Abstract: The present invention introduces magnetoelectric nanoparticles into acupuncture points that interact with cells, receptors, or molecules in the presence of an applied magnetic field to treat various disorders.

Abstract: A pipeline three-dimensional curve measuring robot and implementation method therefor. The measuring robot includes an electronic bin, sliding rods, wheel bracket, walking wheels arranged on wheel bracket, odometer wheels arranged on sliding rod on one side and encoders; the electronic bin is internally provided with an inertia measurement unit, collection control module and power supply module; when measuring, the measuring robot is controlled to move back and forth in a pipeline collecting measuring data; comparing measured data with three-dimensional curve data at pipeline reference moment to obtain deformation quantity of pipeline three-dimensional curve.

Abstract: A method of performing a class incremental learning in a neural network apparatus, the method including training an autoencoder using first input embeddings with respect to a first class group, calculating a contribution value of each of parameters of the autoencoder and calculating a representative value with respect to each of at least one first class included in the first class group in the training of the autoencoder, retraining the autoencoder using second input embeddings with respect to a second class group, and updating the contribution value of the each of the parameters and calculating a representative value with respect to each of at least one second class included in the second class group in the retraining the autoencoder.

Abstract: We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (?15%) frequencies of TERT promoter mutations. The nine TERT-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages. In addition to their implications for understanding the relationship between telomeres and tumorigenesis, TERT mutations provide a biomarker for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.

Abstract: A low voltage sub-nanosecond pulsed current driver for driving current to a load, which comprises a regulated current source connected to the load, for driving controlled current to the load (which may be a laser diode for LIDAR applications); a current routing network, being connected in parallel to the load following the regulated current source and consisting of a plurality of controlled power switches; and a controller for individually timing the operation of the plurality of controlled power switches, to generate a current pulse having desired narrow pulse width and reduced rise and fall times that will be delivered to the load.

Abstract: An active vehicle height control method may include securing a road surface profile for unevenness of a road ahead of a vehicle; forming a target vehicle height profile by filtering the road surface profile; forming, by a controller, a disturbance profile using the road surface profile and the target vehicle height profile; estimating, by the controller, vehicle behavior for the disturbance profile; determining, by the controller, an inverse-phase control force that minimizes the estimated vehicle behavior; and driving, by the controller, an actuator using the inverse-phase control force.

Abstract: Provided is a positive active material in which a compound containing lithium, a transition metal, and oxygen is doped with a doping metal, the positive active material including lithium (Li) layers, in which the lithium layers may include a first lithium layer including only lithium and a second lithium layer in which at least a part of the lithium of the first lithium layer is substituted with a transition metal.

Abstract: A method of accessing a nonvolatile memory device which includes a memory block where semiconductor layers including word lines are stacked includes receiving a write request for the memory block, determining whether the write request corresponds to one or more leading word lines, programming, in response to the write request determined as corresponding to the leading word lines, memory cells connected thereto in a first program mode, and programming, when the write request is determined as corresponding to a following word line different from the leading word lines, memory cells connected to the following word line in a second program mode. The second program mode is performed with a second program parameter including at least one of a number of program pulses, a number of program verify pulses, a program start voltage, and a program end voltage that is different from a corresponding first parameter of the first program mode.

Abstract: The present disclosure generally provides an oscillating heat pipe, wherein the oscillating heat pipe comprises a 3-phase working fluid that includes at least one liquid phase portion, at least one vapor phase portion, and at least one solid phase portion, wherein in addition to a phase change between liquid and vapor, there is also a phase change from solid to liquid during a heat transfer process involving the oscillating heat pipe.

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.

Abstract: The system includes an intermediate-frequency (IF) synthesizer that generates an IF signal based on a reference signal, and a sub-sampling PLL (SSPLL) that generates a high-frequency output signal based on an input. A switch selects either the reference signal or the IF signal to be the input to the SSPLL. When the reference signal is the input to the SSPLL, the frequency synthesizer operates in a low-noise normal-operating mode, and when the IF signal is the input to the SSPLL, the frequency synthesizer operates in a higher-noise, frequency-acquisition mode. A sub-sampling lock detector (SSLD) determines whether the frequency synthesizer becomes unlocked during the normal-operating mode, and if so, activates the switch to move the system into the frequency-acquisition mode. It also determines whether the frequency synthesizer becomes relocked to the target frequency during the frequency-acquisition mode, and if so, activates the switch to move the system into the normal-operating mode.

Abstract: A nanocomposite containing azole modified hollow silica spheres. In particular, the nanocomposite involves a silanization reaction product of an azole-functionalized silane linker and hollow silica spheres. The azole-functionalized silane linker is produced via a ring-opening reaction a silane coupling agent having an epoxide group and an azole compound. A method of making the nanocomposite is also specified.

Abstract: To provide novel compounds that are promising as prodrug-type anticancer agents, a compound represented by general formula (I) or a salt thereof is provided.

Abstract: There is provided a data storage device for managing memory resources by using a flash translation layer (FTL) for condensing mapping information. The FTL divides a total logical address space for input and output requests of a host into n virtual logical address streams, generates a preliminary cluster mapping table in accordance with stream attributes of the n virtual logical address streams, generates a condensed cluster mapping table by performing a k-mean clustering algorithm on the preliminary cluster mapping table, and generates a cache cluster mapping table configured as a part of a condensed cluster mapping table frequently referred to by using a DFTL method. The FTL extends a space of data buffers allotted to non-mapped physical address streams to a DFTL cache map in a data buffer of a volatile memory device by the condensed cluster mapping table.

Abstract: The present invention provides a method for guiding traffic flow in vehicle-dense regions based on a three-dimensional traffic system, relating to a method to alleviate traffic pressure.

Abstract: Provided are compositions for inhibiting cellular proliferation comprising one or more CRL4CDT2 ubiquitin ligase inhibitors. Also provided are uses of the disclosed compositions to prepare medicaments, for treating and/or preventing diseases, disorders, and conditions, particularly for treating cancer, inducing apoptosis and/or rereplication in cells, inhibiting undesirable neddylation, overcoming vemurafenib-resistance in cells, treating melanoma, breast cancer, head and neck squamous carcinoma cell (HNSCC) cancer, a solid tumor, hepatocellular carcinoma, colorectal cancer, a non-small-cell lung cancer, serous ovarian cancer, papillary thyroid carcinoma, or ameloblastoma, and pharmaceutical compositions comprising the same.

Abstract: The present disclosure describes a system, method and software applications for predicting the KAM of a subject for a plurality of gait cycles of a subject. At least one sensor attachable adjacent to the ankle of at least one leg of the subject provides accelerometer and gyroscopic data for the plurality of gait cycles. A processing means receives subject parameters and accelerometer and gyroscopic data from the at least one sensor for evaluation by a neural network of predicted KAM values for the plurality of gait cycles of the subject. The neural network is configured via determining KAM values for each of the plurality of subjects from measurements during a plurality of gait cycles and other parameters.

Abstract: A method for processing speech data for a speech event, wherein the speech data comprises a visible component and an audible component. The method comprises identifying a first visible feature within the visible component that corresponds to a predetermined visible speech feature and determining a first time corresponding to the occurrence of the first visible feature during the speech event. The method further comprises determining a measurement of a characteristic of the audible component at a second time during the speech event, which has a predefined temporal relationship to the first time at which the first visible feature occurred, and using the determined measurement of a characteristic at the second time to output an evaluation of an attribute, with which the predetermined visible speech feature is associated.

Abstract: Provided herein are screening methods for identifying one or more compounds that impart a smell, taste and/or trigeminal sensation, for example, odorants contributing to an olfactory quality. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.