Abstract: A 3D bio-printer capable of detecting cell activity is provided. The 3D bio-printer includes an upper PC and a lower 3D printer. A conveying hose is connected to a printhead base of the printer, and a temperature controller is connected to the conveying hose. A printhead controller is connected to the other end of the conveying hose, a printhead is connected to the bottom of the printhead controller, and a main control cabinet controls the printhead to work via a signal generator. A prototyping table is provided under the printhead and is connected with a cell activity detecting device for detecting activity of a printed product. Cell activity can be detected in the process of printing, which ensures that the printed biological tissues maintain biological activity. It can supply multi-biological raw materials and realize multi-biological material printing, which ensures an environment suitable for biological material printing.

Abstract: The present invention provides laryngeal mask airway for sedative endoscopy, including: a laryngeal mask/endoscope guide unit which is positioned in a larynx region inlet through a patient's oral cavity and guides a supply of air to a respiratory tract and insertion of an endoscope into an esophagus; an airway unit which is connected to the laryngeal mask/endoscope guide unit to supply air to the patient's respiratory tract and to allow the patient's breathing state to be visually checked; a mouthpiece unit which is installed outside the airway unit and fixed between the patient's teeth to protect a tube of the airway and an endoscopic probe inserted into the oral cavity; and an indication end which is positioned at a portion of the mouthpiece positioned outside the oral cavity and moves in accordance with the patient's breathing state to allow spontaneous breathing to be checked, such that the patient's safe airway may be ensured, the insertion of the endoscopic probe and the procedure may be smoothly perfor

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The disclosure is directed to a method and apparatus for performing patterned microscopy. The method includes obtaining a microscopy image of an object based on optical signal from the object in response to a first incoming optical beam; and obtaining a contrast-enhancing image based on optical signal from the object in response to a second incoming optical beam. The method also includes generating a patterned mask based on the contrast-enhancing image. The method further includes applying the patterned mask on the microscopy image to obtain a patterned microscopy image. The microscopy image includes a polarization-analyzed reflection confocal microscopy image. The contrast-enhancing image includes a second-harmonic generation microscopy image. The patterned microscopy image includes a second-harmonic patterned polarization-analyzed reflection confocal microscopy image.

Abstract: The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

Abstract: Disclosed is a three-dimensional tissue comprising cells and collagen including endogenous collagen, wherein at least a portion of the cells is adhered to the collagen, and the content of the collagen is from 10 wt % to 90 wt % based on the three-dimensional tissue.

Abstract: Provided are a method and device for dynamically monitoring suspended matter based on an annular interleaving array. An annular multi-band interleaving array used thereby can be combined with the Doppler effect to on-line measure the concentration and linearity distribution of the suspended matter and a three-dimensional flow velocity of suspended water, thus realizing real-time monitoring of water quality. A frequency range needing to be measured is divided into different frequency bands, and different transceiving transducer arrays are used to transmit and receive measurement signals, so that the concentration and linearity distribution of various suspended matter with an extremely large linearity range can be obtained through one measurement.

Abstract: This invention relates to magnetocaloric materials comprising ternary alloys useful for magnetic refrigeration applications. The disclosed ternary alloys are Cerium, Neodymium, and/or Gadolinium based compositions that are fairly inexpensive, and in some cases exhibit only 2nd order magnetic phase transitions near their curie temperature, thus there are no thermal and structural hysteresis losses. This makes these compositions attractive candidates for use in magnetic refrigeration applications. The performance of the disclosed materials is similar or better to many of the known expensive rare-earth based magnetocaloric materials.

Abstract: The present disclosure relates to a surgical tool for cutting and hemostasis of biological tissues. The surgical tool includes a hollow blade comprising a cutting implement residing within a hollow cavity configured to provide high-pressure steam through an apical surface. The cutting implement can operate independently or in cooperation with the provided high-pressure steam. The surgical tool of the present disclosure applies a directionally-controlled, high-pressure steam flow to a tissue region of interest. A control unit provides temperature-controlled steam at a flow-rate determined in accordance with tissue type and intended procedure.

Abstract: A system may include a radio frequency chain configured to process a signal. The system may further include a reconfigurable antenna including multiple antenna feeds, each of the antenna feeds associated with a beam direction. The system may also include a beam selection network configured to couple the radio frequency chain to a first antenna feed of the multiple antenna feeds to generate a first beam in a first direction, and simultaneously couple the radio frequency chain to a second antenna feed of the multiple antenna feeds to generate a second beam in a second direction.

Abstract: The present disclosure provides recombinant T cells that include a vector encoding one or more of peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1-alpha (PGC1?), mitochondrial transcription factor A (Tfam), GA binding protein transcription factor alpha subunit (GABPA), and estrogen-related receptor alpha (ERR? ). Such recombinant T cells can also include a chimeric antigen receptor (CAR) or a recombinant T cell receptor (TCR). Methods of using these recombinant T cells in cancer immunotherapy are provided. Also provided are kits and compositions that can be used with such methods.

Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.

Abstract: The present invention is directed to methods and uses of a series of compounds and compositions comprising the same for treating diseases, disorders and/or conditions related to fertility and preserving same and conditions related to same. In some aspects, the compounds and or compositions as herein described promote, improve, recover or restore fertility in a subject in need thereof, including in male and/or female subjects. Such methods/uses include promoting, enhancing or improving fertility-associated cell or tissue yield as part of an in vitro fertilization protocol.

Abstract: Provided is a method of detecting a biological material, by which quantitative measurement can be performed easily. The method of detecting a biological material in a sample includes: mixing, with the sample, a fusion protein (C) in which a protein (A) capable of binding the biological material and a chemiluminescent protein (B) are fused together and a substrate for the chemiluminescent protein (B); and observing a luminescent signal from the sample, wherein the protein (A) and the protein (B) are linked in such a manner that resonance energy transfer can occur, the protein (A) is either a protein (A1) that can emit fluorescence in a state where the biological material is bound thereto or a protein (A2) capable of binding an autofluorescent molecule as the biological material, and the protein (B) can excite fluorescence or autofluorescence of the protein (A) with its luminescence energy.

Abstract: The present invention provides compounds and methods for mitigating a clinical condition associated with a neurodegenerative disease or a locomotor dysfunction in a subject. In one particular aspect, the invention relates to compounds and methods for reducing TDP-43 aggregation or toxicity in a subject.

Abstract: Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a tRNA promoter operably connected to a first polynucleotide encoding a first single guide RNA and a second promoter operably connected to a second polynucleotide encoding a Cas9 polypeptide. The first single guide RNA includes a first portion complementary to a strand of a target sequence of a DNA virus and a second portion capable of interacting with the Cas9 polypeptide. Also provided are codon optimized Staphylococcus aureus derived Cas9 polynucleotides and polypeptides with nuclear localization signals and optionally an epitope tag. Also provided are constructs for production of sgRNAs including a tRNA. Methods of inhibiting viral replication, inhibiting expression of a target sequence from a virus or treating a viral infection or viral induced cancer using the compositions are also provided.

Abstract: A device, such as a light-emitting device, e.g. a laser device, comprising: a plurality of group III-V semiconductor NWs grown on one side of a graphitic substrate, preferably through the holes of an optional hole-patterned mask on said graphitic substrate; a first distributed Bragg reflector or metal mirror positioned substantially parallel to said graphitic substrate and positioned on the opposite side of said graphitic substrate to said NWs; optionally a second distributed Bragg reflector or metal mirror in contact with the top of at least a portion of said NWs; and wherein said NWs comprise aim-type doped region and a p-type doped region and optionally an intrinsic region there between.

Abstract: A system for generating electricity, heat, and desalinated water having a gas turbine system connected to a first electric generator, a waste heat recovery boiler (WHRB) system, a combined heat and power (CHP) generation system connected to a second electric generator, one or more solar powered energy systems, and a desalination system. The desalination system is connected to the CHP generation system and the WHRB system. The gas turbine system generates electricity and heat, the WHRB system is connected to and uses the exhaust of the gas turbine system to provide heat and steam power to the CHP generation system. The CHP generation system produces and provides electricity and heat to the desalination system, which produces product water, and at least one solar powered energy system provides thermal energy to one or more of the gas turbine system, the WHRB system, the CHP generation system, and the desalination system.

Abstract: Embodiments disclosed herein are directed to surgical cannulas and methods relating thereto. In some embodiments, a method includes cutting one or more lines in a tubular member to form a tubular body and a hinge of a surgical cannula. In some embodiments, a surgical cannula includes a fiber brag grating (FBG) reflector mounted to a tendon for deflecting a distal tip of the surgical cannula. A controller is coupled to the FBG reflector and is configured to determine a tension in the tendon based on reflected light from the FBG reflector. In some embodiments, a surgical cannula includes a tubular body including a plurality of apertures extending therethrough.

Abstract: The present disclosure relates to a catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.