Abstract: A system and related devices for continuous and real-time monitoring and detection of head impact and corresponding trauma. The system may include a passive sensor mounted to a subject's tooth using dental hardware or adhesive so as to harness the firm coupling between the subject's tooth and cranium. With such firm coupling established, the impact data measured by the tooth-mounted sensor can be manipulated, through the use of a transfer function, by external processors to determine and communicate the impact experienced by the subject's head. The system is configured for use with an external power source whereby the passive tooth-mounted sensor is activated by means of a wireless transfer circuit such as an inductive power transfer circuit or an ultrasound power transfer circuit. The wireless activation of the powerless interior sensor system provides compatibility with multiple external power configurations, thereby enabling efficacious and continuous monitoring of the subject.

Abstract: In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.

Abstract: Diagnostic systems, methods, and devices employing low-cost handheld components are disclosed herein. A diagnostic system can include a diagnostic device that is configured to perform one or more assays on a fluid sample, such as a whole blood sample, in one or more microfluidic channels or chambers. The diagnostic device can move the fluid sample into or through the one or more microfluidic channels or chambers without using any electrical power, for example, using manual actuation to generate a positive or negative pressure within the diagnostic device. The diagnostic device can have a connector for interfacing with a separate handheld unit that can provide power and data processing. For example, the separate handheld unit can be a smartphone or PDA, and the connector can interface with an existing input/output port of the unit to draw power and/or transmit data.

Abstract: The invention relates to a pharmaceutical composition comprising an ionic co-crystal (ICC) of lithium with salicylic acid and 1-proline (LISPRO). The pharmaceutical composition can further comprise an anti-inflammatory agent, for example, salicylic acid. An embodiment of the invention provides a method for treating Fragile X Syndrome (FXS) in a subject by administering to the subject a composition comprising a pharmaceutically effective amount of LISPRO.

Abstract: Compositions containing a porous organic polymer and a heavy metal chelating moiety are provided for binding heavy metals, for example in remediation and purification. The compositions can be stable and recyclable. The compositions can contain heavy metal chelating moieties such as a thiol, a sulfide, an amine, a pyridine, or a combination thereof. The compositions can bind heavy metals such as lead, cadmium, and mercury. The compositions can have a large surface area greater than about 20 m2/g. The compositions can be used for remediation and purification to remove heavy metals from a solution. The compositions can have a maximum metal uptake capacity of more than 500 mg g?1 and/or a metal distribution coefficient of at least 1×107 mL g?1 at 1 atm and 296 K. Methods of making the compositions are provided. Methods of binding heavy metals in remediation and purification are also provided.

Abstract: A user authentication system for an electronic device for use with a plurality of wireless wearable medical sensors (WMSs) and a wireless base station that receives a biomedical data stream (biostream) from each WMS. The system includes a BioAura engine located on a server, the server has a wireless transmitter/receiver with receive buffers that store the plurality of biostreams, the biostream from a single WMS lacks the discriminatory power to identify the user, the BioAura engine has a look up stage and a classifier, the classifier generates an authentication output based on the plurality of biostreams, the authentication output authenticates the user's access to the electronic device. The wireless base station has a transmitter/receiver having receive buffers that store the biomedical data from each WMS, the wireless base station has a communication engine that retrieves the biostream from each WMS and transmits the plurality of biostreams to the server.

Abstract: Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a unit of the analyte. After altering the modified analyte such that the modified analyte advances through the opening, another arresting construct again pauses the analyte, allowing for a second ion current level to be obtained that represents a second unit of the analyte. This process may be repeated until each unit of the analyte is sequenced. Systems for performing such methods are also disclosed.

Abstract: The viscosity of various ionic liquids (IL), the solvent tetraethylene glycol dimethyl ether (G4), and their mixtures, with or without lithium salts, were measured experimentally. Various compositions were studied spectroscopically. Detailed analysis reveals that G4 preferentially solvates cations, leading to a reduction in the interaction energy between cations and anions and a subsequent enhancement in anion mobility. Diffusivity and ionic conductivity of certain compositions were improved at G4 mole fractions below levels required for a “solvate ionic liquid”. When an IL was combined with low amounts of a 1:1 stoichiometric ratio of G4 and lithium salt, the viscosity of composition remained constant and ion mobility increased.

Abstract: Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs based on PD-1 inhibition are also disclosed. Methods and kits useful for identifying agents useful for modulating HIV replication are also disclosed.

Abstract: Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

Abstract: Novel Iridium complexes having three different bidentate ligands useful for phosphorescent emitters in OLEDs are disclosed. At least one of the three different bidentate ligands is a carbene ligand.

Abstract: The present disclosure provides additive manufacturing methods that include depositing onto a substrate a material including a blend of a mechanochromic molecule and a matrix polymer; and fusing the material to provide an article. The mechanochromic molecule has a first end and a second end and includes at least one polymer chain covalently bound to each end.

Abstract: A solid overlay for laser shock peening is described herein. The solid overlay includes a transparent or translucent material, wherein the solid overlay is structured and adapted to a shape of a surface of a component to be treated by the laser shock peening. The solid overlay is configured to confine a plasma plume generated by laser light.

Abstract: A foldable tubular construct/element with one rigid degree of freedom is of a tubular construction formed by a number of single layered annular units which are connected in sequence; each single layered annular unit is of a prism having N ridge lines; two adjacent prisms each having N sides are connected to each other by sharing a polygon with N sides formed on an intersection plane; each prism with N ridge lines is composed of N rigid planar quadrilateral facets; two adjacent single layered annular units comprise N spherical mechanisms formed by the intersections of only four planar quadrilateral facets at each apex; the polygon having N sides formed in the intersection plane of the two adjacent single layered annular units is a planar polygon with an arbitrary number of sides greater than for a triangle; the ridge lines of each prism having N ridge lines are parallel to each other; the connecting ridge lines of the tubular element are coplanar; when the polygon having N sides formed in the intersection plan

Abstract: An identifier for a conduit includes a first tag having a body with a first aperture formed therein for receiving the conduit and a first identifying feature, and a second tag having a body with a second aperture formed therein for receiving the conduit and a second identifying feature that matches the first identifying feature. The first tag is attached to the conduit adjacent one end, the second tag is attached to the conduit adjacent another end, and the ends are identified as ends of the same conduit by the matching first and second identifying features.

Abstract: A method of fabricating a heterogeneous semiconductor wafer includes depositing a III-V type semiconductor epitaxial layer on a first wafer having a semiconductor substrate. The first wafer is then bonded to a second wafer having a patterned silicon layer formed on a semiconductor substrate, wherein the III-V type semiconductor epitaxial layer is bonded to the patterned silicon layer of the second wafer. The semiconductor substrate associated with the first wafer is removed to expose the III-V type semiconductor epitaxial layer.

Abstract: Provided herein are methods of making asymmetric membranes comprising a first layer and a second layer. The methods include preparing a polymeric solution comprising one or more polymers, casting the polymeric solution to form a polymeric film, contacting the polymeric film with a solvent comprising a crosslinker under conditions to form a first layer on the top of the film, wherein the first layer is dense and solvent resistant, and contacting the polymeric film having the dense, solvent-resistant first layer with a non-solvent solution under conditions that form a porous second layer on the bottom of the film.

Abstract: Bacterial strains are provided that can be isolated from the microflora of lowbush blueberry (Vaccinium angustifolium), and that are capable of increasing the antioxidant content of their growth medium. The bacteria can be used, for example, to increase the antioxidant content of various foodstuffs, as probiotics or as additives to animal feed. Antioxidant-enriched compositions produced by fermentation processes utilising the bacteria are also provided. The antioxidant-enriched compositions can be used in the preparation of cosmetics and nutritional supplements. The antioxidant-enriched compositions also have therapeutic applications.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Abstract: Disclosed is a projection image generating method for a 3D space. An exemplary embodiment of the present disclosure provides a projection image generating method, including: estimating a plurality of image obtaining poses and a plurality of depth obtaining poses including obtaining positions and obtaining angles of a plurality of obtained images and a plurality of obtained depth values obtained in an actual 3D space, respectively, with respect to a reference coordinate system; obtaining a user pose including a location and an angle of the user in a virtual 3D space corresponding to the actual 3D space with respect to the reference coordinate system; and generating a projection image obtained by projecting the plurality of obtained depth values into at least one of the plurality of obtained images, based on the corresponding image obtaining pose corresponding to the user pose and at least one corresponding depth obtaining pose.