Abstract: Systems and methods for determining a Material's (“MTL”) mechanical properties. The methods comprise: coupling a first end of MTL to a First Mechanical Mechanism (“FMM”) movable in a First Direction (“FD”) and coupling a second end of MTL to a Second Mechanical Mechanism (“SMM”) movable in a Second Direction (“SD”); applying a first Pulling Force (“PF”) to MTL; applying an Oscillating Force (“OF”) to MTL; applying a second PF to MTL so as to cause any undulations in MTL to be removed and to cause a loading of fibers or polymeric units that support MTL; allowing MTL to oscillate through a series of cycles of loading and unloading; measuring a strain/stress on MTL as a function of time; determining a natural frequency of MTL based on the strain/stress; and determining an elastic modulus of MTL using the natural frequency.

Abstract: A method for an apparatus that supports full-duplex radio (FDR) communication controlling a self-interference duplication signal for removing self-interference comprises the steps of: transmitting two reference signals; and measuring the power of the two reference signals that arrive as self-interference signals; and a self-interference duplication generation unit for duplicating and generating a self-interference signal including three elements controlling two elements of the three elements based on the measured power of a first reference signal of the two reference signals, and controlling the remaining element based on the measured power of a second reference signal, wherein the three elements comprise a time delayer, a phase shifter and an attenuator, and the two reference signals are orthogonal to each other.

Abstract: Provided is a method for quantifying sugar appearing in a biological fluid of a subject, the method include (a) obtaining a biological sample from a subject, who has ingested one or more sugars, over a period of 0 to 24 hours after the ingesting; and (b) measuring the amount of the one or more sugars in the biological sample with an organoborane compound coupled to a fluorophore. Also provided are assays and kits for performing the above methods.

Abstract: Described are positive allosteric modulators of the GLP-1 receptor, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for diabetes mellitus type 2, obesity, depression, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, cognitive dysfunction, learning disability, and asthma in a subject.

Abstract: The intraoral attachment clip for attaching objects to edentulous ridges has a flexible body configured as an elongated U-shaped strip that is designed to be conformed to an edentulous ridge. The clip has a lower or tissue surface adapted for contacting the mucosal surface of the ridge and an upper or oral surface facing the oral cavity. The tissue surface of the clip includes a plurality of micro-projections and an adhesive for securing the device to the underlying mucosal surface of the edentulous ridge. Tracking sensors and/or radiopaque fiducial markers can be attached to the oral surface of the clip for use with surgical navigation systems and imaging procedures. Sustained release drugs may be added to the tissue surface of the device for administering time-release medications through the mucosa over a prolonged period of time.

Abstract: The disclosure teaches antagonists of Hepatitis C Virus (HCV) derived microRNA, which are useful in methods for treating and protecting against HCV-mediated hepatocellular carcinogenesis.

Abstract: The present disclosure provides intramedullary mandibular implants for the temporomandibular joint. The mandibular implants include a stem portion, a collar portion and a head portion. The stem, collar and head portions may be integral. The stem portion may define an inferior end and the head portion may define a superior end of the implants. The head portion may be arcuate in the sagittal plane to provide an articulating surface with a fossa or a fossa component. The collar portion may be intermediate of the head and stem portions and form a channel between an interior surface of the collar portion and an exterior surface of the stem portion. In use, the stem portion may be implanted within a condyle of a mandible such that an end portion of the condyle is situated within the channel of the implant and the head portion articulates with the fossa or fossa component.

Abstract: Methods for diagnosing and treating conditions associated with life-threatening neurological complications are provided. The methods involve in some aspects the identification of oxLDL and LOX-1 as critical players in pregnant subjects and in some cases subjects having severe preeclampsia (early onset preeclampsia). Related products and kits are also provided.

Abstract: Provided herein are methods and compositions for the treatment of wounds in a mammalian subject. Particularly, novel bioactive polypeptides are provided that promote tissue repair and regeneration, including the activation of/stimulation of wound healing and wound closure, stimulate keratinocyte and endothelial cell motility and/or proliferation.

Abstract: Embodiments of the present invention include apparatuses and methods for performing remote experiments in real-time. The method includes sending requests to perform remote experiments for a desired configuration to a first and second facility. The desired configuration may include a first and second configuration. The method includes running a first remote experiment in real-time at the first facility to obtain a first output variable. The first facility may include the first configuration with a first input variable. The method includes simultaneously running a second remote experiment in real-time at a second facility to obtain a second output variable. The second facility may include the second configuration with a second input variable. The first output variable may be set as the second input variable to mimic the desired configuration. The method includes obtaining experimental results of the desired configuration via the first and second input and output variables.

Abstract: Disclosed herein are aptamers that bind specifically to the surface proteins of periodontal pathogens. Disclosed also herein are kits and methods for detecting bacteria associated with periodontal disease by using the present aptamers to analyze a sample taken from the oral cavity of a patient.

Abstract: Methods for classifying subjects and analyzing the relation between subject classification and multiple features of the subjects are provided. Some embodiments of the disclosure provide processes that use clustering analysis as an unsupervised machine learning technique to classify subjects based on multiple features. Some embodiments may associate features of the subjects with a categorical variable on which subject groups are based. This association between the features and the categorical variable of interest (or subject groups) can be obtained by finding featured-based clusters that have similar members as the subject groups. Systems and computer program products implementing the methods are also disclosed.

Abstract: Systems and methods for separating hydrocarbons on an internal combustion powered vehicle via one or more metal organic frameworks are disclosed. Systems and methods can further include utilizing separated hydrocarbons and exhaust to generate hydrogen gas for use as fuel. In one aspect, a method for separating hydrocarbons can include contacting a first component containing a first metal organic framework with a flow of hydrocarbons and separating hydrocarbons by size. In certain embodiments, the hydrocarbons can include alkanes.

Abstract: Provided herein are optimized, recombinant influenza HA polypeptides that elicit immune responses. Also provided are compositions and kits comprising the optimized HA polypeptides as well as methods of making and using the optimized HA polypeptides.

Abstract: A sampling device is constructed having an airflow path from a size-selective inlet to a device outlet, without using any tubing. The size-selective inlet includes at least one of an impactor, a filter, a cyclone, and an inhalable inlet. The device includes a sampling assembly configured to be removably coupled directly to a sampling device housing (e.g., without using tubing), and an airflow assembly that may be constructed without using tubing.

Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.

Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.

Abstract: A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s—NH—(CH2)t, (CH2)s—O—(CH2)t, or (CH2)s—C(NH2)—(CH2)v—NH—(CH2)t, where s, t and v are each, independently an integer from 1 to 5; A and B are each, independently, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; C and D are each, independently, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-C1-6 alkyl, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; each Rg is, independently, halogen, C1-6 alkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, or di-C1-6alkylamino; and n1 and p1 are each, independently, integers from 1 to 10.

Abstract: The present disclosure relates to a method and related system for spectrum optimization of an illumination light source. Spectrum optimization according to the present disclosure can be based on various optimization parameters, including but not limited to luminous efficacy, color rendering effect, luminous efficacy of radiation, mesopic efficacy of radiation, cirtopic efficacy of radiation, etc. The present method and system are capable of optimizing illumination performance of a light source in various aspects in an individual or integrated manner. Further, the present method and system are capable of accommodating different illumination purposes and conditions by combining and prioritizing different optimization parameters.