Abstract: An automatic pressure regulating valve for an electro-pneumatic braking system of a commercial vehicle comprises an upper valve body and a lower valve body. The upper valve body includes a normally open switching valve, a quick-acting intake valve, a normally open quick-acting intake valve, a quick-acting exhaust valve, and a control chamber A. A lower valve body includes a relay valve and a working chamber B. The normally open switching valve has a manually controlled air inlet a and an electronically controlled air inlet b, and an air outlet c connected to an air inlet d of the normally open quick-acting intake valve. An air outlet e of the normally open quick-acting intake valve, an air inlet f of the quick-acting exhaust valve and an air outlet i of the quick-acting air intake valve are connected together to the control chamber A.

Abstract: The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient.

Abstract: The present application belongs to the technical field of proteolysis-targeting chimeras (PROTACs), and discloses a PROTAC molecule and a preparation method and use thereof. A ligand for a target protein in the PROTAC molecule of the present application is a pyridine carboxylic acid-1-oxide derivative. In cell and zebrafish experiments, the PROTAC molecule exhibits no toxic and side effects at a drug concentration allowing a desired effect. At a cellular level, an inhibition level of the PROTAC molecule for human tyrosinase (TYR) reaches less than or equal to 1 ?mol/L. The PROTAC molecule in the present application can significantly reduce the generation of melanin by degrading TYR, and has excellent solubility, safety, and efficacy and a low effective concentration.

Abstract: Systems and methods for spatial graph convolutions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting characteristics for molecules, wherein the method includes performing a first set of graph convolutions with a spatial graph representation of a set of molecules, wherein the first set of graph convolutions are based on bonds between the set of molecules, performing a second set of graph convolutions with the spatial graph representation, wherein the second set of graph convolutions are based on at least a distance between each atom and other atoms of the set of molecules, performing a graph gather with the spatial graph representation to produce a feature vector, and predicting a set of one or more characteristics for the set of molecules based on the feature vector.

Abstract: Described herein are novel ?- and ?-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

Abstract: The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a ?-(1,4)-glucoside bond or/and a lactose with a ?-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that ?-(1,4)-glucoside bond provided by cellobiose or/and ?-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (?-glucosidase or/and ?-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.

Abstract: A method, a system, and a computer program product for localization of wireless devices. At least one of mapping and wireless data describing a physical environment is received. The physical environment includes one or more wireless access points. Using the received mapping and/or wireless data, a location of each of the wireless access points is determined. Using the determined location of the wireless access points, one or more wireless devices positioned in the physical environment are located.

Abstract: The gas measurement device includes a gas sensor disposed in a gas chamber, a filter configured to control passing gas molecules to the gas chamber, and a driving unit configured to move at least a part of a member defining the gas chamber.

Abstract: Octaaminonaphthalene and a method of synthesizing octaaminonaphthalene are described. A two-dimensional coordination polymer and a method of synthesizing the two-dimensional coordination polymer are described. The two-dimensional coordination polymer includes ligands including anchorage sites, and metal linkers, each metal linker including a metal and an organic moiety. Each metal linker is coupled to two ligands via the anchorage sites. Synthesizing the two-dimensional coordination polymer includes contacting a first liquid precursor with a second liquid precursor at an interface, reacting the metal linker and the water-soluble ligand to yield a two-dimensional coordination polymer at the interface, and removing the two-dimensional coordination polymer from the interface.

Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

Abstract: An apparatus for treating clubfoot is provided that includes a pair of vertically stacked and parallel cross bars that are connected to shoe attachment member via four hinges to define a parallelogram shaped gap therebetween. As the user raises a knee, one shoe attachment member can be displaced via the hinges (primarily in the y-axis or anterior/superior plane) relative to the other shoe attachment member, while the distance between the crossbars remains constant.

Abstract: The present invention provides D39-derived mutant PspA that does not undergo deamination and maintains stability as a molecule even around neutral pH range. Specifically, the present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence as set forth in SEQ ID NO: 2 and having pneumococcal vaccine antigenic activity, and a protein substantially identical to the protein; or (b) a protein being a part of the amino acid sequence as set forth in SEQ ID NO: 2, wherein aspartic acid at position 254 is comprised in the part, and having pneumococcal vaccine antigenic activity, and a protein substantially identical to the protein.

Abstract: A method analyzes global average grayscale change of tundish ink tracing experiment. The method includes the following steps: building a water model based on a prototype size and production parameters of a tundish; carrying out experiments by using the water model to obtain a video file of the ink tracing; processing the video file and extracting a characteristic curve of a global average grayscale changing with the time; analyzing the characteristic curve, and extracting a global peak grayscale time, a global tracer residual volume and a global emptying time as indicators for evaluating a tundish structure and flow characteristics of the tundish structure.

Abstract: A magnetic resonance imaging (MRI) apparatus that includes a multi-resonance transmit/receive (T/R) switch, one switch design having a top side and a bottom side of a microstripline based hybrid coupler, a first pin diode, a second pin diode, four vertical transmission lines and six horizontal transmission lines arranged in a bended manner on the microstripline. The top side is associated with a first port and a second port, and electrically connected to the first pin diode and the second pin diode. The bottom side is associated with a third port and a fourth port, and electrically connected with the first pin diode and the second pin diode. The switch receives radio frequency (RF) pulses of different frequencies transmitted to and received from an MRI RF coil where the different frequencies are received concurrently and without tuning by the multi-resonance T/R switch from the MRI RF coil.

Abstract: Ultrasound-guided rete testis injection/aspiration devices and methods are described. Some methods include inserting a needle into the rete testis space of a patient and injecting a therapeutic medium through the needle into the rete testis space and seminiferous tubules of the testis. The therapeutic medium can help to treat infertility. In some examples, the method can include monitoring intra-testicular pressure of the patient. In some examples, the therapeutic medium can include stem cells. In some examples, the therapeutic medium can include gene therapy vectors. In some examples, the method can include flushing the rete testis space and seminiferous tubules with a saline solution through the needle. Exemplary devices can include a dual lumen needle, a collection tube, a dual function pump, and flexible tubing. The dual function pump can include a dual syringe pump and a vacuum pump.

Abstract: An electrocatalyst, a method of producing hydrogen gas by a hydrogen evolution reaction, and a method of producing oxygen gas by an oxygen evolution reaction. The electrocatalyst includes manganese oxide nanoparticles, and silver containing nanoparticles disposed on the manganese oxide nanoparticles, the silver-containing nanoparticles include a shell of silver tungstate disposed on a core of Ag. The electrocatalyst has an electrical resistivity of 0.50×107 ohm (?) to 6.0×107?, a charge transfer resistance of 325? to 450?, a Tafel slope of 55 mV/dec to 125 mV/dec, and an overpotential at 10 mA/cm2 of 0.05 mV to 200 mV.

Abstract: Methods and devices for analyzing and updating intermediate representations containing pointers includes compiling one or more source files into intermediate representations (IRs) having pointers, analyzing the IRs, producing transformed IRs comprising updated pointers, and producing object code from the transformed IRs. The device may include one or more non-transitory computer-readable storage devices having computer-executable instructions, when executed, cause a processing structure to perform the actions described relating to pointers. The analysis and updating of pointers may relate to types of bounds to enhance security of the systems in question by preventing erroneous references to memory space by pointers.

Abstract: Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.

Abstract: Techniques, systems and apparatus are described for magnetic resonance imaging. A method includes generating an MRI image by processing a first image obtained by applying a first order of modules including at least a first control module at a first time point and a first labeling module at a second time point to a target object, wherein the first control module inverts a magnetization of the target object and a second image obtained by applying a second order of modules including at least a second labeling module at a third time and a second control module at a fourth time to the target object, wherein the second labeling module inverts the magnetization of the target object.

Abstract: An end effector assembly for an optical surgical instrument includes a jaw member and a plurality of optical elements positioned within a cavity of the jaw member. The jaw member has a tissue contacting surface. The jaw member has a proximal portion that is configured to secure a fiber optic cable thereto such that a distal end of the fiber optical cable extends into the cavity. The plurality of optical elements are arranged in a staircase-like manner that rises towards the tissue contacting surface as the plurality of optical elements extends distally within the cavity. The plurality of optical elements is configured to direct a beam of light exiting the fiber optic cable towards the tissue contacting surface.