Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.

Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.

Abstract: The present invention provides novel photobioreactors, modules thereof, and methods for use in culturing and harvesting algae and cyanobacteria.

Abstract: The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications.

Abstract: The present invention relates to a plasma biomarker for diagnosing hepatocellular carcinoma (HCC), in particular to the discovery of a protein in plasma using 2-D fluorescence differential gel electrophoresis (2-D DIGE), immunoprecipitation and Nano-liquid chromatography mass spectrometry (Nano-LC-MS/MS) system that was unknown on the basis of conventional techniques. By demonstrating the presence of liver carboxylesterase 1 (hCE1) in human plasma and confirming that its secretion level is higher in patients with HCC than in healthy volunteers, this invention may be used as a screening method to diagnose HCC at an early stage.

Abstract: The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.

Abstract: A non-volatile logic gate, including a magnetic material having a shape induced magnetic anisotropy, wherein a shape of the magnetic material has a first vertex, a second vertex, and a third vertex and supports a single magnetic domain; regions of the magnetic material including a first input region adjacent the first vertex, a second input region adjacent the second vertex, and an output region adjacent a third vertex; the first input region for receiving a first logic input to the logic gate, the second input region for receiving a second logic input to the logic gate, and the output region for outputting at least one logic output of the logic gate; and the shape induced magnetic anisotropy determining at least part of a truth table for the logic gate, so that the logic gate produces the at least one logic output from the logic inputs using the shape.

Abstract: A system for detecting a spinal injury region containing injured spinal nerve cells may include a swarm of nanosensors that are configured to detect chemical signals released by the injured spinal nerve cells, and are coated with a magnetic material. A magnetic field generator may controllably generate a magnetic field so as to magnetically levitate the magnetically coated nanosensors. An imaging subsystem may detect the positions of the nanosensors. A controller may control the intensity and direction of the magnetic field in a feedback loop, in response to the detected positions of the nanosensors, so that the attractive force that attracts each nanosensor toward the injured spinal cell as a result of the chemical affinity of the nanosensor is iteratively supplemented by the magnetic levitation force applied to that nanosensor, until substantially all of the nanosensors are agglutinated around the spinal injury region.

Abstract: A polymer electrolyte membrane for a polymer electrolyte fuel cell, a method of manufacturing the same, and a polymer electrolyte fuel cell system including the same are disclosed, and the polymer electrolyte membrane includes a hydrocarbon-based proton conductive polymer membrane. The polymer membrane has a surface contact angle ranging from 80° to 180°.

Abstract: The disclosed subject matter provides on ore more imaging techniques during passive auditory stimulation to objectively provide a diagnostic indicator of ASD. These techniques include functional MRI (fMRI), diffusion tensor imaging (DTI) and tractography, and combinations thereof. In one embodiment, a method is disclosed that uniquely provides an objective (imaging) physiological technique to diagnose early autism and to monitor progress following therapeutic intervention.

Abstract: Laser-Scanning Intersecting Plane Tomography (L-SIPT) can provide a non-contact imaging geometry that can allow high speed volumetric scanning, such as of non-scattering to moderately scattering tissues. The L-SIPT imaging apparatus can include a first lens, located and configured to receive from a sample light received from different depths of the sample. A first light redirector can be located and configured to receive via the first lens and to redirect light received from the different depths of the sample to provide redirected light to a light detector capable of detecting individual measurements of light at different locations along a first direction.

Abstract: Methods and systems for indoor navigation utilize a smartphone equipped with various sensors. When a person whose initial position is unknown, and in some circumstances whose sight has been impaired, specifies a destination, the navigation system will calculate the coordinates of his/her present location from the sensor readings. It will then calculate the distance to be traveled to the destination and form routes to direct him/her towards the desired location. These steps are carried out using sensor readings and in some cases magnetic maps of the interiors of buildings stored on the smartphone. In some cases dynamic time warping (“DTW”) is used to align a recorded signature of the person's movement through the building with a stored magnetic map in order to identify the person's location within the building.

Abstract: The rare-earth complex of the present invention has high luminous efficiency, since it has a structure represented by the following general formula (I):

Abstract: Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.

Abstract: The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosaccharides.

Abstract: Microreactors, methods of fabricating, and using such microreactors comprises a substrate having an outer periphery and composing two monolithic sections, each of said monolithic sections comprising two opposed main surfaces and one or more edges extending between the main opposed surfaces. One of the main surfaces from each of the monolithic sections are joined together at a substantially planar junction. The microreactor further comprises at least one microcapillary flow passage defined by surfaces within said substrate and having first and second ends. One or more inlets connect the outer periphery of said substrate with the first end of said microcapillary flow passage. One or more outlets connect the outer periphery of said substrate with the second end of said microcapillary flow passage, which may narrowingly taper. The substrate can be made from high purity fused silica. A metallic reagent and/or catalyst can be incorporated in the micro capillary passage.

Abstract: A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

Abstract: A method and apparatus for achieving very high deposition rate magnetron sputtering wherein the surface of a target and especially the race track zone area of the target, in one embodiment may be heated to such a degree that the target material approaches the melting point and sublimation sets in. Controlled heating is achieved primarily through the monitoring of the temperature of the target material and with the aid of a processor subsequently controlling the target temperature by adjustment of the power being inputted to the target. This controlled heating to the sublimation point is particularly effecting in high deposition rate metal coating of parts when used in conjunction with HIPIMS deposition.

Abstract: An organic thin field transistor is disclosed. The organic thin field transistor includes a first and a second insulting layers, a metal structure and an organic layer serving as an active layer. Materials of the first and the second insulting layers are different, and by performing an etching process, a surface of the metal structure and a surface of the second insulting layer are effectively aligned. Because of the high flatness of the surface of the metal structure and the second insulting layer, a continuous film-forming property and crystallinity of the active layer of the organic thin field transistor are improved, so as to achieve a better the electrical characteristic.

Abstract: Disclosed is a sterilizer for foods, which contains calcinated calcium or calcium hydroxide and has a higher sterilizing activity than conventional sterilizers. The sterilizer is made up of an aqueous solution or an aqueous dispersion prepared by blending calcinated calcium or calcium hydroxide, ethanol, and sodium lactate.