Abstract: Disclosed herein are isolated peptides inhibit activity of a cofactor-independent phosphoglycerate mutase. In some examples, the isolated peptide is 6-20 amino acids long and includes the amino acid sequence of any one of SEQ ID NOs: 1-22 or 54, an analog or derivative thereof, or a pharmaceutically acceptable salt or ester thereof. In some examples, the peptide is a cyclic peptide with an N-terminal ring of 6-15 amino acids (for example, 6-10 amino acids) and a C-terminal linear portion of 1-9 amino acids (for example, 3-8 amino acids. Also disclosed h are methods of treating or inhibiting an infection in a subject, including administering to the subject an effective amount of a composition including one of more of the disclosed peptides, or analogs or derivative thereof, or pharmaceutically acceptable salts or esters thereof.

Abstract: The present invention is intended to provide a photoresponsive Smo ligand, in which a photodissociable protective group binds to an active site of a Smo ligand (a site important for agonistic or antagonistic activity). Specifically, the present invention relates to a photoresponsive Smo ligand, in which a photodissociable protective group binds to an active site of a Smo ligand. More specifically, it is a photoresponsive Smo ligand, which is characterized in that the Smo ligand is a 1,4-diaminocyclohexane derivative and the photodissociable protective group comprises an aromatic ring.

Abstract: Additive manufacturing (AM) methods and devices for high-melting-point materials are disclosed. In an embodiment, an additive manufacturing method includes the following steps. (S1) Slicing a three-dimensional computer-aided design model of a workpiece into multiple layers according to shape, thickness, and size accuracy requirements, and obtaining data of the multiple layers. (S2) Planning a forming path according to the data of the multiple layers and generating computer numerical control (CNC) codes for forming the multiple layers. (S3) Obtaining a formed part by preheating a substrate, performing a layer-by-layer spraying deposition by a cold spraying method, and heating a spray area to a temperature until the spraying deposition of all sliced layers is completed. (S4) Subjecting the formed part to a surface modification treatment by a laser shock peening method.

Abstract: A network resource scheduling method, apparatus, an electronic device and a storage medium are disclosed. An embodiment of the method includes: upon receipt of a network data stream, determining a traffic type of the network data stream based on the number of data packets of the network data stream received within a specified period of time, lengths of the data packets and reception times of the data packets; for each data packet comprised in the network data stream, determining a target transmission path for the data packet, based on node state parameters of nodes in the network cluster, link state parameters of links in the network cluster, and the traffic type of the network data stream when the data packet is received; and transmitting the data packet via the target transmission path.

Abstract: Disclosed are indazole compounds and derivatives thereof for use as modulators of the activity of mitogen-activated protein kinase 4 (MEK4). The disclosed compounds include 3-Arylindazoles which may be formulated in pharmaceutical composition for treating cell proliferative diseases and disorders associated with MEK4 activity, including cancer.

Abstract: A controllable preparation method for a plasmonic nanonail structure is provided. A size of a nanomaterial can be controlled at sub-wavelength. The nanomaterial has good localized surface plasmon resonance effect, and the optical, electrical and mechanical properties of the nanometer material all can be regulated. The plasmonic nanonail is composed of two parts, i.e., a silver nanorod, a gold nanorod or a silver-gold-silver alloy nanorod and an approximate equilateral triangular nano-silver plate growing on the nanorod. A length of the nanorod is controlled within 20-30 nanometers, a diameter of the nanorod is controlled within 10-200 nanometers, a side length of the triangular nano-silver plate is controlled within 20 nanometers to 2 microns, and a size of the triangular plate is less than or equal to the length of the nanorod.

Abstract: Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.

Abstract: Disclosed is a method for clean metallurgy of molybdenum, including steps: 1) roasting molybdenite with calcium to obtain calcified molybdenum calcine, and leaching the calcified molybdenum calcine with an inorganic acid to obtain a molybdenum-containing inorganic acid leachate; 2) extracting molybdenum in the leachate with a cationic extractant to obtain an organic phase loaded with molybdyl cations and a raffinate; 3) using a hydrogen peroxide solution as a stripping agent to obtain a molybdenum stripping liquor; and 4) heating the molybdenum stripping liquor to dissociate peroxymolybdic acid therein so as to form a molybdic acid precipitate, and then calcining to obtain a molybdenum trioxide product. The method solves the problem of ammonia nitrogen wastewater production and can also be used for the enrichment and recovery of rhenium.

Abstract: The present invention provides a surface plasmon-optical-electrical hybrid conduction nano heterostructure and a preparation method therefor. The structure includes an exciting light source, a semiconductor nano-structure array, a two-dimensionalplasmonic micro-nano structure, a sub-wavelength plasmon polariton guided wave, an emergent optical wave, a one-dimensionalplasmonic micro-nano structure, a wire, a metal electrode, a conductive substrate, a probe molecule, an atomic-force microscopic conductive probe and a voltage source. The method achieves a semiconductor seed crystal with controllable distribution and density by controlling free metal ions, air, water or oxygen on a metal substrate to achieve highly uniform control of the seed crystal, and then strictly controls a length-to-diameter ratio and distribution of a semiconductor structure by continuous growth. Therefore, a new nano optics platform is provided for studying various novel effects produced by interaction between light and substances.

Abstract: A wheat straw pulp, a preparation method therefor, an application thereof, and a method for adjusting the degree of substitution of CMC. The preparation method for the wheat straw pulp comprises the following steps: using water as a medium, performing ultrasonic crushing on wheat straw, performing solid-liquid separation, and collecting the solid to obtain wheat straw pulp, the temperature of the ultrasonic crushing being 25-100° C. In the preparation method, by using water as a medium, wheat straw is dissociated into wheat straw fibers in water in a mild temperature condition by means of ultrasonic crushing accompanied by H2O2. The wheat straw pulp can be used for preparing CMC. By adjusting different technological conditions to adjust the properties of the wheat straw pulp, CMC having different degrees of substitution can be prepared.

Abstract: Using the characteristics of G-protein coupled receptors (GPCR) for sensing specific ligands and undergoing conformational change, inserting a signal molecule in an intracellular region of the G-protein coupled receptors, converting the conformational change of the G-protein coupled receptors into an optical signal change, and detecting the presence and/or concentration of a specific ligand by means of detecting the change in the optical signal; a GPCR activated fluorescent probe (GRAB probe) is constructed according to this principle. A method for using the GRAB probe to detect a specific ligand.

Abstract: In one example, a processing system including at least one processor may obtain at least one frame of a volumetric video, obtain a first viewport of a client device, render a plurality of two-dimensional subframes comprising two-dimensional projections of the at least one frame of the volumetric video, based upon the first viewport of the client device, and transmit the plurality of two-dimensional subframes to the client device. In another example, a processing system including at least one processor may request a volumetric video from a network-based proxy, provide a viewport to the network-based proxy, obtain a plurality of two-dimensional subframes from the network-based proxy in accordance with the viewport, select at least one of the plurality of two-dimensional subframes to present, and display the at least one two-dimensional subframe that is selected.

Abstract: The invention generally relates to linear-bottlebrush-linear copolymer blocks and methods of making and using same. The disclosed copolymer blocks can be useful in, for example, the formation of polymer networks that replicate biological stress-strain behavior. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: According to some embodiments, a system for widening and densifying a scrape-off layer (SOL) in a field reversed configuration (FRC) fusion reactor is disclosed. The system includes a gas box at one end of the reactor including a gas inlet system and walls of suitable heat bearing materials. The system further includes an exit orifice adjoining the gas box, wherein the exit orifice has a controllable radius and length to allow plasma to flow out from the gas box to populate the SOL with the plasma. The system may also include fusion products, which decrease in speed in the plasma in the SOL, allowing energy to be extracted and converted into thrust or electrical power and further allowing ash to be extracted to reduce neutron emissions and maintain high, steady-state fusion power.

Abstract: A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein includes first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted. When the heterodimeric Fc-fused protein is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.

Abstract: An ordered functional nanoporous material (OFMN) composition includes a pore defined by a sidewall, the sidewall comprising N—C—N linkages therein. A process for synthesis of a reagent includes the reaction of a 6,7-diaminoquinoxaline having R groups with hexaketocyclohexane (HKH) octahydrate, where R is independently in each occurrence H, Cl, Br, I, C4H4S (thiophenyl), SO3?, CO2?, C?CH, CH?CH2, NH2, OH, C?N, C1-C4 alkyl, (CH2)xCH?CH2, or (CH2)yCH?CH(CH2)z where x or (y+z) is an integer of 0 to 4 inclusive, (CH2)jCH?CH, or (CH2)kCH?C(CH2)r where j or (k+r) 0 to 4 inclusive. A process of degasification that includes extracting a gas from a mixture by exposing the mixture to an OFNM to selectively pass the gas therethrough. A process of dehydrogenation includes exposing an aliphatically unsaturated feedstock to platinum modified OFNM under conditions to form hydrogen and selectively passing the hydrogen through the platinum modified OFNM.

Abstract: Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence.

Abstract: A fluxgate detector for buried and abandoned chemical weapons is provided, comprising: a probe for sensing an external magnetic field, comprising a probe input and a probe output; an excitation module electrically connected to the probe input for inputting an excitation signal into the probe; a frequency selection module electrically connected to the probe output for isolating a second harmonic signal in an induced voltage generated by the probe; and a signal acquisition module electrically connected to the frequency selection module. The second harmonic signal in the induced voltage can be isolated by the frequency selection module, transmitted to the signal acquisition module, and converted to an intensity of the magnetic field by the signal acquisition module. The substance detected can be identified according to the intensity of the magnetic field, so that the buried ACWs can be found efficiently and accurately.

Abstract: An oral suction device includes a suction catheter having a suction portion at a first end, a sponge surrounding the suction portion, a hydrogel or non-hydrogel polymer coating on the sponge, and a suction tubing connector on a second end opposite the first end. In some aspects the coating is a hydrogel coating that does not have macropores. A method of making an oral suction device may include dip-coating a sponge and forming macropores in the coating during the coating process.

Abstract: A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.