Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

Abstract: Methods and compositions for treating central nervous system diseases and disorders are disclosed. In a particular embodiment, compositions comprising a nitrated alpha synuclein peptide are provided. The composition may further comprise an adjuvant that stimulates regulatory T cells and/or at least one pharmaceutically acceptable carrier.

Abstract: Described herein relates to a method for pre-processing files that can improve file compression rates of existing general-purpose lossless file compression algorithms, particularly for files on which traditional algorithms perform poorly. The elementary cellular automata (CA) pre-processing technique involves finding an optimal CA state that can be used to transform an original file into a format (i.e., an intermediary file) that is more amenable to compression than the original file format. This technique is applicable to multiple file types and may be used to enhance multiple compression algorithms. Evaluation on generated files, as well as samples selected from online text repositories, finds that the CA pre-processing technique improves compression rates by up to 4% and shows promising results for assisting in compressing data that typically induce worst-case behavior in standard compression algorithms.

Abstract: A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed.

Abstract: Cross-linked polyvinyl polymers comprising charged groups and methods of making are disclosed. The polymers are effective and durable adsorbent of dyes from aqueous solutions. Also, a method of removal of dyes from contaminated water is disclosed.

Abstract: A system and method for performing an automated medical procedure is provided. The method may include positioning an effector unit over a patient, acquiring medical imagery of the patient, analyzing the medical imagery using at least one processor to determine a location, and positioning a subunit of the effector unit to perform the automated medical procedure at the location. The automated medical procedure may be performed using at least one of a plurality of subunits of the effector unit. The automated medical procedure may be a body fluid aspiration procedure and one of the plurality of subunits of the effector unit may include a fluid aspirating cannula. Multiple subunits may be sequentially used to perform the procedure.

Abstract: Disclosed are a system for predicting optical properties of molecules based on machine learning and a method thereof. More particularly, the system for predicting optical properties according to an embodiment includes a preprocessor that receives molecular information of a target molecule and surrounding molecules, and vectorizes the molecular information of a target molecule and surrounding molecules; a feature extractor that receives the vectorized information of the target molecule and surrounding molecules and extracts the features of the target molecule and surrounding molecules; an integrated feature extractor that receives both features of the target molecule and surrounding molecules and extract the integrated features of the target molecule and surrounding molecules by using an algorithm; and an optical property predictor that receives the integrated features of the target molecule and surrounding molecules and predicts optical properties of the target molecule affected by surrounding molecules.

Abstract: Haloalkane sulfonic acids and salts thereof are provided. In embodiments, a haloalkane sulfonic acid or salt thereof comprises an alkyl group, at least one sulfonic acid group, and one or more halogens selected from Cl, Br, I, and F, the haloalkane sulfonic acid having a total number of carbon atoms of from 2 to 9, and wherein if at least one F atom is present, the haloalkane sulfonic acid comprises at least one other halogen selected from Cl, Br, and I. Methods of making and using the haloalkane sulfonic acids/salts are also provided.

Abstract: Provided herein is an IVRO surgical guide for positioning a cutting guide on a mandibular ramus such that the mandibular ramus is clamped between a hooked distal end and a slidable component having a curved claw. The cutting guide is placed at a predetermined distance from the posterior edge of the ramus at the mid-waistline of the mandibular ramus along a curvilinear shaft in contact with the lateral surface of the ramus. The cutting guide can accommodate a saw for performing the osteotomy.

Abstract: The present invention provides a method for analysis and determination of the heavy metal occurrence key mineral phases in industrial solid waste, by performing N concentration gradients dissociation determination of the heavy metal solid waste to be tested under the same dissociation conditions, to give the dissociation degrees of the heavy metal elements to be tested at N different concentration gradients; the dissociated solid residues after dissociation being quantitatively analyzed for the mineral phase, to give the relative content of each mineral phase in the M mineral phases of the heavy metal solid waste to be tested; then calculating to give the occurrence distribution proportion of the heavy metal elements in the mineral phase, which are accumulated from high to low; the occurrence key mineral phase whose cumulative occurrence proportion exceeds the preset cumulative threshold value is determined to be the key mineral phase of the heavy metal elements.

Abstract: The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: The present disclosure provides a method for co-extraction of vanadium, titanium and chromium from vanadium slag. The method selectively reduces pyroxene and fayalite wrapped on spinel through low-temperature hydrogen reduction, iron removal by ferric chloride, and low-temperature leaching of the vanadium slag by oxalic acid, thereby destroying a structure of the spinel, dissociating a spinel phase and a silicate phase, and fully exposing the spinel phase. The method also directly leaches the vanadium slag at a low temperature by acidity and strong complexation of the oxalic acid, and destroys the structure of the spinel, such that vanadium, titanium, chromium and oxalate are complexed into a solution to co-extract vanadium, titanium and chromium. The present disclosure extracts vanadium, titanium and chromium from the vanadium slag, with a leaching rate each being greater than 99%.

Abstract: An assistive device for stair-climbing assistance includes a powered rail-sliding platform that assists its user through a unique human interface. The device provides powered assistance (a gentle pulling force) and protection (through a safety belt) to help users climb or descend stairs.

Abstract: The present invention relates to novel compositions and methods to produce 3D organ equivalents of the brain (i.e. “mini-brains”). The invention also relates to methods of using human induced pluripotent stem cells, a combination of growth and other soluble factors and gyratory shaking. Cells from healthy or diseased donors or animals can be used to allow testing different genetic backgrounds. The model can be further enhanced by using genetically modified cells, adding micro-glia or their precursors or indicator cells (e.g. with reporter genes or tracers) as well as adding endothelial cells to form a blood-brain-barrier.

Abstract: The present disclosure pertains to shortening blend compositions comprising a first oil, a second oil, and an emulsifier. The disclosed shortening blend compositions can comprise a first oil with an oleic acid content of about 50% or more and a saturated fatty acid content of about 35% or less; a second oil with an oleic acid content of about 75% or more and a saturated fatty acid content of about 20% or less; wherein the first oil and the second oil are derived from different sources; and an emulsifier. Also disclosed are methods of making the disclosed shortening blends and food products comprising a disclosed shortening blend. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A steering wheel suspension structure of an omnidirectional mobile robot includes a steering wheel connecting ring, a plurality of leaf spring connecting beams and a chassis mounting section. The steering wheel suspension structure is an integrated plate structure. The steering wheel connecting ring is connected with a steering wheel, and the chassis mounting section is connected with a robot chassis. The leaf spring connecting beam is connected with the steering wheel connecting ring and the chassis mounting section, and the leaf spring connecting beam is used as the main component of suspension deformation. The suspension structure is simple, easy to install, light in weight, less in space, and highly integrated with the steering wheel assembly. When the suspension is deformed by the force, it weakens the radial force and only has the displacement and force in the vertical direction, thus ensuring the handling performance of the chassis.

Abstract: A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.

Abstract: A multi-modal screw propelled excavation system for small body sample collection includes a craft having screw-shaped wheels to traverse the surface of the target body. When the craft is ready to collect a sample, the craft opens a door to an excavation bin on a bottom face of the craft, and uses the screw-shaped wheels to churn up regolith which is captured by closing the door.

Abstract: The present disclosure discloses a three-dimensional integration system of an RFID chip and a supercapacitor and a manufacturing method thereof.

Abstract: Systems and methods for generating ground-level terrain elevation models, preparing vector street data to assist in generating such models, and finding approximate elevation of any point using such terrain models are provided. Lidar data can be analyzed, and Lidar elevation values at roadway/street intersections can be used to determine a model of the ground-level elevation in an area or region. Outliers can be removed. The ground-level elevation at any point in the mapped area can be determined using elevation levels for nearby roadway intersections.