Patents Assigned to University
  • Patent number: 12252746
    Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: March 18, 2025
    Assignee: The Regents of the University of California
    Inventors: Bin Liu, Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens
  • Patent number: 12251234
    Abstract: Methods for the early sensing of tissue ischemia and/or infarctions within organs using the spectroscopic features of serum luminescence include (i) isolating serum from a blood sample, (ii) directing an excitation light at the serum, (iii) receiving an endogenous serum chromophore emission light from the excited serum, and (iv) determining a presence of an ischemic condition based on the intensity of the endogenous serum chromophore emission light. Methods of detecting organ dysfunction can include transmitting excitation light to luminal contents of a mammalian blood vessel comprising trace amounts of exogenous chromophores administered to the subject mammal via the circulatory system. Transdermal luminescence measurements from the trace amounts of exogenous chromophores can then be used to determine organ dysfunction.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: March 18, 2025
    Assignees: University of Macau, CATYDID Technology Ltd.
    Inventor: Tzu-Ming Liu
  • Patent number: 12255338
    Abstract: Atomically dispersed platinum-group metal-free catalyst and method for synthesizing the same. According to one embodiment, the catalyst is made by a method in which, in a first step, an Mn-doped ZIF-8 catalyst precursor is prepared by reacting a first solution comprising zinc nitrate hexahydrate and manganese chloride dissolved in an acid/water solution with a second solution comprising 2-methylimidazole dissolved in water. Then, in a second step, the Mn-doped ZIF-8 catalyst precursor is thermally activated, i.e., carbonized, to form an Mn—N—C catalyst. Preferably, the thermal activation is performed in a multistep fashion, first at a lower temperature of about 800° C. and then at a higher temperature of about 1100° C. After carbonization, the catalyst material may optionally be subjected to an absorption process, followed by a second thermal activation. The absorption process may involve dispersing the catalyst material in a solution of manganese chloride and urea in hydrochloric acid and isopropanol.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: March 18, 2025
    Assignees: The Research Foundation for the State University of New York, Giner, Inc.
    Inventors: Gang Wu, Hui Xu, Mengjie Chen, Fan Yang
  • Patent number: 12255056
    Abstract: A diagnostic method and system for measuring potential and electric field of plasma are provided. According to operation parameters of a magnetic confinement fusion device and relevant parameter data of a plurality of candidate particle elements, signal-noise ratios are calculated. to select a neutral beam particle element. Beam trajectories varying in incident velocity, incident angle and sampling area are obtained by iterative calculation, and a preset parameter which enables the beam trajectories to pass through an entrance slit of an analyzer is obtained. A neutral beam that meets the preset parameter is injected into the plasma. An energy of the primary beam generated by collision ionization in a sampling area is measured, and potential of the sampling area is obtained according to law of conservation of energy. Sampling areas are detected to obtain potential spatial distribution of the plasma and a radial electric field, and the diagnostic is finished.
    Type: Grant
    Filed: June 28, 2024
    Date of Patent: March 18, 2025
    Assignee: Southwest Jiaotong University
    Inventors: Yuhong Xu, Danni Wu, Yucai Li, Haifeng Liu, Jun Cheng, Junfeng Shen, Hai Liu, Xianqu Wang, Jie Huang, Xin Zhang, Jun Hu, Wei Li
  • Patent number: 12255555
    Abstract: A self-aware composite mechanical metamaterial, comprising first and second electrically conductive components disposed relative to each other to act as opposite electrodes to induce contact electrification; wherein the first and second electrically conductive components, along with a dielectric component serving as a skeleton of the self-aware composite mechanical metamaterial, form a lattice of snapping curved semicircular-shaped segments, wherein each of the snapping curved semicircular-shaped segments has an elastic snap-through instability mechanism; and wherein the lattice comprises periodic repeatable parallel rows of the snapping curved semicircular-shaped segments.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: March 18, 2025
    Assignee: University of Pittsburgh-Of The Commonwealth System of Higher Education
    Inventors: Amir Alavi, Kaveh Barri
  • Patent number: 12252591
    Abstract: A healable and recyclable polyimide polymer resin includes a chemical structural unit represented by formula (I), which is defined in the description. The chemical structural unit represented by the formula (I) bonds to at least one condensation-polymerizable monomer, so as to form the healable and recyclable polyimide polymer resin, and the condensation-polymerizable monomer is a diamine monomer or a dianhydride monomer.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: March 18, 2025
    Assignee: National Tsing Hua University
    Inventors: Ho-Hsiu Chou, Kuei-Yi Chuang
  • Patent number: 12255453
    Abstract: A method for aggregating a group of EVs based on EV flexibility includes: obtaining a prediction result on a fast charging demand of each EV based on a preset model; determining a distribution area of each substation involved in an EV activity range as an aggregation area; establishing an aggregation model based on the EV fast charging demand, in which the aggregation model includes energy balance equations and various constraints; obtaining an EV fast charging load power curve and an EV energy curve of each aggregation area based on the aggregation model; determining upper and lower limits of multiple EV fast charging load power curves as a flexibility range for the EV fast charging load power, and determining upper and lower limits of multiple EV energy curves as a flexibility range for the EV energy; and aggregating a group of EVs based on the above flexibility ranges.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: March 18, 2025
    Assignee: Tsinghua University
    Inventors: Qinglai Guo, Mengjie Liu, Yujie Sheng
  • Patent number: 12252743
    Abstract: The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ?95% of them contain the identical mutation.
    Type: Grant
    Filed: November 13, 2023
    Date of Patent: March 18, 2025
    Assignee: The Johns Hopkins University
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Isaac A. Kinde
  • Patent number: 12253582
    Abstract: Described herein relates to an apparatus and method for holding a solid state NMR rotor under vacuum gas exposure during ssMAS experiments. As such, in an embodiment, the novel gas loader cell apparatus may be miniaturized and/or formed from a material other than glass to provide ease of use, efficient use of gaseous materials, affordability, and portability. Additionally, in an embodiment, a novel forming tool may be used to form the cavity holding the rotor end cap.
    Type: Grant
    Filed: April 11, 2023
    Date of Patent: March 18, 2025
    Assignee: University of South Florida
    Inventors: Jason Mast, Edwin Rivera
  • Patent number: 12251099
    Abstract: A medical device includes a surgical needle attached to a hollow tubular suture. The suture is constructed of macroporous hollow tubular wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: March 18, 2025
    Assignee: Northwestern University
    Inventors: Gregory Dumanian, Anandev Gurjala
  • Patent number: 12252598
    Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Igor Bargatin, Zhipeng Lu, Mohsen Azadi
  • Patent number: 12252735
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: April 30, 2024
    Date of Patent: March 18, 2025
    Assignee: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Patent number: 12251401
    Abstract: Novel dinuclear silver(I) pyrazolido complexes and methods of synthesizing them are provided. Advantageously, the novel silver(I) pyrazolido complexes have excellent antimicrobial activity and methods of using said complexes to treat bacterial, fungal, and viral infections are also provided.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: March 18, 2025
    Assignee: The Florida International University Board of Trustees
    Inventors: Raphael G. Raptis, Indranil Chakraborty, Shambhu Kandel
  • Patent number: 12251478
    Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
    Type: Grant
    Filed: January 2, 2024
    Date of Patent: March 18, 2025
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Deepanjan Ghosh
  • Patent number: 12255603
    Abstract: A microelectromechanical resonator device is provided having two-dimensional resonant rods. The resonator device has a piezoelectric layer formed with a plurality of alternating rods and trenches. A bottom electrode is in contact with a bottom surface of the piezoelectric layer. A top electrode metal grating of conductive strips is aligned in contact with corresponding rods of the piezoelectric layer.
    Type: Grant
    Filed: October 10, 2023
    Date of Patent: March 18, 2025
    Assignee: Northeastern University
    Inventors: Cristian Cassella, Xuanyi Zhao
  • Patent number: 12251713
    Abstract: A method for froth-controlled flotation of argillaceous lepidolite ore, including: crushing and grinding an ore, adding water to obtain pulp; adding agents thereto, and conducting roughing to obtain roughing concentrate and roughing tailing; adding agents to the roughing tailing, and conducting first scavenging to obtain first scavenging concentrate and first scavenging tailing; subjecting the first scavenging tailing to second scavenging to obtain second scavenging concentrate and second scavenging tailing; adding agents to the roughing concentrate, conducting first cleaning to obtain first cleaning concentrate and first cleaning tailing; subjecting the first cleaning concentrate to second cleaning to obtain lithium concentrate I and second cleaning tailing; combining the first scavenging concentrate, second scavenging concentrate, first cleaning tailing, and second cleaning tailing to obtain lithium-containing mixed middling, adding agents thereto, and conducting cleaning-scavenging to obtain lithium concen
    Type: Grant
    Filed: July 24, 2024
    Date of Patent: March 18, 2025
    Assignee: Kunming University of Science and Technology
    Inventors: Qicheng Feng, Guang Han, Qian Zhang, Shuming Wen, Dianwen Liu, Wenjuan Zhao
  • Patent number: 12256588
    Abstract: The present disclosure is directed to perovskite-based solar cell device structures and compositions comprising one or more near infrared sensitive semiconducting materials. The near infrared sensitive semiconducting materials can extend the photoresponse spectra of the devices to the near infrared region, thereby improving the power conversion efficiency of the solar cell.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: March 18, 2025
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jinsong Huang, Yuze Lin, Shangshang Chen
  • Patent number: 12253587
    Abstract: The present disclosure provides transmit/receive (T/R) systems for NMR or MRI systems. In one configuration, the systems and methods provided herein may use passively-shielded coils that are compatible with low-field operational environment to replace conventional T/R systems and spatial gradient systems. In some configurations, a low-field imaging T/R system is provided that is designed for nuclear magnetic stimulation and local flux sensitivity, while automatically rejecting incident radiant electromagnetic noise. The design advantageously leverages low required frequencies to distribute the pulse synthesis task, yielding a smaller system with easier maintenance and lower cost. The system may include distributed coil nodes that include a primary radiofrequency (RF) coil configured to transmit and receive RF signals and a secondary coil configured to passively shield the primary RF coil.
    Type: Grant
    Filed: March 10, 2023
    Date of Patent: March 18, 2025
    Assignee: Case Western Reserve University
    Inventors: Nicholas Reid Bolding, Mark A. Griswold
  • Patent number: 12254385
    Abstract: A method for multi-time scale reactive voltage control based on reinforcement learning in a power distribution network is provided, which relates to the field of power system operation and control. The method includes: constituting an optimization model for multi-time scale reactive voltage control in a power distribution network based on a reactive voltage control object of a slow discrete device and a reactive voltage control object of a fast continuous device in the power distribution network; constructing a hierarchical interaction training framework based on a two-layer Markov decision process based on the model; setting a slow agent for the slow discrete device and setting a fast agent for the fast continuous device; and deciding action values of the controlled devices by each agent based on measurement information inputted, so as to realize the multi-time scale reactive voltage control while the slow agent and the fast agent perform continuous online learning.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: March 18, 2025
    Assignee: Tsinghua University
    Inventors: Wenchuan Wu, Haotian Liu, Hongbin Sun, Bin Wang, Qinglai Guo
  • Patent number: 12255456
    Abstract: Demand response methodologies for primary frequency response (PFR) for under or over frequency events. Aspects of the present disclosure include methods for controlling a fleet of distributed energy resources equipped for PFR and quantifying in real time an amount of primary frequency control capacity available in the fleet. In some examples, the DERs may be configured to consume and discharge electrical energy in discrete energy packets and be equipped with a frequency response local control law that causes each DER to independently and instantaneously interrupt an energy packet in response to local frequency measurements indicating a grid disturbance event has occurred.
    Type: Grant
    Filed: May 7, 2024
    Date of Patent: March 18, 2025
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mads Almassalkhi, Hani Mavalizadeh, Luis A. Duffaut Espinosa