Abstract: Systems and methods of fabricating and functionality patterned nanowire probes that are stable under fluid reservoir conditions and have imageable contrast are provided. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.
Type:
Application
Filed:
May 5, 2015
Publication date:
February 23, 2017
Applicant:
The Regents of the University of California
Inventors:
Paul S. Weiss, Anne M. Andrews, Andrea L. Bertozzi, Stanley J. Osher
Abstract: Provided is a combustion experiment device, which includes a reaction tube into which a sample fluid flows and to which a temperature gradient in which a temperature rises toward a downstream side is imparted, and a burner part that is configured to flow a combustible gas along and around the reaction tube from the downstream side to an upstream side of the reaction tube and to maintain a flame surrounding the reaction tube from the outside in a radial direction of the reaction tube.
Abstract: According to the present invention, ultrasonic image quality can be improved by removing side lobe signals using a nonlinear filter that subtracts the side lobe signals calculated from a summed signal resulting from the received channel signals obtained by focusing signals received via an array transducer having a plurality of receiving elements and uses the calculated magnitude of the side lobe signals as a filter coefficient.
Type:
Application
Filed:
April 19, 2016
Publication date:
February 23, 2017
Applicants:
WAYGENCE CO., LTD, Daejin University Center for Educational Industrial Cooperation
Abstract: A method for welding together glass workpieces where one of the workpieces has metal nanoparticles positioned at or near the surface to be welded. The method comprises positioning the workpieces in operative contact at an interface where a weld is to be formed, applying a laser beam to be incident upon the interface wherein energy from the laser beam is absorbed by the nanoparticle bearing workpiece and the energy from the laser beam is transferred to the glass surrounding the metal nanoparticles to heat the glass and to weld the workpieces together.
Abstract: We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybridoma and fused to toxin, carrying a C-terminal peptide which increases retention within cells. The binding affinity and specificity of the recombinant bispecific immunotoxin for the EGFRwt and the EGFRvIII proteins was measured. In vitro cytotoxicity was measured. In vivo activity of the recombinant bispecific immunotoxin was evaluated in subcutaneous models and compared to that of an established monospecific immunotoxin. In our preclinical studies, the bispecific recombinant immunotoxin, exhibited significant potential for treating brain tumors.
Type:
Application
Filed:
October 11, 2016
Publication date:
February 23, 2017
Applicants:
Duke University, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES , N
Inventors:
Darell D. Bigner, Chien-Tsun Kuan, Ira H. Pastan, Charles Pegram
Abstract: Systems and techniques are described to enable the dynamic selection of a transit route through the stop zones of a transit line. Techniques are disclosed for receiving a current location of a transit vehicle on a transit line and determining a transit route through one or more of the vehicle's remaining stop zones by choosing an optimized combination of stop options and route segment options for that specific transit vehicle. Techniques may be performed in some cases by accessing a real-time traffic information service to obtain one or more traffic condition factors on a route segment, determining a dynamic route segment option weight, calculating a dynamic cost function with respect to the weights, and determining an optimized set of the route segments with respect to the cost functions.
Type:
Application
Filed:
August 18, 2015
Publication date:
February 23, 2017
Applicant:
The Florida International University Board of Trustees
Inventors:
Oliver ULLRICH, Naphtali RISHE, Daniel LUCKERATH
Abstract: An enzymatic method is provided for restructuring an affinity ligand bound heterogenous glycoform antibody sample to a substantially homogenous single desired glycoform antibody sample for therapeutic uses and kits for performing the methods. A method for enzymatically altering the Fc region of an affinity ligand bound antibody from a heterogenous glycoform to a substantially homogenous single glycoform comprises: contacting the affinity ligand bound heterogeneous glycoform antibody with a reaction buffer designed for a particular glycoform modification for a time sufficient and under conditions to modify the glycoform of the Fc region to a substantially homogeneous single form; optionally adding one or more nucleotide sugars and/or cofactors; and releasing the substantially homogeneous single glycoform antibody sample from said affinity ligand.
Abstract: A first capturing image unit mounted on a vehicle body captures an image of surroundings of a work vehicle. A second capturing image unit is disposed above the work implement and captures an image of an area in front of the work implement. A first image generation unit generates, from the image captured by the first capturing image unit, a surroundings composite image, which depicts the surroundings of the work vehicle in a bird's-eye view and is synthesized with a vehicle model depicting the work vehicle. A second image generation unit generates, from the image captured by the second image capturing unit, a work implement composite image, which depicts the area in front of the work implement and is synthesized with the vehicle model and the surroundings composite image. A display unit displays a display image including the vehicle model, the surroundings composite image, and the work implement composite image.
Abstract: A method for forming a polyimide-carbon nanotube composite film on a substrate is provided. The method comprises: suspending carbon nanotubes in a solution comprising a poly(amic acid) and a suitable solvent; casting the solution onto a substrate to form a layer on the substrate; and heating the layer to convert the poly(amic acid) into a polyimide to form the polyimide-carbon nanotube composite film. A polyimide-carbon nanotube composite film and an electronic device comprising the polyimide-carbon nanotube composite film are also provided.
Abstract: Disclosed are compositions containing a formula of LixTiyV1Bz wherein x, y, and z are real numbers greater than zero. In certain embodiments, x is not greater than 7, and y is not greater than 6, or a combination thereof. The composition may be a microporous aerogel, a mesoporous aerogel, a crystalline structure, or a combination thereof. In certain embodiments, the composition may be an aerogel, and a surface of the aerogel comprises microcrystals, nanocrystals or a combination thereof. The compositions have very low densities. Also disclosed are methods to produce the composition and use of the composition in energy storage devices.
Abstract: Nanoscale thermocouples are made of a single material and are shape-engineered to contain one or more variations in their width along their length. The mono-metallic nanowire junctions resulting from the width variation(s) exploit a difference in the Seebeck coefficient that is present at these size scales. Such devices have a wide variety of uses and can be coupled with an antenna in order to serve as an infrared detector.
Type:
Grant
Filed:
May 16, 2014
Date of Patent:
February 21, 2017
Assignee:
University of Notre Dame du Lac
Inventors:
Wolfgang Porod, Gary H. Bernstein, Alexei Orlov, Gergo P. Szakmany
Abstract: A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device transmits the test results to a remote server implementing analysis of the visual function results using network service. The network service receives the test results, processes the results, and provides the processed results to a healthcare provider. The processed results may include trends of the user's visual function test performance. The healthcare provider, such as a physician, may optimize and administer treatment based on the data. Early detection of changes in visual function can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.
Type:
Grant
Filed:
April 4, 2016
Date of Patent:
February 21, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method may be used to monitor a power system in real-time by perturbing the source side of an electronic-based component of the power system by injecting a current of about 0.5 to 1 percent of a nominal current of the power system at the source side and perturbing the load side of the power electronic-based component by injecting a voltage of about 0.5 to about 1 percent of a nominal voltage of the power system at the load side and varying the voltage at the load side. Time-domain results of the perturbations may be transferred to frequency-domain results and the stability of the power system may be monitored by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.
Type:
Grant
Filed:
April 18, 2016
Date of Patent:
February 21, 2017
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Mohamadamin Salmani, Chris S. Edrington
Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
Type:
Grant
Filed:
November 15, 2013
Date of Patent:
February 21, 2017
Assignee:
University Health Network
Inventors:
Yong Liu, Heinz W. Pauls, Radoslaw Laufer, Sze-Wan Li, Peter Brent Sampson, Miklos Feher, Grace Ng, Narendra Kumar B. Patel, Yunhui Lang
Abstract: Devices and processes for performing magnetic resonance imaging of the anatomy of a patient during radiation therapy to measure and control the radiation dose delivered to the patient.
Type:
Grant
Filed:
July 23, 2015
Date of Patent:
February 21, 2017
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Disclosed is an AGR2 blocking monoclonal antibody, and in particular, a humanized monoclonal antibody for blocking AGR2. Also disclosed is a pharmaceutical composition containing the antibody and a method for preparing the same, and a use of the antibody in blocking tumor growth and metastasis.
Abstract: High-resolution three-dimensional imaging of a specimen is facilitated. According to an example embodiment of the present invention, a series of very thin slices from a specimen are serially and robustly arranged on an imaging device such as a microscope slide. The slices are imaged and the images are used to reconstruct a three-dimensional image having high resolution at depths into the specimen. The serial arrangement of the slices facilitates the proper ordering of images for reconstruction. Further, the robust nature of the slice arrangement facilitates treatment of the slices and, in some applications, multiple treatments with corresponding imaging sequences for each treatment. Various embodiments are directed to methods and arrangements for three-dimensional characterization of biological specimen and to data that is accessible and/or executable by a computer for linking different images together in order to characterize such biological specimen in three dimensions.
Type:
Grant
Filed:
April 13, 2015
Date of Patent:
February 21, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A detection system includes a first sensor coupled to a pipe associated with a pump and generates temperature data associated with a temperature of the pipe. The system includes a second sensor positioned within an acoustic sensing distance from the pump and that generates sound data associated with a sound of the pump. The system includes a processing device configured to execute data instructions to store a baseline temperature signature and a baseline acoustic signature, and receive the temperature data from the first sensor and the sound data from the second sensor. The processing device is configured to, based on (1) a determination that flow through the pipe is reduced by comparing temperature data to the baseline temperature signature, and (2) a determination that the pump remains operational based on comparing the acoustic data to the baseline acoustic signature, generate an indication that the pipe is blocked.
Type:
Grant
Filed:
June 20, 2014
Date of Patent:
February 21, 2017
Assignees:
University of Southern California, Chevron U.S.A. Inc.
Inventors:
Chengjie Zhang, John Heidemann, Gregory William Laframboise
Abstract: Embodiments of the invention include methods and materials for preparing organic semiconducting layers, for example one used in an organic semiconductor device including a substrate with a nanostructured surface and a polymeric semiconductor film overlying the nanostructured surface. Aspects of the invention use capillary action to modulate polymer chain self-assembly on a surface and unidirectional alignment at a critical buried interface where charge carriers migrate between a dielectric and the polymer. By controlling the properties of the surfaces upon which polymers are disposed, artisans can enhance the transistor saturated mobilities of conjugated polymers.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
February 21, 2017
Assignee:
The Regents of the University of California