Abstract: Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise selecting a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of toremifene and fluconazole or derivatives thereof.

Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.

Abstract: The present invention relates to the field of cardiology. More specifically, the present invention provides methods and compositions for inducing proliferation of cardiomyocytes. In a specific embodiment, a method for inducing proliferation of cardiomyocytes comprises the step of administering an effective amount of an ALMS1 inhibitor.

Abstract: The present invention relates to a nanocrystalline photocatalyst active upon visible light irradiation, with a high degree of dispersion, stable in the form of a transparent colloidal solution in an aqueous environment, containing nanocrystals of titanium dioxide (TiO2) surface-modified via direct chemisorption of organic compounds. The present invention in turn relates to a method of producing the material as well as its use as a photosterilizer, photobacteriocide, photomycocide, and/or photocatalyst, in particular for the sterilization of glass surfaces, transparent plastics and transparent materials, in particular contact lenses, medical catheters, glass and plastic conduits as well as other surfaces, whose sterilization is desirable and/or required.

Abstract: The invention provides a simple and effective method for increasing thermal stability of a wide range of proteins, comprising fusing a self-assembling amphipathic peptide to the C- or N-terminal of target proteins. The fusion protein can have a half life up to 26 times longer than that of the wild type protein.

Abstract: An analog-to-digital (ADC) converter is disclosed that uses aspects of a single-slope ramp ADC, but with jump steps in the ramp voltage to increase speed. A programmable ramp generator can be used to dynamically modify a voltage level associated with the jump step. By programming a voltage level of the jump, a user can dynamically modify the speed of the ADC during operation.

Abstract: An image generation system is provided, the system generating an ultrasound image and a photo-acoustic image of an object and including a dual-wavelength laser source, an optical filter, and an optical-based ultrasound sensor. The laser source generates a first laser pulse with a first wavelength or a second laser pulse with a second wavelength. The optical filter almost completely absorbs the energy of the first laser pulse and by the photo-acoustic effect, generates and transmits an ultrasound to the object so the object scatters and reflects the ultrasound. The second laser pulse almost completely penetrates the optical filter and is transmitted to the object so the object absorbs the energy of the second laser pulse, generates and sends a photo-acoustic signal. The optical-based ultrasound sensor receives the ultrasound and the photo-acoustic signal to generate the ultrasound image and the photo-acoustic image of the object.

Abstract: Examples of the present invention include apparatus and methods for monitoring aging of an item. A solid-state structure is located within, adjacent to, or otherwise proximate the item, the solid-state structure including nanostructures. The electrical resistance and/or magnetization of the solid-state structure is determined to determine the degree of aging of the item. In representative examples, the solid-state structure includes nanostructures of a metal, such as a ferromagnetic metal, within a non-magnetic matrix, such as a semimetal, semiconductor, or insulator.

Abstract: A composition comprising an SL0101 [kaempferol 3-O-(3?,4?-di-O-acetyl-?-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

Abstract: An optical glass including B3+, La3+ and Nb5+ as cationic components constituting the glass, wherein the optical glass satisfies the following expressions represented in cation percentages: 10 cat. %?B3+?50 cat. %; 40 cat. %?La3+?65 cat. %; 0 cat. %?Nb5+?40 cat. %; 80 cat. %?(total amount of B3++La3++Nb5+)?100 cat. %; and 0 cat. %?Si4+?10 cat. %; 0 cat. %?Ge4+?5 cat. %; 0 cat. %?Mg2+?5 cat. %; 0 cat. %?Ba2+?10 cat. %; 0 cat. %?Ca2+?10 cat. %; 0 cat. %?Sr2+?10 cat. %; 0 cat. %?Zn2+?20 cat. %; 0 cat. %?W6+?5 cat. %; 0 cat. %?Zr4+?5 cat. %; 0 cat. %?Ti4+?5 cat. %; 0 cat. %?Bi3+?5 cat. %; 0 cat. %?Ta5+?10 cat. %; 0 cat. %?(total amount of Y3++Gd3+)?20 cat. %; and 0 cat. %?(total amount of Yb3++Lu3+)?10 cat. %.

Abstract: Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular ?-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900.

Abstract: Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy of a signal transduction inhibitor in a patient. Other needs exist for detecting and monitoring certain disease or disorders that are associated with aberrant activation of a signal transduction pathway signaling protein. The present assay provides a highly sensitive assay that is also useful in patient populations in which obtaining a large cellular sample is difficult, for example, neonates.

Abstract: The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties. One aspect of the present invention encompasses a genetically modified phototrophic microorganism capable of controlled adhesion. The microorganism comprises a recombinant nucleic acid construct, wherein the nucleic acid construct comprises an inducible promoter operably-linked to a nucleic acid encoding an adhesion protein.

Abstract: The invention discloses a carpool service providing method and a carpool server using the same. The method includes the following steps: generating a carpool population matrix according to a plurality of carpool requests received from a plurality of passengers and drivers; generating a first carpool matching result and a second carpool matching result according to the carpool population matrix; performing a routing procedure to each of the first and second segments; respectively comparing the segment fitness value of one of the second segments with the segment fitness value of the corresponding first segment and updating the second carpool matching result by replacing the one of the second segments with the corresponding first segment if the segment fitness value of the one of the second segments is worse than the segment fitness value of the corresponding first segment; updating the carpool population matrix according to the updated second carpool matching result.

Abstract: The present disclosure provides a solution for a metal oxide semiconductor thin film, including metal hydroxides dissolved in an aqueous or nonaqueous solvent and an acid/base titrant for controlling solubility of metal hydroxides. A solution is synthesized to improve stability and semiconductive performance of a device through addition of other metal hydroxides. The solution is applied on a substrate and annealed by using various annealing apparatuses to obtain a high-quality metal oxide thin film at low temperatures. The thin film is optically transparent, and thus can be applied to thin films for various electronic devices, solar cells, various sensors, memory devices, and the like.

Abstract: A gas sensing system includes an air intake hole which comprises a plurality of micro-flow channels, a replaceable sensor for receiving an air from the air intake hole and detecting the received air, and a processing unit coupled to the replaceable sensor and doing determination for the component of the air according to a detection result of the replaceable sensor. Wherein, the replaceable sensor includes a plurality of sensing chips arranged in an array and each sensing chip is coated with a sensing thin film separately to detect a different gas.

Abstract: Sources, devices, and techniques for deposition of organic layers, such as for use in an OLED, are provided. A vaporizer may vaporize a material between cooled side walls and toward a mask having an adjustable mask opening. The mask opening may be adjusted to control the pattern of deposition of the material on a substrate, such as to correct for material buildup that occurs during deposition. Material may be collected from the cooled side walls for reuse.

Abstract: A frequency-shift keying (FSK) receiver includes an injection-locking oscillating circuit to receive a FSK input signal, and a phase detecting circuit. The injection-locking oscillating circuit outputs a locked signal having a phase that tracks a phase of the FSK input signal. A difference between the phases of the FSK input signal and the locked signal is associated with a difference between a frequency of the FSK input signal and a free-running frequency of the injection-locking oscillating circuit. The phase detecting circuit receives the FSK input signal and the locked signal, and outputs a baseband logic signal according to the difference between the phases of the FSK input signal and the locked signal.

Abstract: A method of diagnosing tuberculosis (TB) disease and distinguishing between active TB and latent TB infection in a subject is described herein. A sample from the subject is stimulated with at least one Mycobacterium tuberculosis (M.tb) infection phase-dependent antigen selected from Rv0081, Rv2032, Rv1737c, Rv2389c, Rv0867c, TB18.2, Rv2099c, Rv1733c, M.tb PPD, PHA and ESAT-6/CFP-10 and the presence of at least one host marker in the sample is detected, the host marker being selected from EGF, TGF-?, TNF-?, VEGF, RANTES, IL-12(p40), IL-12(p70), IL-10, IP-10, IFN-?2, fractalkine, IFN-?, IL-13, IL-1Ra, IL-3, IL-4, IL-5, MIP-1?, ENA-78, BCA-1, TARC, X6-Ckine, eotaxin, eotaxin-2, SCF, APOA-1, APOE, HPALBN, HCF, Serum amyloid protein A (SAA), C-reactive protein (CRP), serum amyloid protein P (SAP), TIMP-1, MIP-1?, IL-6, GM-CSF, IL-1?, MMP-9, MMP-2, MCP-1, TRAIL, IL-15, IL-17F, IL-22, TNF-?, MCP-2 and MCP-4. Additional host markers may also be detected in an unstimulated sample from the subject.