Patents Assigned to University
  • Activity modulator, medicinal agent comprising same, use of CD300A gene-deficient mouse, and anti-CD300A antibody
    Patent number: 10519233
    Abstract: The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: December 31, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Akira Shibuya, Chigusa Oda, Satoko Tahara, Tsukasa Nabekura, Udayanga Sanath Kankanam Gamage, Haruka Miki, Syuichi Iino
  • Variable thickness diaphragm for a wideband robust piezoelectric micromachined ultrasonic transducer (PMUT)
    Patent number: 10522737
    Abstract: A diaphragm for a piezoelectric micromachined ultrasonic transducer (PMUT) is presented having resonance frequency and bandwidth characteristics which are decoupled from one another into independent variables. Portions of at least the piezoelectric material layer and backside electrode layer are removed in a selected pattern to form structures, such as ribs, in the diaphragm which retains stiffness while reducing overall mass. The patterned structure can be formed by additive, or subtractive, fabrication processes.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: December 31, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bernhard Boser, David Horsley, Richard Przybyla, Ofer Rozen, Stefon Shelton
  • Materials and methods for detecting and monitoring edema and related conditions
    Patent number: 10517533
    Abstract: Provided is a Coupled Domain Sensor (CDS) that can be used to, for example, evaluate hydration and occlusion of blood in patients with edema using electrical and optical measurements. Advantageously, the CDS provides a quicker, more effective and accurate way of monitoring this medical condition.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: December 31, 2019
    Assignees: The Florida International University Board of Trustees, University of South Florida
    Inventors: Shekhar Bhansali, Karina Rincon, Jessica Ramella-Roman, Sanjukta Bhanja
  • Methods of generating beta-lactamase resistant carbapenem compounds
    Patent number: 10519161
    Abstract: The present invention includes compositions, methods of making and using novel carbapenem compounds including active agents, compounds, antibacterial agents, pharmaceutically acceptable salts of C1?-C1? di-substituted carbapenem compounds, C5? substituted carbapenem compounds, C6?-C6? di-substituted carbapenem compounds and combinations thereof.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: December 31, 2019
    Assignee: Southern Methodist University
    Inventor: John D. Buynak
  • Mast cell inhibition in diseases of the retina and vitreous
    Patent number: 10517839
    Abstract: This application discloses methods for treating or preventing an ophthalmic retinal vascular permeability, angiogenic or fibroproliferative disease, disorder or condition that involve administering to a patient in need thereof a composition that can inhibit mast cell migration into the vitreous or the retina, mast cell proliferation in the vitreous or the retina, or mast cell secretion into the vitreous or the retina.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: December 31, 2019
    Assignee: Cornell University
    Inventors: Randi B. Silver, Nathan O'Connor
  • Virus causing respiratory tract illness in susceptible mammals
    Patent number: 10519517
    Abstract: The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 31, 2019
    Assignees: VIRONOVATIVE BV, ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: Jan Cornelius De Jong, Ronaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Jan Groen
  • Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
    Patent number: 10519470
    Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: December 31, 2019
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too
  • Stream sampler—mass reduction system for flowing powders
    Patent number: 10520400
    Abstract: A device for obtaining samples from a flowing powder stream and performing their immediate analysis using a spectroscopic method is provided. Systematic sample size reduction is achieved to provide representative samples and their immediate (real-time) analysis. The powder blends may come from pharmaceutical, vitamin and nutraceutical products, which must fulfill blend homogeneity requirements. All parts of the batch will have the same probability of being selected as a sample. Samples are obtained without disturbing or changing the composition of the powder blend during the sampling process. Unlike the sample thief commonly used in the pharmaceutical industry, the device of the invention does not disturb the powder blend and does not change the properties of the powder blend during the sampling.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 31, 2019
    Assignee: University of Puerto Rico
    Inventors: Rodolfo J. Romanach, Rafael Mendez
  • Conotoxin peptides for use in biofouling deterrence
    Patent number: 10519324
    Abstract: Materials and methods for prevention of biofouling are described that incorporate the presence of a conotoxin peptide on a surface. The conotoxin peptide is either directly or indirectly adhered to the surface and interferes with the ability of biofouling organisms to settle on the surface.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: December 31, 2019
    Assignee: Clemson University Research Foundation
    Inventors: Andrew S. Mount, Bin San Chan, Mary Beth Johnstone
  • Disease severity index for assessment of chronic liver disease
    Patent number: 10520517
    Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: December 31, 2019
    Assignee: The Regents of the University of Colorado, a Body Corporate
    Inventors: Gregory Thomas Everson, Steve Mark Helmke
  • Treatment and prevention of thrombosis using an anti-miR
    Patent number: 10517888
    Abstract: Disclosed are anti-miR compositions and methods of use of the same for treatment of or reducing the occurrence of thrombosis and thrombosis related diseases and disorders by reducing platelet activation.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: December 31, 2019
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Steven E. McKenzie, Yuhang Zhou, Shaji Abraham
  • Compositions and methods for use of anion channel rhodopsins
    Patent number: 10519205
    Abstract: Methods and compositions used to identify and characterize a new class of rhodopsins derived from algae, which are highly sensitive and efficient anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 31, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • Microrna inhibitor system and methods of use thereof
    Patent number: 10519443
    Abstract: The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: December 31, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Brad A. Amendt, Huojun Cao
  • Atomic layer deposition method
    Patent number: 10522361
    Abstract: An atomic layer deposition method is provided. The atomic layer deposition method includes the following steps. A substrate is placed in a reaction chamber. At least one deposition cycle is performed to deposit a metal film on the substrate. The at least one deposition cycle includes the following steps. A metal precursor is introduced in the reaction chamber. A hydrogen plasma is introduced to be reacted with the metal precursor adsorbed on the substrate to form the metal film. An annealing process is performed on the metal film. The at least one deposition cycle is performed in a hydrogen atmosphere under UV light irradiation.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 31, 2019
    Assignee: National Tsing Hua University
    Inventors: Zheng-Yong Liang, Chao-Hui Yeh, Jui-Hsiung Liu, Po-Wen Chiu
  • Method and system to access inapparent conduction abnormalities to identify risk of ventricular tachycardia
    Patent number: 10517494
    Abstract: A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a velocity of the heart vector movement. A change in curvature of the identified heart vector movement is quantified and a risk of ventricular tachycardia is determined based at least on the measured velocity and the quantified change in curvature of the identified heart vector movement.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: December 31, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Johns Hopkins University, Oregon Health and Science University
    Inventors: Larisa G. Tereshchenko, Mark E. Josephson
  • Materials and methods using Fe3+ coordination to carboxylates
    Patent number: 10517997
    Abstract: Uronate-containing polysaccharide hydrogels that can be photo-patterned are described. The method involves forming a hydrogel and imetal-coordinating it with a reducible metallic cation and exposing the hydrogel to light in a desired pattern. The exposure to light reduces the metallic cation and results in an irreversible change in the elastic moduli and pore size of the irradiated portions of the patterned hydrogel. The method aha the benefit of allowing the user to produce such a hydrogel in any pattern desired. Patterned hydrogels and cell substrates formed by this method are also described.
    Type: Grant
    Filed: July 16, 2016
    Date of Patent: December 31, 2019
    Assignee: Bowling Green State University
    Inventors: Alexis Ostrowski, Giuseppe Giammanco
  • Method and device for encoding space-time signals
    Patent number: 10523972
    Abstract: A method for encoding space-time signals comprises: collecting space-time signals of various local spatial positions in a monitoring area, and accumulating the space-time signals according to time, so as to obtain cumulative signal intensity values; transforming the cumulative signal intensity values by means of a filter, and outputting a pulse signal when a transformation result exceeds a specific threshold; arranging pulse signals corresponding to a local spatial position into a sequence according to the time, so as to obtain a pulse sequence expressing the local spatial position signals and a change process thereof; and arranging the pulse sequences of all local spatial positions into a pulse sequence array according to interrelation among the spatial positions to serve as an encoding for dynamic space-time signals of the monitoring area.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 31, 2019
    Assignee: PEKING UNIVERSITY
    Inventor: Tiejun Huang
  • Sulfonamide compounds and their use as STAT5 inhibitors
    Patent number: 10519107
    Abstract: The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 31, 2019
    Assignee: The Governing Council of the University of Toronto
    Inventors: Patrick Thomas Gunning, Abbarna A. Cumaraswamy, Andrew Martin Lewis, Mulu Geletu-Heye
  • Static random access memory including assist circuit
    Patent number: 10522216
    Abstract: Disclosed is a static random access memory including an assist circuit. More particularly, a static random access memory according to an embodiment of the present disclosure may include a bit cell part including at least one bit cell connected between a first ground voltage node and a second ground voltage node; and a controller including a first transistor configured to control connection between the first ground voltage node and the second ground voltage node, a second transistor configured to float a first ground voltage of the first ground voltage node, and a third transistor configured to float a second ground voltage of the second ground voltage node, wherein the controller controls the first and second ground voltages supplied to the bit cell part using the first, second, and third transistors.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: December 31, 2019
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Seong Ook Jung, Se Hyuk Oh, Han Wool Jeong, Ju Hyun Park
  • Fabrication of probiotics nanowhiskers using cheese
    Patent number: 10517905
    Abstract: A method of fabricating probiotics nanowhiskers using cheese comprises cutting and grinding cheese to produce cheese powder; mixing the cheese powder with sulfuric acid to produce a solution; stirring the solution to produce a stirred solution; and filtering the stirred solution to produce the probiotics nanowhiskers. The fabricated probiotics nanowhiskers possess antioxidant, anti-inflammatory, antitumor, and antimicrobial properties. The probiotics nanowhiskers may reduce cadmium concentration in a patient's liver. The probiotics nanowhiskers may also ameliorate the oxidative stress assessed as a decrease in the serum MDA levels in a patient.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 31, 2019
    Assignee: King Saud University
    Inventors: Promy Virk, Manal Ahmed Gasmelseed Awad, Mai Abdelrahman Elobeid, Khalid Mustafa Osman Ortashi, Awatif Ahmed Hendi