Abstract: An encoder employs a trellis coded quantization (TCQ) unit and a compression unit. The TCQ uses a set of polynomials that have been selected to maximize granular gain. The TCQ unit operates on a block of samples from a source. The compression unit compresses bit planes of the TCQ output, using parity check matrices of corresponding LDPC codes, to obtain corresponding syndromes. The parity check matrices are selected so their compression performance approaches close to the limit for Slepian-Wolf coding. A decoder employs a decoding unit and an estimation unit. The decoding unit decodes the syndromes using side information to produce an estimate for the TCQ output. The side information is correlated with the source. The estimation unit estimates the block of source samples using the estimated TCQ output and the side information. Trellis coded vector quantization may be used as an alternative to TCQ.

Abstract: The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.

Abstract: An emotion recognition system for assessing human emotional behavior from communication by a speaker includes a processing system configured to receive signals representative of the verbal and/or non-verbal communication. The processing system derives signal features from the received signals. The processing system is further configured to implement at least one intermediate mapping between the signal features and one or more elements of an emotional ontology in order to perform an emotion recognition decision. The emotional ontology provides a gradient representation of the human emotional behavior.

Abstract: A Multi-Threshold CMOS NULL Convention Logic asynchronous circuit (MTNCL). The MTNCL circuit provides delay-insensitive logic operation with significant leakage power and active energy reduction. The MTNCL circuit is also capable of functioning properly under extreme supply voltage scaling down to the sub-threshold region for further power reduction. Four MTNCL architectures and four MTNCL threshold gate designs offer an asynchronous logic design methodology for glitch-free, ultra-low power, and faster circuits without area overhead.

Abstract: The present invention provides methods of utilizing a nucleoside derivative having the chemical formula of Formula (I) to downregulate expression of an anti-apoptotic protein such as survivin in a cell, induce apoptosis in a cell, inhibit angiogenesis in a cell, inhibit binding of p53 to DNA in a cell, inhibit phosphorylation of Akt in a cell and inhibit HIV transcription in a cell, by administering to the cell or tissue an amount of a compound of Formula (I) sufficient to achieve the desired activity. Formula (I): wherein the substituents Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri and Rk are as defined in the specification. A particularly preferred nucleoside derivative is ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carboxamide).

Abstract: The phase locked loop has a phase-frequency detector (PFD), a loop filter (LF), a voltage controlled oscillator (VCO), and a 3-stage frequency divider. The PFD receives a reference signal and a feedback signal to determine phase and frequency errors. The LF), coupled to the phase-frequency detector, filters the phase and frequency errors to generate a control voltage. The VCO, coupled to the loop filter, generates a VCO output signal according to the control voltage. The 3-stage frequency divider, coupled to the voltage controlled oscillator, divides the frequency of the VCO output signal 3 times to generate the feedback signal. The 3-stage frequency divider comprises three cascaded frequency dividers with different rangers of operating frequencies.

Abstract: Receivers and reception methods conduct spread spectrum reception using the energy of multiple bits, preferably a substantial number of bits, in a packet for correct alignment of the spreading code at the receiver. Code acquisition, as well as packet detection and acquisition are provided by embodiments of the invention. Preferred embodiment receivers and reception methods provide packet detection at low SINR looking at energy of multiple bits of the packet, frame synchronization using short preamble, timing recovery at low SINR looking at energy of multiple bits of the packet, quick code acquisition using parallel search for all possible code phases, code acquisition at low SINR, and tracking of acquired timing and code phase. Preferred embodiment receivers and reception methods use the energy of multiple bits for making decisions.

Abstract: A method for analysis of distributed device rule-sets for compliance with global policies includes enabling an administrator to specify a network topology with intercommunicating elements and parameters required to secure the intercommunication with access control elements of the network topology; establishing connections to the access controls elements to capture a snapshot configuration of device rule-sets of the access control elements; enabling the administrator to specify a set of global access constraints with reference to the access control elements; enabling the administrator to select between exhaustive analysis and statistical analysis; conducting the selected analysis to determine violations by the device rule-sets that fail to comply with the set of global access constraints, wherein statistical analysis quantitatively characterizes a level of compliance without conducting analysis of all potential network paths; and providing results of the selected analysis to the administrator through a graphic

Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Medical imaging often involves the collective use of information presented in multiple images of an individual, such as images generated through different imaging modalities (X-ray, CT, PET, etc.) The use of a composite of these images may involve image registration to adjust for the variable position and orientation discrepancies of the individual during imaging. However, registration may be complicated by soft tissue deformation between images, and implementations (particularly pure software implementations) of the mathematical models used in image registration may be computationally complex and may require up to several hours. Hardware architectures are presented that apply the mathematical techniques in an accelerated manner, thereby providing near-realtime image registration that may be of particular use for the short timeframe requirements of surgical environments.

Abstract: The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

Abstract: Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.

Abstract: A device for sensing a physiological signal comprises: two sensing units connected to the palms a subject respectively to receive a first electrocardiogram (ECG) signal; a filter for generating a second ECG signal by filtering the first ECG signal; an amplifying unit for generating a third ECG signal by amplifying the second ECG signal; an analog to digital converting unit for converting the third ECG signal into a digital signal; an operating unit for generating a plurality of analysis data by operationally analyzing the digital signal; and a display unit for displaying the plurality of analysis data. Therefore, the accuracy of the ECG is improved and the operation is simplified.

Abstract: A nanoimprint resist that includes a hyperbranched polyurethane oligomer (HP), a perfluoropolyether (PFPE), a methylmethacrylate (MMA), a diluent solvent and a photo initiator. A method of a nanoimprint lithography is also provided.

Abstract: A ground-plane slotted type signal transmission circuit board is proposed, which is designed for use with a high-speed digital signal processing system for providing a low-loss signal transmission function. The proposed circuit board structure is characterized by the formation of a slotted structure (i.e., elongated cutaway portion) in the ground plane at the beneath of each signal line. Since the slotted structure is a void portion, the electric field of a gigahertz signal being transmitting through the overlaying signal line would be unable to induce electric currents in the void portion of the ground plane. This feature allows the prevention of a leakage current that would otherwise flow from the signal line to the ground plane, and therefore can help prevent unnecessary power loss of the transmitted signal.

Abstract: Systems, methods, and computer readable media for fractional pre-emphasis of multi-mode interconnect are disclosed. According to one aspect, the subject matter described herein includes a method for fractional pre-emphasis of multi-mode interconnect. Multiple bits of binary data are periodically received. For each period, the multiple bits of binary data are encoded into multiple scalar values, each value representing a level of an analog signal to be output over a multi-mode interconnect system during the current period. Multiple analog signal outputs are generated corresponding to multiple scalar values, each signal output being driven to a level according to its corresponding scalar value. For each representative scalar value, a difference between the scalar value generated during the current period and the scalar value generated during the previous period is determined, and a pre-emphasis signal that is proportional to the difference is generated.

Abstract: The present invention relates generally to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of inhibitors of endocannabinoid membrane transport and combinations thereof.

Abstract: A pixel-based video encoding apparatus includes a block prediction unit, a residual image generation unit, a pixel prediction unit, and an entropy-coding unit. The block prediction unit performs temporal or spatial prediction between a reference image and a current image in order to generate a prediction block corresponding to a current block to be encoded. The residual image generation unit generates a residual image block composed of a residual signal corresponding to a difference between pixels of the prediction block and pixels of the current block. The pixel prediction unit determines whether to apply differential pulse coded modulation to each of pixels of the residual image block based on a rate distortion optimization value. The entropy-coding unit performs entropy-coding on the residual image block.

Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.

Abstract: Devices for generating a laser beam are disclosed. The devices include a silicon micro ring having at least one silicon optical waveguide disposed at a distance from the micro ring. The radius and the cross-sectional dimension of the micro ring, the cross-sectional dimension of the waveguide, and the distance between the micro ring and the waveguide are determined such that one or more pairs of whispering gallery mode resonant frequencies of the micro ring are separated by an optical phonon frequency of silicon. Methods of manufacturing a lasing device including a silicon micro ring coupled with a silicon waveguide are also disclosed.