Abstract: The present invention pertains a turbine arrangement comprising a compressor, a recuperator, a combustion chamber with the combustion air supply, a gas turbine, a heat exchanger, an expansion turbine for expanding the vaporized working medium, and wherein the compressor, the gas turbine and the expansion turbine are arranged on a common shaft which is connected to a generator for generating electrical energy.

Abstract: Provided are automated cell culture systems and related in vitro cell culture methods, including for a co-culture of different cell populations having different cell culture conditions. For example, the system may comprise a bioreactor having a plurality of cell culture compartments, the bioreactor having a fluid port fluidly connected to the plurality of cell culture compartments. A pump fluidly connected to the fluid port can provide a cell culture medium to the plurality of culture compartments. A sensor is operably connected to at least one of the plurality of cell culture compartments for measuring at least one cell culture parameter. In this manner, a controller electronically connected the pump and sensor, is configured to automatically adjust a pump flow rate and/or a cell culture gas content to provide a desired steady-state cell culture parameter for facilitating cells interactions and collection of products representative of said interactions.

Abstract: Provided herein are methods for treating nonalcoholic steatohepatitis (NASH) in a subject, comprising administering to a subject having NASH an effective amount of a CCK receptor inhibitor.

Abstract: Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA.

Abstract: An ultrafast non-volatile memory cell for wafer-scale integration includes a voltage divider that outputs an output voltage. The voltage divider includes a reference resistive device that is a reference magnetic tunnel junction or another reference resistive component and a switchable magnetic tunnel junction that includes a free magnet and a fixed magnet. The switchable magnetic tunnel junction configured such that the free magnet is light switchable between a high impedance state and a low impedance state upon application of an electric signal and incident light. A transistor switch is configured to activate the voltage divider for memory write and read operations. A light modulator is in electrical communication with the output voltage from the voltage divider. The light modulator is configured to modulate a guided light beam for memory read operations. Arrays of the memory cells are also provided.

Abstract: A ride system includes one or more sensors and a controller. The controller receives, from the one or more sensors, position data indicative of the position of a body and/or face of guest on the ride. Using the position data, the one or more controllers, determine a face direction, face rotation, or both of the guest, independent of sensor observations of the face direction and rotation. One or more features of the ride are controlled based upon the determined face direction and/or face rotation.

Abstract: Disclosed are compounds, pharmaceutical compositions, and methods of treatment. The disclosed compounds are based on fused 1,4-diazepine and pyrrolidinedione scaffolds.

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

Abstract: The present disclosure provides a method for performing a handoff by a vehicle in an IP-based vehicular network, the method including: transmitting a first router solicitation (RS) message to a first road-side unit (RSU) to access the vehicular network, the first RS message including mobility information of the vehicle; and receiving a first router advertisement (RA) message from the first RSU as a response to the first RS message, the first RA message including a first prefix of the first RSU for configuring an address of the vehicle, wherein the vehicle performs a first address registration procedure based on the first prefix.

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

Abstract: Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A dynamic capacitive sensor configuration is disclosed which imposes minimal force and resistance to motion on the moving electrode. Moving electrodes avoid adverse effects of large bias voltages such as pull-in instability, despite arbitrary levels of compliance. This configuration facilitates incorporation of highly compliant and thin electrode materials that present the least possible resistance to motion. This type of material is particularly useful for sensing sound. A large bias voltage can be applied without influencing its motion, e.g., 400 V. The electrical sensitivity to sound is high, e.g., approximately 0.5 volts/pascal, two orders of magnitude greater than typical acoustic sensors.

Abstract: The present invention provides a magnetic-control measurement system, comprises a reaction container and a programable magnetron measurement unit.

Abstract: Systems and methods for providing a decentralized marketplace for patient-generated health data are provided. The systems and methods can store medical records on an interplanetary file system (IPFS) and blockchain, with the ability to encrypt and decrypt data on the IPFS and blockchain. This can securely associate and/or dissociate users from their “owned” property, securely transfer the ownership of records, securely share the records to other users, facilitate payment for nonfungible token (NFT) records, and/or facilitate transfers to aggregators of health records.

Abstract: An information interaction system and method for heterogeneous detection and recognition devices for a low-altitude unmanned aerial vehicle (UAV) are provided, where each edge data unit is connected to a uniquely corresponding low-altitude UAV detection and sensing device and an access and distribution unit. The access and distribution unit is connected to a storage service unit and at least one scheduling and calculation unit. Each scheduling and calculation unit is connected to a comprehensive calculation and display unit. The comprehensive calculation and display unit is connected to the storage service unit. The storage service unit sends historical data to the comprehensive calculation and display unit after being authorized. The method is applied to the information interaction system for heterogeneous detection and recognition devices for a low-altitude UAV. A problem of data collaborative application of different low-altitude UAV detection devices is resolved.

Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.

Abstract: Methods for the early sensing of tissue ischemia and/or infarctions within organs using the spectroscopic features of serum luminescence include (i) isolating serum from a blood sample, (ii) directing an excitation light at the serum, (iii) receiving an endogenous serum chromophore emission light from the excited serum, and (iv) determining a presence of an ischemic condition based on the intensity of the endogenous serum chromophore emission light. Methods of detecting organ dysfunction can include transmitting excitation light to luminal contents of a mammalian blood vessel comprising trace amounts of exogenous chromophores administered to the subject mammal via the circulatory system. Transdermal luminescence measurements from the trace amounts of exogenous chromophores can then be used to determine organ dysfunction.

Abstract: The present invention provides a multi-wavelength spectral thermometry based on mobile narrow-band window and optimization and belongs to the field of thermal radiation temperature detection. A continuous spectrum of a thermal radiation object is collected by a spectrometer; the spectrum of the thermal radiation object is denoised, windowed and standardized; the whole detection wavelength range is traversed within an appropriate narrow-band window; through comparison with windowed and standardized black-body radiation spectra at different temperatures in a corresponding spectral window, the temperature and emissivity distribution of the thermal radiation object is calculated with high accuracy without depending on emissivity model estimation, and high universality and noise resistance are achieved.

Abstract: A fluidized coal mining method utilizing self-energy storage of a coal seam is provided, and includes developing a mine roadway, uncovering coal actively, mining coal in fluidization, and backfilling a goaf. Dynamic phenomenon is induced by uncovering the coal actively, a coal-mining drilling well is established from a ground to the coal seam, and the coal seam is subjected to hydraulic in-situ cutting, and a coal-rock mixture subjected to hydraulic cutting flows into a roadway system along a floor roadway, and then coal, gangue and water in the mixture are separated and recycled in a subsequent circulating coal mining process.