Abstract: The present disclosure provides an artificial lens fixing sac for fixing an artificial lens for cataract surgery. The artificial lens fixing sac for fixing an artificial lens for cataract surgery of the present disclosure is installed at a position of a lens that is removed by cataract surgery, and the artificial lens fixing sac includes an implantation hole in which an artificial lens, which is inserted into an internal space of the artificial lens fixing sac, is implanted at the position of the removed lens, and fixing threads installed at predetermined intervals on an outer peripheral edge of the artificial lens fixing sac to fix the artificial lens fixing sac to a sclera.

Abstract: A composition composed of highly reactive metal particles that are ball milled, bead milled or blended and dispersed in a solvent with/without polymer for significantly reducing the viscosity of heavy oil for extracting viscous heavy oil, such that the composition reacts with water and oil to produce heat, H2 gas, and hydroxide to lower the oil viscosity and facilitate extraction from an underground formation or transport of heavy oil, such as in a pipe from one place to another place.

Abstract: An expanding dowel-pin comprises an upper-collet, inside-conical bore with one or more upper-collet slits. The expanding dowel pin further includes a double-tapered cylinder with tapered cones tapering more narrowly from its middle. The expanding dowel pin further includes a lower collet with a lower-collet, inside-conical bore which has one or more lower-collet slits. The lower collet further includes a lower-collet, inside-straight bore with lower-collet internal screw threads. The upper collet, the double-tapered cylinder, and the lower collet are, in that order, configured to have a bolt pass therethrough. The lower-collet internal screw threads are configured to engage the bolt, such that, when the bolt is rotated a first direction relative to the lower collet, the upper collet and the lower collet are configured to be compressed together by the bolt. The compression by the bolt results in the expansion of the upper-collet and the lower-collet.

Abstract: Systems, methods, and techniques are described herein for characterizing well treatment fluids and well treatment fluid performance. For example, well treatment fluids can be characterized using microfluidic chips to determine fluid properties, with very small amounts of fluid used for the characterization process. Optical analysis and electrical conductivity analysis of well treatment fluids as they pass through different microfluidic pathways with different cross-sectional dimensions can be used to gain information about the well treatment fluid's composition, structure, and performance. In some cases, microfluidic pathways can be functionalized as a model for a wellbore and a reservoir (e.g., rock in the reservoir) to evaluate the performance of well treatment fluids by imaging the well treatment fluid as it flows into or through the functionalized model. These systems, methods, and techniques can allow for optimization of well treatment fluids prior to or during drilling or completion operations.

Abstract: Systems and methods for optimizing data-driven decision-making in multi-agent systems are described. The system may construct an equilibrium concept to capture multi-layer and/or k-level depth reasoning by agents. The system may determine best-response type conjectures for agents to interact with one another. In some examples, the system may include a machine or an algorithm interacting with a strategic agent (e.g., a human or an entity). The system may include methods for: (1) data-driven estimation and/or learning of conjectures and associated depth; and (2) data-driven design of algorithmic mechanisms for exploring the conjectural equilibrium (CE) space by influencing the strategic agent(s) behaviors through adaptively adjusting and estimating deployed strategies.

Abstract: A method and apparatus for training a neural network model are provided. The method of training a neural network model includes storing replay samples selected from among online stream samples in a replay buffer, selecting batch samples from the replay samples based on selection frequencies of the respective replay samples, determining a freeze layer group of the neural network model based on forward propagation of the neural network model using the batch samples, and training the neural network model based on backward propagation of layers not in the freeze layer group.

Abstract: Systems and methods for providing a decentralized marketplace for patient-generated health data are provided. The systems and methods can store medical records on an interplanetary file system (IPFS) and blockchain, with the ability to encrypt and decrypt data on the IPFS and blockchain. This can securely associate and/or dissociate users from their “owned” property, securely transfer the ownership of records, securely share the records to other users, facilitate payment for nonfungible token (NFT) records, and/or facilitate transfers to aggregators of health records.

Abstract: In various embodiments, the present invention provides a drug-loaded amino acid-based poly(ester urea) film for controlled local release of non-opioid analgesic compounds and various methods for their making and use. In one or more embodiments, he present invention is directed to a drug-loaded amino acid-based poly(ester urea) film for controlled local release of non-opioid analgesic compounds comprising an amino acid-based poly(ester urea) polymer or copolymer and a therapeutically effective amount of a non-opioid analgesic compound. In various embodiments, these amino acid-based poly(ester urea) polymers or copolymers will comprise a plurality of diester monomer units connected by a carboxyl group to form a poly(ester urea) (PEU) polymer.

Abstract: Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as memory formation. However, the molecular mechanisms by which NK cells persist to form memory cells are not well understood. Using single cell RNA sequencing, we identified two distinct effector NK cell (NKeff) populations following mouse cytomegalovirus (MCMV) infection. Ly6C? memory precursor (MP) NK cells displayed enhanced survival during the contraction phase in a Bcl2-dependent manner, and differentiated into Ly6C+ memory NK cells. Our studies show that a NK cell-intrinsic checkpoint is controlled by the transcription factor Fli1 which limits MP NK formation by regulating early effector NK cell fitness during viral infection. Building upon this discovery, we have designed methods and materials for modulating the molecular mechanisms that regulate memory cell fate in NK cells, such as genetically modified NK cells having a deletion in the gene for the transcription factor Fli1.

Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. The fasting mimicking diet provides the subject with at most 50% to 75% of the subject's normal caloric intake. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

Abstract: Methods are disclosed for generating a target mean arterial pressure (MAP) for a patient during a surgery. In some implementations, the disclosed methods include calculating the target MAP based on the age, biological sex, emergent surgery status, and American Society of Anesthesiology (ASA) physical status (PS) class of the patient, and a predetermined intraoperative hypotension (IOH) risk benchmark. Treating the patient to maintain a MAP at or above the target MAP during the surgery reduces a risk of IOH during the surgery, a risk of administering an unnecessary therapy to avoid IOH during the surgery; and a risk of not administering a therapeutic MAP-decreasing action during the surgery. In some implementations, the method further comprises conducting the surgery on the patient and treating the patient to maintain the MAP of the patient at or above the target MAP during the surgery. Also provided are systems for implementing the disclosed methods.

Abstract: A method of adaptively scanning a selected area that includes selecting an imaging mode, performing a scan of the selected area using the imaging mode, detecting an item of interest, automatically selecting a new imaging mode in response to detecting the item of interest, and performing a scan of the item of interest using the new imaging mode. The imaging mode may determine at least one of a scanning pattern, a scanning speed, and a scanning rate. Spectral data and image data may be gathered and used to detect the item of interest. The method may also include providing a scanning spectrometer system that has a gimbal system configured to provide at least two degrees of freedom to the scanning spectrometer system. The gimbal system may have a spectrometer and a camera each mounted on the gimbal system and configured to gather the spectral data and the image data, respectively.

Abstract: Methods and compositions for nuclear delivery and transcriptional repression employ a cell-penetrant MeCP2 fusion protein.

Abstract: A temperature-corrected biochemical sensor includes an optical resonator disposed proximate a single-mode optical fiber, the optical resonator being optically coupled to the optical fiber to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect the optical whispering-gallery output light to provide sensor signals; a temperature-correcting optical system to provide a reference beam of light to be combined at least partially coherently with a return light from the resonator to provide an interference light and convert, the interference light to temperature-correction signals; a data storage device comprising temperature calibration data for at least the optical fiber and the optical resonator; and a data processing system to calculate at least one physical property of a particle in contact with the optical resonator using the sensor signals such that the calculated physical property is temperature corrected using the temperature calibration data and the temper

Abstract: The invention relates to a perovskite solar cell modified by a chelating layer and its preparation method, within the field of perovskite material preparation. The process involves spin-coating N, N?-bis(4-pyridyl)-1,4,5,8-naphthalenetetracarboxylic diimide (DPNDI) solution on the perovskite surface, followed by annealing. This modification forms a chelating structure on the surface, passivating defect sites and grain boundaries, promoting charge transfer with optimized energy levels and carrier mobility. The Pb (II) coordination polymer layer enhances bonding strength and adhesion, effectively suppressing traps. The treated perovskite solar cell achieves a photoelectric conversion efficiency (PCE) of 24.2%, with a T80 lifetime retaining over 95% (40° C.) and 85% (85° C.) of the initial PCE after 2000 hours. This modified film inhibits ion migration, providing enhanced stability and high photoelectric conversion efficiency in optoelectronic devices.

Abstract: Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. The adaptor mates with an ultrasound probe to provide the medical operator ultrasound feedback of the position of the member, thus allowing internal placement without the need for more specialized medical equipment.

Abstract: A system implements a modeling (ClassGP) and an optimization (ClassBO) framework that models heterogeneous functions with knowledge of individual partitions within classes, i.e., heterogeneous functions including non-stationary functions which can be divided into locally stationary functions over partitions of input space with an active stationary function in each partition. The framework constructs a class likelihood for the class by combining log marginal likelihoods associated with each partition of the plurality of partitions within the class. The framework aims to improve analysis of systems that are characterized by a discrete and finite number of “classes” of behaviors.

Abstract: A precursor is made of a polymer or the polymer and a high-temperature material. The polymer includes at least one of silicone material, cellulose, hydrogel, and acrylic acid ammonium salt polymer. The silicone material is silicone rubber, and the high-temperature material includes one of ceramics, glass, metal, diamond, and high-temperature composite material.

Abstract: A glass fiber-based structural composite offers an alternative or supplement to carbon fibers in areas such as battery storage. Through electroless deposition of conductive materials like copper and nickel, the glass fiber surface is made conducting and functions as a good current collector. By using anode and cathode materials like manganese (II, III) oxide and Zinc, cathode and anode mats on the copper- and nickel-coated glass fibers are created via hydrothermal and electro-deposition methods. In one example application, the anode and cathode mats are in an alternate square patterned arrangement using copper and nickel-coated glass fiber as a current collector. The device, with a capacity of >300 mAh/g at 0.1 A/g is assembled using an alternate system of epoxy and electrolyte. Uncoated pristine glass fiber ladened and patterned with electrolyte are used as a separator. Uncoated pristine glass fiber ladened with epoxy can be used as an insulator between two devices.

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.