Abstract: A compound of Formula Ir(LA)x(LB)y(LC)z is provided, where the first ligand LA comprises a structure of Formula I, ?the ligand LB comprises a structure of Formula II, ?and the ligand LC is a bidentate ligand. In the compound, each of A1 to A8, X1 to X4, Z1, and Z2 is C or N; at least one of X1 to X4 is N, or at least one RA is electron withdrawing group, a silyl group, a germyl group, a heteroalkyl group, a cycloalkyl group, a hetrocycloalkyl group, an alkyl group having three or more carbon atoms, or combinations thereof; Y is a linking group; moiety C is a monocyclic ring or a polycyclic fused ring system; and each R, R?, R1, R2, R3, R4, RA, RB, RC, and RD is hydrogen or a General Substituent defined herein. Formulations, OLEDs, and consumer products containing the compound are also provided.

Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.

Abstract: Provided herein are rAAV and other vectors and compositions useful for treating a patient having CMT2 comprising: (a) a recombinant nucleic acid sequence encoding an engineered human mitofusin 2 coding sequence operably linked to regulatory sequences which direct expression thereof in a human target cell. Also provided are rAAV and other vectors and compositions useful for treating a patient having CMT2 comprising: (b) a nucleic acid sequence encoding at least one miRNA specific for an endogenous human mitofusin 2 sequence in a human CMT2A subject, wherein the miRNA coding sequence is operably linked to regulatory sequences which direct expression thereof in the subject. Further provided are compositions containing both the engineered hMfn2 coding sequence and the at least one miRNA coding sequence, wherein the engineered human mitofusin 2 coding sequence has a sequence which differs from endogenous human mitofusin 2 in the CMT2A patient in the target site of the encoded miRNA.

Abstract: Hybrid carbon nanofiber (Cnf) products (e.g., mats, yarns, webs, etc.) and methods of fabricating the same are provided. The hybrid Cnf products are flexible and lightweight and have high thermal conductivity. An electrospinning process can be used to fabricate the hybrid Cnf products and can include preparation of an electrospinning solution, electrospinning, and carbonization (e.g., under a vacuum condition).

Abstract: The present invention relates to novel fused imidazo pyrazole derivatives of formula (I), and formula (II), and methods for preparation thereof, in the presence of a chitosan-Al2O3 nanocomposite film. The invention also relates to pharmaceutical compositions comprising compounds of the invention as active ingredients as well as the use of compounds of the invention for antimicrobial action.

Abstract: The present disclosure provides ASC inhibitors, compositions comprising said ASC inhibitors, methods of identifying said ASC inhibitors, and therapeutic and prophylactic methods of using said ASC inhibitors.

Abstract: Methods are disclosed for producing populations of cardiomyocytes from pluripotent stem cells. Populations may be enriched for either atrial or ventricular cardiomyocytes and the resulting ventricular population may be essentially free of pacemaker cells. The method includes incubating pluripotent stem cells in a suitable medium with a BMP component, and an activin component, the amounts of activin may be varied to enrich for either atrial or ventricular cardiomyocytes. The enriched populations, as well as methods of using the same to treat patients in need of cardiac repair are disclosed.

Abstract: Disclosed are an image encoding/decoding method and apparatus. The method and apparatus select at least one reference pixel line from among multiple reference pixel lines and derive a predicted value of a pixel within a current block by using the value of at least one pixel within the selected reference pixel line(s). Alternatively, the method and apparatus derive an intra prediction mode of a reconstructed pixel region on the basis of a reference pixel region of at least one reconstructed pixel region, derive an intra prediction mode of a current block on the basis of the derived intra prediction mode of the reconstructed pixel region, obtain an intra prediction block of the current block by using the derived intra prediction mode, and reconstruct the current block by summing the obtained intra prediction block and a residual block of the current block.

Abstract: Disclosed are a bus parking allocation method and apparatus considering operational preferences. The method includes: obtaining a bus station dataset, a parking lot dataset, a bus information dataset, and a bus departure/return dataset; obtaining a distance dataset containing distances between bus stations and parking lots; building a parking allocation model considering operational preferences; building an objective function of the parking allocation model, where one group of buses are allocated to one group of parking lots, with each bus being allocated to at most one parking lot, and the number of buses parked in each parking lot is less than or equal to a capacity of the parking lot; building bus preference lists and parking lot preference lists, and calculating the objective function while satisfying the preference lists, to minimize total parking costs of all buses, thereby obtaining parking allocation results considering operational preferences; and designing multiple visualization views for display.

Abstract: An organic light emitting device (OLED) having an anode; a cathode; and an emissive layer, disposed between the anode and cathode is provided, where the emissive layer includes a first compound of Formula I, and a second compound of Formula II, In the OLED, the LUMO energy of the second compound is ? to ?2.33 eV and at least one RD substituent is not hydrogen.

Abstract: Provided herein are AAVrh74 capsid proteins comprising one or more amino acid substitutions or deletions that confer a liver-detargeting property to AAV particles comprising them. Provided herein are AAVrh74 capsid proteins comprising one or more amino acid substitutions that confer an improved transduction efficiency (e.g., in muscle cells). Also provided herein are methods of using AAVrh74 capsid proteins comprising one or more amino acid substitutions or deletions.

Abstract: A two-dimensional hyperspectral imaging system for imaging a plurality of light signals of a sample by Fourier spectroscopy includes a first optical element, a second optical element, a phase difference modulator and an image sensor. The light signals pass by the first optical element. The second optical element is spaced away from and parallel to the first optical element, and the light signals pass by the second optical element. The phase difference modulator is closer to the first optical element than the second optical element to the first optical element, and configured for modifying a phase difference of adjacent two of the light signals. The image sensor is configured for receiving the light signals reflected from the first optical element and the second optical element, and operating Fourier transforming on the light signals. The second optical element is between the first optical element and the image sensor.

Abstract: A graphite structure includes multiple graphite blocks and one or more connection links connecting multiple graphite blocks to each other.

Abstract: Methods for producing single N-terminal domain functional camelid-derived heavy (H)-chain antibody fragments (VHH) that specifically bind to a receptor binding domain (RBD) of SARS-CoV-2 spike protein include transgenic plants, plant parts, plant cells, plant tissue, and seeds that express the VHH that specifically binds to an RBD of SARS-CoV-2 spike protein.

Abstract: A method for producing crystalline ?-Fe2O3 nanoparticles involving ultrasonic treatment of a solution of an iron (III)-containing precursor and an extract from the seeds of a plant in the family Linaceae. The method involves preparing an aqueous extract from the seeds of a plant in the family Linacae and dropwise addition of the extract to the solution of an iron (III)-containing precursor. The method yields crystalline nanoparticles of ?-Fe2O3 having a spherical morphology with a diameter of 100 nm to 300 nm, a mean surface area of 240 to 250 m2/g, and a type-II nitrogen adsorption-desorption BET isotherm with a H3 hysteresis loop. A method for the photocatalytic decomposition of organic pollutants using 10 the nanoparticles is disclosed. An antibacterial composition containing the crystalline ?-Fe2O3 nanoparticles is also disclosed.

Abstract: A strain sensor utilizes an ohmic-based contact switch to detect strain. The sensor can be incorporated into other structures, such as an artificial flapping wing, to detect strain and other parameters, including air flow disturbances. The sensors are fabricated using an additive manufacturing process, with a layer of gold or other conductive material applied for electrical conductivity and UV laser ablation for electrical isolation. The sensor design incorporates mechanical amplification, converting small strains into larger displacements that close contact pads, resulting in an ohmic switch activated at a specific strain threshold. Unlike traditional sensors, the switch provides a high or low state output directly without the need for additional amplification or post-processing. The device can detect disturbances in flapping wing cycles and obtain yaw rotation information, with potential applications in other aircraft for disturbance detection.

Abstract: Systems and methods for molecular simulation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting a relationship between a ligand and a receptor. The method includes steps for identifying a plurality of conformations of a receptor, computing docking scores for each of the plurality of conformations and a set of one or more ligands, and predicting a relationship between the set of one or more ligands and the plurality of conformations of the receptor.

Abstract: A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

Abstract: A collaboration of miners cooperatively notarizes transactions to be added to a distributed ledger. A solution space is identified for notarizing the transactions, such as an integer space that may contain a nonce that, when hashed with the transactions or block, yields a hash value that satisfies specified criteria. The solution space is apportioned so that each miner has a discrete slice of the space in which to search for the nonce: different slices may be of equal or different sizes. All miners search their slices in parallel. If no miner announces success (e.g., within a specified time period), the solution space shifts so that each miner becomes responsible for a different slice. All miners may be rewarded when a solution is found, but a miner that failed to discover the nonce, despite searching a slice that contained it, is penalized and may not share in the reward.

Abstract: A climate technology ecosystem is disclosed that automates the collection and processing of data by way of programmed computer software to automatically generate uniform encrypted carbon credit certificates that can be traded on peer-to-peer exchanges or as derivatives. The Autonomous Climate Technology Ecosystem (ACTE) creates a network of information derived from nine systems designed to: sensor, qualify, measure, encode, encrypt, issue, index, register, and exchange, all of which rely upon artificial intelligence to identify, calculate and quantify the source and origin of carbon and automatically generate uniform encrypted carbon credit certificates based upon the nature and attributes of the carbon and associated CO2e.