Abstract: This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.
Type:
Grant
Filed:
September 5, 2016
Date of Patent:
November 19, 2019
Assignee:
University of the Witwatersrand, Johannesburg
Inventors:
Viness Pillay, Yahya Essop Choonara, Pradeep Kumar, Lisa Claire Du Toit, Poornima Ramburrun
Abstract: The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.
Type:
Grant
Filed:
August 17, 2016
Date of Patent:
November 19, 2019
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFONIA
Abstract: Provided is a caption replacement service system and method for servicing an interactive advertisement on a video on demand (VOD). A system for making an annotation may include an annotation creator configured to create annotation information on a moving object included in a video and an annotation player configured to play a preview on the annotation information based on a frame unit or a shot unit of the video. The video and the annotation information may be used to provide an interactive advertisement by replacing a caption system of the video with a meaningful annotation.
Type:
Grant
Filed:
September 8, 2017
Date of Patent:
November 19, 2019
Assignee:
INHA University Research and Business Foundation
Abstract: A surgical grasper includes a first handle arm, a second handle arm pivotally coupled to the first handle arm, a tool body pivotally coupled to both the first handle arm and the second handle arm, a first jaw member pivotally coupled to the tool body, a second jaw member pivotally coupled to the tool body, a first tension element coupled to both the first handle arm and to the first jaw member, a second tension element coupled to both the second handle arm and to the second jaw member, and a lock that locks relative movement between the first and second handle arms. Rotational movement of the first and second handle arms generates correlated rotational movement of the first and second jaw members.
Abstract: The present invention relates to a hydrochromic polydiacetylene composite composition, a hydrochromic thin film using same, and a use thereof, and more specifically, to a hydrochromic polydiacetylene composite composition reacting sensitively to moisture, providing the hydrochromic thin film using same, and to applying same to biorecognition or fingerprint recognition. According to the present invention, moisture secreted from a fingerprint or pores on the skin can be detected with high sensitivity. Thus, the position of pores unique to a fingerprint of an organism can be amplified and displayed through selective color change and fluorescent change patterns exhibited when moisture is absorbed.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
November 19, 2019
Assignee:
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
Inventors:
Jong-Man Kim, Chan Woo Lee, Joosub Lee, Dong-Hoon Park
Abstract: A core holder for a reservoir rock core sample for MR or MRI measurement including a casing and a chamber internal to the core holder, an inlet and an outlet in the core holder for circulating a confining fluid in the chamber, a sample housing in the chamber for containing the core sample, the sample housing including an inlet and an outlet in the sample holder for circulating fluid to and from the sample, and a membrane for isolating the sample from fluid contact with the confining fluid but permitting fluid pressure to be exerted on the sample when the confining fluid is pressurized, the space in the chamber not occupied by the sample housing defining a void space, an RF probe in the void space and at least partially surrounding the sample housing, whereby confining fluid introduced into the chamber circulates in the void space around the RF probe.
Abstract: Disclosed is a composition including: an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (BMSCs), wherein the BMSCs express neuronal markers, and wherein the neuronal markers are PGP9.5, NSE, Tuj1, HuC/D and neuronal nitric oxide synthase (nNOS). Methods of preparing the BMSCs are also provided. In addition, the present disclosure is directed to a method of treating an enteric nervous system-related disorder including: administering to a subject in need thereof a pharmaceutical composition including the in vitro pre-conditioned BMSC population and a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
August 3, 2016
Date of Patent:
November 19, 2019
Assignees:
THE JOHNS HOPKINS UNIVERSITY, UNION HOSPITAL, TONGJI MEDICAL COLLEGE, HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
Type:
Grant
Filed:
June 28, 2016
Date of Patent:
November 19, 2019
Assignees:
Bristol-Myers Squibb Company, The Rockefeller University
Inventors:
Jeffrey V. Ravetch, Rony Dahan, Bryan C. Barnhart, Brigitte Devaux, Aaron P. Yamniuk, Shannon L. Okada, Brenda L. Stevens
Abstract: A virtual force controlled collapse chip connection (C4) pad placement optimization frame-work for 2D power delivery grids is proposed. The present optimization framework regards power pads as mobile “positive charged particles” and current resources as a “negative charged back-ground.” The virtual electrostatic force is calculated from voltage gradients. This optimization framework optimizes pad locations by moving pads according to the virtual forces exerted on them by other pads and current sources in the system. Within this framework, three algorithms are proposed to meet various requirements of optimization quality and speed. These algorithms minimize resistive voltage drop (IR drop), the maximum current density, and power distribution network metal power dissipation at the same time.
Type:
Grant
Filed:
January 19, 2016
Date of Patent:
November 19, 2019
Assignee:
University of Virginia Patent Foundation
Inventors:
Ke Wang, Kevin Skadron, Mircea R. Stan, Runjie Zhang, Brett Meyer
Abstract: A method for forming an adherent metal based nanoparticle material layer upon a substrate includes an electrophoretic deposition method for depositing a metal nanoparticle material layer upon the substrate. The metal nanoparticle material layer may then be treated to form the adherent metal based nanoparticle material layer comprising a material selected from the group consisting of a metal oxide material, a metal nitride material, a metal oxynitride material and a metal chalcogenide material. The method is particularly useful for fabricating a battery electrode comprising a Co3O4 nanoparticle material layer, for use within a lithium ion battery. Other applications include fuel cells, capacitors and catalytic reactors.
Abstract: A method of measuring a center error between bearings includes disposing both sides of a rotation shaft on inner circumferential surfaces of a magnetic bearing and a backup bearing, applying current to the magnetic bearing to produce movement of the rotation shaft, determining a contact point between the rotation shaft and the backup bearing according to movement of the rotation shaft, determining a final target value using the contact point and predetermined position information of the magnetic bearing, determining a magnetic center of the magnetic bearing through the final target value, comparing the magnetic center of the magnetic bearing and a mechanical center of the backup bearing to determine a center error, and aligning the magnetic center of the magnetic bearing and the mechanical center of the backup bearing based on the determined center error.
Type:
Grant
Filed:
June 6, 2017
Date of Patent:
November 19, 2019
Assignees:
LG Electronics Inc., The Industry & Academic Cooperation in Chungnam National University
Inventors:
Namsoo Lee, Myounggyu Noh, Soyoon Kim, Seongmin Jang, Jinhee Jeong, Seongki Baek, Sunggyu Nam
Abstract: A system for running a Linux based Android container platform with a processor and a memory is disclosed. The system includes a Linux host, an Android container which runs on the Linux host, and an integrated security module including a Linux security module having a Linux policy of a process running on the Linux host, and an Android security module having an Android policy of a process running on the Android container. The integrated security module is mounted in a directory shared between the Linux host and the Android container and the integrated security module overwrites a pre-existing Linux security module.
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
November 19, 2019
Assignee:
Foundation of Soongsil University-Industry Cooperation
Abstract: A Schottky diode includes an insulating substrate and at least one Schottky diode unit. The at least one Schottky diode unit is located on a surface of the insulating substrate. The at least one Schottky diode unit includes a first electrode, a semiconductor structure and a second electrode. The semiconductor structure comprising a first end and a second end. The first end is laid on the first electrode, the second end is located on the surface of the insulating substrate. The semiconducting structure includes a carbon nanotube structure. The second electrode is located on the second end.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
November 19, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: A fuel cell electrode, comprising: a porous metal structure; and a carbon nanotube structure comprising a plurality of carbon nanotubes, the carbon nanotube structure is fixed on a surface of the porous metal structure, wherein the porous metal structure and the carbon nanotube structure are shrunk together to form a plurality of wrinkled parts.
Type:
Grant
Filed:
October 31, 2017
Date of Patent:
November 19, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: VO2 and V2O5 nano- or micro-materials. The VO2 nano-materials and micro-materials have an M1 phase structure and oxygen stoichiometry that deviates 2% or less from theoretical stoichiometry. The VO2 nano-materials and micro-materials may doped with cation dopants and/or anion dopants. The VO2 and V2O5 nano- or micro-materials can be made by hydrothermal methods starting with V3O7.H2O nano- or micro-material. The VO2 and V2O5 nano- or micro-materials can be used as, for example, thermochromic window coatings.
Type:
Grant
Filed:
August 26, 2015
Date of Patent:
November 19, 2019
Assignee:
The Research Foundation for The State University of New York
Abstract: The invention, in some embodiments, relates to the field of global navigation satellite systems, and more particularly to the field of methods and devices for improving accuracy of position determination by receivers of global navigation satellite systems. Some embodiments of the invention relate to methods for generating a three-dimensional (3-D) representation of an urban area by a receiver of a global navigation satellite system using blocked lines of sight to satellites of the system. Additional embodiments of the invention relate to methods for transmitting a three-dimensional (3-D) representation of an urban area by a receiver of a global navigation satellite system for improving calculation of location by the global navigation satellite system receiver.
Type:
Grant
Filed:
August 24, 2016
Date of Patent:
November 19, 2019
Assignee:
Ariel-University Research and Development Company Ltd.
Abstract: Provided is a photovoltaic device prepared with a semiconductor including a localized level or an intermediate band in a forbidden band and capable of improving the performance than before. The photovoltaic device includes a plurality of first layers made of a first semiconducting material and a plurality of second layers made of a second semiconducting material that is different from the first semiconducting material, wherein the second semiconducting material includes a localized level or intermediate band in a forbidden band, the first layers and the second layers are alternately laminated one by one, at least two of the second layers are each disposed between a pair of the first layers, and a thickness of each of the second layers is thinner than a thickness of four molecular layers of the first semiconducting material.
Type:
Grant
Filed:
May 15, 2012
Date of Patent:
November 19, 2019
Assignees:
TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
Abstract: An effective amount of botulinum toxin type B is administered to a subject in need thereof for treating Raynaud's phenomenon. Botulinum toxin type B may be in a form of an injection, and may be locally administered to a disease affected site, in a dose of 200 to 400 units per disease affected site.
Type:
Grant
Filed:
March 30, 2018
Date of Patent:
November 19, 2019
Assignee:
NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
Abstract: The present invention relates to an shock absorber based on the cutting, inward-folding and crushing of composite tube, comprising a destructing cap, a flat-pressing cap, a cutter and a positioning tube. The cutter is positioned in the destructing cap, and has a lower end connected to an inner flange of the destructing cap and an upper end connected to the positioning tube. The positioning tube is positioned in the destructing cap and closely connected to the inner wall of the destructing cap, and has a lower surface in contact with the cutter. The destructing cap, the positioning tube and the composite tube are respectively provided with aligned pin holes, and bound together with a pin. Energy is absorbed through destruction generated due to cutting and inward-folding of the composition tube. Energy can also be absorbed through destruction generated due to the inward-folding of the composite tube, without using the cutter.