Abstract: A multilevel inverter includes an inner DC source group circuit that generates a plurality of voltage levels, and an outer DC source group circuit that generates a substantially sinusoidal output voltage. The substantially sinusoidal output voltage is generated using, at least in part, the plurality of voltage levels generated by the inner DC source group circuit. An H-bridge circuit supplies the substantially sinusoidal output voltage at alternating polarities to a load.

Abstract: An integrated chemical looping combustion (CLC) electrical power generation system and method for diesel fuel combining four primary units including: gasification of diesel to ensure complete conversion of fuel, chemical looping combustion with supported nickel-based oxygen carrier on alumina, gas turbine-based power generation and steam turbine-based power generation is described. An external combustion and a heat recovery steam generator (HRSG) are employed to maximize the efficiency of a gas turbine generator and steam turbine generator. The integrated CLC system provides a clean and efficient diesel fueled power generation plant with high CO2 recovery.

Abstract: A method for preparing a label-free aptamer electrochemical sensor of ?-interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is provided. The nanocomposite is drip-coated on a surface of an electrode to prepare a modified electrode, and a terminal sulfhydryl group of a ?-interferon aptamer chain is connected to the gold nanoparticle via Au—S bond to obtain a nanocomposite-aptamer modified electrode. When ?-interferon is present, the ?-interferon specifically binds to the aptamer chain on the sensor, resulting in the aptamer's hairpin structure being opened and stretched, which can effectively adsorb methylene blue MB in the electrolyte, causing significant enhancement of MB redox signal. A linear relationship between a current intensity of MB oxidation peak and a concentration of the ?-interferon is fitted to construct the label-free aptamer electrochemical sensor of ?-interferon.

Abstract: The invention relates to the treatment or control of unipolar depressive disorder by administering a compound of Formula I or a salt thereof to a subject; wherein: E is S or Se; R1 and R2 are optional substituents, and are at each occurrence independently selected from: (1) a halogen, which is preferably selected from F, Cl and Br; (2) C1-C4 alkyl, such as C1-C2 alkyl or C1 alkyl, optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; and (3) C1-C4 alkoxy, such as C1-C2 alkoxy or C1 alkoxy; optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; m is an integer in the range of from 0 to 5; and n is an integer in the range of from 0 to 4.

Abstract: The present invention relates to a catalyst precursor for forming a molybdenum disulfide catalyst through a reaction with sulfur in heavy oil and to a method for hydrocracking heavy oil by using same. According to the present invention, the yield of a low-boiling liquid product with a high economic value in the products by heavy oil cracking can be increased, and the yield of a relatively uneconomical gas product or coke (toluene insoluble component), which is a byproduct, can be significantly lowered.

Abstract: Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.

Abstract: A respiratory training device providing both inspiratory and expiratory functional evaluation and training, as well as independent regulation of both the inspiratory and expiratory airway resistance levels used during training. The respiratory training device also includes data acquisition, recording, storage, retrieval and display functions for airway pressure monitoring data to provide functional evaluation, physiological monitoring, and diagnostic features. The respiratory training device allows the user to easily develop and follow precise and advanced training protocols, and utilize the respiratory device in both the clinical and home setting.

Abstract: The present disclosure relates to a method and an apparatus for training a 6D pose estimation network based on deep learning iterative matching. The method includes: obtaining a rendered image and a first segmentation mask of a target object by using a 3D model and an initial 6D pose estimation of the target object; inputting the rendered image, the first segmentation mask, an observed image of the target object, and a second segmentation mask of the target object in the observed image into a deep convolutional neural network to obtain a 6D pose estimation, a third segmentation mask and an optical flow; and performing said obtaining and said inputting again by updating the initial 6D pose estimation using the obtained relative 6D pose estimation and replacing the second segmentation mask with the third segmentation mask, to iteratively train the deep convolutional neural network.

Abstract: An intelligent stereo garage system based on Internet+ and a vehicle parking and pick-up method. The system includes a mobile APP (10), a cloud server (20), a computer system (30), a programmable logic controller (PLC) system (40), a stereo garage (50), and an all-in-one touch machine (60), where the all-in-one touch machine (60) is deployed next to the stereo garage (50), and the computer system (30) is deployed outside or inside the stereo garage (50). A fully-automatic parking method uses different parking and pick-up modes, which technically ensures that users can get their vehicles in time without hindering other users, and allows users to truly experience the system intelligence. This deeply embodies the smart city's idea of interconnecting everything with a mobile phone. The method largely solves problems such as parking difficulty, illegal parking, unauthorized charges, traffic jams, traffic noise, traffic accidents, and vehicle pollution.

Abstract: An arteriovenous graft and methods of reducing the risk of graft thrombosis and extending patency of the arteriovenous graft are provided herein. The arteriovenous graft is operable for attaching to a vein at a venous anastomosis. In some aspects, the arteriovenous graft includes a plurality of grooves at a venous anastomosis end of the arteriovenous graft and the venous anastomoses may be arranged such that the arteriovenous graft and the vein meet at an angle of 30° or less.

Abstract: The present invention provides a new gene mutation assessment system which makes it possible, even when a gene mutation has considered to be apparently not associated with a trait from mutation information at a single position, to pick the gene mutation as a gene mutation candidate showing an association with the trait.

Abstract: The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of the present technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection.

Abstract: New synthetic methods to provide access to previously unexplored functionality at the C8 position of imidazotetrazines. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

Abstract: The present invention discloses a large-current power supply and a constant-current control method and system thereof. The large-current power supply provided by the present invention includes: a primary power supply, an energy-feedback circuit and a direct-current (DC) large-current generator; the energy-feedback circuit includes a freewheel diode and a magnetic reset winding; and a secondary coil of the DC large-current generator is connected to a load. Without an output rectifier diode and a filter capacitor at a load end of the large-current power supply provided by the present invention, the power consumption problem of the output rectifier diode at a large current is unnecessarily considered, and an electrolytic capacitor does not need to be used for filtration; and therefore, the service life of the power supply is greatly prolonged, a larger current is output easily by extending, and the power supply has the advantages of simple circuit, small size, easy control and high working reliability.

Abstract: A method for identifying a medium structure coupling and a fracture network morphology of a shale gas reservoir includes the following steps. Firstly, performing a fracturing test on shale cores by using a modified Brazilian disc test and categorizing the fracture network morphology. Secondly, performing a shale matrix-fracture structure and stress sensitivity test on the shale cores having different fracture network morphology. After that, determining a stress sensitivity constant of different fracture network morphology according to indoor core data and finally preparing an identification chart of the fracture network morphology based on an indoor core stress sensitivity text combined with a production practice. The identification chart can be applied to an actual fracturing well, and the fracture network morphology is directly identified by a real-time effective stress and a normalized flow.

Abstract: Disclosed herein is a chemical delivery system having: i) a cargo compound comprising a first reactive moiety covalently bonded to a first enrichment moiety and a tethered cargo moiety, wherein the first reactive moiety is bonded to the tethered cargo moiety via a cleavable linker; and ii) a trigger compound comprising a second reactive moiety covalently bonded to a second enrichment moiety and a cargo-releasing moiety. The first enrichment moiety and the second enrichment moiety cause an increase in concentration of the cargo compound and the concentration of the trigger compound at a target site, causing a bimolecular reaction between the first reactive moiety and the second reactive moiety to form a cyclization precursor compound. The cargo moiety is then released from the cyclization precursor compound in a unimolecular cyclization reaction. Methods for treating conditions such as cancer, inflammatory conditions, and infections with the chemical delivery systems are also described.

Abstract: Disclosed herein are a method and apparatus for filtering a reference pixel. A method of smoothing a reference pixel may include determining whether or not to perform smoothing on a reference pixel based on the size of a transform block and information about an intra-prediction mode for the transform block and determining a smoothing method by comparing the size of the transform block with the size of a maximum transform block. Accordingly, image coding efficiency can be increased, and picture quality can be improved.

Abstract: Gracilin A congeners and methods for their use as immunosuppressive and neuroprotective agents.

Abstract: An electrochemical measurement apparatus includes: a tank containing electrolytic solution and a sample that generates or consumes measurement target substances in the electrolytic solution; a plurality of uniformly mixed working electrodes; and a counter electrode; the apparatus adapted to simultaneously apply a voltage between each of the working electrodes and the counter electrode; and the apparatus configured to measure a current that flows between each of the working electrodes and the counter electrode; wherein any two working electrode groups are mutually different in at least any of the determined voltage, presence/absence of a molecular modification of an electrode surface, and a species of the molecular modification; and whereby a distribution in measurement area of the currents that flow through the working electrodes is acquired.

Abstract: A storage memory device includes a vertical field effect transistor including a semiconductor substrate; a pillar extending upwardly from the substrate and containing a source, a drain, and a channel disposed therebetween; a first insulating layer surrounding the channel; a stacked structure surrounding the first insulating layer; and a gate unit. The stacked structure includes a charge trapping layer and a composite element. The composite element includes a ferroelectric layer made of a doped hafnium oxide-based material that has a predominantly orthorhombic phase and exhibits a negative capacitance; and an antiferroelectric layer made of a zirconium oxide-based material that has a predominantly tetragonal phase.