Abstract: We have developed an environmentally-friendly new process for producing textile yarns. The process involves chemical modification of cellulose with subsequent dissolution of the chemically modified cellulose with chitosan or other amine group-containing compounds which yields a highly viscous gel. The chemical modification of cellulose employs a known process of periodate oxidation which we have modified to obtain fibers with a low degree of aldehyde groups (˜2 mmol/g cellulose) that still remain insoluble in water. After washing, the chemically modified fibers can be cross-linked with chitosan or other amine group-containing compounds to produce the viscous gel. The viscous gel can then be extruded through a syringe nozzle in the form of textile yarns.
Abstract: Compositions and methods are provided for determining platelet reactivity where the levels of Fc?RIIa on the surface of platelets is measured and if the levels of Fc?RIIa are greater than a reference value, the platelets have enhanced reactivity.
Type:
Grant
Filed:
May 23, 2013
Date of Patent:
December 10, 2019
Assignee:
The University of Vermont And State Agriculture College
Abstract: Disclosed are multi-compartmental nanoparticulate systems for imaging as well as the diagnosis, monitoring, and treatment of inflammation and/or disease. These multicompartmental nanoparticulate systems can be used to target specific cells or cellular structures. Furthermore, these systems are capable of simultaneous delivery of hydrophilic and lipophilic compositions. Finally, these systems also allow for temporal control of drug delivery.
Type:
Grant
Filed:
March 24, 2011
Date of Patent:
December 10, 2019
Assignee:
Northeastern University
Inventors:
Mansoor M. Amiji, Mayur Kalariya, Shardool Jain, Husain Attarwala
Abstract: Pharmaceutical complexes composed of drug molecules entrapped in cyclodextrin-based MOFs (CD-MOFs) are provided. Pharmaceutical tablets incorporating crystals of the pharmaceutical complexes for oral administration to a patient are also provided. In addition, methods of making the pharmaceutical complexes using anion-exchange reactions and methods of making the pharmaceutical complexes based on the co-crystallization of the drug molecules with cyclodextrin are provided. The pharmaceutical complexes include a CD-MOF and deprotonated drug anions associated with alkali metal cations in the CD-MOF superstructure.
Type:
Grant
Filed:
November 14, 2016
Date of Patent:
December 10, 2019
Assignees:
Northwestern University, King Abdulaziz City for Science and Technology
Inventors:
Karel J. Hartlieb, James M. Holcroft, James Fraser Stoddart, Daniel Patrick Ferris
Abstract: Apparatus and method are provided for remediating trichloroethylene-polluting soils by integrated rotated migration and PRB. The apparatus includes a device of electrokinetic remediation, a PRB and a device of injection of surface active agents. The main components of the device of electrokinetic remediation and PRB include cathode, anode, electrode chamber and PRB. A liquid injection pipe is installed between various electrodes and PRBs. The operation of each device is controlled by each control system. The disclosure integrated rotated migration and PRB for remediating contaminants. Surface active agents is helpful for dispersing TCE from soil. The arrangement of the electrode and the PRB greatly shortens distances and time of pollutant migration, which accelerate the speed of remediation and reduce post-processing procedures. In the process of treatment, the three technical methods promote each other, and have the advantages of good repair effect, short time, no secondary pollution and easy operation.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
December 10, 2019
Assignee:
NORTH CHINA ELECTRIC POWER UNIVERSITY
Inventors:
Hongwei Lu, Lixia Ren, Li He, Yizhong Chen, Jing Li
Abstract: A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.
Abstract: Described herein are methods of identifying tumor-specific epitopes from the cancer tissue DNA of cancer patients using both DNA sequencing and bioinformatics techniques. The identification of tumor-specific epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a novel index called the Differential Agretopic Index (DAI) for the epitope which allows prediction of whether immunization with a particular epitope will be protective against the tumor. Pharmaceutical compositions and methods of administration are also included.
Type:
Grant
Filed:
September 27, 2013
Date of Patent:
December 10, 2019
Assignee:
UNIVERSITY OF CONNECTICUT
Inventors:
Pramod K. Srivastava, Ion Mandoiu, Fei Duan
Abstract: Provided is a method for producing a beta zeolite, which is a seed crystal addition method that is capable of reducing the environmental load as much as possible. A method for producing a beta zeolite according to the present invention comprises a step wherein a reaction mixture that contains a silica source, an alumina source, an alkali source and water and a seed crystal that is composed of a beta zeolite are mixed with each other and heated. A beta zeolite which comprises particles having a particle size of 10 ?m or less in an amount of 90% or more on a volume basis in the particle size distribution as determined by a laser diffraction/scattering particle size distribution measuring method, and which is synthesized without using an organic structure-directing agent is used as the seed crystal.
Type:
Grant
Filed:
February 8, 2016
Date of Patent:
December 10, 2019
Assignees:
Mistui Mining & Smelting Co., Ltd., The University of Tokyo
Inventors:
Keiji Itabashi, Shanmugam Palani Elangovan, Kyosuke Sodeyama, Tatsuya Okubo
Abstract: The present invention discloses a sulfonate lycine type hydrophobic associated polymer and a preparation method thereof. A preparation process of the sulfonate lycine type hydrophobic associated polymer comprises the following steps: firstly, mixing acrylamide and acrylic acid in an aqueous solution; adjusting pH of the system to be around 6 to 8; adding 3-(dimethylamino propyl methacrylamide) propanesulfonate, N-aryl-N-alkyl (methyl) acrylamide and lauryl sodium sulfate and stirring till the solution is clear; and after nitrogen is introduced for deoxidization, adding a photoinitiator azobis (isobutylamidine hydrochloride) for performing polymerization under photoinitiation conditions.
Abstract: Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient comprising a head mount for disposition on the head of a patient, and a plurality of magnet assemblies for releasable mounting on the head mount. The magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents for modifying the natural electrical activity of the brain of the patient. The number of magnet assemblies mounted, their individual positioning, and their selective provision of a rapidly changing magnetic field is selected to allow spatial, strength and temporal characteristics of the magnetic field to be tailored for the patient, to provide patient-specific IMS therapy, assist in diagnosis, or map out brain function. The magnet assembles can comprise magnets for provide a rapidly changing magnetic field of at least 500-600 Tesla/second corresponding to a magnet movement speed of no less than 400 Hertz.
Type:
Grant
Filed:
September 30, 2016
Date of Patent:
December 10, 2019
Assignees:
THE METHODIST HOSPITAL, CORNELL UNIVERSITY
Abstract: Technologies are described for semiconductor radiation detectors. The semiconductor radiation detectors may comprise a semiconductor material. The semiconductor material may include a first surface and a second surface. The first surface may be opposite from the second surface. The semiconductor material may include at least one metal component. The semiconductor material may be effective to absorb radiation and induce a current pulse in response thereto. The semiconductor radiation detector may comprise an electrode contact. The electrode contact may include a metal doped oxide deposited on the first surface of the semiconductor material. The metal doped oxide may include the metal component element of the semiconductor material.
Type:
Grant
Filed:
February 12, 2016
Date of Patent:
December 10, 2019
Assignees:
BROOKHAVEN SCIENCE ASSOCIATES, LLC, NORFOLK STATE UNIVERSITY
Inventors:
Utpal N. Roy, Ralph B. James, Giuseppe Camarda, Yonggang Cui, Anwar Hossain, Ge Yang, Aswini Pradhan, Rajeh Mundle
Abstract: An object of the present invention is to provide a novel method that is excellent in superovulation induction efficiency. Specifically, it is an object to provide a method giving superior superovulation induction efficiency as compared with conventional methods using equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG). The present invention provides a superovulation inducing method, comprising simultaneously administering anti-inhibin antibody and equine chorionic gonadotropin (eCG), then, administering human chorionic gonadotropin (hCG), to a female mouse.
Type:
Grant
Filed:
February 19, 2016
Date of Patent:
December 10, 2019
Assignee:
National University Corporation Kumamoto University
Abstract: Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
December 10, 2019
Assignee:
Vanderbilt University
Inventors:
Steve Fesik, Alex Waterson, Michael Burns, Qi Sun, Jason Phan, James M. Salovich, Jason R. Abbott, Andrew Little
Abstract: A method for forming an antifuse on a substrate is provided, which comprises: forming a first conductive material on the substrate; placing the first conductive material in an electrolytic solution; performing anodic oxidation on the first conductive material to form a nanowire made of the first conductive material and surrounded by a first dielectric material formed during the anodic oxidation and to form the antifuse on the nanowire; and forming a second conductive material on the antifuse to sandwich the antifuse between the first conductive material and the second conductive material.
Type:
Grant
Filed:
March 29, 2018
Date of Patent:
December 10, 2019
Assignees:
Taiwan Semiconductor Manufacturing Company Limited, National Taiwan University
Inventors:
Jenn-Gwo Hwu, Wei-Cheng Tian, Samuel C. Pan, Chao-Hsiung Wang, Chi-Wen Liu
Abstract: A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease or non-disease propagation for containment and forecasting purposes.
Type:
Grant
Filed:
July 27, 2017
Date of Patent:
December 10, 2019
Assignee:
Georgetown University
Inventors:
Ahmed A. Humayun, Steven J. Silverstein, Gregory P. Zalasky, Kevin D. Jones
Abstract: Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or more biocompatible binders, one or more biocompatible mediators, an enzyme, an enzyme stabilizer, and a conductive material. The system includes a dispenser including a chamber to hold the enzymatic-ink and an applicator to apply the enzymatic ink dispensed from the chamber onto a target substrate.
Type:
Grant
Filed:
February 5, 2016
Date of Patent:
December 10, 2019
Assignee:
The Regents of the University of California
Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.
Type:
Grant
Filed:
January 10, 2017
Date of Patent:
December 10, 2019
Assignees:
The Board of Trustees of the University of Illinois, X-Celeprint Limited
Inventors:
John Rogers, Ralph Nuzzo, Matthew Meitl, Etienne Menard, Alfred Baca, Michael Motala, Jong-Hyun Ahn, Sang-Il Park, Chang-Jae Yu, Heung Cho Ko, Mark Stoykovich, Jongseung Yoon
Abstract: A lithium metal composite oxide includes a primary particle having a hexagonal crystal structure, and a primary particle having a cubic crystal structure.
Type:
Grant
Filed:
August 1, 2017
Date of Patent:
December 10, 2019
Assignees:
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY), ENERCERAMIC INC.
Inventors:
Yangkook Sun, Chongseung Yoon, Gangjun Park, Jangwook Park
Abstract: The present invention discloses use of a polyenylpyrrole derivative in preparation of an anti-oral cancer drugs. The polyenylpyrrole derivative synthesized by polyvinylpyrrole, auxarconjugatin A and 12E-isorumbrin inhibits the cell proliferation, migration, tumor sphere formation abilities and xenograft tumorigenicity of oral cancer cells.
Abstract: The present invention provides methods for development of a virulent bacteriophage-based treatment for the control of plant diseases caused by Xylella fastidiosa. The invention further provides methods of isolating and propagating bacteriophage virulent to X. fastidiosa in a Xanthomonas bacterial host and for treating or reducing symptoms of X. fastidiosa infection in a plant. The invention further provides methods of isolating and propagating bacteriophage virulent to Xanthomonas axonopodis pv. citri and for treating or reducing symptoms of Xanthomonas axonopodis pv. citri infection in a plant.
Type:
Grant
Filed:
October 18, 2013
Date of Patent:
December 10, 2019
Assignee:
The Texas A&M University System
Inventors:
Carlos F. Gonzalez, Stephen J. Ahern, Mayukh Das, Ryland F. Young, III, Tushar Suvra Bhowmick