Patents Assigned to University
  • Methods for treating muscle specific receptor kinase (MuSK) myasthenia gravis with the Ig1 domain of MuSK
    Patent number: 9574015
    Abstract: Agents, compositions, and medicaments that reduce interactions between muscle specific kinase receptor (MuSK) and pathogenic immunoglobulin G4 (IgG4) antibodies specific for the first Ig-like domain of MuSK and methods and uses thereof to reduce such interactions are encompassed herein. Also encompassed are screening assays to identify inhibitors of these pathogenic antibodies, particularly those that reduce binding to MuSK. Agents identified using the screening assays described herein are envisioned for use as therapeutics, alone or in compositions or in medicaments, to improve motor function in subjects afflicted MuSK-MG.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: February 21, 2017
    Assignees: New York University, Leiden University Medical Center
    Inventors: Steven J. Burden, Wei Zhang, Maartje Huijbers, Johannes J. Verschuuren, Silvère M. van der Maarel
  • Context based algorithmic framework for identifying and classifying embedded images of follicle units
    Patent number: 9576359
    Abstract: The subject invention provides a method for detecting and analyzing the hair follicles on a scalp to assist with hair follicle transplantation. The methods of the subject invention are able to count the number of hair follicle groups and the number of follicles within each group based upon a microscopic image of a sample from a human scalp. An algorithm is then used to cluster the follicles and generate a neighboring connected graph to calculate the inter object distances. A report can then be generated that provides information regarding the density, placement, and percentage of hair follicle type in different areas of the scalp. This report can be used to generate a hair follicle transplant strategy to assist a physician or robotic system.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: February 21, 2017
    Assignees: The Florida International University Board of Trustees, NRG Medical, LLC
    Inventors: Md Mahbubur Rahman, S. S. Iyengar, Wei Zeng, Frank Hernandez, Bernard Nusbaum, Paul Rose
  • Systems and methods for a content-adaptive photo-enhancement recommender
    Patent number: 9576343
    Abstract: Systems and methods for a content-adaptive photo-enhancement recommender that produces multiple enhanced images based on content and color layout parameters derived from related high-quality images are disclosed. In some embodiments, a user-uploaded image is enhanced based on parameters learned from high-quality images similar in content to the user-uploaded image and obtained using content-based image retrieval techniques.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: February 21, 2017
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Baoxin Li, Parag Shridhar Chandakkar, Qiongjie Tian
  • Polyisobutylene-based polyurethanes
    Patent number: 9574043
    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: February 21, 2017
    Assignee: University of Massachusetts Lowell
    Inventors: Rudolf Faust, Umaprasana Ojha
  • Method of inducing a T lymphocyte response using T-cell immunogens derived from anti-viral proteins
    Patent number: 9572873
    Abstract: Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: February 21, 2017
    Assignee: The Regents of the University of California
    Inventors: Douglas F. Nixon, Stephane Champiat, Keith Garrison
  • Method for decellularization of tissue grafts
    Patent number: 9572911
    Abstract: The subject invention pertains to materials and methods for processing tissue to produce a natural, acellular replacement tissue that is immunocompatible with a recipient. According to the subject invention, harvested tissue is subjected to wash solutions wherein only amphoteric detergent(s) are used (e.g., anionic detergents are excluded). Following extraction by amphoteric detergent(s), the tissue is washed with a buffer system to facilitate the clearance of cellular components and detergent. In one embodiment, the subject invention pertains to a replacement tissue that is a nerve graft that supports axonal regeneration, guides axons toward the distal nerve end and/or is immunologically tolerated. Preferably, the nerve graft retains essential extracellular matrix scaffolding as well as biological components that promote nerve regeneration through the nerve graft.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 21, 2017
    Assignee: University of Florida Research Foundation, Incorporated
    Inventor: David F. Muir
  • Benzo lipoxin analogues
    Patent number: 9573880
    Abstract: Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: February 21, 2017
    Assignee: University of Southern California
    Inventor: Nicos A. Petasis
  • Inputting fingertip sleeve
    Patent number: 9575598
    Abstract: An apparatus is disclosed. The apparatus includes a sleeve and an inputting end. The sleeve is configured to receive a finger. The inputting end is fixed on the sleeve. The inputting end includes a supporter and a conductive layer. The conductive layer is located on a surface of the supporter. The conductive layer includes at least one graphene layer.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 21, 2017
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Kai-Li Jiang, Shou-Shan Fan
  • Radiotherapy system adapted to monitor a target location in real time
    Patent number: 9572545
    Abstract: The present invention provides a radiotherapy system that can monitor a target location in real time. The radiotherapy system includes a remote control system operable to actuate a real-time image capturing device to acquire images in real time for monitoring the target location. The system also includes an image registration system that can register the acquired image with an image previously captured for the treatment plan, whereby it can be determined whether the patient's tumor is in the beam's eye view of the treatment plan. By confirming that the tumor is in the range of the beam's eye view, the accuracy of the treatment can be improved, and the irradiated area can be reduced, which makes the radiation treatment safer.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: February 21, 2017
    Assignees: Mackay Memorial Hospital, National Taipei University of Technology
    Inventors: Yu-Jen Chen, Chia-Yuan Liu, Wen-Chung Chang, Chin-Sheng Chen
  • Therapeutic compounds
    Patent number: 9573906
    Abstract: The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: February 21, 2017
    Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on behalf of Arizona State University
    Inventors: Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall
  • CTP-based insulin analogs for treatment of diabetes
    Patent number: 9573987
    Abstract: Insulin analogs comprising a non-native glycosylation site sequence are provided having high potency and specificity for the insulin receptor. In one embodiment a peptide sequence of greater than 18 amino acids is used as a linking moiety to link human insulin A and B chains, or analogs or derivatives thereof, to provide high potency single chain insulin analogs. In one embodiment the linking moiety comprises one or more glycosylation sites. Also disclosed are prodrug and conjugate derivatives of the insulin analogs.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: February 21, 2017
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Richard D. Dimarchi, Pengyun Li
  • Retro-aldol reaction products and methods of making and using same
    Patent number: 9573876
    Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to retro-aldol reaction products and methods of making and using same. More particularly, but without limitation, the methods disclosed herein for producing the retro-aldol reaction products are performed in a non-aqueous/solvent-free based process. The reaction products obtained from the process include, for example, dihydroxyacetone, glyceraldehyde, glycolaldehyde, and combinations thereof. In one particular embodiment, the process of making such retro-aldol reaction products includes, without limitation, the step of mechanocatalytically reacting a heterogeneous catalyst with one or more sugar reactants.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: February 21, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Richard Blair
  • Compounds and methods for inhibiting fascin
    Patent number: 9573946
    Abstract: Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in need thereof.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: February 21, 2017
    Assignees: Novita Pharmaceuticals, Inc., Cornell University
    Inventors: Xin-Yun Huang, Christy Young Shue
  • N-heterocyclic carbene gold complexes with anticancer properties and methods of use thereof
    Patent number: 9573967
    Abstract: Monomeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one N-heterocyclic carbene ligand and one monodentate dithiocarbamate-based ligand. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: February 21, 2017
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Muhammad Altaf, Anvarhusein Abdulkadir Isab
  • Making nanocrystalline mesoporous spherical particles
    Patent number: 9573194
    Abstract: Spherical particles of one or more elemental metals and elemental carbon are prepared from a precursor in the form of a metal oleate. The metal oleate precursor is dispersed in a liquid vehicle and aerosol droplets of the dispersed precursor are formed in a stream of an inert gas. The aerosol droplets are heated in the stream to decompose the oleate ligand portion of the precursor and form spherical particles that have a mesoporous nanocrystalline structure. The open mesopores of the spherical particles provide a high surface area for contact with fluids in many applications. For example, the mesopores can be infiltrated with a hydrogen absorbing material, such as magnesium hydride, in order to increase the hydrogen storage capacity of the particles.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: February 21, 2017
    Assignees: GM Global Technology Operations LLC, The Regents of the University of California
    Inventors: Qiangfeng Xiao, Mei Cai, Hiesang Sohn, Yunfeng Lu
  • Epsilon toxin epitopes from with reduced toxicity
    Patent number: 9573981
    Abstract: There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: February 21, 2017
    Assignee: University of Exeter
    Inventors: Richard W. Titball, Monika Bokori-Brown, Claire Naylor
  • Method and apparatus for generating acceleration structure in ray tracing system
    Patent number: 9576389
    Abstract: Provided are an apparatus and method for generating an acceleration structure in a ray tracing system. The method of generating an acceleration structure includes splitting, at an acceleration structure generator, a space comprising a three-dimensional (3D) object into a plurality of sub spaces, calculating costs for traversing the plurality of sub spaces based on occlusion information of primitives in the plurality of sub spaces, selecting the plurality of sub spaces that minimize the costs for traversing, and generating an acceleration structure based on setting the selected plurality of sub spaces as nodes.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: February 21, 2017
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Jaedon Lee, Jinwoo Kim, Youngsam Shin, Minwoo Lee, Wonjong Lee, Tackdon Han
  • Systems, transceivers, receivers, and methods including cancellation circuits having multiport transformers
    Patent number: 9577683
    Abstract: Example apparatuses and methods for cancellation of transmitter self-interference leakage in a transceiver are described. An example transceiver includes a multiport transformer that may be used as a part of the impedance matching network on the receiver side of the transceiver. One primary port of the multiport transformer may form a portion of a cancellation circuit that, along with other components in a cancellation path, provide amplitude and/or phase modulation to a cancellation signal. The cancellation circuit may tunable and may include only reactive components in some examples.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: February 21, 2017
    Assignee: University of Washington Through Its Center For Commercialization
    Inventors: Jacques Christophe Rudell, Tong Zhang, Apsara Ravish Suvarna
  • Vapor-condensation-assisted optical microscopy system
    Patent number: 9575299
    Abstract: A vapor-condensation-assisted optical microscopy system comprises a vapor-condensation-assisted device and an optical microscope. The vapor-condensation-assisted device comprises air blowing device, a vapor producing device and a guide pipe. The vapor producing device connects the air blowing device with the guide pipe. The optical microscope comprises an observing device, an image processing device, a support frame and a stage. The stage, the guide pipe of the vapor-condensation-assisted device, the observing device, and the image processing device are fixed on the support frame. The vapor-condensation-assisted device is configured to provide a vapor to sample on the stage in application.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 21, 2017
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Jiang-Tao Wang, Tian-Yi Li, Qing-Yu Zhao, Kai-Li Jiang, Shou-Shan Fan
  • Light modulator and exposure head
    Patent number: 9575389
    Abstract: A first electro-optic crystal substrate and a second electro-optic crystal substrate are provided as an electro-optic crystal substrate. The first electro-optic crystal substrate comprises a first periodic polarization reversal structure in which first polarization pairs, in each of which the directions of polarization in response to electric fields are opposite to each other, are arranged in a first period along a first arrangement direction which is orthogonal or inclined with respect to the direction of propagation, and light passes through the first periodic polarization reversal structure.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 21, 2017
    Assignees: Screen Holdings Co., Ltd., Osaka University
    Inventors: Masahide Okazaki, Toshiaki Suhara