Abstract: The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.

Abstract: Provided is a green-yellow fluorescent protein with high pH stability (with reduced pH sensitivity). In one or more embodiments, the fluorescent protein is a fluorescent protein comprising an amino acid sequence from position 2 to 225 of the amino acid sequence of SEQ ID NO: 1, at least a mutation being introduced into the sequence, wherein the above-mentioned mutation is selected from the group consisting of F149T or S or A, L158T or S or A, H160T or S or A, Y174T or S or A, and Y192T or S or A as well as combinations of 2 to 5 thereof.

Abstract: The present invention generally relates to polyurethanes and polyurethane nanocomposites having improved mechanical, rheological, and thermal properties over ordinarily produced polyurethanes and polyurethane nanocomposites. Such polyurethanes and polyurethane nanocomposites include very small amounts of a small chain diol, such as glycerol, and more specifically, between 0.01 and 4 weight percent of the small chain diol, based on the total polymer composition.

Abstract: Provided herein are recombinant adeno-associated virus (rAAV) nucleic acid vectors that comprise one or more modifications within at least one inverted terminal repeat (ITR) region. Exemplary modifications include ITR sequences comprising a glucocorticoid responsive element and/or a transcription factor binding site. Also provided are plasmids, libraries, rAAV particles, compositions, kits, and methods related to such vectors.

Abstract: Methods, systems, and apparatus for detecting single event effects. The system includes a first-modulus digital logic unit and a second-modulus digital logic unit each configured to reduce one or more operands by a respective modulus, apply an arithmetic compute logic to the reduced operands to produce a respective compute output, and reduce the respective compute output by their respective modulus. The system includes a kernel digital logic unit configured to apply the arithmetic compute logic to the operands to produce a kernel compute output, output the kernel compute output reduced by the first modulus, and output the kernel compute output reduced by the second modulus. The system includes a detector configured to detect a single event effect based on the reduced first compute output, the kernel compute output reduced by the first modulus, the reduced second compute output, and the kernel compute output reduced by the second modulus.

Abstract: A real-time, stream data information integration and analytics system can include an information engine that performs real-time entity extraction to create key-value pairs of attributes for a personal profile and integrates similar personal profiles generated from same or different data sources into a single person-of-interest profile. The real-time, stream data information integration and analytics system can further include a real-time analytics module that performs a variety of analytics using the person-of-interest profiles and updates the person-of-interest profiles with scores and other results of the variety of analytics. The variety of real-time analytics can include sentiment analysis and at least some aspects of threat detection analysis. The sentiment analysis can be used to provide a recommender system and the threat detection analysis can be used to identify and predict threats and opportunities.

Abstract: A semi-crystalline thiourethane polymer. The semi-crystalline thiourethane polymer comprises a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages. Each of the first type of monomer includes two or more thiol functional groups and each of the second type of monomer includes two or more isocyanate functional groups. The first and second types of monomers are polymerized together in an anionic step-growth polymerization reaction that is catalyzed by a non-nucleophillic base having a pKa greater than 7, produced by photo-initiated decomposition of a photolatent base. A method of synthesizing, and polymer jetting and stereolithography methods of manufacturing a polymer part, are also disclosed.

Abstract: A platinum complex includes a structure of Formula (I). A method for treating a subject suffering from cancer includes a step of administering an effective amount of the platinum complex to the subject. A method for inhibiting the growth of cancer cells includes the step of contacting a population of cancer cells with an effective amount of the platinum complex. The platinum complexes are particularly suitable for treatment of cancer through, in particular, photodynamic therapy.

Abstract: Provided are a pressure sensor which exhibits exceptional performance and a method of producing the same. The pressure sensor includes: a silicon substrate having a cavity; a diaphragm which is formed of a metallic glass and has a tensile stress in a range in which a resonant frequency is higher than an audible range; and a counter electrode which is insulated from the diaphragm and has a plurality of holes. The diaphragm and the counter electrode are disposed on the silicon substrate to face each other with a gap therebetween, the diaphragm and the counter electrode being released from the silicon substrate by the cavity.

Abstract: Connecting rod ultrasonic-assisted splitting machining method and a machining device thereof, relating to the field of machining of a connecting rod. The machining device comprises a rack, a fixing block, a sliding block, a sliding block base, a vertical locking oil cylinder, a wedge-shaped pull rod, an adjusting block body, etc. By means of the method and the device thereof, the range of the material used for splitting the connecting rod is enlarged, the splitting force required during the splitting of the connecting rod, deformation of fracture surfaces, residues generated during the splitting process, out-of-roundness of big end holes of the connecting rod, and other situations are reduced, and the engaging accuracy of the connecting rod and the joint face of a connecting rod cover and the assembly quality of the connecting rod are improved.

Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.

Abstract: The disclosure relates to compositions and methods for treating a subject suffering from anti-NMDA receptor encephalitis. The method comprises administering to a patient in need of treatment an effective amount of tramadol before and/or during administration of therapeutic plasma exchange.

Abstract: An apparatus or method determines a salinity or metal content a liquid sample by scanning the liquid sample using a PXRF spectrometer, receiving a PXRF spectra from the PXRF spectrometer, baseline correcting and smoothing the received PXRF spectra, extracting a K? emission line of one or more elements from the baseline corrected and smoothed PXRF spectra using only one beam from the PXRF spectrometer, determining the salinity or the metal content of the liquid sample using the one or more processors and a predictive model that relates the K? emission line of the one or more elements to the salinity or the metal content of the liquid sample, and providing the salinity or the metal content of the liquid sample to the one or more input/output interfaces.

Abstract: The purpose of the present invention is to make it possible to efficiently generate information for cell analysis. A feature-group information generating unit generates, as feature-group information, information including values of N types of feature parameters (wherein N represents an integer having a value of 1 or more) about a morphological feature of a single cell of a plurality of cells or a morphological feature of a cell population based on data of one or more cell images included in a unit, the one or more cell images in the unit being selected from cell images capturing the cell population including the cells in accordance with a predetermined requirement.

Abstract: CEST imaging technique and MR scanning are used as an MRI method for detecting levels of lactate in vivo by exploiting the exchange of —OH protons on lactate with bulk water. In accordance with this method, one first obtains a lactate CEST MRI map of a slice of the body of a patient. A contrast agent such as pyruvate, glucose or glutamine is administered and a post-administration CEST MRI map is obtained. The difference in the spatial maps indicates the level of expression of lactate in the tissue of interest.

Abstract: Methods and apparatus for providing all-optically generated, on-chip propagated and high-efficiency tunable plasmons are described. The plasmon generating apparatus includes a graphene based silicon nitride waveguide (GSiNW) utilizing ‘C+L’ band light sources and detectors that take advantage of the surface 2nd nonlinearity on graphene. The optical generation is accomplished via one or more optical communication lasers through the difference-frequency generation process. The THz frequency and intensity is tunable via an external gate voltage. Using such a device the optical to THz conversion may be made at least an order of magnitude more efficient than prior THz sources, and can be used to make chip-scale room-temperature THz sources, switches, modulators and detectors based on graphene.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The techniques described herein may include memory allocation techniques that provide improved security and performance. In embodiments, a method implemented in a computer system may include a processor and a memory, the method may comprise mapping a block of memory, dividing the block of memory into a plurality of heaps, dividing each heap into a plurality of sub-heaps, wherein each sub-heap is associated with one thread of software executing in the computer system, dividing each sub-heap into a plurality of bags, wherein each bag is associated with one size class of objects, and storing a plurality of objects in at least some of the bags, wherein each object is stored in a bag having size class corresponding to a size of the object.

Abstract: Described herein is a glass bottle configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip-free pouring. The dripping is prevented over a full range of pouring angles, which vary depending on the amount of liquid held in the glass bottle. A method of making the glass bottle and a method of enabling drip-free pouring using the glass bottle are also disclosed.

Abstract: A needle-shaped body protrudes from a cantilever made of Si. Furthermore, the rear face of the cantilever is coated with aluminum (first metal) having a Fermi level higher than that of Si. The cantilever is dipped into an aqueous silver nitride solution containing the ions of Ag serving as a second metal. The electrons of Si flow out to the aqueous silver nitride solution due to the existence of the aluminum, and Ag nanostructures are precipitated at the tip end of the needle-shaped body. A probe for tip-enhanced Raman scattering in which the Ag nanostructures are fixed to the tip end of the needle-shaped body is manufactured. The sizes and shapes of the Ag nanostructures can be controlled properly by adjusting the concentration of the aqueous silver nitride solution and the time during which the cantilever is dipped into the aqueous silver nitride solution.