Abstract: An electroactive bio-carrier module and a sewage treatment device using same are provided, which relate to the field of bioelectrochemistry and sewage treatment. The electroactive bio-carrier module is composed of an anode module and a cathode module made of a conductive material. The anode module is formed by connecting carbon fiber brushes in series and is of a vertically ring type structure; the cathode module is formed by connecting stainless steel meshes in series; the stainless steel meshes are in a folded horizontal stacked design; the anode and cathode modules are connected through an external lead wire to form a circuit. Surfaces of the anode and cathode modules can both enrich microorganisms, biofilms are formed on the surfaces. The electrode module is arranged in an up-flow type sewage treatment device and is used as an electroactive bio-carrier, to form a hybrid sewage treatment device with a built-in electroactive bio-carrier.

Abstract: The present invention relates to a spectrally selective emitter and a design method thereof. The designed emitter has a one-dimensional layered structure, including a first layer, a second layer and a third layer arranged in sequence, wherein both the first and third layers are hafnium oxide layers, and the second layer is a hafnium oxide layer with multiple erbium oxide nanoparticles distributed. The designed emitter is a material-type emitter with spectrally selective emittance. Compared with the traditional structure-type emitter, the material-type emitter has high thermal stability and oxidation resistance, which can fundamentally solve the high-temperature degradation problem.

Abstract: The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.

Abstract: A method for manufacturing a nitride semiconductor device includes formation of a gate insulation film above a nitride semiconductor layer. The formation of the gate insulation film includes formation of silicon oxynitride film in contact with a surface of the nitride semiconductor layer. The formation of the silicon oxynitride film includes oxidation of a film source material having both of silicon and nitride in a molecule to form the silicon oxynitride film.

Abstract: A method and system for quantifying semantic variance between neural network representations is provided. Two neural network representations to be compared are first extracted, the weight of each filter in an intermediate layer corresponding to each semantic concept is learned on a reference dataset using the Net2Vec method, then set IoU of each representation for all semantic concepts in the reference dataset are calculated, and finally variance between the set IoU of the two representations for all the semantic concepts are integrated to obtain semantic variance between the two neural network representations. The method solves the problem of lack of accurate measurement on the variance between neural network representations on a semantic information level, and has an accurate measurement effect.

Abstract: A holographic 3D display system based on virtual array splicing of a spatial light modulator includes a laser configured to generate a coherent light beam, first, second and third beam splitters, first and second reflectors, a shutter array, a spatial filter array, a solid lens, first and second light beam deflection elements and a spatial light modulator. The first and second beam splitters and the first reflector are configured to split the light beam generated by the laser into three parallel light beams to irradiate the shutter array. The shutter array is configured to control the three parallel light beams to sequentially pass therethrough according to a set time sequence. The three parallel light beams passing through the shutter array are expanded and collimated by the spatial filter array and the solid lens to form three parallel light beams with the same size and uniform intensity.

Abstract: This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.

Abstract: Pore-forming peptides or proteins modified utilizing DNA nanotechnology, which provides definition and control of pore size, an increase in stability when inserted in a lipid membrane, and membrane affinity. Chemical modifications are easily made on the compound through hybridization to the oligonucleotide attached to the peptide or protein. The compound can hybridize to a DNA template thereby defining the number of monomers assembled to a pore and thus the size of the formed pore. The DNA template can range from a unique single strand composed of multiple hybridization sites separated by flexible linkers to a complex rigid DNA nanoconstruct, such as a DNA origami-based ring, serving as a scaffold for pore formation. Hydrophilic modification at the transmembrane segment or terminus of the peptide provides long-lived pores and keeps the compound in a membrane-spanning conformation.

Abstract: A method of making boron oxide nanoparticles. The method can comprise sonochemically treating a composition comprising a boron oxide to form boron oxide nanoparticles. The method allows for the formation of these nanoparticles from non-toxic, inexpensive reagents and ambient reaction conditions. Additionally, the nanoparticles produced by the teachings described herein can be easily surface functionalized.

Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.

Abstract: An instrument for analyzing ions may include an ion source to generate ions, at least one ion processing instrument to process the generated ions by one or both of filtering the ions according to a molecular characteristic and dissociating the ions, and an electrostatic linear ion trap (ELIT) to receive and trap ions exiting the at least one ion processing instrument. The ELIT has first and second ion mirrors separated by a charge detection cylinder, and is configured such that trapped ions oscillate back and forth through the charge detection cylinder between the first and second ion mirrors with a duty cycle, corresponding to a ratio of time spent by the trapped ions traversing the charge detection cylinder and total time spent by the trapped ions traversing a combination of the first and second ion mirrors and the charge detection cylinder during one complete oscillation cycle, of approximately 50%.

Abstract: The disclosure discloses Bifidobacterium longum with the ability to relieve atopic dermatitis and its application, and belongs to the technical fields of microorganisms and medicine. The Bifidobacterium longum of the disclosure has the effects of relieving atopic dermatitis, and the effects are specifically embodied in: (1) significantly improving the degree of ear swelling in mice with atopic dermatitis; (2) significantly improving skin pathological symptoms and inflammatory cell infiltration in mice with atopic dermatitis; (3) significantly reducing the serum IgE level in mice with atopic dermatitis; (4) significantly reducing the levels of IL-4 and IL-13 in the skin tissues of mice with atopic dermatitis; and (5) significantly reducing the level of histamine in the skin tissues of mice with atopic dermatitis. Therefore, the Bifidobacterium longum has great application prospects in the preparation of products for the prevention and/or treatment of atopic dermatitis.

Abstract: Self-healing, hydrophobic composites and related methods are provided. A method of repelling water may comprise forming a layer of a self-healing, hydrophobic composite comprising a porous network of entangled polymer fibers and a hydrophobic phase change material infused throughout the network, on a surface of a substrate to form a treated surface; and exposing the treated surface to water, wherein the treated surface exhibits a native water droplet contact angle which is greater than that of an untreated surface without the layer of the composite.

Abstract: A wearable haptic modulation device for real-time simulation of texture properties of a material surface in mixed reality environments is provided. Particularly, it includes a U-shaped pneumatic actuator surrounds a user's fingertip, a finger-housing support creating a space for fingertip containment, a resonant actuator on the finger-housing support generating vibrotactile feedback to enhance perceived roughness on touched physical surfaces, and a pneumatic control system generating pneumatic actuation to reduce the perceived roughness on touched physical surface. Notably, the U-shaped pneumatic actuator allows direct contact of the user's fingerpad with the touched physical surface.

Abstract: The present disclosure provides a stretchable and flexible sweat-activated graphene-coated Ni foam-based Mg—O2 battery capable of powering an intelligent and flexible electronics for health monitoring purposes with different biosensors.

Abstract: Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model. When administered to mice having knocked out endogenous CPS1 expression, mice from this model demonstrate homologous recombination and reconstitution of the codon optimized CPS1 gene, expression of the CPS1 protein and the associated control of plasma ammonia following the administered AAVs comprising the CPS1 gene sequences. While all control mice perish, the mice in this model live and have normal behavior. As there is no effective therapy for human patients with the CPS1 disorder, this invention can address this unmet need for these patients.

Abstract: The present invention discloses a cooling type dry powder fire extinguishing agent and a preparation method and application thereof, which belongs to the technical field of fire control. Through a static mixing technology, an aqueous solution and a solid hydrophobic material are dispersed and mixed efficiently to form a cooling type dry powder fire extinguishing agent. The fire extinguishing agent is a micron solid particle of the aqueous solution wrapped by the hydrophobic material microscopically, and is in a dry powder state macroscopically, which can significantly reduce the electrical conductivity of the fire extinguishing agent. Meanwhile, a field rapid preparation method is adopted, which can realize real-time preparation. The preparation method is simple and efficient. The technology can be used for fighting a battery fire, has significant cooling and anti-reignition effects and can avoid the problem of electrical conduction of a traditional water-based fire extinguishing agent.

Abstract: Provided herein are methods and systems for targeted gene disruption (knock-out, missense mutation) and targeted gene knock-in in mammalian cells using base editors and guide RNAs (gRNAs) designed to target splice acceptor-splice donor sites. Also provided herein are universally acceptable genetically engineered cells comprising targeted disruptions in immunotherapy-related genes and comprising a CAR/TCR for therapeutic applications.

Abstract: The present invention discloses a photon enhancement apparatus comprising a reflective component and 4f coherent imaging system, which increases a photon collection efficiency. The present invention also provides a microscope comprising said photon enhancement apparatus and methods of improving photon collection efficiency, signal-to-noise ratio, and/or optical resolution using the said photon enhancement apparatus.

Abstract: A method for foundation consolidation combining vacuum preloading and geomembrane bag assembly loading, which comprises: digging a slurry pit, filling mud into the slurry pit and conducting vacuum preloading pumpdrainage for multiple times, laying the geomembrane bag assemblies above the soft slurry seam processed through vacuum preloading pumpdrainage inside the slurry pit to form a plurality of loading layers, and laying the geomembrane bag assemblies by piling geomembrane bags. In view of the engineering complexity and uneven settlement resulting from conventional vacuum preloading using slag loading, geomembrane bag for loading to overcome the adverse effects of slag loading. In the present invention, the drainage system and the geomembrane bag assemblies are laid out to fully leverage their perspective properties, so as to improve the transmission of vacuity in the whole soil mass, speed up the drainage rate, and increase the degree of consolidation.