Abstract: RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

Abstract: An exemplary, highly integrated, SPM-based system for measuring the conductivity and/or force of substance under programmable engaging/stretching processes is described. A sample bias is applied across two electrodes. A substance to be measured is sandwiched between them. A first electrode is first brought relative to a second electrode (engaging) in programmable pathways that can be described as stretching distance versus time curves. The process of engaging the electrodes continues until a certain current reached, a certain force reached and whichever case happens first. The electrodes are then separated (stretching) in programmable pathways that can be described as stretching distance versus time curves. A periodic modulation can be applied to the engaging/stretching process to realize different stretch pathways. The sample bias across the electrodes is kept constant or swept in a programmable shape over time, described as a voltage-versus time curve.

Abstract: The present embodiments provide methods for facilitating closure of a bodily opening. In one exemplary method, at least a portion of a first tacking device is disposed through at least a portion of tissue at a first location in a vicinity of an opening in the tissue. Then, at least a portion of a second tacking device is disposed through at least a portion of tissue at a second location in the vicinity of an opening in the tissue. A closure member having at least one loop portion is advanced towards the first and second tacking devices, and the loop portion is positioned around at least a portion of the first tacking device and at least a portion of the second tacking device. The closure member then is actuated to urge the first tacking device towards the second tacking device to provide a compressive force upon the opening.

Abstract: A method assigns importance ranks to nodes in a linked database, such as any database of documents containing citations, the world wide web or any other hypermedia database. The rank assigned to a document is calculated from the ranks of documents citing it. In addition, the rank of a document is calculated from a constant representing the probability that a browser through the database will randomly jump to the document. The method is particularly useful in enhancing the performance of search engine results for hypermedia databases, such as the world wide web, whose documents have a large variation in quality.

Abstract: The method for generating an integrated guidance law for aerodynamic missiles uses a strength Pareto evolutionary algorithm (SPEA)-based approach for generating an integrated fuzzy guidance law, which includes three separate fuzzy controllers. Each of these fuzzy controllers is activated in a unique region of missile interception. The distribution of membership functions and the associated rules are obtained by solving a nonlinear constrained multi-objective optimization problem in which final time, energy consumption, and miss distance are treated as competing objectives. A Tabu search is utilized to build a library of initial feasible solutions for the multi-objective optimization algorithm. Additionally, a hierarchical clustering technique is utilized to provide the decision maker with a representative and manageable Pareto-optimal set without destroying the characteristics of the trade-off front. A fuzzy-based system is employed to extract the best compromise solution over the trade-off curve.

Abstract: A system analyzes content accessed at a network site to determine whether it is malicious. The system employs a tool able to identify spyware that is piggy-backed on executable files (such as software downloads) and is able to detect “drive-by download” attacks that install software on the victim's computer when a page is rendered by a browser program. The tool uses a virtual machine (VM) to sandbox and analyze potentially malicious content. By installing and running executable files within a clean VM environment, commercial anti-spyware tools can be employed to determine whether a specific executable contains piggy-backed spyware. By visiting a Web page with an unmodified browser inside a clean VM environment, predefined “triggers,” such as the installation of a new library, or the creation of a new process, can be used to determine whether the page mounts a drive-by download attack.

Abstract: Transmission efficiency and/or spatial resolution provided by resonant apertures can be enhanced by disposing a tip on part of the screen that extends laterally into the aperture. For example, a tip disposed on the ridge of a C-shaped aperture can dramatically improve performance. A spatial resolution of ?/50 has been experimentally demonstrated with this approach. The combination of high spatial resolution and high transmission efficiency provided by this approach enables many applications, such as near field optical probes for near field scanning optical microscopy (NSOM). Another application is high resolution electron sources, where an photoelectron emitter can be disposed at or near a tip+aperture structure such that the high resolution optical near-field provides a correspondingly high resolution electron source.

Abstract: Systems, apparatus and methods that use a hidden Markov model to estimate motion of a sample under measurement and to reduce a motion-induced effect in the measurement. MRI systems and other sample measurement systems can be implemented based on motion sensing using the hidden Markov model. Recursive and non-recursive estimation processes are described.

Abstract: An ignition system (10) comprises a spark plug (12) having a first end (14) defining a spark gap (16) between a first electrode (18) and a second electrode (20). A transformer (46) comprising a primary winding 44 and a secondary winding (50) also forms part of the system. The secondary winding is connected in a secondary circuit to the first electrode 18 and the secondary winding has a resistance of less than 1 k? and an inductance of less than 0.25 H. A drive circuit (26) is connected to the primary winding.

Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Abstract: A fabric strain sensor (10) for measuring in-plane unidirectional strain, the sensor (10) comprising a mixture (20) of electrically conductive particles or fibers and an elastomer matrix, applied onto an elastic fabric substrate (30).

Abstract: A composition for diagnosing amyloid-related diseases, which comprises a flavone derivative, a chalcone derivative, a styrylchromone derivative, or a coumarin derivative, is provided. These compounds have high binding specificity to an amyloid ? protein, high permeability to a blood-brain barrier, and ability to rapidly disappear from sites other than cerebral senile plaque. Accordingly, the composition of the present invention using these compounds enables the diagnosis of amyloid-related diseases with high precision.

Abstract: Methods and systems for image registration implementing a feature-based strategy that uses a retinal vessel network to identify features, uses an affine registration model estimated using feature correspondences, and corrects radial distortion to minimize the overall registration error. Also provided are methods and systems for retinal atlas generation. Further provided are methods and systems for testing registration methods.

Abstract: A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red light when the nanorod is in a first position. The short axis of the gold nanorod scatters green light when the nanorod is in a second position. A polarizing filter filters the red and green light to detect the rotational motion by observing alternating red and green lights. A detection DNA stand (50) is coupled between the gold nanorod and the molecular structure. The detection DNA strand hybridizes with a target DNA strand (58) if the target DNA strand matches the detection DNA strand to form a structural link between the molecular structure and gold nanorod.

Abstract: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes.

Abstract: A method of controlled p-type conductivity in (Al,In,Ga,B)N semiconductor crystals. Examples include {10 11} GaN films deposited on {100} MgAl2O4 spinel substrate miscut in the <011> direction. Mg atoms may be intentionally incorporated in the growing semipolar nitride thin film to introduce available electronic states in the band structure of the semiconductor crystal, resulting in p-type conductivity. Other impurity atoms, such as Zn or C, which result in a similar introduction of suitable electronic states, may also be used.

Abstract: The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A2B adenosine receptors (ARs).

Abstract: Provided herein is are unified control methods and implementations for controlling single and three-phase power converters. In an exemplary embodiment, a unified controller is provided that can be used to control a three-phase three-wire Voltage Source Inverter (VSI), a three-phase four-wire VSI, a three-phase grid-connected power converter for current shaping, and a single-phase full bridge VSI.

Abstract: The present disclosure relates to cationic divalent metal catalysts useful for the polymerization of cyclic esters, methods for their preparation and uses thereof.

Abstract: The invention provides a compound comprising a xanthone or thiaxanthone sensitizing moiety, capable of coordinating to a lanthanide ion by the nitrogen atom of an integral pyridyl group or a related group able to bind a lanthanide ion.