Abstract: Identified are markers whose de novo synthesis or levels in blood provide are correlative information on the status of pathology, regardless of whether or not they correlate with the status in the relevant organ. The de novo synthesis or levels in blood can be used for patient stratification and monitoring the efficacy of treatment of diseases, such as fragile X syndrome.

Abstract: An implantable medical device (IMD) configured to communicate with an external device (ED). The ED supports two way RF communications and has a light source. The IMD includes a processor coupled to an optical detector, the processor is configured to verify that light is being received from the ED light source and that the ED is a trusted device, establishing a unidirectional optical channel from the ED to the IMD. An RF transceiver is coupled to the processor, the processor being configured permit two way RF communications with the ED only under a condition that the ED is verified as a trusted device. The processor may be configure to wake up periodically or aperiodically to check for the presence of light from the ED light source. The processor may be configured to detect a multi-bit message from the ED via the unidirectional optical channel. The multi-bit message may include a key.

Abstract: Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.

Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.

Abstract: Methods, systems, and computer readable media for image overlap detection. An example method includes identifying, by one or more computers, a collection of images; streaming, by the one or more computers, each image from the collection of images so that, in one or a limited number of passes through the collection of images, each image is loaded only once from an input source and each image is discarded after a processing time for the image is exceeded; and during the streaming, for each image in at least a first subset of the images in the collection, determining whether the image overlaps with at least one other image in the at least a first subset of the images.

Abstract: Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an aziridinated triglyceride having the structure described herein. In various embodiments, the present invention provides a method of making the aziridinated triglyceride, a method of crosslinking the aziridinated triglyceride to form a polymer, the polymer formed from the aziridinated triglyceride, a triglyceride with at least one pendent unsaturated group that can be used to form the aziridinated triglyceride, and a method of making the triglyceride having at least one pendent unsaturated group.

Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.

Abstract: Dispenser devices suitable for use on unmanned aerial vehicles are described having utility for dispensing solid larvicides to difficult to reach insect habitats.

Abstract: Provided are therapeutic methods for treating a patient with lymphedema, or prophylactically treating an individual susceptible to lymphedema, by inhibiting synthesis activity of leukotriene B4.

Abstract: A method includes generating style values and experiential language tags (ELTs) for a plurality of books based on retrieved book content and reader reviews, respectively. The method further includes generating an ELT prediction model based on the style values and the ELTs. The ELT prediction model is configured to receive a set of style values for a new book and output a set of predicted ELTs for the new book, the set of predicted ELTs indicating predicted reader experiences with the new book. The method further includes receiving user-submitted book content from a remote user device, determining style values for the user-submitted book content, and determining a list of predicted ELTs for the user-submitted book content using the style values for the user-submitted book content and the ELT prediction model. Additionally, the method includes transmitting, to the user device, the list of predicted ELTs for the user-submitted book content.

Abstract: The invention provides evolved red-shifted smURFPs. In some embodiments, the smURFPs are characterized by a) increased Fluorescence of smURFP as compared to infrared FPs IFP1.4 and iRFP713; b) expressing efficiently with minimal toxicity; c) does not require a lyase to covalently attach its chromophore, wherein the chromophore is biliverdin; d) exhibit a wavelengths longer than attainable with jellyfish- or coral-derived FPs using smURFP and IFP2.0; e) allows for functional fusion to hCdt1(30/120) as compared to jellyfish- or coral-derived FPs mAG, eGFP, and mRFP1 which are nonfunctional; and f) allows for deep tissue imaging.

Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.

Abstract: The invention discloses a silver-chromium alloy nanowire having a diameter of 18 to 60 nm, a length of 5 to 100 ?m, wherein a molar ratio of the silver to chromium is 1:0.01-3. The preparation method of the silver-chromium alloy nanowire comprises the steps of: a. preparing a reaction solution: formulating a silver source, a chromium source, polyvinylpyrrolidone and a reductive agent into a reaction solution, or adding the materials into deionized water to formulate a reaction solution; and b. performing a reductive reaction: performing a reductive reaction by maintaining the reaction vessel at a temperature of 120° C. to 200° C. for 2-10 hours to obtain a silver-chromium alloy nanowire suspension. The minimum diameter of the silver-chromium alloy nanowire of the present invention may reach 18 nm and its length is usually 20 ?m or above. Thus, it has a broad application prospect.

Abstract: Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of the present invention which include administering an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, ester, amide, isomer or derivative thereof characterized by anti-bacterial activity, to the subject.

Abstract: Provided is a 3D micro lithography-printing system using tilting and rotational UV-LEDs, in which a lithography module provided with LED lens for irradiating ultraviolet light for lithography is provided rotatable or revolvable in a left and right horizontal direction, and a substrate stage with a lithography object mounted thereto is provided movable forward and backward, changeable in forward and backward angles, and horizontally rotatable left and right, and thus, by changing the irradiation direction of ultraviolet light in a three-dimensional manner, a high-aspect ratio pillar and a 3D structure can be formed. In addition, various types of 3D structure can also be formed through a multi-layer lithography to a lithography object, and micro-forming within a range of approximately 5 ?m is also possible.

Abstract: A rotatable wrist connecting a gripper tool to the distal end of a positioning shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. A wrist capstan is rotatably connected to the wrist hub and non-rotatably connected to an actuatable device (e.g., a gripper). A flexible wire loop extends through the wrist hub and partially contacts the wrist capstan. Linear movement of the flexible wire loop through the shaft causes rotation of the wrist capstan due to friction between the flexible wire loop and the wrist capstan. The wrist also supports selective detachability and control of roll, pitch and roll, pitch yaw and roll according to different embodiments.

Abstract: The disclosure describes a tunneling field effect transistor having an overlapping structure between the source and drain regions providing a greater tunneling area. The source or drain region may be a doped region in a semi-conductive substrate. The other source or drain region may be formed by epitaxial deposition over the doped region. The gate is formed over the epitaxial region where the doped and epitaxial regions overlap. The doped region may be formed in a fin structure with the epitaxial region and gate being formed on the top and sides of the fin.

Abstract: Provided herein are methods and compositions for inhibiting epithelial to mesenchymal transition of a cell.

Abstract: A functionally graded carbide body (400) can include a group 5 metal carbide substrate having a bulk composition region (410) that contains at least 70 wt % of a rhombohedral ?-phase carbide. A ?-phase-rich region (420) having a ?-phase-rich composition can be at a surface (430) of the substrate, and a phase composition gradient region (440) can transition from the ?-phase-rich composition region at the surface to the bulk composition region at a gradient depth (450) below the surface.

Abstract: The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber. The various phases comprised within the fiber can vary in terms of in terms of hydrophobic/hydrophilic character, solid/fluid, or gel crosslink density, which allows for the introduction of heterogeneous microenvironments within the fiber, each of which with distinct solubility characteristics, permeability, and mechanical properties. Various compounds and materials can be encapsulated in the different microcompartments of the fiber for storage and delivery applications, as well as to provide multifunctionality to the fiber structure.