and method for aligning discontinuous fibers, manufacturing tailored preforms, and composite materials comprised of highly aligned discontinuous fibers.
Type:
Application
Filed:
August 3, 2018
Publication date:
February 14, 2019
Applicant:
University of Delaware
Inventors:
John Tierney, Alex Vanarelli, Dirk Heider, Shridhar Yarlagadda, John W. Gillespie, JR.
Abstract: The present invention relates to a non-direct measurement temperature-compensating model correction method in the on-line application of a near-infrared spectrum analyzer, which comprises: acquiring a near-infrared spectrum of each sample under different temperature levels; respectively carrying out preprocessing and principal component analysis on the acquired spectra for temperatures and to-be-measured physical property parameters: then merging the obtained spectra to generate new spectral data: using partial least squares to model the spectral data to obtain measured values at the current moment; finally, constructing an on-line recursive algorithm, and thereby on-line near-infrared measurement with a non-direct measurement temperature compensation function is fulfilled.
Abstract: This biomarker is a biomarker for testing a food allergy, and comprises at least one species selected from the group consisting of LTE4, 14,15-LTE4, 11-trans LTE4, 11-dehydro 11-dehydro TXB2, 2,3-dinor-8-iso Prostaglandin F2?, 13,14-dihydro-15-keto-tetranor PGF1?, 6,15-diketo-13,14-dihydro PGF1?, tetranor-PGFM, 20-OH PGE2, PGE3, PGD3, 13,14-dihydro-15-keto-tetranor PGD2, and 13,14-dihydro-15-keto-tetranor PGE2.
Abstract: Disclosed are recombinant spike ectodomain proteins, compositions, vectors, kits, and methods for inducing an immune response against avian infectious bronchitis virus (IBV). In particular, the recombinant proteins, compositions, vectors, kits, and methods relate to, include, and/or utilize a soluble, multimerized form of the (IBV) spike (S) protein ectodomain. The recombinant proteins, compositions, vectors, kits, and methods may be utilized to immunize poultry against disease associated with IBV infection or to protect poultry from IBV infection.
Abstract: This invention discloses a nucleic acid aptamer AS1411 modified DNA tetrahedron. The preparation method includes the steps of (1) binding an AS1411 sequence to the 5? terminal of any DNA single-strand in a DNA tetrahedron, synthesizing the DNA, dissolving obtained DNA powder with ddH2O; (2) measuring an absorbance of the DNA and then calculating a total volume of the four single strands; (3) pipetting the DNA obtained in step (1) according to the calculation results in step (2), mixing the DNA with a TM buffer, mixing the mixture uniformly with vortex vibration, and performing a PCR progress. The preparation method is simple. The produced product can effectively solve the problem that the unmodified DNA tetrahedron cannot enter the nucleus and the problem that the AS1411 cannot carry drugs directly.
Abstract: The present invention provides a RO membrane or a FO membrane comprising a coating layer made of a phospholipid bilayer membrane and formed on a surface of a porous membrane body, having a high water permeate flow rate and salt rejection performance, the membrane being a permselective membrane comprising a porous membrane having a pore size of 5 nm to 50 nm and a coating layer made of a phospholipid bilayer and formed on a surface of the porous membrane, wherein (i) the phospholipid bilayer comprises phospholipid, amphotericin B, and ergosterol; (ii) a content of the amphotericin B is 3 to 20 mol % based on the phospholipid bilayer; (iii) a total content of the ergosterol and the amphotericin B in the phospholipid bilayer is 10 to 30 mol %.
Type:
Application
Filed:
March 3, 2017
Publication date:
February 14, 2019
Applicants:
Kurita Water Industries Ltd., National University Corporation Kobe University
Abstract: Anode materials comprising various compositions of strontium iron cobalt molybdenum oxide (SFCM) for low- or intermediate-temperature solid oxide fuel cell (SOFCs) are provided. These materials offer high conductivity achievable at intermediate and low temperatures and can be used to prepare the anode layer of a SOFC. A method of making a low- or intermediate temperature SOFC having an anode layer including SFCM is also provided.
Type:
Application
Filed:
March 17, 2017
Publication date:
February 14, 2019
Applicant:
University of Maryland, College Park
Inventors:
Ke-Ji PAN, Eric D. WACHSMAN, Mohammed Hussain ABDUL JABBAR
Abstract: The present invention separates radiation from an object by a polarization filter 3 into polarized light beams, causes one of the beams to enter a spectrum analyzer 7 through a first optical path, causes the other to enter the spectrum analyzer 7 through a second optical path, and measures the two-color ratio, while causes radiation of a blackbody 2 placed in a vacuum ultralow temperature thermostatic chamber 1 in a quasi-thermal equilibrium state at an ultralow temperature in vacuo to enter the polarization filter 3 through a third optical path, separates the radiation into polarized light beams, causes the beams to each enter the same optical paths as the respective optical paths for the radiation of the object, causes the beams to enter the spectrum analyzer 7, measures the two-color ratio, and accurately obtains the temperature of the object on the basis of these two two-color ratios.
Type:
Application
Filed:
February 8, 2017
Publication date:
February 14, 2019
Applicant:
Inter-University Research Institute Corporation High Energy Accelerator Research Organization
Abstract: [Problem] To provide a method for detecting high-risk prostate cancer, for the purpose of providing useful information, such as necessity of biopsy, to a test-positive patient in a PSA test. [Solution] The method for detecting high-risk prostate cancer according to the present invention comprises reacting a PSA contained in a sample composed of urine collected from a human body which is suspected to be suffering from prostate cancer with (1) a fucose ?1?6 affinitive lectin which has a characteristic property that the lectin has affinity expressed by a binding constant of 1.0×104 M?1 or more (at 25° C.) for an ?1?6 fucose sugar chain No. 405. The fucose ?1?6 affinitive lectin is preferably (2) a fucose ?1?6 specific lectin which has a characteristic property that the lectin has a binding constant of 1.0×104 M?1 or less (at 25° C.) for a sugar chain No. 003 that does not contain ?1?6 fucose and a glycolipid-type sugar chain No. 909 that does not contain ?1?6 fucose.
Abstract: Novel means capable of detecting an arteriosclerotic lesion in a body by a less invasive, simple method is disclosed. The method for detecting arteriosclerosis according to the present invention comprises measuring the myosin heavy chain 11 level in a blood sample isolated from a subject. A myosin heavy chain 11 level higher than that of a healthy individual is indicative of the presence of arteriosclerosis in the subject. Since the present invention enables detection of arteriosclerosis by a blood test, a less invasive, simple test can be carried out. Unlike methods for testing only particular regions such as carotid artery ultrasonography, the present invention is expected to reflect the conditions of blood vessels in the whole body.
Type:
Application
Filed:
February 15, 2017
Publication date:
February 14, 2019
Applicants:
Public University Corporation Yokohama City University, TOSOH CORPORATION
Abstract: In one aspect, a process to decompose a hydrocarbon such as methane into carbon (graphitic powder) and hydrogen (H2 gas) without secondary production of carbon dioxide, employing a cycle in which a secondary chemical can be recycled and reused, is disclosed.
Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
Type:
Application
Filed:
October 25, 2018
Publication date:
February 14, 2019
Applicants:
The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
Inventors:
Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
Abstract: The present invention relates to a method for preparing superabsorbent polymer that has antibacterial activity, in which the basic properties of superabsorbent polymer are maintained or improved, and may exhibits excellent bacterial proliferation inhibition effect, and superabsorbent polymer prepared thereby. The preparation method of superabsorbent polymer comprises the steps of: forming base polymer powder using hydogel polymer comprising crosslinked polymer, and then, surface crosslinking the base polymer powder using a surface crosslinking solution comprising a surface crosslinking agent and cuprous oxide, wherein the cuprous oxide is included in the content of 0.001 to 2.5 parts by weight, based on 100 parts by weight of the base polymer powder.
Type:
Application
Filed:
November 27, 2017
Publication date:
February 14, 2019
Applicants:
LG Chem, Ltd., Seoul National University R&DB Foundation
Inventors:
Yong Seok Choi, Young Sam Kim, Jong Doo Lim, Jong-Chan Lee, Na Kyung Kim, Jinseok Kim
Abstract: A method of using an exchange-induced remnant magnetization (EXIRM) technique for label free detection of short strands of nucleotides and cancer biomarkers, such as DNA and microRNA strands, DNA/RNA-binding biomarkers, and cancer-specific antigens, with high sensitivity, high specificity, and broad dynamic range. The method may provide a label-free approach aimed to facilitate high reliability, and to require a minimum amount of biochemical reagents.
Type:
Application
Filed:
October 25, 2018
Publication date:
February 14, 2019
Applicant:
University of Houston System
Inventors:
Shoujun XU, Li YAO, Yuhong WANG, Qiongzheng HU, Haopeng YANG
Abstract: A metal-hydrogen battery includes a first electrode, a second electrode, and an electrolyte disposed between the first electrode and the second electrode. The second electrode includes a bi-functional catalyst to catalyze both hydrogen evolution reaction and hydrogen oxidation reaction at the second electrode.
Type:
Application
Filed:
August 8, 2018
Publication date:
February 14, 2019
Applicant:
The Board of Trustees of the Leland Stanford Junior University