Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
Type:
Grant
Filed:
December 10, 2015
Date of Patent:
August 29, 2017
Assignees:
The Regents of the University of California, North Carolina State University, National Technology & Engineering Solutions of Sandia, LLC
Inventors:
Joseph Wang, Joshua Ray Windmiller, Roger Narayan, Philip Miller, Ronen Polsky, Thayne L. Edwards
Abstract: Transgenic plants that have enhanced yield-related traits, such as increased seed oil production, are produced by genetically engineering the plants to down-regulate the expression of at least one BPM protein. Such transgenic plants can, for example, be cultivated and yield higher seed oil production than control plants which have not been genetically engineered for down regulation of a BPM protein.
Abstract: The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each construct can, independently, further comprise one or more genes encoding a recombinase capable of recognizing the pair of recombinase recognition sequences of the construct. The recombinase can be an orthogonal (non-cross reacting), site-selective recombinase (OSSR).
Type:
Grant
Filed:
April 15, 2011
Date of Patent:
August 29, 2017
Assignee:
The Regents of the University of California
Inventors:
Joshua M. Gilmore, J. Christopher Anderson, John E. Dueber
Abstract: A gas flow sensing device, and related method of manufacturing, comprising a conductive layer encapsulated in dielectric film, suspended over a cavity to form a diaphragm. The conductive layer functions as both a heating a sensing element and is patterned to provide uniform heat distribution across the diaphragm. The device is designed to sense flow from any direction relative to the device and the design of the dielectric film and diaphragm reduces sensor drift during prolonged operation.
Type:
Grant
Filed:
April 11, 2013
Date of Patent:
August 29, 2017
Assignee:
University of Virginia Patent Foundation
Abstract: A method of determining a treatment for an inflammatory disorder in a subject, is disclosed. The method comprises determining an amount of SRSF6 in a sample from the subject, wherein an amount of the SRSF6 is indicative of the treatment. Methods of diagnosing inflammatory disorders and treating same are also disclosed.
Type:
Grant
Filed:
May 16, 2013
Date of Patent:
August 29, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Rotem Karni, Vered Ben Hur, Avraham Maimon
Abstract: The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (PDNF), or fragment of PDNF. The invention also provides compositions featuring PDNF, or a fragment thereof, and methods for using such compositions for the proliferation and/or mobilization of a stem cell (e.g., cardiac stem cell) or progenitor cell (e.g., hepatic progenitor cell). In one aspect, the invention provides a method of decreasing inflammation in a nonneuronal tissue of a subject. In another aspect, the invention provides a method of decreasing inflammation in a cardiac, liver, pancreas, or gastrointestinal tissue of a subject. In still another aspect, the invention provides a method of increasing expression of an anti-inflammatory factor in a non-neuronal cell or tissue.
Abstract: Disclosed herein is a method of manufacturing a zinc oxide nanosheet structure. The zinc oxide nanosheet structure may be manufactured by forming a zinc oxide seed on a substrate and growing zinc oxide from the zinc oxide seed in a zinc oxide growth solution in which zinc precursors and a doping-element-containing compound are dissolved.
Type:
Grant
Filed:
October 21, 2015
Date of Patent:
August 29, 2017
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
Sang-Woo Kim, Keun-Young Lee, Ju-Hyuck Lee
Abstract: An Advanced Biopsy Needle is disclosed that provides both fine needle aspiration and core biopsy with a single insertion, thus reducing trauma and pain to the patient. An inner needle for aspiration and an outer needle for core biopsy are in coaxial relation to each other, thus providing both histology and cytology functions with a single medical device and also with a single insertion. Lateral cutting edges along fenestration openings in the outer needle ensure that adequate tissue samples are taken. A syringe is attached to the inner needle for collection of aspirate.
Abstract: The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
Type:
Grant
Filed:
March 15, 2014
Date of Patent:
August 29, 2017
Assignees:
The Trustees of the University of Pennsylvania, Novartis AG
Abstract: The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
Type:
Grant
Filed:
April 9, 2014
Date of Patent:
August 29, 2017
Assignee:
The Regents of the University of California
Inventors:
Jennifer A. Doudna, Lei S. Qi, Rachel E. Haurwitz, Adam P. Arkin
Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
August 29, 2017
Assignees:
BioSpecifics Technologies Corp., Duke University, North Carolina Central University
Inventors:
Phyllis Carolyn Leppert, Thomas L. Wegman, Darlene K. Taylor
Abstract: Disclosed are compositions and methods for antimicrobial use. The compositions contain a small antimicrobial agent and a permeabilizing agent. The antimicrobial compositions can be antifungal or antibacterial compositions.
Abstract: Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.
Type:
Grant
Filed:
November 7, 2014
Date of Patent:
August 29, 2017
Assignee:
The Regents of the University of California
Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
Type:
Grant
Filed:
June 29, 2016
Date of Patent:
August 29, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ada Shuk Yan Poon, Alexander Jueshyan Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
Abstract: An extreme index finder and a digital value finding method are provided. The extreme index finder includes a plurality of digital-to-time converters (DTCs) and a first arbiter apparatus. The DTCs respectively receive a plurality of input signals and perform a digital-to-time converting operation on each of the input signals to respectively generate a plurality of time-domain signals. The first arbiter apparatus finds a position of a extreme value in the time-domain signals according to transition speeds of the time-domain signals and compares transition speed of the extreme value with each of the time-domain signals to find an extreme input signal corresponding to the extreme value in the input signals.
Abstract: The present invention relates to the well drilling field in petroleum industry, in particular to an additive composition suitable for viscosity reduction of oil-based drilling fluids, an oil-based drilling fluid and use thereof. The double-block copolymer mainly consists of a block A and a block B, wherein, the block A is composed of structural units represented by formula (1), the block B is composed of structural units represented by formula (2), and the number-average molecular weight of the block A is 1,500-10,000. The double-block copolymer provided in the present invention can be used as a viscosity reducer in oil-based drilling fluids, especially can be used as a viscosity reducer in high-density clay-free oil-based drilling fluids, and can greatly decrease the apparent viscosity and plastic viscosity of oil-based drilling fluids in high-temperature and high-pressure reservoir while maintaining appropriate shearing force, so as to increase the drilling rate and reduce drilling difficulties.
Type:
Grant
Filed:
March 22, 2017
Date of Patent:
August 29, 2017
Assignee:
China University of Petroleum (Beijing)
Inventors:
Guancheng Jiang, Shuanglei Peng, Yinbo He, Zhengqiang Deng, Lili Yang, Fan Liu, Deli Gao, Xinliang Li, Yawei Shi, Kai Wang, Chunlei Wang, Guangchang Ma, Li Zhao, Gang Qu
Abstract: Lithium metal oxides may be regenerated under ambient conditions from materials recovered from partially or fully depleted lithium-ion batteries. Recovered lithium and metal materials may be reduced to nanoparticles and recombined to produce regenerated lithium metal oxides. The regenerated lithium metal oxides may be used to produce rechargeable lithium ion batteries.
Abstract: A differential microphone array includes a number (M) of microphone sensors for converting sound to a number of electrical signals, and a processor, operably coupled to the microphone sensors, to specify a target differential order (N) for the differential microphone array, and wherein M>N+1, specify a steering matrix D comprising N+1 steering vectors, calculate a respective one of a plurality of linearly specify a steering matrix D comprising N+1 steering vectors-constrained minimum variance filters based on the steering matrix, apply the respective one of the plurality of linearly-constrained minimum variance filters to a respective one of the electrical signals to calculate a respective frequency response of the electrical signals, wherein the respective frequency response comprises a plurality of components associated with a plurality of subbands, and sum the frequency responses of the electrical signals with respect to each subband to calculate an estimated frequency spectrum of the sound.
Abstract: The invention is directed to a composition comprising an (one or more) isolated peptide comprising a BF01 peptide, variants of a BF01 peptide and/or mutants of a BF01 peptide. In particular aspects, the composition is a pharmaceutical composition. The composition(s) can be used to inhibit thrombogenesis, selectively inhibit the intrinsic pathway of blood coagulation and selectively inhibit FX1 in an individual in need thereof comprising administering an effective amount of all or a biologically active portion of a BF01 peptide, one or more variants thereof and/or one or more mutants thereof.
Type:
Grant
Filed:
July 1, 2014
Date of Patent:
August 29, 2017
Assignee:
National University of Singapore
Inventors:
Wan Chen, Tse Siang Kang, Manjunatha Ramachandra Kini
Abstract: Systems and methods are disclosed for removing nano-particulates from a gas. The systems may include a chamber to contain the particulate-containing gas, a source of the gas, a source of water vapor, a source of a supersonic gas, and at least one ultrasonic transducer in contact with the chamber. The chamber may also include one or more receptacles to receive the particulates. The methods may include introducing the particulate-containing gas and the water vapor into the chamber. A gas may be introduced into the chamber at supersonic speeds thereby cooling the water vapor to form nucleating ice crystals. The ultrasonic transducers may then introduce ultrasonic power into the chamber thereby causing the particulates to contact the ice crystals. The nucleating crystals, with their attached particulates, may then fall under gravity to be captured in the receptacles.