Patents Assigned to University
  • Method for analysis using nucleic acid microarray
    Patent number: 9034796
    Abstract: An analytical method aided with a nucleic acid microarray, the nucleic acid microarray having a spot (X 1) onto which a first probe nucleic acid is immobilized, the method includes: allowing a labeled sample nucleic acid (A 1) of a sample to be tested to hybridize with the first probe nucleic acid; providing the spot (X 1) with a labeled verification nucleic acid (B) that has a sequence capable of hybridizing with at least a part of the first probe nucleic acid and is labeled with a label different from the labeled sample nucleic acid (A 1), and allowing the labeled verification nucleic acid (B) to hybridize with at least the first probe nucleic acid at all spots; measuring a labeled quantity value (F 1) of the labeled sample nucleic acid (A 1); and measuring a labeled quantity value (Fc 1) of the labeled verification nucleic acid (B).
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: May 19, 2015
    Assignees: FUJIFILM Corporation, National University Corporation Tokyo Medical and Dental University
    Inventors: Dai Ujihara, Hideyuki Kanehara, Johji Inazawa, Issei Imoto
  • Gold coating of rare earth nano-phosphors and uses thereof
    Patent number: 9034204
    Abstract: Novel core-shell nanoparticles comprising a phosphorescent core and metal shell as well as methods of synthesizing and using said core-shell nanoparticles are provided. In a preferred embodiment, the phosphorescent core comprises an upconverting phosphor and the shell comprises gold.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: May 19, 2015
    Assignee: The Regents of the University of California
    Inventors: Ian M. Kennedy, Sudheendra Lakshmana
  • Membrane surface modification
    Patent number: 9033159
    Abstract: Processes for preparation of macroporous membranes having unusually high equilibrium protein binding capacities are described. Membranes include a self-supporting porous membrane substrate and a grafted polymeric film on the pore surfaces of the substrate. A polymeric film may be grafted to the porous membrane substrate using surface-initiated polymerization. The grafted polymer chains within the polymeric film can act as molecular ‘brushes’ or ‘tentacles’ in solution and can contain one or more capture chemistries for biomolecules. Membranes can be used in the separation and purification of biomolecules such as proteins, nucleic acids, virus or virus-like particles, endotoxins, and the like.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: May 19, 2015
    Assignee: Clemson University
    Inventors: Scott M. Husson, Bharat V. Bhut
  • Compositions and methods for treating biofilms
    Patent number: 9034812
    Abstract: Compositions and methods for treating biofilm formation and growth on a substrate are provided. The composition comprises 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The method comprises contacting the substrate with 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The compositions and methods are effective for preventing, reducing or eliminating biofilm formation or biofilm growth or both, as well as eradicating established, recalcitrant biofilms, particularly biofilms comprising sulfate reducing bacteria that are known to cause microbiologically influenced corrosion, biofouling, or both.
    Type: Grant
    Filed: August 26, 2012
    Date of Patent: May 19, 2015
    Assignee: Ohio University
    Inventors: Tingyue Gu, Dake Xu
  • Method for making metal-based nano-composite material
    Patent number: 9034073
    Abstract: A method for making a metal-based nano-composite material is disclosed. In the method, a semi-solid state metal-based material is provided. The semi-solid state metal-based material is stirred and nano-sized reinforcements are added into the semi-solid state metal-based material to obtain a semi-solid state mixture. The semi-solid state mixture is heated to a temperature above a liquidus temperature of the metal-based material, to achieve a liquid-metal-nano-sized reinforcement mixture. The liquid-metal-nano-sized reinforcement mixture is ultrasonically processed at a temperature above the liquidus temperature by conducting ultrasonic vibrations to the liquid-metal-nano-sized reinforcement mixture along different directions at the same time.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: May 19, 2015
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Wen-Zhen Li, Shi-Ying Liu
  • Composition and methods for treating glioblastoma
    Patent number: 9034895
    Abstract: The disclosure provides methods of treating glioblastoma, methods of screening for compounds that treat glioblastoma, and pharmaceutical compositions useful the treatment of glioblastoma.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: May 19, 2015
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Nephi Stella, Toni Kline
  • ATF4 inhibitors and their use for neural protection, repair, regeneration, and plasticity
    Patent number: 9034299
    Abstract: In one aspect, the invention relates to a method for identifying a drug candidate with activity as a neuroprotective agent. The method includes determining whether a compound reduces ATF4 activity; and identifying the compound that reduces ATF4 activity as a drug candidate.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: May 19, 2015
    Assignee: Cornell University
    Inventor: Rajiv R. Ratan
  • Arrayed detector system for measurement of anti-viral immune response
    Patent number: 9034638
    Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: May 19, 2015
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Tim R. Mosmann, Robert C. Rose, Charles R. Mace
  • Dihydroethidine analogues and uses thereof
    Patent number: 9035057
    Abstract: Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: May 19, 2015
    Assignee: Washington University
    Inventors: Robert H. Mach, Mark Mintun, Wenhua Chu, Laura Dugan
  • Fuel carburetor
    Patent number: 9033317
    Abstract: A fuel carburetor includes a fuel passage, a heat medium passage, a space part, and an absorbent material. Ammonia as fuel flows through the fuel passage. The heat medium passage is arranged adjacent to the fuel passage, and a heat medium flows through the heat medium passage. Ammonia gas leaking out of the fuel passage flows into the space part. The absorbent material is provided in the space part for absorbing the ammonia gas. The fuel carburetor is configured to exchange heat between the fuel flowing through the fuel passage and the heat medium flowing through the heat medium passage so as to heat and vaporize the fuel.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: May 19, 2015
    Assignees: DENSO CORPORATION, National University Corporation Nagoya University
    Inventors: Takuya Fuse, Kazutoshi Kuwayama, Mitsuhiro Kubota, Ryo Yamanouchi
  • Method of tracking a position of an eye and a medical head lamp using the same
    Patent number: 9033505
    Abstract: A method of tracking a position of an eye is provided. The method of tracking a position of an eye includes converting an obtained image into a binary number image, classifying the corner of the eye, maximum and minimum values of a pupil of the eye, and extracting a feature point from the binary number image on which the binarization step is completed, calculating a distance and inclination between the corner and the pupil of the eye using the feature point extracted through the feature point extraction step, and determining a gaze direction of the eye based on the distance and inclination calculated through the distance and inclination calculation step.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: May 19, 2015
    Assignee: Dongguk University Industry-Academic Cooperation Foundation
    Inventors: Sung Min Kim, Sang Hoon Hong, Chan Beom Jeong, Jeon Pil Han, Kwon Hee Lee
  • Nanostructured thermoplastic polyimide films
    Patent number: 9034426
    Abstract: Structured films containing multi-walled carbon nanotubes (“MWCNTs”) have enhanced mechanical performance in terms of strength, fracture resistance, and creep recovery of polyimide (“PI”) films. Preferably, the loadings of MWCNTs can be in the range of 0.1 wt % to 0.5 wt %. The strength of the new PI films dried at 60° C. increased by 55% and 72% for 0.1 wt % MWCNT and 0.5 wt % MWCNT loadings, respectively, while the fracture resistance increased by 23% for the 0.1 wt % MWCNTs and then decreases at a loading of 0.5 wt % MWCNTs. The films can be advantageously be created by managing a corresponding shift in the annealing temperature at which the maximum strength occurs as the MWCNT loadings increase.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 19, 2015
    Assignee: Tuskegee University
    Inventor: Heshmat Aglan
  • Temperature sensitive conjugate compositions
    Patent number: 9035028
    Abstract: This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: May 19, 2015
    Assignees: Emory University, Baker IDI Heart & Diabetes Institute Holdings Ltd.
    Inventors: Elliot L. Chaikof, Karlheinz Peter, Danijal Topcic, Carolyn A. Haller, Wookhyun Kim
  • Bufferless nonblocking networks on chip
    Patent number: 9036482
    Abstract: Network on Chips (NoC)s with a bufferless and nonblocking architecture are described. Core processors are communicatively coupled together on a substrate with a set of routing nodes based on nonblocking process. A network component routes data packets through the routing nodes and the core processors via communication links. A bufferless cross bar switch facilitates the communication of the data packets and/or path setup packets through the communication links among source processors and destination processors. The communication links include one or more channels, in which a channel comprises a data sub-channel, an acknowledgement sub-channel and a release sub-channel.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 19, 2015
    Assignee: The Hong Kong University of Science and Technology
    Inventor: Chin Tau Lea
  • pH-sensitive polymer-drug conjugates for targeted delivery of therapeutics
    Patent number: 9034829
    Abstract: Polymeric delivery systems for boronic acid-containing therapeutics, related compounds and methods of use, for a pH-sensitive chemoselective approach to delivery of such a therapeutic.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: May 19, 2015
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Jing Su, Vincent L. Cryns
  • Agents for reversing epigenetic silencing of genes
    Patent number: 9034574
    Abstract: The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: May 19, 2015
    Assignee: The Johns Hopkins University
    Inventors: William G. Nelson, Srinivasan Yegnasubramanian, Xiaohui Lin, Traci J. Speed, Zachery Reichert
  • Pitcher training apparatus and method using a ball with an embedded inertial measurement unit
    Patent number: 9032794
    Abstract: A measurement system having a miniature, wireless inertial measurement unit (IMU) disposed within or on a moving object, such as a ball or other member, to calculate the kinematics of the moving object.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: May 19, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Noel Perkins, Ryan McGinnis
  • Apparatus and method for generating Gaussian pulse and ultra wideband communication apparatus for generating Gaussian pulse
    Patent number: 9036679
    Abstract: A pulse generation apparatus includes a delay pulse generator configured to generate a plurality of delay pulses, an amplitude modulator configured to modulate amplitudes of the plurality of delay pulses, and a Gaussian pulse generator configured to generate a Gaussian pulse based on the amplitude-modulated delay pulses.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: May 19, 2015
    Assignees: Samsung Electronics Co., Ltd., Tsinghua University
    Inventors: Shuli Geng, Woogeun Rhee, Jong Jin Kim, Dong Wook Kim, Zhihua Wang
  • Catalyst for organic reaction and method of use thereof
    Patent number: 9035075
    Abstract: A catalyst for an organic reaction and a method of using a catalyst in an organic reaction are provided. The catalyst for an addition or condensation reaction includes a graphene oxide including an oxygen functional group, and the catalyst is configured to promote the addition or condensation reaction by bonding the oxygen functional group with an alkali metal ion or alkali earth metal ion during the addition or condensation reaction.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: May 19, 2015
    Assignee: Research & Business Foundation Sungkyunkwan University
    Inventors: Hyoyoung Lee, Youngmin Kim, Surajit Some
  • Flux balance analysis with molecular crowding
    Patent number: 9037445
    Abstract: Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: May 19, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Zoltan N. Oltvai, Alexei Vazquez