Abstract: Compounds of formula: and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3. Pharmaceutically compositions and medicaments containing a compound of the invention are provided. The invention provides methods of treatment of protein kinase-related disease, disorders or conditions. The invention provides methods of treatment of GSK-3-related diseases, disorders or conditions.

Abstract: The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

Abstract: A loudspeaker includes an enclosure and at least one sound wave generator disposed in the enclosure. The sound wave generator includes at least one carbon nanotube structure. The carbon nanotube structure is capable of converting electrical signals into heat. The heat is transferred to a medium and causes a thermoacoustic effect.

Abstract: A method for inhibiting electromigration-induced phase segregation suitable for solder joint configurations used in a chip package is described as following. First, a chip package including a wiring board, a chip and numbers of solder joints is provided, wherein the chip is disposed on the wiring board, and the solder joints are disposed between the chip and the wiring board to electrically connect the chip to the wiring board. Next, a first current and a second current are alternately applied to a side of the solder joints, wherein flowing directions of the first current and the second current are opposite. The current density of the first current is 103˜105 A/cm2, and the current density of the second current is 103˜105 A/cm2.

Abstract: A metal oxide film suitable for protection of metals, composed mainly of aluminum. A metal oxide film includes a film of an oxide of a metal composed mainly of aluminum, having a thickness of 10 nm or greater, and exhibiting a moisture release rate from the film of 1E18 mol./cm2 or less. Further, there is provided a process for producing a metal oxide film, wherein a metal composed mainly of aluminum is subjected to anodic oxidation in a chemical solution of 4 to 10 pH value so as to obtain a metal oxide film.

Abstract: A method and apparatus are disclosed for predicting the service life of a metallic structure subjected to cyclic loading. Such structures experience fatigue, which can lead to failure after a number of loading cycles. The disclosed invention allows for an accurate prediction of the number of cycles to failure for a metallic structure by observing the slope of the rise in surface temperature of the structure after the cyclic loading has begun. The method of this invention provides early and accurate predictions of service life and does not require destructive testing. The method and apparatus of the present invention may be installed on working equipment, thus providing service life predictions for materials in real world use. The invention uses an empirically derived relationship that was confirmed using analytical relationships and material properties. The derived formula uses two constants that may be determined empirically using a disclosed process. The constants also may be estimated mathematically.

Abstract: A method of constructing a voided drilled shaft concrete structure is provided. Drilled shafts are large-diameter cast-in-place concrete structures that can generate extremely high temperatures during the concrete hydration/curing phase. The method includes creating an excavation, inserting a cage or an inner casing into the excavation, and filling with concrete the space between the outer surface of the cage or inner surface and the inner surface of the excavation.

Abstract: The present invention provides methods and compositions for identifying compounds which modulate cellular glycosylation. The invention further provides methods for treating subjects suffering from or at risk of developing a glycosylation associated disorder.

Abstract: Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.

Abstract: A method for identifying a person using their finger-joint print including the outer skin around the proximal interphalangeal joint of a finger, the method comprising: capturing (10) an image of the finger-joint print of the person; extracting (12) a region of interest (ROI) based on a local convexity property of the finger-joint print; extracting (13) features representing the orientation of the lines in a finger-joint print image from the ROI using an extended Gabor phase coding scheme and the extracted features are represented in competitive code maps; wherein angular distance between the competitive code maps is compared (14) with a reference set in a database to identify the person.

Abstract: A laser system provides harmonic generation in a laser beam pulse. In another aspect of the present invention, a laser operably remits a laser pulse, a gaseous optical medium operably creates third or greater harmonic generation in the pulse, and a controller characterizes and compensates for distortions in the pulse. A further aspect of the present invention employs multiple optical media arranged to cause cascading harmonic generations in a laser pulse.

Abstract: A motion function of a biological tissue is efficiently evaluated on the basis of image data collected from different medical image diagnostic apparatuses. In terms of a common analysis algorithm applied to subject's time-series image data supplied from a separate medical image diagnostic apparatus, a setting part sets a plurality of interest points on a myocardial tissue of a reference image data extracted from the image data, and a tracking process part measures a motion parameter on the basis of displacement information of the myocardial tissue at the interest points obtained by a tracking process between the reference image data and subsequent image data thereof. Meanwhile, a data creating unit creates parameter image data showing two-dimension distribution of the motion parameter or parameter time-series data showing a variation in time of the motion parameter as parameter data on the basis of the measurement result, and displays the parameter data.

Abstract: The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts and antimicrobial agents in coatings for medical articles. The coatings have an anti-irritant effect and inhibit transmission of infectious disease.

Abstract: A method for forming photonic particles, where the method includes the steps of preparing a porous photonic material layer, patterning a soluble polymer on the porous photonic material layer, leaving dividing portions of the material layer untreated, infusing the polymer into the material layer, and removing the dividing portions of the material to obtain the photonic particles.

Abstract: Methods are described for screening a subject for risk of Charcot-Marie-Tooth Disease Type 2A or for diagnosing Charcot-Marie-Tooth disease or a predisposition for developing Charcot-Marie-Tooth disease in a subject, by detecting the presence or absence of a mutation in the mitofusin gene in a biological sample collected from the subject. Methods are also described for detecting the presence of a genetic polymorphism associated with Charcot-Marie-Tooth Disease Type 2A in a sample of patient nucleic acid, by amplifying a mitofusin gene sequence in the patient nucleic acid to produce an amplification product; and identifying the presence of a Charcot-Marie-Tooth Disease Type 2A associated polymorphism in the amplification product.

Abstract: A method for amplifying a trace amount of mRNA includes adding a dummy RNA to a solution containing the trace amount of mRNA, so as to prepare a mixed solution; synthesizing an anti-sense DNA by reverse transcription, which uses the mixed solution as a template; synthesizing a sense DNA which is complementary to the anti-sense DNA thus synthesized, so as to generate a double-strand DNA made of the sense DNA and the anti-sense DNA; ligating an RNA polymerase promoter sequence to the double-strand DNA thus generated, on a sense DNA 5? end side of the double-strand DNA, so as to prepare a double-strand DNA for amplification; and amplifying, by using RNA polymerase, an RNA from the double-strand DNA for amplification.

Abstract: A data visualization system may allow an untrained user to easily, rapidly, and unambiguously specify the content and format of a report about information. A user interface may present to a user and receive from the user a selection of a plurality of selectable visualization types, selectable data objects, and selectable data specifications. The user interface may display all of the selections which the user makes as a single composite phrase.

Abstract: A frame includes a pair of parallel arms that are transversely spaced apart from one another. A first brace interconnects the parallel arms at their respective leading ends and a second brace interconnects the parallel arms at their respective mid-lengths. A table has a first end hingedly connected to the second brace. A first and second plurality of teeth is provided along an extent of the first and second arms, respectively. First and second support struts hingedly interconnect the table to preselected teeth when the table is in a first angular position relative to the frame. First and second book supports are slideably mounted on the table and lockable into any selected position. The parallel arms are releasably attached to the armrests of a conventional wheelchair. The support struts are disengaged from the teeth to enable folding the table into a horizontal storage position where it overlies the frame.

Abstract: A routing method of a wireless network system is provided. Paths of the wireless network system are divided into down-stream and up-stream paths. The up-stream paths are reset for each period, or whenever a network is changed, or whenever transmission of data fails more than a predetermined number of times. Accordingly, it is possible to secure an average lifetime of a wireless network system by previously preventing a bottleneck from occurring at a specific node, increase a transmission speed of data by reducing the hop count to the sink node connected to the information collector, and reduce power consumption of a battery.

Abstract: The invention provides a target and methods for specific binding and inhibition of RNAP from bacterial species. The invention is directed to a method for identifying agents that bind to a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, comprising preparing a reaction solution comprising the agent to be tested and an entity comprising a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, and detecting presence or amount of binding. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.