Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

Abstract: The present disclosure provides a mass spectrometry cartridge and methods of use thereof.

Abstract: A pixel having a variable exposure for a scene capture device, the pixel comprising a photodiode, a buffer and a memory element and a switching mechanism. The memory element is configured to store an exposure control bit and the switching mechanism configured to control a variable exposure period of the photodiode based on the exposure control bit and to reset a voltage on said photodiode to a reference voltage.

Abstract: Neurological Disease Mechanism Analysis for Diagnosis, Drug Screening, (Deep) Brain Stimulation Therapy design and monitoring, Stem Cell Transplantation therapy design and monitoring, Brain Machine Interface design, control, and monitoring.

Abstract: Provided herein is a peptide, a cosmetic composition comprising the same, and a method for inhibiting skin-aging or skin-wrinkle formation using the same, the peptide having activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins.

Abstract: Wood fibers possess natural unique hierarchical and mesoporous structures that enable a variety of new applications beyond their traditional use. For the first time we dramatically modulate the propagation of light through random network of wood fibers. A highly transparent and clear paper with transmittance >90% and haze <1.0% applicable for high-definition displays is achieved. By altering the morphology of the same wood fibers that form the paper, highly transparent and hazy paper targeted for other applications such as solar cell and anti-glare coating with transmittance >90% and haze >90% is also achieved. A thorough investigation of the relation between the mesoporous structure and the optical properties in transparent paper was conducted, including full-spectrum optical simulations.

Abstract: Provided is a film-type biomedical signal measuring apparatus configured in a such a way that a plurality of metallic thin film electrodes and a circuit unit are formed on a film-type piezoelectric element so as to easily attach the apparatus to the skin and an electrical signal as well as an electrical signal of a human body is simultaneously measured using the plurality of metallic thin film electrodes and the circuit unit. Accordingly, the film-type biomedical signal measuring apparatus simultaneously measures electrocardiogram (ECG) and ballistocardiogram (BCG) from the simultaneously measured electrical signal and vibration signal of the human body and extracts biomedical information of various types of health indexes such as a heart rate, a stress index, BCG, a blood pressure, an amount of physical activity, a respiration rate, and VO2max from the two different biomedical signals.

Abstract: A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.

Abstract: Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.

Abstract: Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.

Abstract: In a PESI ion source, a solvent supply unit (8) is placed above the liver (101), which is the object of measurement, and by moving a probe (6) up and down such that the tip of the probe (6) passes through the solvent supply unit (8) and is inserted into the liver (101), a sample is captured by the tip of said probe. The solvent supply unit (8) includes a container unit comprising a liquid-blocking upper film body (81) stretched over the bottom surface opening of a cylindrical body (80), and a liquid-blocking lower film body (82) which is stretched out approximately in parallel with the upper film body (81) with a spacer interposed therebetween; the container unit houses a solvent (84). Because the tip of the probe (6) passes through the solvent (84) during the up-and-down movement of the probe (6), sufficient solvent adheres to the sample and when a high voltage is applied to the probe (6), components in the sample are favorably ionized.

Abstract: A first device is provided. The device includes a print head. The print head further includes a first nozzle hermetically sealed to a first source of gas. The first nozzle has an aperture having a smallest dimension of 0.5 to 500 microns in a direction perpendicular to a flow direction of the first nozzle. At a distance from the aperture into the first nozzle that is 5 times the smallest dimension of the aperture of the first nozzle, the smallest dimension perpendicular to the flow direction is at least twice the smallest dimension of the aperture of the first nozzle.

Abstract: An object of the present invention is to provide a novel substance that has a high reactivity as a fluorinating agent, is effectively used in various fluorination reactions, and is safely handled even in air. As the solution for achieving this object, the present invention provides a complex obtained by reacting bromine trifluoride with at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals in a nonpolar solvent. This complex serves as a fluorinating agent that provides excellent fluorination performance and that is stable in air.

Abstract: A device that uses a grating to carry out high sensitivity radiographic image shooting using the wave nature of x-rays or the like can shoot a sample that moves relative to a device. A pixel value computation section determines, using a plurality of intensity distribution images of a sample that moves in a direction that traverses the path of radiation, whether or not a point (p, q) on the sample belongs in a region (Ak) on each intensity distribution image. Further, the pixel value computation section obtains a sum pixel value (Jk) for each region (Ak) by summing pixel values on the each intensity distribution image for point (p, q) that belongs to each region (Ak). An image computation section creates a required radiographic image using the sum pixel values (Jk) of the region (Ak).

Abstract: A biochip device for detection of biologic molecules in a fluidic sample is disclosed in this invention. The biochip device comprises a plastic substrate, an IC chip, a sealing cover and a vacuum bag. The plastic substrate comprises a variety of microfluidic structures including an inlet region of loading the fluidic sample, a separation structure, a microfluidic channel, a structure for slowing the flow of the fluidic sample, a reaction region, a detection zone groove, and a closed area for collecting the fluidic sample. The plastic substrate is embedded with an IC chip and covered by a sealing cover made of polydimethylsiloxane, which is encapsulated by a vacuum bag, whereby the microfluidic structures in the plastic substrate are kept in vacuum state inside the vacuum bag.

Abstract: Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of treating a subject having, or at risk of developing, muscular dystrophy, sarcopenia, heart disease, or cachexia are also provided. The methods may include administering a pharmaceutical composition including the micro-dystrophin gene and a delivery vehicle to a subject. Further, the methods may include administering the pharmaceutical composition a subject having Duchenne muscular dystrophy or Becker muscular dystrophy.

Abstract: The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

Abstract: Graphene ink compositions as can be utilized with gravure and screen printing processes, to provide flexible electronic components with high-resolution printed graphene circuitry.

Abstract: An object of the present invention is to widen a range in which line of sight change is possible, particularly in a pan direction. According to the present invention it is possible to acquire high line of sight changing speed. A pan mirror is capable of rotation in forward and reverse directions about a third rotational axis. Also, the third rotational axis extends in a direction that is substantially parallel to a line of sight direction directed from a tilt direction control section to the pan mirror. An angle ? formed by the pan mirror and the third rotational axis is set in a range 0°<?<90°. The tilt direction control section can scan line of sight direction with respect to a virtual plane formed by a rotation locus of the pan mirror. The tilt direction control section can also control tilt angle of the line of sight direction from the pan mirror to a physical object.